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7. On early brain folding patterns using biomechanical growth modeling

Author

Wang, Xiaoyu, Bohi, Amine, Harrach, Mariam Al, Dinomais, Mickael, Lefèvre, Julien, and Rousseau, François

Subjects
Physics - Medical Physics, Physics - Biological Physics, Quantitative Biology - Neurons and Cognition
Abstract

Abnormal cortical folding patterns may be related to neurodevelopmental disorders such as lissencephaly and polymicrogyria. In this context, computational modeling is a powerful tool to provide a better understanding of the early brain folding process. Recent studies based on biomechanical modeling have shown that mechanical forces play a crucial role in the formation of cortical convolutions. However, the correlation between simulation results and biological facts, and the effect of physical parameters in these models remain unclear. In this paper, we propose a new brain longitudinal length growth model to improve brain model growth. In addition, we investigate the effect of the initial cortical thickness on folding patterns, quantifying the folds by the surface-based three-dimensional gyrification index and a spectral analysis of gyrification. The results tend to show that the use of such biomechanical models could highlight the links between neurodevelopmental diseases and physical parameters., Comment: 4 pages, 4 figures, 41st EMB Conference

Published
2019

8. Global Perturbation of Initial Geometry in a Biomechanical Model of Cortical Morphogenesis

Author

Bohi, Amine, Wang, Xiaoyu, Harrach, Mariam Al, Dinomais, Mickael, Rousseau, François, and Lefèvre, Julien

Subjects
Physics - Biological Physics, Computer Science - Graphics, Mathematics - Spectral Theory, Quantitative Biology - Quantitative Methods
Abstract

Cortical folding pattern is a main characteristic of the geometry of the human brain which is formed by gyri (ridges) and sulci (grooves). Several biological hypotheses have suggested different mechanisms that attempt to explain the development of cortical folding and its abnormal evolutions. Based on these hypotheses, biomechanical models of cortical folding have been proposed. In this work, we compare biomechanical simulations for several initial conditions by using an adaptive spherical parameterization approach. Our approach allows us to study and explore one of the most potential sources of reproducible cortical folding pattern: the specification of initial geometry of the brain., Comment: 4 pages 2 columns (IEEE style), 41st EMB Conference

Published
2019

10. A New Blood Pressure Estimation Approach Using PPG Sensors: Subject Specific Evaluation over a Long-term Period

Author

Mouney, Franck, Tiplica, Teodor, Fasquel, Jean-Baptiste, Hallab, Magid, Dinomais, Mickael, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin (Sherman), Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Paiva, Sara, editor, Lopes, Sérgio Ivan, editor, Zitouni, Rafik, editor, Gupta, Nishu, editor, Lopes, Sérgio F., editor, and Yonezawa, Takuro, editor

Published
2021
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19. Associations between Adult Primary Brain Tumor Survivors' Behavioral Executive Functions, Health Related Quality of Life and their Caregivers' Health Related Quality : A cross-sectional study.

Author

Cantisano, Nicole, Menei, Philippe, Roualdes, Vincent, Seizeur, Romuald, Allain, Philippe, Le Gall, Didier, Roy, Arnaud, Dinomais, Mickaël, and Besnard, Jérémy

Subjects
CANCER patient psychology, EXECUTIVE function, RESEARCH, CROSS-sectional method, MULTIPLE regression analysis, SELF-evaluation, MENTAL health, ACTIVITIES of daily living, BEHAVIOR, BRAIN tumors, PSYCHOLOGY of caregivers, QUALITY of life, DESCRIPTIVE statistics, QUESTIONNAIRES, RESEARCH funding, STATISTICAL correlation, ADULTS
Abstract

The present study focused on adult primary brain tumor (PBT) survivors' caregivers. The main objective was to study associations between PBT survivors' health-related quality of life (HRQOL), their behavioral executive functions (EF) and their caregivers' HRQOL. Forty PBT survivors of PBT and 37 caregivers (mostly patient's spouses 81.08%; n = 30) participated in the study. PBT survivors completed a cancer related Quality of Life (QOL) questionnaire. Caregivers completed informant rated HRQOL and behavioral EF reports relating to PBT survivors and a self-rated HRQOL questionnaire relating to themselves. Correlational and multiple regression analyses were conducted. No associations were found between caregivers' physical HRQOL and PBT survivors' HRQOL nor behavioral EF. Analyses yielded several significant correlations between caregivers' mental HRQOL and variables pertaining to PBT survivors' HRQOL and behavioral EF. Multiple regression analyses showed that caregivers' mental HRQOL is predicted by PBT survivors' mental HRQOL, global cancer-related QOL scores and global behavioral EF scores. This study provides evidence suggesting that during the survivorship phase, at an average of 3.67 (SD = 2.31) years following treatment for a PBT, caregivers mental HRQOL is linked to PBT survivors' long-term effects. These findings shed some light regarding post-cancer care for both PBT survivors and their caregivers. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Multimodal Outcome at 7 Years of Age after Neonatal Arterial Ischemic Stroke

Author

Darteyre, Stéphane, Dégano, Céline, Delion, Matthieu, Groeschel, Samuel, Hertz-Pannier, Lucie, Husson, Béatrice, Presles, Emilie, Ravel, Magaly, Vuillerot, Carole, Chabrier, Stéphane, Peyric, Emeline, Drutel, Laure, Deron, Johanna, Kossorotoff, Manoëlle, Dinomais, Mickaël, Lazaro, Leila, Lefranc, Jérémie, Thébault, Guillaume, Dray, Gérard, Fluss, Joel, Renaud, Cyrille, and Nguyen The Tich, Sylvie

Published
2016
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26. Parent satisfaction with medical and rehabilitation services for children with physical disabilities during lockdown

Author

Filly, Emmanuelle, Mensah-Gourmel, Johanne, Génot, Amélie, Ropars, Juliette, Toullet, Philippe, De Lattre, Capucine, Klinger, Evelyne, Laffont, Isabelle, Sitruk, Clara, Van Boagert, Patrick, Tessiot, Chantal, Cacioppo, Marine, Lucas, Clémence, Dai, Shenhao, Bailly, Rodolphe, Pérennou, Dominic, Varengue, Roxane, Houx, Laetitia, Lempereur, Mathieu, Kandalaft, Christèle, Chatelin, Alain, Vagnoni, Jacky, Vuillerot, Carole, Gautheron, Vincent, Dinomais, Mickael, Dheilly, Elea, Bouvier, Sandra, Brochard, Sylvain, and Pons, Christelle

Published
2023
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27. The influence of biophysical parameters in a biomechanical model of cortical folding patterns

Author

Wang, Xiaoyu, Lefèvre, Julien, Bohi, Amine, Harrach, Mariam Al, Dinomais, Mickaël, Rousseau, François, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Traitement de l'Information Medicale (LaTIM), Institut National de la Santé et de la Recherche Médicale (INSERM)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Département lmage et Traitement Information (IMT Atlantique - ITI), IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS), Université d'Angers (UA), The research leading to these results has been supported by the Fondation pour la Recherche Médicale (Grant DIC20161236453)., Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut Brestois Santé Agro Matière (IBSAM), IMT Atlantique (IMT Atlantique), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Jonchère, Laurent

Subjects
[SDV.IB] Life Sciences [q-bio]/Bioengineering, Cerebral Cortex, Science, Applied mathematics, Biophysical Phenomena, Article, Mechanical engineering, Biomechanical Phenomena, Humans, Medicine, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Computer Simulation, Biological physics
Abstract

International audience; Abnormal cortical folding patterns, such as lissencephaly, pachygyria and polymicrogyria malformations, may be related to neurodevelopmental disorders. In this context, computational modeling is a powerful tool to provide a better understanding of the early brain folding process. Recent studies based on biomechanical modeling have shown that mechanical forces play a crucial role in the formation of cortical convolutions. However, the effect of biophysical parameters in these models remain unclear. In this paper, we investigate the effect of the cortical growth, the initial geometry and the initial cortical thickness on folding patterns. In addition, we not only use several descriptors of the folds such as the dimensionless mean curvature, the surface-based three-dimensional gyrification index and the sulcal depth, but also propose a new metric to quantify the folds orientation. The results demonstrate that the cortical growth mode does almost not affect the complexity degree of surface morphology; the variation in the initial geometry changes the folds orientation and depth, and in particular, the slenderer the shape is, the more folds along its longest axis could be seen and the deeper the sulci become. Moreover, the thinner the initial cortical thickness is, the higher the spatial frequency of the folds is, but the shallower the sulci become, which is in agreement with the previously reported effects of cortical thickness.

Published
2021

33. Specific age‐correlated activation of top hierarchical motor control areas during gait‐like plantar stimulation: An fMRI study

Author

Jeanvoine, Henry, primary, Labriffe, Matthieu, additional, Tannou, Thomas, additional, Navasiolava, Nastassia, additional, Ter Minassian, Aram, additional, Girot, Jean‐Baptiste, additional, Leiber, Louis‐Marie, additional, Custaud, Marc‐Antoine, additional, Annweiler, Cédric, additional, and Dinomais, Mickaël, additional

Published
2021
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34. Volumetric Brain Changes in Older Fallers: A Voxel-Based Morphometric Study

Author

Le Floch, Maxime, Ali, Pauline, Asfar, Marine, Sánchez-Rodríguez, Dolores, Dinomais, Mickaël, and Annweiler, Cédric

Subjects
brain, motor control, Bioengineering and Biotechnology, brain mapping, accidental falls, older adults, Original Research
Abstract

Background Falls are frequent and severe in older adults, especially among those with cognitive impairments due to altered motor control. Which brain areas are affected among fallers remains yet not elucidated. The objective of this cross-sectional analysis was to determine whether the history of falls correlated with focal brain volume reductions in older adults. Methods Participants from the MERE study (n = 208; mean, 71.9 ± 5.9 years; 43% female; 38% cognitively healthy, 41% with mild cognitive impairment and 21% with dementia) were asked about their history of falls over the preceding year and received a 1.5-Tesla MRI scan of the brain. Cortical gray and white matter subvolumes were automatically segmented using Statistical Parametric Mapping. Age, gender, use of psychoactive drugs, cognitive status, and total intracranial volume were used as covariates. Results Fifty-eight participants (28%) reported history of falls. Fallers were older (P = 0.001), used more often psychoactive drugs (P = 0.008) and had more often dementia (P = 0.004) compared to non-fallers. After adjustment, we found correlations between the history of falls and brain subvolumes; fallers exhibiting larger gray matter subvolumes in striatum, principally in bilateral caudate nucleus, than non-fallers. By stratifying on cognitive status, these neuroanatomical correlates were retrieved only in participants with MCI or dementia. There were no correlations with the subvolumes of white matter. Conclusion Older fallers had larger subvolumes in bilateral striatum than non-fallers, principally within the caudate nucleus. This suggests a possible brain adaptative mechanism of falls in people with neurocognitive decline.

Published
2021

36. HABIT-ILE chez les enfants d’âge préscolaire atteints de paralysie cérébrale unilatérale : un essai contrôlé randomisé multisite

Author

Araneda, Rodrigo, Ebner-Karestinos, Daniela, Paradis, Julie, Bailly, Rodolphe, Bouvier, Sandra, Klöcker, Anne, Saussez, Geoffroy, Demas, Josselin, Sizonenko, Stéphane, Newman, Christopher, Dinomais, Mickael, Legal, Grégoire, Nowak, Emmanuel, Guzzetta, Andrea, Brochard, Sylvain, and Bleyenheuft, Yannick

Published
2023
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39. Specific age‐correlated activation of top hierarchical motor control areas during gait‐like plantar stimulation: An fMRI study.

Author

Jeanvoine, Henry, Labriffe, Matthieu, Tannou, Thomas, Navasiolava, Nastassia, Ter Minassian, Aram, Girot, Jean‐Baptiste, Leiber, Louis‐Marie, Custaud, Marc‐Antoine, Annweiler, Cédric, and Dinomais, Mickaël

Subjects
FUNCTIONAL magnetic resonance imaging, OLDER people, GAIT disorders, MONTE Carlo method, PREFRONTAL cortex
Abstract

A better understanding of gait disorders that are associated with aging is crucial to prevent adverse outcomes. The functional study of gait remains a thorny issue due to technical constraints inherent to neuroimaging procedures, as most of them require to stay supine and motionless. Using an MRI‐compatible system of boots reproducing gait‐like plantar stimulation, we investigated the correlation between age and brain fMRI activation during simulated gait in healthy adults. Sixty‐seven right‐handed healthy volunteers aged between 20 and 77 years old (49.2 ± 18.0 years; 35 women) were recruited. Two paradigms were assessed consecutively: (a) gait‐like plantar stimulation and (b) chaotic and not gait‐related plantar stimulation. Resulting statistical parametric maps were analyzed with a multiple‐factor regression that included age and a threshold determined by Monte‐Carlo simulation to fulfill a family‐wise error rate correction of p <.05. In the first paradigm, there was an age‐correlated activation of the right pallidum, thalamus and putamen. The second paradigm showed an age‐correlated deactivation of both primary visual areas (V1). The subtraction between results of the first and second paradigms showed age‐correlated activation of the right presupplementary motor area (Brodmann Area [BA] 6) and right mid‐dorsolateral prefrontal cortex (BA9‐10). Our results show age‐correlated activity in areas that have been associated with the control of gait, highlighting the relevance of this simulation model for functional gait study. The specific progressive activation of top hierarchical control areas in simulated gait and advancing age corroborate a progressive loss of automation in healthy older adults. [ABSTRACT FROM AUTHOR]

Published
2022
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44. Manual dexterity, but not cerebral palsy, predicts cognitive functioning after neonatal stroke

Author

Thébault, Guillaume, Martin, Sophie, Brouillet, Denis, Brunel, Lionel, Dinomais, Mickaël, Presles, Emilie, Fluss, Joel, Chabrier, Stéphane, Darteyre, Stéphane, Dégano, Céline, Delion, Matthieu, Deron, Johanna, Dray, Gérard, Drutel, Laure, Groeschel, Samuel, Hertz‐Pannier, Lucie, Husson, Béatrice, Kossorotoff, Manoelle, Lazaro, Leila, Lefranc, Jérémie, Nguyen The Tich, Sylvie, Peyric, Emeline, Ravel, Magaly, Renaud, Cyrille, Vuillerot, Carole, Dynamique des capacités humaines et des conduites de santé (EPSYLON), Université de Montpellier (UM)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université Montpellier 1 (UM1), Institut national de recherches archéologiques préventives (Inrap), Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS), Université d'Angers (UA), Groupe de recherche sur la thrombose (GRT (EA 3065)), Université Jean Monnet [Saint-Étienne] (UJM), service de médecine physique et réadaptation pédiatrique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Bellevue-CHU de Saint-Etienne, Département de neurochirurgie [Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Service de neurologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Génétique Clinique, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-hôpital Sud, CHRU de Brest - Département de Pédiatrie (CHU BREST Pédiatrie), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Service de neurologie pédiatrique, Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Pédiatrie hospices civils de Lyon, hôpital Femme-Mère-Enfant, Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UM3)-Université de Montpellier (UM), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Sud, Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université de Montpellier (UM), and CHU Necker - Enfants Malades [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)

Subjects
Male, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Population, Stroke/complications/diagnosis/physiopathology/psychology, Functional Laterality, Cerebral palsy, Brain Ischemia, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Physical medicine and rehabilitation, Cognition, Sex Factors, Developmental Neuroscience, 030225 pediatrics, Medicine, Humans, Cognitive skill, education, Child, Motor skill, Neonatal stroke, ComputingMilieux_MISCELLANEOUS, Wechsler Intelligence Scale for Children, education.field_of_study, ddc:618, business.industry, Cerebral Palsy, Hand/physiopathology, medicine.disease, Hand, Stroke, Socioeconomic Factors, Motor Skills, Pediatrics, Perinatology and Child Health, Linear Models, Female, Neurology (clinical), Cerebral Palsy/complications/diagnosis/physiopathology/psychology, business, Brain Ischemia/complications/diagnosis/physiopathology/psychology, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Follow-Up Studies
Abstract

Aim To disentangle the respective impacts of manual dexterity and cerebral palsy (CP) in cognitive functioning after neonatal arterial ischaemic stroke. Method The population included 60 children (21 females, 39 males) with neonatal arterial ischaemic stroke but not epilepsy. The presence of CP was assessed clinically at the age of 7 years and 2 months (range 6y 11mo-7y 8mo) using the definition of the Surveillance of CP in Europe network. Standardized tests (Nine-Hole Peg Test and Box and Blocks Test) were used to quantify manual (finger and hand respectively) dexterity. General cognitive functioning was evaluated with the Wechsler Intelligence Scale for Children, Fourth Edition. Simple and multiple linear regression models were performed while controlling for socio-economic status, lesion side, and sex. Results Fifteen children were diagnosed with CP. In simple regression models, both manual dexterity and CP were associated with cognitive functioning (β=0.41 [p=0.002] and β=0.31 [p=0.019] respectively). However, in multiple regression models, manual dexterity was the only associated variable of cognitive functioning, whether or not a child had CP (β=0.35; p=0.007). This result was reproduced in models with other covariables (β=0.31; p=0.017). Interpretation As observed in typically developing children, manual dexterity is related to cognitive functioning in children having suffered a focal brain insult during the neonatal period. What this paper adds Manual dexterity predicts cognitive functioning after neonatal arterial ischaemic stroke. Correlations between manual dexterity and cognitive functioning occur irrespective of sex, lesion side, presence of cerebral palsy, and socio-economic status. Residual motor ability may support cognitive functioning.

Published
2018

45. Does Contralesional Hand Function After Neonatal Stroke Only Depend on Lesion Characteristics?

Author

Dinomais, Mickaël, Hertz-Pannier, L., Groeschel, Samuel, Delion, M., Husson, B., Kossorotoff, M., Renaud, C., Chabrier, S., Nguyen The Tich, Sylvie, Study, AVCnn, Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS), Université d'Angers (UA), Département de Médecine Physique et de Réadaptation , CHU Angers , Angers , France., UNIACT-Neurospin, CEA-Saclay, InsermU1129 and Paris-Descartes University, Sorbonne Paris-Cité, Paris, France, Department of Child Neurology, University Hospital Tübingen, Tübingen, Germany, Département de Neurochirurgie [CHU Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Pediatric Radiology Department, University Hospital Bicêtre, Pediatric Neurology Department, University Hospital Necker, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Pediatric PRM Department, University Hospital Saint-Étienne, Saint-Étienne, France, Pediatric Neurology Department and Environnement Périnatale et Santé, University Hospital Lille, Lille University, Lille, France, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
Male, medicine.medical_specialty, Internal capsule, [SDV]Life Sciences [q-bio], Corpus callosum, Infant, Newborn, Diseases, Brain Ischemia, White matter, Brain ischemia, 03 medical and health sciences, 0302 clinical medicine, atrophy, 030225 pediatrics, Internal medicine, medicine, Humans, magnetic resonance imaging, Gray Matter, Child, Neonatal stroke, Advanced and Specialized Nursing, cerebral palsy, cerebral peduncle, medicine.diagnostic_test, business.industry, Cerebral peduncle, Infant, Newborn, Magnetic resonance imaging, Anatomy, Hand, medicine.disease, White Matter, stroke, medicine.anatomical_structure, dexterity, Motor Skills, Corticospinal tract, Cardiology, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery, motor system
Abstract

Background and Purpose— In children having suffered from neonatal arterial ischemic stroke, the relationship between contralesional hand performance and structural changes in brain areas remote from the infarct site was examined. Methods— Using voxel-based morphometry, we correlated contralesional gross manual dexterity assessed by the box and block test and whole-brain gray and white-matter volume changes on high-resolution magnetic resonance imaging in 37 7-year-old post–neonatal arterial ischemic stroke children. We also compared the volume of the identified structures with magnetic resonance imaging data of 10 typically developing age-matched children. Results— Areas showing the highest positive correlation with the box and block test scores were ipsilesional mediodorsal thalamus, contralesional cerebellar lobule VIIa Crus I, and ipsilesional corticospinal tract at the level of superior corona radiata, the posterior limb of the internal capsule, and the cerebral peduncle and the ipsilesional body of corpus callosum. When compared with typically developing age-matched children, post–neonatal arterial ischemic stroke children with severe contralesional hand motor deficit exhibited significant volume reductions in these structures (except the cerebellum), whereas no differences were found with those with good manual dexterity. No negative correlation was found between box and block test scores and brain areas. Conclusions— Contralesional hand performance after neonatal arterial ischemic stroke is correlated with atrophy in brain areas directly or functionally connected but anatomically remote from the infarct. Our study suggests a role of the cerebellar lobule VIIa Crus I and mediodorsal thalamus in manual dexterity. Clinical Trial Registration— URL: https://clinicaltrials.gov . Unique identifier: NCT02511249.

Published
2016

48. The Authors Respond

Author

Frémondière, Flavie, Lacoeuille, Franck, Sher, Avigaëlle, Couturier, Olivier, Menei, Philippe, Richard, Isabelle, and Dinomais, Mickaël

Published
2016
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49. Association of transcallosal motor fibres with function of both hands after unilateral neonatal arterial ischemic stroke

Author

Groeschel, Samuel, Hertz‐Pannier, Lucie, Delion, Matthieu, Loustau, Sébastien, Husson, Béatrice, Kossorotoff, Manoelle, Renaud, Cyrille, Nguyen The Tich, Sylvie, Chabrier, Stéphane, Dinomais, Mickaël, Darteyre, Stéphane, Dégano, Céline, Deron, Johanna, Dray, Gérard, Drutel, Laure, Lazaro, Leila, Lefranc, Jérémie, Peyric, Emeline, Presles, Emilie, Ravel, Magaly, Thébault, Guillaume, Vuillerot, Carole, Department of Child Neurology, University Hospital Tübingen, Tübingen, Germany, Unité de recherche en NeuroImagerie Applicative Clinique et Translationnelle (UNIACT), Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Département de neurochirurgie [Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Laboratoire d'Analyse, Topologie, Probabilités (LATP), Université Paul Cézanne - Aix-Marseille 3-Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), Service de neurologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Groupe de recherche sur la thrombose (GRT (EA 3065)), Université Jean Monnet [Saint-Étienne] (UJM), Service de neurologie pédiatrique, service de médecine physique et réadaptation pédiatrique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Bellevue-CHU de Saint-Etienne, Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS), Université d'Angers (UA), PRES Université Nantes Angers Le Mans (UNAM), Department of Pediatrics, French Polynesia Hospital, Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Service de pédiatrie, Le CHCB, Centre Hospitalier de la Côte Basque, CHRU de Brest - Département de Pédiatrie (CHU BREST Pédiatrie), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Dynamique des capacités humaines et des conduites de santé (EPSYLON), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université de Montpellier (UM), Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL), Universitätsklinikum Tübingen - University Hospital of Tübingen, Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT), Laboratoire Angevin de Recherche en Mathématiques (LAREMA), Université d'Angers (UA)-Centre National de la Recherche Scientifique (CNRS), Hôpital Bicêtre, Université Paris-Sud - Paris 11 (UP11), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), CHU Lille, AVCnn study group: Stéphane Darteyre, Céline Dégano, Johanna Deron, Gérard Dray, Laure Drutel, Manoëlle Kossorotoff, Leila Lazaro, Jérémie Lefranc, Emeline Peyric, Emilie Presles, Magaly Ravel, Guillaume Thébault, Carole Vuillerot, Gerard, Marie-Françoise, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UM3)-Université de Montpellier (UM), CHU Necker - Enfants Malades [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), and ANR-11-LABX-0020,LEBESGUE,Centre de Mathématiques Henri Lebesgue : fondements, interactions, applications et Formation(2011)

Subjects
Male, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Pyramidal Tracts, Lesion volume, Motor Activity, Corpus callosum, Functional Laterality, Brain Ischemia, Corpus Callosum, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Developmental Neuroscience, 030225 pediatrics, medicine.artery, medicine, Humans, Association (psychology), Child, medicine.diagnostic_test, Motor Cortex, Magnetic resonance imaging, Anatomy, Organ Size, Hand, Arterial Ischemic Stroke, Magnetic Resonance Imaging, [SDV] Life Sciences [q-bio], Stroke, Diffusion Tensor Imaging, Pediatrics, Perinatology and Child Health, Corticospinal tract, Middle cerebral artery, Female, Neurology (clinical), Psychology, 030217 neurology & neurosurgery, Diffusion MRI
Abstract

International audience; AIM: The objective of this study was to investigate the involvement of the motor fibres of the corpus callosum after unilateral neonatal arterial ischemic stroke (NAIS) of the middle cerebral artery territory and the relationship to both ipsilesional and contralesional hand function.METHOD: Using high-resolution structural magnetic resonance imaging (MRI), functional MRI, and magnetic resonance diffusion-tractography, we compared the midsagittal area of the motor part of the corpus callosum (defined by the fibres connecting the precentral gyri) between 33 7-year-old children after unilateral NAIS and 31 typically developing 7-year-old children. Hand motor performance was assessed by the box and blocks test.RESULTS: Children after NAIS showed on average significantly smaller motor corpus callosum area compared to typically developing children (p|t|)=0.034) and ipsilesional hand motor performance (Pr(>|t|)=0.006) after controlling for lesion volume and sex. In a post-hoc analysis the additional contribution of corticospinal tract damage was evaluated.INTERPRETATION: Compared to typically developing children, children after NAIS exhibited a smaller motor part of their corpus callosum associated with reduced contralesional but also ipsilesional manual dexterity. These results indicate that the affection of transcallosal motor fibres in unilateral NAIS might be of functional relevance and an important part of the involved structural network that should be elucidated in further studies.TRIAL REGISTRATION: ClinicalTrials.gov NCT02511249.© 2017 Mac Keith Press.

Published
2017

50. Vitamin D concentration and focal brain atrophy in older adults: a voxel‐based morphometric study.

Author

Ali, Pauline, Labriffe, Matthieu, Navasiolava, Nastassia, Custaud, Marc‐Antoine, Dinomais, Mickaël, and Annweiler, Cédric

Subjects
OLDER people, CEREBRAL atrophy, VITAMIN D, VOXEL-based morphometry
Abstract

Vitamin D is involved in brain health and function. Our objective was to determine whether lower 25‐hydroxyvitamin D (25OHD) concentration was associated with focal brain volume reduction in older adults. Serum 25OHD concentration was measured among 53 older adults (72 ± 5 years; 38% female; mean 25OHD = 67.3 ± 20.8 nmol/L). Gray matter volume (GMV) was automatically segmented using voxel‐based morphometry with CAT12 software. Covariables were age, gender, education, total intracranial volume, and season. Serum 25OHD was positively associated with GMV in left calcarine sulcus (P < 0.05, TFCE, FWE‐corrected). We found atrophy of the calcarine sulcus with lower 25OHD concentrations in older adults. [ABSTRACT FROM AUTHOR]

Published
2020
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