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12 results on '"Ditse, Zanele"'

1. Antepartum SARS-CoV-2 infection and adverse birth outcomes in South African women

Author

Nunes, Marta C, primary, Jones, Stephanie, additional, Strehlau, Renate, additional, Baba, Vuyelwa, additional, Ditse, Zanele, additional, da Silva, Kelly, additional, Bothma, Lané, additional, Serafin, Natali, additional, Baillie, Vicky L, additional, Kwatra, Gaurav, additional, Burke, Megan, additional, Wise, Amy, additional, Adam, Mary, additional, Mlandu, Philiswa, additional, Melamu, Mpolokeng, additional, Phelp, Juliette, additional, Fraser, Wendy, additional, Wright, Colleen, additional, Zell, Elizabeth, additional, Adam, Yasmin, additional, and Madhi, Shabir A, additional

Published
2022
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2. Active Intrapartum SARS-CoV-2 Infection and Pregnancy Outcomes

Author

Nunes, Marta C., additional, Jones, Stephanie, additional, Strehlau, Renate, additional, Baba, Vuyelwa, additional, Ditse, Zanele, additional, da Silva, Kelly, additional, Bothma, Lané, additional, Serafin, Natali, additional, Baillie, Vicky L., additional, Kwatra, Gaurav, additional, Burke, Megan, additional, Wise, Amy, additional, Adam, Mary, additional, Mlandu, Philiswa, additional, Melamu, Mpolokeng, additional, Phelp, Juliette, additional, Fraser, Wendy, additional, Wright, Colleen, additional, Zell, Elizabeth, additional, Adam, Yasmin, additional, and Madhi, Shabir A., additional

Published
2022
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3. Maternal–foetal transfer of severe acute respiratory syndrome coronavirus 2 antibodies among women with and those without HIV infection

Author

Nunes, Marta C., primary, Jones, Stephanie, additional, Ditse, Zanele, additional, da Silva, Kelly, additional, Serafin, Natali, additional, Strehlau, Renate, additional, Wise, Amy, additional, Burke, Megan, additional, Baba, Vuyelwa, additional, Baillie, Vicky L., additional, Nzimande, Ayanda, additional, Jafta, Nwabisa, additional, Adam, Mary, additional, Mlandu, Philiswa, additional, Melamu, Mpolokeng, additional, Phelp, Juliette, additional, Feldman, Charles, additional, Adam, Yasmin, additional, Madhi, Shabir A., additional, and Kwatra, Gaurav, additional

Published
2022
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5. Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

Author

Dejnirattisai, Wanwisa, Huo, Jiandong, Zhou, Daming, Zahradník, Jiří, Supasa, Piyada, Liu, Chang, Duyvesteyn, Helen M.E., Ginn, Helen M., Mentzer, Alexander J., Tuekprakhon, Aekkachai, Nutalai, Rungtiwa, Wang, Beibei, Dijokaite, Aiste, Khan, Suman, Avinoam, Ori, Bahar, Mohammad, Skelly, Donal, Adele, Sandra, Johnson, Sile Ann, Amini, Ali, Ritter, Thomas, Mason, Chris, Dold, Christina, Pan, Daniel, Assadi, Sara, Bellass, Adam, Omo-Dare, Nikki, Koeckerling, David, Flaxman, Amy, Jenkin, Daniel, Aley, Parvinder K, Voysey, Merryn, Clemens, Sue Ann Costa, Naveca, Felipe Gomes, Nascimento, Valdinete, Nascimento, Fernanda, Fernandes da Costa, Cristiano, Resende, Paola Cristina, Pauvolid-Correa, Alex, Siqueira, Marilda M., Baillie, Vicky, Serafin, Natali, Ditse, Zanele, Da Silva, Kelly, Madhi, Shabir, Nunes, Marta C, Malik, Tariq, Openshaw, Peter JM, Baillie, J Kenneth, Semple, Malcolm G, Townsend, Alain R, Huang, Kuan-Ying A., Tan, Tiong Kit, Carroll, Miles W., Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Constantinides, Bede, Webster, Hermione, Crook, Derrick, Pollard, Andrew J, Lambe, Teresa, Paterson, Neil G., Williams, Mark A., Hall, David R., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Schreiber, Gideon, Stuart, David I., and Screaton, Gavin R

Subjects
Article
Abstract

SummaryOn the 24th November 2021 the sequence of a new SARS CoV-2 viral isolate spreading rapidly in Southern Africa was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titres of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic as well as Alpha, Beta, Gamma, Delta are substantially reduced or fail to neutralize. Titres against Omicron are boosted by third vaccine doses and are high in cases both vaccinated and infected by Delta. Mutations in Omicron knock out or substantially reduce neutralization by most of a large panel of potent monoclonal antibodies and antibodies under commercial development. Omicron S has structural changes from earlier viruses, combining mutations conferring tight binding to ACE2 to unleash evolution driven by immune escape, leading to a large number of mutations in the ACE2 binding site which rebalance receptor affinity to that of early pandemic viruses.

Published
2021

6. Association of antepartum and intrapartum SARS-CoV-2 infection on pregnancy outcomes in South African women, two observational studies

Author

Nunes, Marta, primary, Jones, Stephanie, additional, Strehlau, Renate, additional, Baba, Vuyelwa, additional, Ditse, Zanele, additional, Silva, Kelly Da, additional, Bothma, Lane, additional, Serafin, Natali, additional, Baillie, Vicky, additional, Kwatra, Gaurav, additional, Burke, Megan, additional, Wise, Amy, additional, Adam, Mary, additional, Mlandu, Philiswa, additional, Melamu, Mpolokeng, additional, Phelp, Juliette, additional, Fraser, Wendy, additional, Wright, Colleen, additional, Zell, Elizabeth, additional, Adam, Yasmin, additional, and Madhi, Shabir, additional

Published
2021
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7. Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

Author

Liu, Chang, primary, Ginn, Helen M., additional, Dejnirattisai, Wanwisa, additional, Supasa, Piyada, additional, Wang, Beibei, additional, Tuekprakhon, Aekkachai, additional, Nutalai, Rungtiwa, additional, Zhou, Daming, additional, Mentzer, Alexander J., additional, Zhao, Yuguang, additional, Duyvesteyn, Helen M.E., additional, López-Camacho, César, additional, Slon-Campos, Jose, additional, Walter, Thomas S., additional, Skelly, Donal, additional, Johnson, Sile Ann, additional, Ritter, Thomas G., additional, Mason, Chris, additional, Costa Clemens, Sue Ann, additional, Gomes Naveca, Felipe, additional, Nascimento, Valdinete, additional, Nascimento, Fernanda, additional, Fernandes da Costa, Cristiano, additional, Resende, Paola Cristina, additional, Pauvolid-Correa, Alex, additional, Siqueira, Marilda M., additional, Dold, Christina, additional, Temperton, Nigel, additional, Dong, Tao, additional, Pollard, Andrew J., additional, Knight, Julian C., additional, Crook, Derrick, additional, Lambe, Teresa, additional, Clutterbuck, Elizabeth, additional, Bibi, Sagida, additional, Flaxman, Amy, additional, Bittaye, Mustapha, additional, Belij-Rammerstorfer, Sandra, additional, Gilbert, Sarah C., additional, Malik, Tariq, additional, Carroll, Miles W., additional, Klenerman, Paul, additional, Barnes, Eleanor, additional, Dunachie, Susanna J., additional, Baillie, Vicky, additional, Serafin, Natali, additional, Ditse, Zanele, additional, Da Silva, Kelly, additional, Paterson, Neil G., additional, Williams, Mark A., additional, Hall, David R., additional, Madhi, Shabir, additional, Nunes, Marta C., additional, Goulder, Philip, additional, Fry, Elizabeth E., additional, Mongkolsapaya, Juthathip, additional, Ren, Jingshan, additional, Stuart, David I., additional, and Screaton, Gavin R., additional

Published
2021
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8. Effect of HIV Envelope Vaccination on the Subsequent Antibody Response to HIV Infection

Author

Ditse, Zanele, primary, Mkhize, Nonhlanhla N., additional, Yin, Michael, additional, Keefer, Michael, additional, Montefiori, David C., additional, Tomaras, Georgia D., additional, Churchyard, Gavin, additional, Mayer, Kenneth H., additional, Karuna, Shelly, additional, Morgan, Cecilia, additional, Bekker, Linda-Gail, additional, Mlisana, Koleka, additional, Gray, Glenda, additional, Moodie, Zoe, additional, Gilbert, Peter, additional, Moore, Penny L., additional, Williamson, Carolyn, additional, and Morris, Lynn, additional

Published
2020
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10. Replication fidelity in the mircroevolution of mycobacteria

Author

Ditse, Zanele, Warner, Digby F, and Mizrahi, Valerie

Subjects
Medical Microbiology
Abstract

This thesis aimed to elucidate the structure-function relationships determining the differential fidelities of the dnaE1- and dnaE2-encoded mycobacterial PolIIIα subunits under conditions of genotoxic stress. To this end, the role in DnaE1 intrinsic fidelity of highly conserved PHP domain residues was explored by site-directed replacement of targeted amino acids, resulting in a panel of Mycobacterium smegmatis mutants carrying selected dnaE1 alleles. A complementary approach investigated the contribution of the mycobacterial proofreading DnaQ subunit homolog to the maintenance of DnaE1-dependent replicative fidelity by generating a targeted dnaQ knockout mutant. The third component of this study focused on the inferred role of a highly-conserved N-terminal extension and C-terminal pentapeptide motif in the function of the alternative, error-prone DNA PolIIIα subunit, DnaE2.

Published
2015

11. Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.

Author

Dejnirattisai W, Huo J, Zhou D, Zahradník J, Supasa P, Liu C, Duyvesteyn HME, Ginn HM, Mentzer AJ, Tuekprakhon A, Nutalai R, Wang B, Dijokaite A, Khan S, Avinoam O, Bahar M, Skelly D, Adele S, Johnson SA, Amini A, Ritter T, Mason C, Dold C, Pan D, Assadi S, Bellass A, Omo-Dare N, Koeckerling D, Flaxman A, Jenkin D, Aley PK, Voysey M, Clemens SAC, Naveca FG, Nascimento V, Nascimento F, Fernandes da Costa C, Resende PC, Pauvolid-Correa A, Siqueira MM, Baillie V, Serafin N, Ditse Z, Da Silva K, Madhi S, Nunes MC, Malik T, Openshaw PJ, Baillie JK, Semple MG, Townsend AR, Huang KA, Tan TK, Carroll MW, Klenerman P, Barnes E, Dunachie SJ, Constantinides B, Webster H, Crook D, Pollard AJ, Lambe T, Paterson NG, Williams MA, Hall DR, Fry EE, Mongkolsapaya J, Ren J, Schreiber G, Stuart DI, and Screaton GR

Abstract

On the 24 th November 2021 the sequence of a new SARS CoV-2 viral isolate spreading rapidly in Southern Africa was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titres of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic as well as Alpha, Beta, Gamma, Delta are substantially reduced or fail to neutralize. Titres against Omicron are boosted by third vaccine doses and are high in cases both vaccinated and infected by Delta. Mutations in Omicron knock out or substantially reduce neutralization by most of a large panel of potent monoclonal antibodies and antibodies under commercial development. Omicron S has structural changes from earlier viruses, combining mutations conferring tight binding to ACE2 to unleash evolution driven by immune escape, leading to a large number of mutations in the ACE2 binding site which rebalance receptor affinity to that of early pandemic viruses.

Published
2021
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12. DNA Replication in Mycobacterium tuberculosis.

Author

Ditse Z, Lamers MH, and Warner DF

Subjects
Animals, Humans, Adaptation, Biological, DNA Replication, Mutation, Mycobacterium tuberculosis genetics, Mycobacterium tuberculosis growth & development
Abstract

Faithful replication and maintenance of the genome are essential to the ability of any organism to survive and propagate. For an obligate pathogen such as Mycobacterium tuberculosis that has to complete successive cycles of transmission, infection, and disease in order to retain a foothold in the human population, this requires that genome replication and maintenance must be accomplished under the metabolic, immune, and antibiotic stresses encountered during passage through variable host environments. Comparative genomic analyses have established that chromosomal mutations enable M. tuberculosis to adapt to these stresses: the emergence of drug-resistant isolates provides direct evidence of this capacity, so too the well-documented genetic diversity among M. tuberculosis lineages across geographic loci, as well as the microvariation within individual patients that is increasingly observed as whole-genome sequencing methodologies are applied to clinical samples and tuberculosis (TB) disease models. However, the precise mutagenic mechanisms responsible for M. tuberculosis evolution and adaptation are poorly understood. Here, we summarize current knowledge of the machinery responsible for DNA replication in M. tuberculosis, and discuss the potential contribution of the expanded complement of mycobacterial DNA polymerases to mutagenesis. We also consider briefly the possible role of DNA replication-in particular, its regulation and coordination with cell division-in the ability of M. tuberculosis to withstand antibacterial stresses, including host immune effectors and antibiotics, through the generation at the population level of a tolerant state, or through the formation of a subpopulation of persister bacilli-both of which might be relevant to the emergence and fixation of genetic drug resistance.

Published
2017
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