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20 results on '"Dinyari P"'

1. Learning to Play by Imitating Humans

Author

Dinyari, Rostam, Sermanet, Pierre, and Lynch, Corey

Subjects
Computer Science - Robotics, Computer Science - Artificial Intelligence, Computer Science - Machine Learning, Electrical Engineering and Systems Science - Systems and Control
Abstract

Acquiring multiple skills has commonly involved collecting a large number of expert demonstrations per task or engineering custom reward functions. Recently it has been shown that it is possible to acquire a diverse set of skills by self-supervising control on top of human teleoperated play data. Play is rich in state space coverage and a policy trained on this data can generalize to specific tasks at test time outperforming policies trained on individual expert task demonstrations. In this work, we explore the question of whether robots can learn to play to autonomously generate play data that can ultimately enhance performance. By training a behavioral cloning policy on a relatively small quantity of human play, we autonomously generate a large quantity of cloned play data that can be used as additional training. We demonstrate that a general purpose goal-conditioned policy trained on this augmented dataset substantially outperforms one trained only with the original human data on 18 difficult user-specified manipulation tasks in a simulated robotic tabletop environment. A video example of a robot imitating human play can be seen here: https://learning-to-play.github.io/videos/undirected_play1.mp4 more...

Published
2020

2. Nuclear-spin-dependent coherent population trapping of single nitrogen vacancy centers in diamond

Author

Golter, D. Andrew, Dinyari, Khodadad N., and Wang, Hailin

Subjects
Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Atomic Physics
Abstract

Coherent population trapping (CPT) provides a highly sensitive means for probing the energy level structure of an atomic system. For a nitrogen vacancy center in diamond, the CPT offers an alternative to the standard optically-detected magnetic resonance method for measuring the hyperfine structure of the electronic ground states. We show that the nuclear spin dependent CPT measures directly the hyperfine splitting of these states due to the 14N nuclear spin. The CPT spectral response obtained in the presence of a strong microwave field, resonant or nearly resonant with a ground state spin transition, maps out the dynamic Stark splitting induced by the coherent spin excitation. more...

Published
2013
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5. ALEMTUZUMAB INDUCTION AND TAC/MMF MAINTENANCE SUBSTANTIALLY IMPROVES LONG TERM INSULIN INDEPENDENCE RATES AFTER CLINICAL ISLET TRANSPLANTATION, AND STRONGLY SUPPRESSES BOTH AUTO AND ALLOREACTIVITY

Author

Shapiro, A. M.J., primary, Toso, C., additional, Koh, A., additional, Calne, S. R., additional, Kin, T., additional, OʼGorman, D., additional, Malcolm, A., additional, Dinyari, P., additional, Imes, S., additional, Owen, R., additional, Kneteman, N. M., additional, Bigam, D., additional, Senior, P., additional, and Roep, B., additional more...

Published
2010
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7. Computational study on stereoselective synthesis of substituted 1H-tetrazoles via a click reaction: DFT and QTAIM approaches.

Author

Hosseinnejad, Tayebeh and Dinyari, Mahnaz

Subjects
STEREOSELECTIVE reactions, TETRAZOLES, CLICK chemistry, HETEROCYCLIC compounds synthesis, DENSITY functional theory, ACRYLONITRILE
Abstract

In the present research, the observed stereoselectivity in catalyst-free click synthesis of 1H-tetrazole-5-yl-acrylonitriles has been modeled by means of density functional theory (DFT) employed to investigate the structural and thermochemical aspects of this synthesis in the gas and solution phases. Comparison of our calculated structural parameters of the title compound with the available X-ray crystallographical data demonstrated a reliable agreement. Then, the effect of five different solvents, benzene, chloroform, ethanol, methanol and water was examined via polarized continuum model (PCM) calculations, showing a significant decrease in the computed values of the reaction enthalpy and free energy changes compared with the gas phase results and also the thermodynamical preference in using water solution in comparison with nonpolar solvents such as benzene and other protic and aprotic polar ones such as methanol, ethanol and chloroform that is in confirmation with the experimental observations. Additionally, we have concentrated on origins of the observed stereoselectivity by means of topological electronic indices via quantum theory of atoms in molecule (QTAIM) approach. In this respect, we have assessed the variation of electronic density and its Laplacian at some selected bond critical points of stereoisomer products, their corresponded transition states and intermediate and also construe the experimental elucidations. [ABSTRACT FROM AUTHOR] more...

Published
2015
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9. Soluble Donor DNA and Islet Injury After Transplantation

Author

Gadi, Vijayakrishna K., Nelson, J. Lee, Guthrie, Katherine A., Anderson, Colin C., Boespflug, Nicholas D., Redinger, Jeffrey W., Paul, Biswajit, Dinyari, Parastoo, and Shapiro, A.M. James

Abstract

A large proportion of clinical islet transplant recipients fail to initially achieve or sustain meaningful independence from exogenous insulin use. We hypothesized that immediate allograft injury is a key constraint on independence from exogenous insulin use. more...

Published
2011
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10. Supplemental Islet Infusions Restore Insulin Independence After Graft Dysfunction in Islet Transplant Recipients

Author

Koh, Angela, Imes, Sharleen, Kin, Tatsuya, Dinyari, Parastoo, Malcolm, Andrew, Toso, Christian, Shapiro, A M. James, and Senior, Peter

Abstract

The ability of supplemental islet infusions (SII) to restore insulin independence in islet transplant recipients with graft dysfunction has been attributed to the coadministration of exenatide. However, improving islet transplant outcomes could explain the success of SII. We aimed to determine the effect on islet graft function and insulin independence of SII using these new protocols, without the use of exenatide. more...

Published
2010
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11. Insulin-Heparin Infusions Peritransplant Substantially Improve Single-Donor Clinical Islet Transplant Success

Author

Koh, Angela, Senior, Peter, Salam, Abdul, Kin, Tatsuya, Imes, Sharleen, Dinyari, Parastoo, Malcolm, Andrew, Toso, Christian, Nilsson, Bo, Korsgren, Olle, and Shapiro, A. M. James

Abstract

Successful islet transplantation can result in insulin independence in many patients with type 1 diabetes mellitus, but it often requires more than one islet infusion. The ability to achieve insulin independence with a single donor is an important goal in clinical islet transplantation due to the limited organ supply. more...

Published
2010
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12. Histologic Graft Assessment After Clinical Islet Transplantation

Author

Toso, Christian, Isse, Kumiko, Demetris, Anthony J., Dinyari, Parastoo, Koh, Angela, Imes, Sharleen, Kin, Tatsuya, Emamaullee, Juliet, Senior, Peter, and Shapiro, A M. James

Abstract

An accurate monitoring would help understanding the fate of islet grafts after transplantation.

Published
2009
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14. Quality of Life After Islet Transplant Impact of the Number of Islet Infusions and Metabolic Outcome

Author

Toso, Christian, Shapiro, A M. James, Bowker, Samantha, Dinyari, Parastoo, Paty, Breay, Ryan, Edmond A., Senior, Peter, and Johnson, Jeffrey A.

Abstract

The health-related quality of life (HRQL; Health Utilities Index Mark 2) and the fear of hypoglycemia (Hypoglycemia Fear Survey) were assessed after islet transplant; the impact of a single islet infusion and of the metabolic outcome were determined. A control group included 166 patients with type 1 diabetes. Islet transplant had no impact on overall HRQL. Prior to transplant, islet recipients had more fear of hypoglycemia than controls (P<0.000001), but this improved up to 36 months after transplant (P<0.00001, pretransplant vs. each time point). With a single islet infusion, this fear improved substantially (P<0.00001), but improved further with subsequent islet infusions (P≤0.01). Fear of hypoglycemia correlated with the occurrence of hypoglycemia (r0.47, P0.01), and even more so with blood glucose stability (r0.56, P0.0007) and insulin requirement (r0.69, P0.000002). more...

Published
2007
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17. Impairment of the Fibrinolytic System is Present and is a Marker for Endothelial Dysfunction in Adolescents after Kawasaki Disease

Author

McCrindle, Brian W, Albisetti, Manuela, Chan, Anthony KC, Wong, Derek, Vegh, Patricia, Adams, Margaret, Dinyari, Maria, Monagle, Paul, and Andrew, Maureen

Abstract

Impairment of the fibrinolytic system is one of the most sensitive markers of endothelial dysfunction, and a major risk factor for future cardiovascular disease in adults. Persistent endothelial dysfunction, which is an early pathophysiological event in atherogenesis, occurs in some patients following Kawasaki disease (KD). The aim of this study was to assess whether impaired fibrinolysis is present in long-term survivors of KD. The study included 42 children with a documented history of KD presenting without coronary lesions (n = 22), with resolved coronary aneurysms (n = 13), or with persistent giant aneurysms (n = 7), and 26 healthy age-matched teenagers as controls. Blood samples were collected from all patients and controls prior to and following venous occlusion (VO) stress testing, and assayed for tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI)-1, plasminogen, alpha2-antiplasmin (a2-AP), alpha2-macroglobulin (a2-M), D-Dimer, fibrinogen, and von Willebrand factor (vWF). Significantly decreased fibrinolytic activity following VO was detected in patients compared to controls due to decreased tPA antigen, and increased PAI-1 activity. In addition, patients had significantly increased plasma concentrations of plasminogen and fibrinogen, which were related to similar increases of a2-M compared to controls. Decreased fibrinolytic activity was found in patients with coronary aneurysms but also in those without coronary lesions. In summary, a decreased fibrinolytic activity reflects persistent endothelial damage following acute KD, potentially predisposing these patients to accelerated atherosclerosis and cardiovascular disease in early adult life. more...

Published
2003
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18. Comparison of metabolic responses to the mixed meal tolerance test vs the oral glucose tolerance test after successful clinical islet transplantation.

Author

Forbes S, Lam A, Koh A, Imes S, Dinyari P, Malcolm AJ, Shapiro AMJ, and Senior PA

Subjects
Adult, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, ROC Curve, Diabetes Mellitus, Type 1 surgery, Fasting, Glucose Tolerance Test methods, Graft Survival, Islets of Langerhans Transplantation methods, Meals, Postprandial Period
Abstract

Following islet transplantation, mixed meal tolerance tests (MMTs) are routinely utilized to assess graft function, but how the 90-minute MMTT glucose value relates to a 120-minute glucose concentration of ≥11.1 mmol/L used to diagnose diabetes following a standardized 75 g-OGTT, is not known. We examined this relationship further. Thirteen subjects with Type 1 diabetes and stable transplant grafts, not on exogenous insulin with HbA1c < 7% (53 mmol/mol), were studied on 17 occasions with paired OGTTs and MMTTs. Receiver operating characteristic (ROC) curves were constructed to derive the 90-minute MMTT glucose threshold associated with a 120-minute glucose concentration following a 75 g-OGTT (OGTT 120 ) ≥11.1 mmol/L and their diagnostic accuracy. Studies with OGTT 120 ≥11.1 mmol/L (n = 5) had diminished C-peptide: glucose, greater integrated glucose and diminished insulin: glucose area under the curve (AUC) ratios (0-120 minutes) and disposition indices; all P < .05, contrasting with MMTTs where no difference in the 90-minute glucose concentrations, C-peptide:glucose, integrated glucose, C-peptide and C-peptide: glucose AUCs (0-90 minutes) was seen; all P > .05. A 90-minute MMTT glucose concentration ≥8.0 mmol/L demonstrated a sensitivity and specificity of ≥80% for the diagnosis of OGTT 120 ≥11.1 mmol/L; area under ROC curve (mean ± SEM) 73 ± 13%. A 90-minute MMTT glucose ≥8.0 mmol/L, identifies islet transplant recipients who may require closer monitoring for graft dysfunction., (© 2018 The Authors. Clinical Transplantation Published by John Wiley & Sons Ltd.) more...

Published
2018
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19. Purified Human Pancreatic Islets, CIT Culture Media with Lisofylline or Exenatide.

Author

Ansite J, Balamurugan AN, Barbaro B, Battle J, Brandhorst D, Cano J, Chen X, Deng S, Feddersen D, Friberg A, Gilmore T, Goldstein JS, Holbrook E, Khan A, Kin T, Lei J, Linetsky E, Liu C, Luo X, McElvaney K, Min Z, Moreno J, O'Gorman D, Papas KK, Putz G, Ricordi C, Szot G, Templeton T, Wang L, Wilhelm JJ, Willits J, Wilson T, Zhang X, Avila J, Begley B, Cano J, Carpentier S, Holbrook E, Hutchinson J, Larsen CP, Moreno J, Sears M, Turgeon NA, Webster D, Deng S, Lei J, Markmann JF, Bridges ND, Czarniecki CW, Goldstein JS, Putz G, Templeton T, Wilson T, Eggerman TL, Al-Saden P, Battle J, Chen X, Hecyk A, Kissler H, Luo X, Molitch M, Monson N, Stuart E, Wallia A, Wang L, Wang S, Zhang X, Bigam D, Campbell P, Dinyari P, Kin T, Kneteman N, Lyon J, Malcolm A, O'Gorman D, Onderka C, Owen R, Pawlick R, Richer B, Rosichuk S, Sarman D, Schroeder A, Senior PA, Shapiro AMJ, Toth L, Toth V, Zhai W, Johnson K, McElroy J, Posselt AM, Ramos M, Rojas T, Stock PG, Szot G, Barbaro B, Martellotto J, Oberholzer J, Qi M, Wang Y, Bayman L, Chaloner K, Clarke W, Dillon JS, Diltz C, Doelle GC, Ecklund D, Feddersen D, Foster E, Hunsicker LG, Jasperson C, Lafontant DE, McElvaney K, Neill-Hudson T, Nollen D, Qidwai J, Riss H, Schwieger T, Willits J, Yankey J, Alejandro R, Corrales AC, Faradji R, Froud T, Garcia AA, Herrada E, Ichii H, Inverardi L, Kenyon N, Khan A, Linetsky E, Montelongo J, Peixoto E, Peterson K, Ricordi C, Szust J, Wang X, Abdulla MH, Ansite J, Balamurugan AN, Bellin MD, Brandenburg M, Gilmore T, Harmon JV, Hering BJ, Kandaswamy R, Loganathan G, Mueller K, Papas KK, Pedersen J, Wilhelm JJ, Witson J, Dalton-Bakes C, Fu H, Kamoun M, Kearns J, Li Y, Liu C, Luning-Prak E, Luo Y, Markmann E, Min Z, Naji A, Palanjian M, Rickels M, Shlansky-Goldberg R, Vivek K, Ziaie AS, Fernandez L, Kaufman DB, Zitur L, Brandhorst D, Friberg A, and Korsgren O more...

Published
2017

20. Effect of different induction strategies on effector, regulatory and memory lymphocyte sub-populations in clinical islet transplantation.

Author

Toso C, Edgar R, Pawlick R, Emamaullee J, Merani S, Dinyari P, Mueller TF, Shapiro AM, and Anderson CC

Subjects
Alemtuzumab, Antibodies, Monoclonal, Humanized, Antilymphocyte Serum, Daclizumab, Female, Flow Cytometry, Humans, Male, Middle Aged, Prospective Studies, Antibodies, Monoclonal pharmacology, Antibodies, Neoplasm pharmacology, Immunoglobulin G pharmacology, Immunosuppressive Agents pharmacology, Islets of Langerhans Transplantation immunology, Lymphocyte Subsets drug effects, Lymphocyte Subsets immunology
Abstract

This prospective study assessed lymphocyte subsets in the peripheral blood of 42 islet allograft recipients using flow cytometry from 2 weeks and up to 2 years post-transplantation. Subjects received daclizumab (n = 16), Thymoglobulin (n = 12) or alemtuzumab (n = 14). Alemtuzumab was associated with an early (within 1 month) and transient (up to 6 months) increase in the frequency of CD3(+) CD4(+) Foxp3(+) T cells, while daclizumab induced a near complete loss of these cells (P more...

Published
2009
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