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26 results on '"Ditsiou, Angeliki"'

4. Kinome‐Wide Synthetic Lethal Screen Identifies PANK4 as a Modulator of Temozolomide Resistance in Glioblastoma

Author

Vella, Viviana, primary, Ditsiou, Angeliki, additional, Chalari, Anna, additional, Eravci, Murat, additional, Wooller, Sarah K., additional, Gagliano, Teresa, additional, Bani, Cecilia, additional, Kerschbamer, Emanuela, additional, Karakostas, Christos, additional, Xu, Bin, additional, Zhang, Yongchang, additional, Pearl, Frances M.G., additional, Lopez, Gianluca, additional, Peng, Ling, additional, Stebbing, Justin, additional, Klinakis, Apostolos, additional, and Giamas, Georgios, additional

Published
2024
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5. Exploring Emerging Therapeutic Targets and Opportunities in Neuroendocrine Tumors: Updates on Receptor Tyrosine Kinases.

Author

Toffoli, Lara, Ditsiou, Angeliki, and Gagliano, Teresa

Subjects
*VASCULAR endothelial growth factor receptors, *INSULIN-like growth factor receptors, *NEUROENDOCRINE tumors, *EPIDERMAL growth factor receptors, *KINASES
Abstract

Neuroendocrine tumors (NETs) represent a diverse group of neoplasms originating from neuroendocrine cells, presenting varied clinical behaviors and posing significant challenges in management. This review explores the emerging roles of receptor tyrosine kinases (RTKs) in the pathogenesis and progression of NETs, including vascular endothelial growth factor receptors (VEGFRs), insulin-like growth factor receptors (IGF-1R), RET, epidermal growth factor receptor (EGFR), and ALK. The dysregulation of RTK signaling pathways contributes to key cellular processes such as proliferation, survival, and invasion in NETs. We discuss the potential of targeting RTKs as therapeutic strategies in NETs, with a focus on recent developments in RET inhibitors and the therapeutic implications of RTK alterations. [ABSTRACT FROM AUTHOR]

Published
2024
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8. PIK3C[delta] expression by fibroblasts promotes triple-negative breast cancer progression

Author

Gagliano, Teresa, Shah, Kalpit, Gargani, Sofia, Lao, Liyan, Alsaleem, Mansour, Chen, Jianing, Ntafis, Vasileios, Huang, Penghan, Ditsiou, Angeliki, Vella, Viviana, Yadav, Kritika, Bienkowska, Kamila, Bresciani, Giulia, Kang, Kai, Li, Leping, Carter, Philip, Benstead-Hume, Graeme, OHanlon, Timothy, Dean, Michael, Pearl, Frances M.G., Lee, Soo-Chin, Rakha, Emad A., Green, Andrew R., Kontoyiannis, Dimitris L., Song, Erwei, Stebbing, Justin, and Giamas, Georgios

Subjects
Genetic engineering -- Analysis, Idelalisib -- Analysis, Breast cancer -- Development and progression, Cancer metastasis -- Development and progression, RNA -- Analysis, Health care industry
Abstract

As there is growing evidence for the tumor microenvironment's role in tumorigenesis, we investigated the role of fibroblast-expressed kinases in triple-negative breast cancer (TNBC). Using a high-throughput kinome screen combined with 3D invasion assays, we identified fibroblast-expressed PIK3C[delta] (f- PIK3C[delta]) as a key regulator of cancer progression. Although PIK3C[delta] was expressed in primary fibroblasts derived from TNBC patients, it was barely detectable in breast cancer (BC) cell lines. Genetic and pharmacological gain- and loss-of-function experiments verified the contribution of f-PIK3C[delta] in TNBC cell invasion. Integrated secretomics and transcriptomics analyses revealed a paracrine mechanism via which f-PIK3C[delta] confers its protumorigenic effects. Inhibition of f-PIK3C[delta] promoted the secretion of factors, including PLGF and BDNF, that led to upregulation of NR4A1 in TNBC cells, where it acts as a tumor suppressor. Inhibition of PIK3C[delta] in an orthotopic BC mouse model reduced tumor growth only after inoculation with fibroblasts, indicating a role of f-PIK3C[delta] in cancer progression. Similar results were observed in the MMTV-PyMT transgenic BC mouse model, along with a decrease in tumor metastasis, emphasizing the potential immune-independent effects of PIK3C[delta] inhibition. Finally, analysis of BC patient cohorts and TCGA data sets identified f-PIK3C[delta] (protein and mRNA levels) as an independent prognostic factor for overall and disease-free survival, highlighting it as a therapeutic target for TNBC., Introduction Triple-negative breast cancer (TNBC; [ER.sup.-], [PR.sup.-], [HER2.sup.-]) represents a molecularly diverse and highly heterogeneous subtype of breast cancer (BC) (15%-20%) with a poor prognosis and high rates of recurrence [...]

Published
2020
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9. LMTK3 confers chemo-resistance in breast cancer

Author

Stebbing, Justin, Shah, Kalpit, Lit, Lei Cheng, Gagliano, Teresa, Ditsiou, Angeliki, Wang, Tingting, Wendler, Franz, Simon, Thomas, Szabó, Krisztina Sára, O’Hanlon, Timothy, Dean, Michael, Roslani, April Camilla, Cheah, Swee Hung, Lee, Soo-Chin, and Giamas, Georgios

Published
2018
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10. The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor

Author

Agnarelli, Alessandro, primary, Lauer Betrán, Andrea, additional, Papakyriakou, Athanasios, additional, Vella, Viviana, additional, Samuels, Mark, additional, Papanastasopoulos, Panagiotis, additional, Giamas, Christina, additional, Mancini, Erika J., additional, Stebbing, Justin, additional, Spencer, John, additional, Cilibrasi, Chiara, additional, Ditsiou, Angeliki, additional, and Giamas, Georgios, additional

Published
2023
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15. Additional file 2 of LMTK3 inhibition affects microtubule stability

Author

Cilibrasi, Chiara, Ditsiou, Angeliki, Papakyriakou, Athanasios, Mavridis, George, Eravci, Murat, Stebbing, Justin, Gagliano, Teresa, and Giamas, Georgios

Abstract

Additional file 2: Supplementary Figure S1. Effects of C28 on microtubule organization in BC and non-transformed breast cell lines and schematic model depicting the proposed mechanism of action of C28 inhibitor. (a) MCF7, T47D, MDA-MB-231 and MCF12A cells were treated with 10 μM of C28 for 48 h. Cells were fixed and stained with anti-α-tubulin antibody (green) while the nuclear DNA was stained by DAPI (blue). Representative confocal microscopy images of mitotic phase cells are shown. Scale bar, 5 μm. (b) C28 binds to LMTK3 promoting its proteasome-mediated degradation. Downregulation of LMTK3 leads to a decrease in NUSAP1 and downstream proteins CDK1 and phospho-β III tubulin (S172), resulting in cell cycle arrest, abnormal spindles and microtubules instability.

Published
2021
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16. The structure-function relationship of oncogenic LMTK3

Author

Ditsiou, Angeliki, primary, Cilibrasi, Chiara, additional, Simigdala, Nikiana, additional, Papakyriakou, Athanasios, additional, Milton-Harris, Leanne, additional, Vella, Viviana, additional, Nettleship, Joanne E., additional, Lo, Jae Ho, additional, Soni, Shivani, additional, Smbatyan, Goar, additional, Ntavelou, Panagiota, additional, Gagliano, Teresa, additional, Iachini, Maria Chiara, additional, Khurshid, Sahir, additional, Simon, Thomas, additional, Zhou, Lihong, additional, Hassell-Hart, Storm, additional, Carter, Philip, additional, Pearl, Laurence H., additional, Owen, Robin L., additional, Owens, Raymond J., additional, Roe, S. Mark, additional, Chayen, Naomi E., additional, Lenz, Heinz-Josef, additional, Spencer, John, additional, Prodromou, Chrisostomos, additional, Klinakis, Apostolos, additional, Stebbing, Justin, additional, and Giamas, Georgios, additional

Published
2020
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17. Global kinome silencing combined with 3D invasion screening of the tumor microenvironment identifies fibroblast-expressed PIK3Cδ involvement in triple-negative breast cancer progression

Author

Gagliano, Teresa, primary, Shah, Kalpit, additional, Gargani, Sofia, additional, Lao, Liyan, additional, Alsaleem, Mansour, additional, Chen, Jianing, additional, Ntafis, Vasileios, additional, Huang, Penghan, additional, Ditsiou, Angeliki, additional, Vella, Viviana, additional, Yadav, Kritika, additional, Bienkowska, Kamila, additional, Bresciani, Giulia, additional, Kang, Kai, additional, Li, Leping, additional, Carter, Philip, additional, Benstead-Hum, Graeme, additional, O’Hanlon, Timothy, additional, Dean, Michael, additional, Pearl, Frances M.G., additional, Lee, Soo-Chin, additional, Rakha, Emad A, additional, Green, Andrew R, additional, Kontoyiannis, Dimitris L., additional, Song, Erwei, additional, Stebbing, Justin, additional, and Giamas, Georgios, additional

Published
2019
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