281 results on '"Divanoglou A"'
Search Results
2. A Qualitative Phenomenological Philosophy Analysis of Affectivity and Temporality in Experiences of COVID-19 and Remaining Symptoms after COVID-19 in Sweden
- Author
-
Zeiler, Kristin, Jämterud, Sofia Morberg, Bredström, Anna, Divanoglou, Anestis, and Levi, Richard
- Published
- 2024
- Full Text
- View/download PDF
3. The Swedish version of the Moorong Self-Efficacy Scale (s-MSES) – translation process and psychometric properties in a community setting
- Author
-
Mangold, Jasmin, Divanoglou, Anestis, Middleton, James W., and Jörgensen, Sophie
- Published
- 2024
- Full Text
- View/download PDF
4. Enriching the lives of children with acquired brain injury and their caregivers: experiences from peer mentorship sports camps
- Author
-
Pia Wedege, Silje Mæland, Anestis Divanoglou, and Frank Eirik Abrahamsen
- Subjects
peer mentorship ,peer support ,acquired brain injury ,sports camp ,Active Rehabilitation ,qualitative study ,Other systems of medicine ,RZ201-999 ,Medical technology ,R855-855.5 - Abstract
Peer-based community interventions have shown promise in improving health management and fostering coping skills and psychosocial functioning among individuals with a disability. Active Rehabilitation camps are examples of peer-based community interventions that provide structured, time-limited peer mentorship in conjunction with sports and leisure activities. These camps hold potential benefits for individuals with acquired neurological injury. However, the specific impact of Active Rehabilitation camps on children or individuals with acquired brain injury remains unexplored. In this longitudinal, qualitative study, we explored children with an acquired brain injury and their caregivers' experiences with an Active Rehabilitation camp in Norway through observations and interviews with nine children and ten caregivers. Using an abductive thematic analysis, we identified an overarching theme: Active Rehabilitation peer mentorship camps enrich the lives of children with acquired brain injury and their caregivers. The theme contains three sub-themes: (1) Interacting with peers made me wiser, (2) Nudging from peer mentors made me feel better, and (3) A sense of companionship through meeting peers. Peer mentorship, sports and leisure activities, and the safe camp atmosphere benefitted children with acquired brain injury and their caregivers. The children gained knowledge, motivation, and self-worth, and their caregivers had greater impetus to prioritize their children's independence. Meeting peers and peer mentors led to friendships and sustained social connections. The Self-Determination Theory was of assistance in explaining the informants' experiences. Active Rehabilitation camps provide children with acquired brain injury and their caregivers with an opportunity to develop better coping skills, improve psychological functioning, and build more robust social networks.
- Published
- 2024
- Full Text
- View/download PDF
5. Temporal changes in demographic and injury characteristics of traumatic spinal cord injuries in Nordic countries - a systematic review with meta-analysis
- Author
-
Moschovou, Maria, Antepohl, Wolfram, Halvorsen, Annette, Pettersen, Ann Louise, and Divanoglou, Anestis
- Published
- 2022
- Full Text
- View/download PDF
6. The incidence and characteristics of ventilator-associated pneumonia in a regional nontertiary Australian intensive care unit: A retrospective clinical audit study
- Author
-
Watson, Kirsty, Reoch, Josephine, Heales, Luke J., Fernando, Jeremy, Tan, Elise, Smith, Karen, Austin, David, and Divanoglou, Anestis
- Published
- 2022
- Full Text
- View/download PDF
7. Rehabilitation needs following COVID-19: Five-month post-discharge clinical follow-up of individuals with concerning self-reported symptoms
- Author
-
Wahlgren, Carl, Divanoglou, Anestis, Larsson, Melanie, Nilsson, Emma, Östholm Balkhed, Åse, Niward, Katarina, Birberg Thornberg, Ulrika, Lilliecreutz Gudmundsson, Eva, and Levi, Richard
- Published
- 2022
- Full Text
- View/download PDF
8. Rehabilitation needs and mortality associated with the Covid-19 pandemic: a population-based study of all hospitalised and home-healthcare individuals in a Swedish healthcare region
- Author
-
Divanoglou, Anestis, Samuelsson, Assoc. Prof Kersti, Sjödahl, Prof. Emer. Rune, Andersson, Christer, and Levi, Prof. Richard
- Published
- 2021
- Full Text
- View/download PDF
9. Association of Vitamin D Receptor Gene Polymorphisms with Serum Vitamin D Levels in a Greek Rural Population (Velestino Study)
- Author
-
Natalia Divanoglou, Despina Komninou, Eleni A. Stea, Anagnostis Argiriou, Grigorios Papatzikas, Andreas Tsakalof, Kalliopi Pazaitou-Panayiotou, Marios K. Georgakis, and Eleni Petridou
- Subjects
nutrigenetics ,vitamin d receptor ,vitamin d receptor polymorphisms ,serum 25(oh)d3 levels ,deficiency ,Genetics ,QH426-470 - Abstract
Background/Aim: An alarming increase in vitamin D deficiency even in sunny regions highlights the need for a better understanding of the genetic background of the vitamin D endocrine system and the molecular mechanisms of gene polymorphisms of the vitamin D receptor (VDR). In this study, the serum levels of 25(OH)D3 were correlated with common VDR polymorphisms (ApaI, BsmI, FokI, and TaqI) in 98 subjects of a Greek homogeneous rural population. Methods: 25(OH)D3 concentration was measured by ultra-HPLC, and the VDR gene polymorphisms were identified by quantitative real-time PCR followed by amplicon high-resolution melting analysis. Results: Subjects carrying either the B BsmI (OR: 0.52, 95% CI: 0.27–0.99) or t TaqI (OR: 2.06, 95%: 1.06–3.99) allele presented twice the risk for developing vitamin D deficiency compared to the reference allele. Moreover, subjects carrying 1, 2, or all 3 of these genotypes (BB/Bb, Tt/tt, and FF) demonstrated 2-fold (OR: 2.04, 95% CI: 0.42–9.92), 3.6-fold (OR: 3.62, 95% CI: 1.07–12.2), and 7-fold (OR: 6.92, 95% CI: 1.68–28.5) increased risk for low 25(OH)D3 levels, respectively. Conclusions: Our findings reveal a cumulative effect of specific VDR gene polymorphisms that may regulate vitamin D concentrations explaining, in part, the paradox of vitamin D deficiency in sunny regions, with important implications for precision medicine.
- Published
- 2021
- Full Text
- View/download PDF
10. Enriching the lives of children with acquired brain injury and their caregivers: experiences from peer mentorship sports camps
- Author
-
Wedege, Pia, Maeland, Silje, Divanoglou, Anestis, Abrahamsen, Frank Eirik, Wedege, Pia, Maeland, Silje, Divanoglou, Anestis, and Abrahamsen, Frank Eirik
- Abstract
Peer-based community interventions have shown promise in improving health management and fostering coping skills and psychosocial functioning among individuals with a disability. Active Rehabilitation camps are examples of peer-based community interventions that provide structured, time-limited peer mentorship in conjunction with sports and leisure activities. These camps hold potential benefits for individuals with acquired neurological injury. However, the specific impact of Active Rehabilitation camps on children or individuals with acquired brain injury remains unexplored. In this longitudinal, qualitative study, we explored children with an acquired brain injury and their caregivers' experiences with an Active Rehabilitation camp in Norway through observations and interviews with nine children and ten caregivers. Using an abductive thematic analysis, we identified an overarching theme: Active Rehabilitation peer mentorship camps enrich the lives of children with acquired brain injury and their caregivers. The theme contains three sub-themes: (1) Interacting with peers made me wiser, (2) Nudging from peer mentors made me feel better, and (3) A sense of companionship through meeting peers. Peer mentorship, sports and leisure activities, and the safe camp atmosphere benefitted children with acquired brain injury and their caregivers. The children gained knowledge, motivation, and self-worth, and their caregivers had greater impetus to prioritize their children's independence. Meeting peers and peer mentors led to friendships and sustained social connections. The Self-Determination Theory was of assistance in explaining the informants' experiences. Active Rehabilitation camps provide children with acquired brain injury and their caregivers with an opportunity to develop better coping skills, improve psychological functioning, and build more robust social networks.
- Published
- 2024
- Full Text
- View/download PDF
11. Structured, time-limited peer mentorship activity programmes for individuals with acquired brain or spinal cord injuries: a mixed methods systematic review of characteristics and outcomes
- Author
-
Wedege, P., Maeland, S., Abrahamsen, F. E., Divanoglou, Anestis, Wedege, P., Maeland, S., Abrahamsen, F. E., and Divanoglou, Anestis
- Abstract
PurposeTo determine the characteristics and outcomes of structured, time-limited peer mentorship activity programmes for individuals with acquired brain or spinal cord injury.Materials and methodsA mixed methods systematic review with an advanced convergent qualitative meta-integration synthesis design was adopted. Seven databases were searched, with two reviewers independently screening, selecting, and extracting data and evaluating the methodological quality of the included studies.ResultsThe review included ten original studies: five qualitative, four quantitative, and one mixed methods. The peer mentorship programmes were conducted in Europe, Oceania, the United States, and Africa, lasting from two days to 2.5 weeks. The programmes had diverse focuses, but all addressed mentees' independence, health, or quality of life in some way. None was based on a theoretical framework. Programme participation positively impacted cognition, emotions, independence, and social life. The safe and supportive environments the mentees and peer mentors created facilitated the outcomes. The evidence of programme participation on life satisfaction and community participation was inconclusive.ConclusionDespite their short duration, structured, time-limited peer mentorship activity programmes can strengthen community rehabilitation of individuals with acquired brain or spinal cord injury. It is recommended that peer mentorship programmes are grounded on a theoretical framework. Structured, time-limited peer mentorship activity programmes impact mentees' thoughts and emotions, social lives, and independence in daily lives.Being able to challenge oneself in a safe and supportive environment created by mentees and peer mentors is essential for achieving positive outcomes.Peer mentorship programme organisers should establish clearly defined programme aims and base their rationale on how to reach these aims on relevant theoretical frameworks., Funding Agencies|Norwegian School of Sport Science librarians
- Published
- 2024
- Full Text
- View/download PDF
12. Seven Domains of Persisting Problems after Hospital-treated Covid-19 Indicate a Need For a Multiprofessional Rehabilitation Approach
- Author
-
Lovisa Hellgren, Richard Levi, Anestis Divanoglou, Ulrika Birberg-Thornberg, and Kersti Samuelsson
- Subjects
Activities of Daily Living ,Cognition ,Expressed emotions ,Mental fatigue ,Participation ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Objectives: To identify domains of persisting problems at 4 months after discharge in patients previously hospitalized due to COVID-19, with a focus on a subgroup of patients reporting symptoms to an extent indicative of rehabilitation needs. Design: Ambidirectional observational cohort study. Patients: All patients with a laboratory-confirmed COVID-19 diagnosis admitted to hospital in a Swedish healthcare region during the period 1 March to 31 May 2020. After exclusion, 94% of all survivors (n = 433) participated in the study. Forty-three percent (n = 185) of these reported persisting problems indicating rehabilitation needs and formed a subgroup. Methods: Explorative factor analysis based on results from comprehensive telephone interviews covering persisting symptoms, including assessment of impact on daily life. Results: Seven domains were identified, comprising problems related to vision, cognition, mental fatigue, swallowing, voice, sensorimotor dysfunction, and feeling anxious/depressed. The patients in the subgroup reported a median of 8 symptoms/limitations affecting everyday life, and two-thirds reported symptoms/limitations in 3 or more domains. Conclusion: Seven problem domains corresponding to specific modalities of rehabilitative interventions were identified. A majority of patients reported problems from several domains, indicating the need for multiprofessional teams in post-COVID-19 rehabilitation. Screening of patients previously hospitalized due to COVID-19 should cover all 7 domains of persisting problems. LAY ABSTRACT More than 70% of patients with COVID-19 have previously been shown to experience 1 or several of a multitude of persisting problems several months after infection. This study aimed to identify areas of persisting problems among a broad spectrum of self-reported problems. Survivors of COVID-19 who had been discharged from hospital 4 months previously participated in a telephone interview covering persisting problems, including assessment of impact on daily life. The persisting problems clustered into 7 functional areas. Mental fatigue, cognitive- and sensorimotor problems were reported most frequently. A potential rehabilitation need was seen in more than 40% of patients interviewed. These patients reported approximately 8 different problems affecting their everyday life, and a majority of these patients reported problems from 3 or more areas. These findings highlight the need for multiprofessional teams in post-COVID-19 rehabilitation. Screening of patients previously hospitalized due to COVID-19 should cover all 7 areas of persisting problems.
- Published
- 2022
- Full Text
- View/download PDF
13. ‘We’re all on the same journey; some are just a bit further down the road than others’: a qualitative study exploring peer mentors’ experiences in Active Rehabilitation camps for individuals with acquired brain injury.
- Author
-
Wedege, P., Divanoglou, A., Abrahamsen, F. E., and Mæland, S.
- Subjects
- *
SELF-determination theory , *COMMUNITY involvement , *SPORTS camps , *BRAIN injuries , *PHYSICAL activity - Abstract
AbstractPurposeMethodsResultsConclusion\nIMPLICATIONS FOR REHABILITATIONThis study aimed to explore how peer mentors experience their role and practice in Active Rehabilitation camps for individuals with acquired brain injury.Sixteen peer mentors with acquired brain injury were interviewed, and the data were analysed using Systematic text condensation. Self-determination theory was used to interpret the results.Six themes were constructed: “Altruistic motives drive peer mentors” engagement”, “What does it mean to be a peer mentor?”, “Peer mentors question their qualifications”, “Camp is tough—Nothing can compare”, “Being a peer mentor—A part of one’s rehabilitation process”, and “Closeness and trust—A bubble of understanding”. The peer mentors reported personal benefits, such as increased knowledge about brain injury, self-esteem, motivation, physical activity, community participation, and social networks. They perceived that mutual understanding among peer mentors and mentees created a safe camp atmosphere, which led to positive experiences.The peer mentors benefitted from their role and described it as part of their rehabilitation journey. We recommend that peer mentors receive training before entering this position, feedback on their performance, and camp schedules that accommodate time for rest and informal meetings between mentees and peer mentors.Peer mentorship interventions for individuals with acquired neurological injury are becoming more popular. Because peer mentors are vital in such interventions, learning more about their perspectives is essential.Peer mentors with acquired brain injury (ABI) who engage in Active Rehabilitation camps report various personal benefits, such as heightened self-esteem, increased community participation, and establishment of a broader support network.To address challenges that peer mentors may perceive, we recommend that the organisers of these interventions ensure mentors receive adequate training before taking on their roles and receive ongoing feedback on their performance.Individuals with ABI who are interested in peer mentoring and fulfil the organisers’ criteria should be encouraged to apply for this role, as it can become a natural extension of their rehabilitation process.Peer mentorship interventions for individuals with acquired neurological injury are becoming more popular. Because peer mentors are vital in such interventions, learning more about their perspectives is essential.Peer mentors with acquired brain injury (ABI) who engage in Active Rehabilitation camps report various personal benefits, such as heightened self-esteem, increased community participation, and establishment of a broader support network.To address challenges that peer mentors may perceive, we recommend that the organisers of these interventions ensure mentors receive adequate training before taking on their roles and receive ongoing feedback on their performance.Individuals with ABI who are interested in peer mentoring and fulfil the organisers’ criteria should be encouraged to apply for this role, as it can become a natural extension of their rehabilitation process. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
14. Structured, time-limited peer mentorship activity programmes for individuals with acquired brain or spinal cord injuries: a mixed methods systematic review of characteristics and outcomes
- Author
-
Wedege, P., primary, Mæland, S., additional, Abrahamsen, F. E., additional, and Divanoglou, A., additional
- Published
- 2024
- Full Text
- View/download PDF
15. INTERnational Project for the Evaluation of 'activE Rehabilitation' (inter-PEER) – a protocol for a prospective cohort study of community peer-based training programmes for people with spinal cord injury
- Author
-
Anestis Divanoglou, Tomasz Tasiemski, and Sophie Jörgensen
- Subjects
Community rehabilitation ,Active rehabilitation ,Spinal cord injuries ,Peer mentor ,Mentoring ,Peer support ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background Active Rehabilitation (AR) is a community peer-based concept for people with spinal cord injury (SCI) that is primarily delivered through brief residential training programmes. Despite a plethora of positive anecdotal evidence of AR programmes as life-changing experiences, the effects of AR-programmes have not been evaluated scientifically. Here, we present the protocol of the INTERnational Project for the Evaluation of “activE Rehabilitation” (inter-PEER) aiming to evaluate the effects of AR training programmes on community-dwelling individuals with SCI. Methods International prospective cohort study that recruits consecutive participants in AR training programmes. Evaluation is conducted through a web-based survey at 3 time-points: at the commencement and completion of the training programme, and 3 months after the end of the training programme. Evaluation also includes a practical wheelchair skills test at the first two time-points. The primary outcome measures are the Spinal Cord Independence Measure Self-report (SCIM-SR), the Queensland Evaluation of Wheelchair Skills test (QEWS), the Wheelchair Skills Test Questionnaire (WST-Q) and the Moorong Self-Efficacy Scale (MSES). The secondary outcome measures are the 11-item Life Satisfaction Questionnaire (LiSat-11), the Utrecht Scale for Evaluation of Rehabilitation-Participation (USER-Participation), the Leisure Time Physical Activity Questionnaire for people with SCI (LTPAQ-SCI) and the 10-item Connor-Davidson Resilience Scale (CD-RISC-10). We piloted the implementation of the protocol in Sweden in 7 participants with diverse SCI and sociodemographic characteristics and collected feedback from participants and peer-mentors about study procedures through interviews, a workshop and field observations. Discussion Inter-PEER is the first initiative to propose a systematic evaluation of the effects of AR training programmes among individuals with SCI. The project is a collaborative work of multiple stakeholders, including researchers, clinicians, peer mentors with SCI, and administrators of organisations providing AR programmes. The inter-PEER uses standardised outcome measures relevant to the AR context, it will facilitate quality evaluations of community peer-based programmes, stimulate international collaborations, and inform the design of randomised controlled trials on the effects of AR training programmes.
- Published
- 2020
- Full Text
- View/download PDF
16. Rehabilitation needs following COVID-19: Five-month post-discharge clinical follow-up of individuals with concerning self-reported symptoms
- Author
-
Carl Wahlgren, Anestis Divanoglou, Melanie Larsson, Emma Nilsson, Åse Östholm Balkhed, Katarina Niward, Ulrika Birberg Thornberg, Eva Lilliecreutz Gudmundsson, and Richard Levi
- Subjects
SARS-CoV-2 ,Post-COVID-19 ,PACS ,Rehabilitation ,Consequences ,Residual symptoms ,Medicine (General) ,R5-920 - Abstract
Background: This report describes and objectivizes reported problems among a cohort of previously hospitalized COVID-19 patients by clinical examination and determination of the required level of rehabilitation sevices. Methods: This report forms part of the Linköping COVID-19 Study (LinCoS) that included 745 individuals from one of 21 Swedish healthcare regions, Region Östergötland (RÖ), admitted to hospital for COVID-19 during March 1st–May 31st, 2020. In this descriptive ambidirectional cohort study, all 185 individuals who had reported concerning persisting symptoms were invited to a multi-professional clinical assessment of somatic, functional, affective, neuropsychological status and rehabilitation needs. Rehabilitation needs were assessed using three sub-scales of the Rehabilitation Complexity Scale-Extended. Findings: Among the 158 (85·4%) cases consenting and included in the analysis, we found a broad array of symptoms and signs attributable to COVID-19 involving respiratory, visual, auditory, motor, sensory and cognitive functions that could be confirmed clinically at five months post-discharge. This translated into 16% [95% CI 13–20] of survivors (70/433) of the total regional cohort of hospitalised patients requiring further rehabilitative interventions at follow-up. Weakness in extremities was reported in 28·5% [21·6, 36·2] (45/158). On examination, clinically overt muscle weakness could be corroborated in 15 individuals (10·5%) [6·1, 16·4]. 48% [40, 56] (76/158) reported cognitive symptoms, while the physician noted overt cognitive impairments in only 3% [1·1, 7·5]. In neuropsychological testing, 37% [28–46] (45/122) performed 1.5 SD below the norm, indicating neurocognitive deficits. Fifty-five individuals (34·8%) [27·4, 42·8] reported new or aggravated pain. In three fourths of them, it exerted a ‘moderate’ or worse detrimental effect on their ability to work. Interpretation: Our study underscores the importance of providing extensive examination of cases with persisting problems after COVID-19, especially since symptoms such as fatigue and breathlessness are highly nonspecific, but may represent significant underlying functional impairments. Robust neurocognitive testing should be performed, as cognitive problems may easily be overlooked during routine medical consultation. In the Swedish context, most rehabilitative interventions could be provided in a primary care setting. A substantial minority of patients should be triaged to specialized rehabilitation services.
- Published
- 2022
- Full Text
- View/download PDF
17. Does face-to-face pre-operative joint replacement education reduce hospital costs in a regional Australian hospital? A descriptive retrospective clinical audit
- Author
-
Lewis, Daniel, Fullard, Katherine, Kolbe, Tyrone, Chapman, Sally, Divanoglou, Anestis, Doran, Christopher, Hutton, Victoria, Santamaria, Joel, and Heales, Luke J.
- Published
- 2020
- Full Text
- View/download PDF
18. Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study
- Author
-
Anestis Divanoglou, Lovisa Hellgren, Ulrika Birberg Thornberg, Kersti Samuelsson, Richard Levi, and Ida Blystad
- Subjects
Medicine - Abstract
Objectives To report findings on brain MRI and neurocognitive function, as well as persisting fatigue at long-term follow-up after COVID-19 hospitalisation in patients identified as high risk for affection of the central nervous system.Design Ambidirectional observational cohort study.Setting All 734 patients from a regional population in Sweden with a laboratory-confirmed COVID-19 diagnosis admitted to hospital during the period 1 March to 31 May 2020.Participants A subgroup (n=185) with persisting symptoms still interfering with daily life at a telephone follow-up 4 months after discharge were invited for a medical and neuropsychological evaluation. Thirty-five of those who were assessed with a neurocognitive test battery at the clinical visit, and presented a clinical picture concerning for COVID-19-related brain pathology, were further investigated by brain MRI.Main outcome measures Findings on brain MRI, neurocognitive test results and reported fatigue.Results Twenty-five patients (71%) had abnormalities on MRI; multiple white matter lesions were the most common finding. Sixteen patients (46%) demonstrated impaired neurocognitive function, of which 10 (29%) had severe impairment. Twenty-six patients (74%) reported clinically significant fatigue. Patients with abnormalities on MRI had a lower Visuospatial Index (p=0.031) compared with the group with normal MRI findings.Conclusions In this group of patients selected to undergo MRI after a clinical evaluation, a majority of patients had abnormal MRI and/or neurocognitive test results. Abnormal findings were not restricted to patients with severe disease.
- Published
- 2021
- Full Text
- View/download PDF
19. Physiotherapy Student Perspectives on Synchronous Dual-Campus Learning and Teaching
- Author
-
Divanoglou, Anestis, Chance-Larsen, Kenneth, Fleming, Julie, and Wolfe, Michele
- Abstract
An increasing number of universities offer educational programmes across multiple campuses, as a way of facilitating access to tertiary education and filling the shortage of health professionals in rural and regional settings. Offering an equitable learning experience across all sites has been considered an important aspect in any learning and teaching approach. This qualitative study analysed data from 10 focus group discussions and 11 unit evaluations, to explore student perceptions of synchronous dual-campus delivery of a physiotherapy programme in Central Queensland, Australia. An inductive approach to thematic analysis was used. Three themes emerged: (1) Student location influences learning; (2) Videoconferencing impacts learning and teaching; and (3) Dual-campus delivery determines teaching structures and shapes teaching processes. Difficulties related to cross-campus communication, logistics, and opportunities for interaction and engagement were seen as detrimental to synchronous dual-campus delivery. Skill-based demonstrations added another level of complexity. However, students identified a potential benefit from accessing expertise from both campuses. With careful planning and consideration of the potential barriers and facilitators, synchronous dual-campus learning environments can be an effective delivery option for higher education institutions. This study builds on existing literature and suggests a number of strategies that are specific to this mode of programme delivery.
- Published
- 2018
- Full Text
- View/download PDF
20. Rehabilitation needs and mortality associated with the Covid-19 pandemic: a population-based study of all hospitalised and home-healthcare individuals in a Swedish healthcare region
- Author
-
Anestis Divanoglou, PT, PhD, Assoc. Prof Kersti Samuelsson, OT, PhD, Prof. Emer. Rune Sjödahl, MD, PhD, Christer Andersson, MD, PhD, and Prof. Richard Levi, MD, PhD
- Subjects
Medicine (General) ,R5-920 - Abstract
Background: This first report of the Linköping Covid-19 Study (LinCoS) aimed at determination of Covid-19-associated mortality, impairments, activity and participation limitations denoting rehabilitation needs four months after discharge from hospital. Methods: An ambidirectional population-based cohort study including all confirmed Covid-19 cases admitted to hospital during 1/03-31/05 and those living in home healthcare settings identified through a regional registry and evaluated through medical records, including WHO Clinical Progression Scale (CPS). All patients discharged from hospital were followed-up by structured telephone interview at 4 months post-discharge. Respondents indicated any new or aggravated persisting problems in any of 25 body functions and 12 activity/participation items and rated them for impact on daily life. Findings: Out of 734 hospitalised patients, 149 were excluded, 125 died, and 460 were alive at 4-month follow-up of whom 433 (94.1%) were interviewed. In total, 40% reported impairments and activity/participation limitations affecting daily life and warranted further multi-professional rehabilitation assessment, predominantly those with severe disease and a considerable proportion of those with moderate disease. Cognitive and affective impairments were equally common in all groups and were reported by 20-40% of cases. Limb weakness was reported by 31%, with CPS 7-9 being four times more likely to report this problem as compared to CPS 4-5. 26% of those working or studying reported difficulties returning to these activities, this being 3.5 times more likely in CPS 7-9 as compared to CPS 4-5. 25% reported problems walking >1 km, with CPS 7-9 over three times more likely to report this as compared to the other two sub-groups. 90-day mortality rate of Covid-19 associated deaths was 15.1%. Interpretation: Most rehabilitation needs after Covid-19 involved higher cerebral dysfunction both in patients with moderate and severe disease. This should be considered when designing services aiming at minimizing long-term disability. Funding: ALF grant and Region Östergötland.
- Published
- 2021
- Full Text
- View/download PDF
21. Sound psychometric properties of the Swedish version of the Spinal Cord Independence Measure Self-Report
- Author
-
Sophie Jörgensen, Emelie Butler Forslund, Ulrica Lundström, Erika Nilsson, Richard Levi, Erik Berndtsson, and Anestis Divanoglou
- Subjects
outcome measures ,psychometrics, rehabilitation ,spinal cord injury ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Objective: To describe data completeness, targeting and reliability of the Swedish version of the Spinal Cord Independence Measure Self-Report (s-SCIM-SR). Design: Translation and reliability study. Subjects: Programme participants (n = 48) and peer mentors (n = 42) with spinal cord injury enrolled in the INTERnational Project for the Evaluation of “activE Rehabilitation” (inter-PEER). Methods: The translation process was based on guidelines/recommendations, and involved expert competence, including consumers. The s-SCIM-SR was distributed online, once for programme participants and twice for peer mentors. Results: Sixty-nine individuals (77%) obtained a total score. Most missing data were found in the items Respiration and Using the toilet. Cronbach’s alpha for the full scale was 0.89, for Self-care 0.92, for Respiration and sphincter management 0.37 and for Mobility 0.86. The intraclass correlation coefficient was excellent for all subscales and the full scale. Measures of variability showed high sensitivity to changes and Bland Altman analyses revealed no systematic changes between evaluation points. Conclusion: These results support the data completeness, targeting and reliability of the Swedish version of the SCIM-SR. However, some problems were found in the subscale Respiration and sphincter management. The s-SCIM-SR can be considered psychometrically sound and suitable to assess physical independence among persons with spinal cord injury in Swedish community settings.
- Published
- 2021
- Full Text
- View/download PDF
22. Active Rehabilitation for persons with spinal cord injury in Botswana – effects of a community peer-based programme
- Author
-
Divanoglou, Anestis, Trok, Katarzyna, Jörgensen, Sophie, Hultling, Claes, Sekakela, Kobamelo, and Tasiemski, Tomasz
- Published
- 2019
- Full Text
- View/download PDF
23. The vulnerable superhero—a qualitative study investigating how spinal cord injury peer mentors experience their role in Active Rehabilitation training programs
- Author
-
Lindén, Josefine, primary, Stenberg, Gunilla, additional, and Divanoglou, Anestis, additional
- Published
- 2023
- Full Text
- View/download PDF
24. Tapping into the unimpossible: Philosophical health in lives with spinal cord injury
- Author
-
de Miranda, Luis, primary, Levi, Richard, additional, and Divanoglou, Anestis, additional
- Published
- 2023
- Full Text
- View/download PDF
25. INTERnational Project for the Evaluation of “activE Rehabilitation” (inter-PEER) – a protocol for a prospective cohort study of community peer-based training programmes for people with spinal cord injury
- Author
-
Divanoglou, Anestis, Tasiemski, Tomasz, and Jörgensen, Sophie
- Published
- 2020
- Full Text
- View/download PDF
26. Neurocognitive deficits in COVID-19 patients five months after discharge from hospital.
- Author
-
Birberg Thornberg, Ulrika, Andersson, Agnes, Lindh, Malin, Hellgren, Lovisa, Divanoglou, Anestis, and Levi, Richard
- Subjects
COVID-19 ,HOSPITAL admission & discharge ,SHORT-term memory ,EXECUTIVE function ,NEUROPSYCHOLOGICAL tests ,STUDENT adjustment - Abstract
This observational cohort study explored objective neurocognitive deficits in COVID-19 patients five months after discharge, and any associations with demographic factors and disease severity indicators. Medical notes of all COVID-19 patients admitted to hospital in Region Östergötland, Sweden, March-May 2020, were reviewed. After applying exclusion criteria, 433 patients were screened by telephone. Of these, 185 patients reported persistent and concerning post-COVID-19 problems, including but not restricted to cognitive functions, and were invited to a clinical evaluation. The Repeatable Battery for Assessment of Neuropsychological Status (RBANS) and Colour-Word Interference Test (CWIT) were used to assess immediate memory, visuo-spatial function, language, attention, delayed memory, and executive function. A total of 133 patients had valid test performances. Mean RBANS Global Cognition Score was 83.4, with 37% scoring below cut-off (1.5 SD). Deficits in Attention and Memory indices were most common, each affecting approximately 30% of the patients. After adjustment for sex, language, level of education and premorbid function, neurocognitive performance was positively associated with length of hospital stay, but not with the disease severity indicators WHO CPS and CRP. Findings support that comprehensive neuropsychological assessment should be performed when patients report post-COVID-19 symptoms that affect daily life. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
27. Two-year follow-up of patients with post-COVID-19 condition in Sweden: a prospective cohort study
- Author
-
Wahlgren, Carl, Forsberg, Gustaf, Divanoglou, Anestis, Östholm Balkhed, Åse, Niward, Katarina, Berg, Sören, Levi, Richard, Wahlgren, Carl, Forsberg, Gustaf, Divanoglou, Anestis, Östholm Balkhed, Åse, Niward, Katarina, Berg, Sören, and Levi, Richard
- Abstract
Background Few studies have reported the long-term health effects of COVID-19. The regional population-based Linkoping COVID-19 study (LinCoS) included all patients hospitalised due to COVID-19 during the first pandemic wave. Four months post-discharge, over 40% (185/433) experienced persisting symptoms and activity/ participation limitations, indicating post-COVID-19 condition (PCC). The present follow-up study aimed to determine the long-term recovery among these patients 24 months post-admission.Methods This prospective cohort study included all patients from LinCoS with PCC at four months post-discharge. We repeated the same structured interview at a 24-month follow-up to identify persisting symptoms and their impact on daily life. Intercurrent health issues were identified by reviewing medical records.Findings Of 185 patients with PCC at 4 months post-discharge, 181 were alive at the 24-month assessment and 165 agreed to participate. Of those, 21% (35/165) had been readmitted to hospital for various causes in the interim period. The majority of patients (139/165, 84%) reported persisting problems affecting everyday life at 24 months. Significant improvements were seen in the prevalence and magnitude of some symptoms/limitations compared with four months post-discharge. Cognitive, sensorimotor, and fatigue symptoms were the most common persisting symptoms at 24 months. No clear difference was evident between individuals treated in the intensive care unit (ICU) and non-ICU-treated individuals. Approximately half of those who were on sick leave related to PCC at four months after infection were on sick leave at 24 months.Interpretation This is one of the first studies to report 2-year outcomes in patients with PCC following COVID-19 hospitalisation. Despite some improvements over time, we found a high prevalence of persisting symptoms and a need for long-term follow-up and rehabilitation post COVID-19 infection.
- Published
- 2023
- Full Text
- View/download PDF
28. Tapping into the unimpossible: Philosophical health in lives with spinal cord injury
- Author
-
de Miranda, Luis, Levi, Richard, Divanoglou, Anestis, de Miranda, Luis, Levi, Richard, and Divanoglou, Anestis
- Abstract
Background: We investigated the personal philosophies of eight persons with a tetraplegic condition (four male, four female), all living in Sweden with a chronic spinal cord injury (SCI) and all reporting a good life. Our purpose was to discover if there is a philosophical mindset that may play a role in living a good life with a traumatic SCI. Methods: Two rounds of in-depth qualitative interviews were performed by the same interviewer, a philosophical practitioner by training (de Miranda). The second round systematically covered the following elements: bodily sense, sense of self, sense of belonging, sense of the possible, sense of purpose and philosophical sense. This six-step method developed by de Miranda is called SMILE_PH, an acronym for Sense-Making Interviews Looking at Elements of Philosophical Health. Results: All the interviewees, as a consequence of their trauma, reported having gone through a reinvention of themselves which implied questioning the meaning and purpose of their life in particular and life in general. A philosophical rather than realistic sense of the possible was abstracted toward teleological growth. All interviewees developed a sense of purpose based on self-interested altruism and solidarity with disabled peers. Conclusions: To reinvent a good life with SCI, in addition to physical training and willpower, one needs to consider philosophical questions about the self and life, what Kant called the cosmic interests of reason: What may I hope? What must I do? What can I know? Our results indicate that we should, in the future, explore what the philosophical health approach may bring to rehabilitation processes in the months or years that follow the trauma.
- Published
- 2023
- Full Text
- View/download PDF
29. The vulnerable superhero : a qualitative study investigating how spinal cord injury peer mentors experience their role in Active Rehabilitation training programs
- Author
-
Lindén, Josefine, Stenberg, Gunilla, Divanoglou, Anestis, Lindén, Josefine, Stenberg, Gunilla, and Divanoglou, Anestis
- Abstract
Study design: Qualitative study. Objectives: To explore how peer mentors with spinal cord injury (SCI) experience their role in Active Rehabilitation programs in Sweden. Setting: Community peer-based training programs in Sweden. Methods: Twenty active peer mentors were strategically selected and invited to participate. Nine individuals of diverse age, level of SCI and time since injury participated in semi-structured interviews via video link. Qualitative content analysis was used to analyze the data. Results: The theme: Being a vulnerable superhero—a balancing act with rewards was based upon five categories: Being a suitable fit for a demanding culture, Offering a shortcut to coping with spinal cord injury life, Feeling rewarded by helping others, Building trust is reciprocal, and Constituting the norm in a temporary community. The peer mentors expressed vulnerability of sharing life experiences, being a role model and building relationships with mentees. The theme emerged from notions of high expectations and demands of the SCI peer mentor role. Being a peer mentor empowered, educated and inspired the peer mentors themselves. Conclusions: Peer mentors were continuously balancing between being open and vulnerable, and being strong and capable. Personality traits were reported as more important aspects of the role than physical skills. The individual mentor-mentee meetings and relationships were considered more important than the actual training sessions. Feeling part of a community and the norm through meeting others in a similar situation was perceived as a reward and motivation for participating as a peer mentor.
- Published
- 2023
- Full Text
- View/download PDF
30. The incidence and characteristics of ventilator-associated pneumonia in a regional nontertiary Australian intensive care unit: A retrospective clinical audit study
- Author
-
Karen Smith, Jeremy Fernando, Luke J. Heales, Kirsty Watson, David Austin, Josephine Reoch, Elise Tan, and Anestis Divanoglou
- Subjects
Adult ,Clinical audit ,medicine.medical_specialty ,medicine.medical_treatment ,Emergency Nursing ,Critical Care Nursing ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,medicine ,Humans ,030212 general & internal medicine ,Retrospective Studies ,Mechanical ventilation ,Clinical Audit ,business.industry ,Incidence ,Incidence (epidemiology) ,Australia ,Ventilator-associated pneumonia ,Pneumonia, Ventilator-Associated ,030208 emergency & critical care medicine ,medicine.disease ,Intensive care unit ,Confidence interval ,respiratory tract diseases ,Intensive Care Units ,Pneumonia ,Emergency medicine ,business ,Body mass index - Abstract
Ventilator-associated pneumonia (VAP) is a common complication of mechanical ventilation in the intensive care unit. The incidence, patient characteristics, and outcomes have not been described in a regional Australian setting.Τhe primary objective was to establish the incidence of VAP in a regional intensive care unit using predetermined diagnostic criteria. The secondary objective was to compare the agreement between criteria-based and physician-based diagnostic processes. The tertiary objectives were to compare patient characteristics and clinical outcomes of cases with and without VAP.A retrospective clinical audit was performed of adult patients admitted to Rockhampton Intensive Care Unit, Australia, between 2013 and 2016. We included all patients ventilated for ≥72 h and not diagnosed with a pneumonia before or during the first 72 h of ventilation.A total of 170 cases met the inclusion criteria. The incidence of VAP as per the criteria-based diagnosis was 27.3 cases per 1000 ventilator days (95% confidence interval [CI]: 18.4-36.2) and as per the physician-based diagnosis was 25.8 cases per 1000 ventilator days (95% CI: 17.1-34.4). There was a moderate chance-corrected agreement between the criteria- and physician-based diagnosis. Very obese cases (body mass index [BMI] ≥40) were nearly four times more likely to develop VAP than cases with normal BMI (BMI30) (odds ratio: 3.664; 95% CI: 1.394-9.634; p = 0.008). After controlling for sex, BMI category, comorbidities, and Acute Physiology and Chronic Health Evaluation II scores, there was a trend (p = 0.283) for higher adjusted mortality rate for cases with VAP (10.1%, 95% CI: 4.8-21.5) than for those without VAP (6.1%, 95% CI: 3.0-12.4). Cases with VAP had a higher total hospital cost ($123,223 AUD vs $66,425 AUD, p 0.001), than cases without VAP.This is the first study reporting incidence of VAP in an Australian regional intensive care unit setting. An increased length of stay and significantly higher hospital costs warrant research investigating reliable and valid clinical prediction rules to forecast those at risk of VAP.
- Published
- 2022
31. Two-year follow-up of patients with post-COVID-19 condition in Sweden: a prospective cohort study
- Author
-
Wahlgren, Carl, primary, Forsberg, Gustaf, additional, Divanoglou, Anestis, additional, Östholm Balkhed, Åse, additional, Niward, Katarina, additional, Berg, Sören, additional, and Levi, Richard, additional
- Published
- 2023
- Full Text
- View/download PDF
32. Temporal changes in demographic and injury characteristics of traumatic spinal cord injuries in Nordic countries - a systematic review with meta-analysis
- Author
-
Maria Moschovou, Wolfram Antepohl, Annette Halvorsen, Ann Louise Pettersen, and Anestis Divanoglou
- Subjects
Paraplegia ,Neurology ,Norway ,Incidence ,Humans ,Neurology (clinical) ,General Medicine ,Scandinavian and Nordic Countries ,Spinal Cord Injuries - Abstract
Systematic review with meta-analysis.To explore temporal changes in incidence rates, demographic and injury characteristics of incident traumatic spinal cord injury (TSCI) in Nordic countries.Peer-reviewed publications and periodic reports about epidemiology of TSCI in the Nordic countries (Denmark, Finland, Iceland, Norway, Sweden) are identified, reviewed and included in the meta-analysis. Data are stratified into 20-year intervals to allow for chronological comparisons. Pooled estimates are derived using random effects meta-analysis.Twenty-three data sources are included presenting a total of 5416 cases. The pooled incidence rate for 2001-2020 is 15.4 cases/million/year compared to 17.6 and 18.3 cases/million/year during the two previous 20-year intervals. The proportion of cases with TSCI in the 15-29 age-group decreases from 50% (1961-1980) to 20% (2001-2020), while it increases from 9% to 35% in 60+ age-group. Transportation-related injuries decrease from 44% (1961-1980) to 27% (2001-2020). Conversely, fall-related injuries increase from 32% (1961-1980) to 46% (2001-2020). The proportion of individuals with incomplete tetraplegia increases from 31% (1961-1980) to 43% (2001-2020), while complete paraplegia decreases from 25% to 16%.The characteristics of TSCI in the Nordic countries have changed drastically over the last six decades, in line with clinical experiences, and limited research evidence from other countries. These changes indicate the need for adapting research focus, prevention strategies, design and provision of care, rehabilitation and community services towards older individuals, fall-related injuries, and incomplete injuries in Nordic countries and other settings internationally where such changes occur.
- Published
- 2022
33. Neurocognitive deficits in COVID-19 patients five months after discharge from hospital
- Author
-
Birberg Thornberg, Ulrika, primary, Andersson, Agnes, additional, Lindh, Malin, additional, Hellgren, Lovisa, additional, Divanoglou, Anestis, additional, and Levi, Richard, additional
- Published
- 2022
- Full Text
- View/download PDF
34. Seven Domains of Persisting Problems after Hospital-treated Covid-19 Indicate a Need For a Multiprofessional Rehabilitation Approach
- Author
-
Hellgren, Lovisa, primary, Levi, Richard, additional, Divanoglou, Anestis, additional, Birberg-Thornberg, Ulrika, additional, and Samuelsson, Kersti, additional
- Published
- 2022
- Full Text
- View/download PDF
35. Two-year follow-up of patients with post-COVID-19 condition in Sweden: a prospective cohort study
- Author
-
Carl Wahlgren, Gustaf Forsberg, Anestis Divanoglou, Åse Östholm Balkhed, Katarina Niward, Sören Berg, and Richard Levi
- Subjects
Oncology ,Health Policy ,Internal Medicine - Published
- 2023
36. Association of Vitamin D Receptor Gene Polymorphisms with Serum Vitamin D Levels in a Greek Rural Population (Velestino Study)
- Author
-
Despina Komninou, Eleni A. Stea, Anagnostis Argiriou, Natalia Divanoglou, Kalliopi Pazaitou-Panayiotou, Marios K. Georgakis, Eleni Petridou, Andreas Tsakalof, and Grigorios Papatzikas
- Subjects
Rural Population ,medicine.medical_specialty ,TaqI ,Medicine (miscellaneous) ,Serum 25(OH)D3 levels ,Deficiency ,Vitamin D receptor ,Nutrigenetics ,Vitamin D receptor polymorphisms ,QH426-470 ,Calcitriol receptor ,vitamin D deficiency ,chemistry.chemical_compound ,Internal medicine ,serum 25(oh)d3 levels ,Genotype ,Genetics ,Vitamin D and neurology ,Humans ,Medicine ,Genetic Predisposition to Disease ,Vitamin D ,Allele ,nutrigenetics ,Polymorphism, Genetic ,Greece ,biology ,vitamin d receptor polymorphisms ,business.industry ,vitamin d receptor ,deficiency ,medicine.disease ,FokI ,Endocrinology ,chemistry ,biology.protein ,Receptors, Calcitriol ,business ,Food Science - Abstract
Background/Aim: An alarming increase in vitamin D deficiency even in sunny regions highlights the need for a better understanding of the genetic background of the vitamin D endocrine system and the molecular mechanisms of gene polymorphisms of the vitamin D receptor (VDR). In this study, the serum levels of 25(OH)D3 were correlated with common VDR polymorphisms (ApaI, BsmI, FokI, and TaqI) in 98 subjects of a Greek homogeneous rural population. Methods: 25(OH)D3 concentration was measured by ultra-HPLC, and the VDR gene polymorphisms were identified by quantitative real-time PCR followed by amplicon high-resolution melting analysis. Results: Subjects carrying either the B BsmI (OR: 0.52, 95% CI: 0.27–0.99) or t TaqI (OR: 2.06, 95%: 1.06–3.99) allele presented twice the risk for developing vitamin D deficiency compared to the reference allele. Moreover, subjects carrying 1, 2, or all 3 of these genotypes (BB/Bb, Tt/tt, and FF) demonstrated 2-fold (OR: 2.04, 95% CI: 0.42–9.92), 3.6-fold (OR: 3.62, 95% CI: 1.07–12.2), and 7-fold (OR: 6.92, 95% CI: 1.68–28.5) increased risk for low 25(OH)D3 levels, respectively. Conclusions: Our findings reveal a cumulative effect of specific VDR gene polymorphisms that may regulate vitamin D concentrations explaining, in part, the paradox of vitamin D deficiency in sunny regions, with important implications for precision medicine.
- Published
- 2021
37. Seven Domains of Persisting Problems after Hospital-Treated Covid-19 Indicate a Need For a Multiprofessional Rehabilitation Approach
- Author
-
Hellgren, Lovisa, Levi, Richard, Divanoglou, Anestis, Birberg Thornberg, Ulrika, Samuelsson, Kersti, Hellgren, Lovisa, Levi, Richard, Divanoglou, Anestis, Birberg Thornberg, Ulrika, and Samuelsson, Kersti
- Abstract
Objectives: To identify domains of persisting problems at 4 months after discharge in patients previously hospitalized due to COVID-19, with a focus on a subgroup of patients reporting symptoms to an extent indicative of rehabilitation needs. Design: Ambidirectional observational cohort study. Patients: All patients with a laboratory-confirmed COVID-19 diagnosis admitted to hospital in a Swedish healthcare region during the period 1 March to 31 May 2020. After exclusion, 94% of all survivors (n = 433) participated in the study. Forty-three percent (n = 185) of these reported persisting problems indicating rehabilitation needs and formed a subgroup. Methods: Explorative factor analysis based on results from comprehensive telephone interviews covering persisting symptoms, including assessment of impact on daily life. Results: Seven domains were identified, comprising problems related to vision, cognition, mental fatigue, swallowing, voice, sensorimotor dysfunction, and feeling anxious/depressed. The patients in the subgroup reported a median of 8 symptoms/limitations affecting everyday life, and two-thirds reported symptoms/limitations in 3 or more domains. Conclusion: Seven problem domains corresponding to specific modalities of rehabilitative interventions were identified. A majority of patients reported problems from several domains, indicating the need for multiprofessional teams in post-COVID-19 rehabilitation. Screening of patients previously hospitalized due to COVID-19 should cover all 7 domains of persisting problems., Funding Agencies|regional ALF grant; Ostergotland healthcare region; Futurum (the Academy of Health Care at Jonkoping healthcare -region)
- Published
- 2022
- Full Text
- View/download PDF
38. Improved 60-day survival but impaired general health in Swedish ICU-COVID patients: An ambidirectional population-based study
- Author
-
Forsberg, Gustaf, Berg, Sören, Divanoglou, Anestis, Levi, Richard, Ekqvist, David, Östholm Balkhed, Åse, Niward, Katarina, Forsberg, Gustaf, Berg, Sören, Divanoglou, Anestis, Levi, Richard, Ekqvist, David, Östholm Balkhed, Åse, and Niward, Katarina
- Abstract
Background Survival among critically ill COVID-19 patients varies between countries and time periods. Mortality rates up to 60% have been reported in intensive care units (ICUs). Standard-of-care has evolved throughout the pandemic. The purpose of the study was to explore management and mortality of COVID-19 ICU-patients during the first pandemic wave and assess their post-ICU health status. Methods We conducted an exploratory observational ambidirectional population-based study of ICU-patients with COVID-19 in a Swedish county during 1 March-30 June 2020. Primary outcome was 60-day mortality with secondary outcomes including treatments, complications, self-reported general health and dyspnoea post-discharge. Patients were consecutively divided into equal tertiles with cut-offs on April 4 and April 20, 2020, to analyse time trends. Results One hundred patients, median age was 63 years, were included, and 60-day mortality rate was 22%. Ninety-one percent had moderate/severe ARDS and 88% required mechanical ventilation. In the first tertile of patients 60-day mortality was 33%, declining to 15% and 18% in the following two. This reduction paralleled increased use of thromboprophylaxis, less steep rise of treated ICU-patients per day and expanded ICU resources. Four months post-discharge, 63% of survivors reported self-assessed decline in general health retrospectively compared to prior COVID-19. Conclusions In this cohort, the initial 60-day mortality quickly declined, despite continuous admittance of critically ill patients. This was parallel to adaptation to increased workload and more intense thromboembolic prophylaxis. A majority of survivors reported declined general health four months after discharge. Further studies on long-term health status of ICU-survivors are indicated., Funding Agencies|Swedish Intensive Care Registry; ALF grants from the Region of ostergotland, Sweden
- Published
- 2022
- Full Text
- View/download PDF
39. Improved 60‐day survival but impaired general health in Swedish ICU‐COVID patients: An ambidirectional population‐based study
- Author
-
Forsberg, Gustaf, primary, Berg, Sören, additional, Divanoglou, Anestis, additional, Levi, Richard, additional, Ekqvist, David, additional, Östholm Balkhed, Åse, additional, and Niward, Katarina, additional
- Published
- 2022
- Full Text
- View/download PDF
40. Seven Domains of Persisting Problems after Hospital-Treated Covid-19 Indicate a Need For a Multiprofessional Rehabilitation Approach
- Author
-
Kersti Samuelsson, Lovisa Hellgren, Ulrika Birberg Thornberg, Richard Levi, and Anestis Divanoglou
- Subjects
COVID-19 Testing ,Rehabilitation ,Övrig annan medicin och hälsovetenskap ,COVID-19 ,Humans ,Physical Therapy, Sports Therapy and Rehabilitation ,Survivors ,General Medicine ,Delivery of Health Care ,Hospitals ,Other Medical Sciences not elsewhere specified ,activities of daily living ,cognition ,expressed emotions ,mental fatigue ,participation - Abstract
Objectives: To identify domains of persisting problems at 4 months after discharge in patients previously hospitalized due to COVID-19, with a focus on a subgroup of patients reporting symptoms to an extent indicative of rehabilitation needs.Design: Ambidirectional observational cohort study.Patients: All patients with a laboratory-confirmed COVID-19 diagnosis admitted to hospital in a Swedish healthcare region during the period 1 March to 31 May 2020. After exclusion, 94% of all survivors (n = 433) participated in the study. Forty-three percent (n = 185) of these reported persisting problems indicating rehabilitation needs and formed a subgroup.Methods: Explorative factor analysis based on results from comprehensive telephone interviews covering persisting symptoms, including assessment of impact on daily life.Results: Seven domains were identified, comprising problems related to vision, cognition, mental fatigue, swallowing, voice, sensorimotor dysfunction, and feeling anxious/depressed. The patients in the subgroup reported a median of 8 symptoms/limitationsaffecting everyday life, and two-thirds reported symptoms/limitations in 3 or more domains.Conclusion: Seven problem domains corresponding to specific modalities of rehabilitative interventions were identified. A majority of patients reported problems from several domains, indicating the need for multiprofessional teams in post-COVID-19 rehabilitation. Screening of patients previously hospitalized due to COVID-19 should cover all 7 domains of persisting problems. LAY ABSTRACTMore than 70% of patients with COVID-19 have previously been shown to experience 1 or several of a multitude of persisting problems several months after infection. This study aimed to identify areas of persisting problems among a broad spectrum of self-reported problems. Survivors of COVID-19 who had been discharged from hospital 4 months previously participated in a telephone interview covering persisting problems, including assessment of impact on daily life. The persisting problems clustered into 7 functional areas. Mental fatigue, cognitive- and sensorimotor problems were reported most frequently. A potential rehabilitation need was seen in more than 40% of patients interviewed. These patients reported approximately 8 different problems affecting their everyday life, and a majority of these patients reported problems from 3 or more areas. These findings highlight the need for multiprofessional teams in post-COVID-19 rehabilitation. Screening of patients previously hospitalized due to COVID-19 should cover all 7 areas of persisting problems.
- Published
- 2022
41. Swedish version of Moorong Self-efficacy scale (s-MSES)
- Author
-
Jörgensen, Sophie, Divanoglou, Anestis, Forslund, Emelie Butler, Lundström, Ulrica, Levi, Richard, Lyckow, Gunilla, Nilsson, Erika, and Berndtsson, Erik
- Published
- 2022
- Full Text
- View/download PDF
42. Improved 60-day survival but impaired general health in Swedish ICU-COVID patients: An ambidirectional population-based study
- Author
-
Gustaf Forsberg, Sören Berg, Anestis Divanoglou, Richard Levi, David Ekqvist, Åse Östholm Balkhed, and Katarina Niward
- Subjects
Sweden ,Respiratory Distress Syndrome ,Critical Illness ,Aftercare ,Anticoagulants ,COVID-19 ,General Medicine ,Venous Thromboembolism ,Middle Aged ,Respiration, Artificial ,Patient Discharge ,Intensive Care Units ,Anesthesiology and Pain Medicine ,Humans ,Retrospective Studies - Abstract
Survival among critically ill COVID-19 patients varies between countries and time periods. Mortality rates up to 60% have been reported in intensive care units (ICUs). Standard-of-care has evolved throughout the pandemic. The purpose of the study was to explore management and mortality of COVID-19 ICU-patients during the first pandemic wave and assess their post-ICU health status.We conducted an exploratory observational ambidirectional population-based study of ICU-patients with COVID-19 in a Swedish county during 1 March-30 June 2020. Primary outcome was 60-day mortality with secondary outcomes including treatments, complications, self-reported general health and dyspnoea post-discharge. Patients were consecutively divided into equal tertiles with cut-offs on April 4 and April 20, 2020, to analyse time trends.One hundred patients, median age was 63 years, were included, and 60-day mortality rate was 22%. Ninety-one percent had moderate/severe ARDS and 88% required mechanical ventilation. In the first tertile of patients 60-day mortality was 33%, declining to 15% and 18% in the following two. This reduction paralleled increased use of thromboprophylaxis, less steep rise of treated ICU-patients per day and expanded ICU resources. Four months post-discharge, 63% of survivors reported self-assessed decline in general health retrospectively compared to prior COVID-19.In this cohort, the initial 60-day mortality quickly declined, despite continuous admittance of critically ill patients. This was parallel to adaptation to increased workload and more intense thromboembolic prophylaxis. A majority of survivors reported declined general health four months after discharge. Further studies on long-term health status of ICU-survivors are indicated.
- Published
- 2021
43. Rehabilitation needs following COVID-19: Five-month post-discharge clinical follow-up of individuals with concerning self-reported symptoms
- Author
-
Emma Larsdotter Nilsson, Richard Levi, Eva Lilliecreutz Gudmundsson, Åse Östholm-Balkhed, Melanie Larsson, Katarina Niward, Anestis Divanoglou, Ulrika Birberg Thornberg, and Carl Wahlgren
- Subjects
medicine.medical_specialty ,Weakness ,Medicine (General) ,medicine.medical_treatment ,Psychological intervention ,Physical examination ,SARS-CoV-2 ,Post-COVID-19 ,PACS ,Rehabilitation ,Consequences ,Residual symptoms ,Long-term follow-up ,Article ,R5-920 ,Övrig annan medicin och hälsovetenskap ,medicine ,medicine.diagnostic_test ,business.industry ,Neuropsychology ,General Medicine ,Other Medical Sciences not elsewhere specified ,Cohort ,Physical therapy ,medicine.symptom ,business ,Neurocognitive ,Cohort study - Abstract
Background This report describes and objectivizes reported problems among a cohort of previously hospitalized COVID-19 patients by clinical examination and determination of the required level of rehabilitation sevices. Methods This report forms part of the Linkoping COVID-19 Study (LinCoS) that induded 745 individuals from one of 21 Swedish healthcare regions, Region Ostergotland (RO), admitted to hospital for COVID-19 during March 1st-May 31st, 2020. In this descriptive ambidirectional cohort study, all 185 individuals who had reported concerning persisting symptoms were invited to a multi-professional dinical assessment of somatic, functional, affective, neuropsychological status and rehabilitation needs. Rehabilitation needs were assessed using three sub-scales of the Rehabilitation Complexity Scale-Extended. Findings Among the 158 (85.4%) cases consenting and included in the analysis, we found a broad array of symptoms and signs attributable to COVID-19 involving respiratory, visual, auditory, motor, sensory and cognitive functions that could be confirmed clinically at five months post-discharge. This translated into 16% [95% CI 13-20] of survivors (70/433) of the total regional cohort of hospitalised patients requiring further rehabilitative interventions at follow-up. Weakness in extremities was reported in 28.5% [21.6, 36.2] (45/158). On examination, clinically overt muscle weakness could be corroborated in 15 individuals (10.5%) [6.1, 16.4]. 48% [40, 56] (76/158) reported cognitive symptoms, while the physician noted overt cognitive impairments in only 3% [1.1, 7.5]. In neuropsychological testing, 37% [28-46] (45/122) performed 1.5 SD below the norm, indicating neurocognitive deficits. Fifty-five individuals (34.8%) [27.4, 42.8] reported new or aggravated pain. In three fourths of them, it exerted a moderate or worse detrimental effect on their ability to work. Interpretation Our study underscores the importance of providing extensive examination of cases with persisting problems after COVID-19, especially since symptoms such as fatigue and breathlessness are highly nonspecific, but may represent significant underlying functional impairments. Robust neurocognitive testing should be performed, as cognitive problems may easily be overlooked during routine medical consultation. In the Swedish context, most rehabilitative interventions could be provided in a primary care setting. A substantial minority of patients should be triaged to specialized rehabilitation services. Funding Agencies: ALF grant and RÖ
- Published
- 2021
44. Rehabilitation needs and mortality associated with the Covid-19 pandemic: a population-based study of all hospitalised and home-healthcare individuals in a Swedish healthcare region
- Author
-
Kersti Samuelsson, Richard Levi, Christer Andersson, Anestis Divanoglou, and Rune Sjödahl
- Subjects
medicine.medical_specialty ,Medicine (General) ,medicine.medical_treatment ,Population ,Disease ,01 natural sciences ,03 medical and health sciences ,0302 clinical medicine ,R5-920 ,Health care ,medicine ,Övrig annan medicin och hälsovetenskap ,030212 general & internal medicine ,0101 mathematics ,education ,education.field_of_study ,Rehabilitation ,business.industry ,Mortality rate ,Medical record ,010102 general mathematics ,General Medicine ,Other Medical Sciences not elsewhere specified ,Telephone interview ,Emergency medicine ,business ,Cohort study ,Research Paper - Abstract
BackgroundThis first report of the Linköping Covid-19 Study (LinCoS) aimed at determination of Covid-19-associated mortality, impairments, activity and participation limitations denoting rehabilitation needs four months after discharge from hospital.MethodsAn ambidirectional population-based cohort study including all confirmed Covid-19 cases admitted to hospital during 1/03-31/05 and those living in home healthcare settings identified through a regional registry and evaluated through medical records, including WHO Clinical Progression Scale (CPS). All patients discharged from hospital were followed-up by structured telephone interview at 4 months post-discharge. Respondents indicated any new or aggravated persisting problems in any of 25 body functions and 12 activity/participation items and rated them for impact on daily life.FindingsOut of 734 hospitalised patients, 149 were excluded, 125 died, and 460 were alive at 4-month follow-up of whom 433 (94.1%) were interviewed. In total, 40% reported impairments and activity/participation limitations affecting daily life and warranted further multi-professional rehabilitation assessment, predominantly those with severe disease and a considerable proportion of those with moderate disease. Cognitive and affective impairments were equally common in all groups and were reported by 20-40% of cases. Limb weakness was reported by 31%, with CPS 7-9 being four times more likely to report this problem as compared to CPS 4-5. 26% of those working or studying reported difficulties returning to these activities, this being 3.5 times more likely in CPS 7-9 as compared to CPS 4-5. 25% reported problems walking >1 km, with CPS 7-9 over three times more likely to report this as compared to the other two sub-groups. 90-day mortality rate of Covid-19 associated deaths was 15.1%.InterpretationMost rehabilitation needs after Covid-19 involved higher cerebral dysfunction both in patients with moderate and severe disease. This should be considered when designing services aiming at minimizing long-term disability.FundingALF grant and Region Östergötland.
- Published
- 2021
45. Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study
- Author
-
Hellgren, Lovisa, primary, Birberg Thornberg, Ulrika, additional, Samuelsson, Kersti, additional, Levi, Richard, additional, Divanoglou, Anestis, additional, and Blystad, Ida, additional
- Published
- 2021
- Full Text
- View/download PDF
46. Does face-to-face pre-operative joint replacement education reduce hospital costs in a regional Australian hospital? A descriptive retrospective clinical audit
- Author
-
Joel Santamaria, Daniel Lewis, Anestis Divanoglou, Victoria Hutton, Christopher M. Doran, Luke J. Heales, Tyrone Kolbe, Sally Chapman, and Katherine Fullard
- Subjects
Male ,musculoskeletal diseases ,Clinical audit ,medicine.medical_specialty ,Total cost ,Joint replacement ,Cost effectiveness ,Arthroplasty, Replacement, Hip ,medicine.medical_treatment ,Pharmacist ,03 medical and health sciences ,0302 clinical medicine ,Patient Education as Topic ,Cost Savings ,Acute care ,Humans ,Medicine ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Hospital Costs ,Arthroplasty, Replacement, Knee ,Aged ,Retrospective Studies ,030222 orthopedics ,Clinical Audit ,business.industry ,Medical record ,Length of Stay ,Middle Aged ,Hospitals, District ,Preoperative Period ,Physical therapy ,Female ,Surgery ,Queensland ,business ,Patient education - Abstract
To evaluate whether attending a face-to-face pre-operative joint replacement education in a regional setting reduces overall hospital costs and length of stay (LOS) following total knee replacement (TKR) or total hip replacement (THR). A retrospective clinical audit reviewed the medical records of all patients who underwent an elective THR or TKR at Rockhampton Hospital in regional Queensland, Australia, between 03/2015 and 12/2016 (22 months). The pre-operative joint replacement education class was provided by a multidisciplinary team that included a physiotherapist, an occupational therapist, a dietician, a pharmacist and a social worker. In addition to demographic data, we extracted and analysed data related to total acute care and total healthcare cost, prevalence of post-operative complications, discharge destination and comorbidities (using the Functional Comorbidity Index). Out of 326 cases that were included in the analysis, 115 cases with TKR and 51 cases with THR attended a pre-operative education class. Demographic characteristics between those attending and not attending the class were largely similar, except from more females attending in the THR group. There was no difference in hospital costs or LOS between those who attended the class compared to those who did not for both the TKR and THR groups. Outcomes related to total acute stay costs, total cost including travel and education and score for Functional Comorbidities Index were similar between those who attended the class and those who did not. Pre-operative education does not reduce hospital costs (surgery and hospital stay) in Central Queensland.
- Published
- 2019
47. The Swedish version of Spinal Cord Independence Measure (s-SCIM-III)
- Author
-
Jörgensen, Sophie, Divanoglou, Anestis, Forslund, Emelie Butler, Lundström, Ulrica, Bergmark, Lisa Holmlund Previously, Lofvenmark, Inka, Levi, Richard, Berndtsson, Erik, Nilsson, Erika, Wangdell, Johanna, and Lili, Lamprini
- Published
- 2021
- Full Text
- View/download PDF
48. The Swedish version of the Spinal Cord Independence Measure Self-Report (s-SCIM-SR)
- Author
-
Jörgensen, Sophie, Divanoglou, Anestis, Forslund, Emelie Butler, Lundström, Ulrica, Levi, Richard, Nilsson, Erika, and Berndtsson, Erik
- Published
- 2021
- Full Text
- View/download PDF
49. Association of Vitamin D Receptor Gene Polymorphisms with Serum Vitamin D Levels in a Greek Rural Population (Velestino Study)
- Author
-
Divanoglou, Natalia Komninou, Despina Stea, Eleni A. and Argiriou, Anagnostis Papatzikas, Grigorios Tsakalof, Andreas and Pazaitou-Panayiotou, Kalliopi Georgakis, Marios K. Petridou, Eleni
- Abstract
Background/Aim: An alarming increase in vitamin D deficiency even in sunny regions highlights the need for a better understanding of the genetic background of the vitamin D endocrine system and the molecular mechanisms of gene polymorphisms of the vitamin D receptor (VDR). In this study, the serum levels of 25(OH)D-3 were correlated with common VDR polymorphisms (ApaI, BsmI, FokI, and TaqI) in 98 subjects of a Greek homogeneous rural population. Methods: 25(OH)D-3 concentration was measured by ultra-HPLC, and the VDR gene polymorphisms were identified by quantitative real-time PCR followed by amplicon high-resolution melting analysis. Results: Subjects carrying either the B BsmI (OR: 0.52, 95% CI: 0.27-0.99) or t TaqI (OR: 2.06, 95%: 1.06-3.99) allele presented twice the risk for developing vitamin D deficiency compared to the reference allele. Moreover, subjects carrying 1, 2, or all 3 of these genotypes (BB/Bb, Tt/tt, and FF) demonstrated 2-fold (OR: 2.04, 95% CI: 0.42-9.92), 3.6-fold (OR: 3.62, 95% CI: 1.07-12.2), and 7-fold (OR: 6.92, 95% CI: 1.68-28.5) increased risk for low 25(OH)D-3 levels, respectively. Conclusions: Our findings reveal a cumulative effect of specific VDR gene polymorphisms that may regulate vitamin D concentrations explaining, in part, the paradox of vitamin D deficiency in sunny regions, with important implications for precision medicine.
- Published
- 2021
50. Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation : an observational cohort study
- Author
-
Hellgren, Lovisa, Birberg Thornberg, Ulrika, Samuelsson, Kersti, Levi, Richard, Divanoglou, Anestis, Blystad, Ida, Hellgren, Lovisa, Birberg Thornberg, Ulrika, Samuelsson, Kersti, Levi, Richard, Divanoglou, Anestis, and Blystad, Ida
- Abstract
Objectives To report findings on brain MRI and neurocognitive function, as well as persisting fatigue at long-term follow-up after COVID-19 hospitalisation in patients identified as high risk for affection of the central nervous system. Design Ambidirectional observational cohort study. Setting All 734 patients from a regional population in Sweden with a laboratory-confirmed COVID-19 diagnosis admitted to hospital during the period 1 March to 31 May 2020. Participants A subgroup (n=185) with persisting symptoms still interfering with daily life at a telephone follow-up 4 months after discharge were invited for a medical and neuropsychological evaluation. Thirty-five of those who were assessed with a neurocognitive test battery at the clinical visit, and presented a clinical picture concerning for COVID-19-related brain pathology, were further investigated by brain MRI. Main outcome measures Findings on brain MRI, neurocognitive test results and reported fatigue. Results Twenty-five patients (71%) had abnormalities on MRI; multiple white matter lesions were the most common finding. Sixteen patients (46%) demonstrated impaired neurocognitive function, of which 10 (29%) had severe impairment. Twenty-six patients (74%) reported clinically significant fatigue. Patients with abnormalities on MRI had a lower Visuospatial Index (p=0.031) compared with the group with normal MRI findings. Conclusions In this group of patients selected to undergo MRI after a clinical evaluation, a majority of patients had abnormal MRI and/or neurocognitive test results. Abnormal findings were not restricted to patients with severe disease., Funding Agencies|ALF grant
- Published
- 2021
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.