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180 results on '"Dix, Richard"'

2. Encephalitis and poor neuronal death–mediated control of herpes simplex virus in human inherited RIPK3 deficiency

Author

Liu, Zhiyong, primary, Garcia Reino, Eduardo J., additional, Harschnitz, Oliver, additional, Guo, Hongyan, additional, Chan, Yi-Hao, additional, Khobrekar, Noopur V., additional, Hasek, Mary L., additional, Dobbs, Kerry, additional, Rinchai, Darawan, additional, Materna, Marie, additional, Matuozzo, Daniela, additional, Lee, Danyel, additional, Bastard, Paul, additional, Chen, Jie, additional, Lee, Yoon Seung, additional, Kim, Seong K., additional, Zhao, Shuxiang, additional, Amin, Param, additional, Lorenzo, Lazaro, additional, Seeleuthner, Yoann, additional, Chevalier, Remi, additional, Mazzola, Laure, additional, Gay, Claire, additional, Stephan, Jean-Louis, additional, Milisavljevic, Baptiste, additional, Boucherit, Soraya, additional, Rozenberg, Flore, additional, Perez de Diego, Rebeca, additional, Dix, Richard D., additional, Marr, Nico, additional, Béziat, Vivien, additional, Cobat, Aurelie, additional, Aubart, Mélodie, additional, Abel, Laurent, additional, Chabrier, Stephane, additional, Smith, Gregory A., additional, Notarangelo, Luigi D., additional, Mocarski, Edward S., additional, Studer, Lorenz, additional, Casanova, Jean-Laurent, additional, and Zhang, Shen-Ying, additional

Published
2023
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3. JMC ensures munitions readiness for the total force

Author

Dix, Richard B.

Subjects
United States. Department of Defense, Soldiers -- Military aspects, General interest, Military and naval science
Abstract

In today's dynamic environment of multiple threats to our national defense, logistics must move quickly to meet demands. With this consideration at the forefront of its mission planning, the Joint [...]

Published
2017

16. AMC support to reconstitution in Afghanistan

Author

Seidler, Wayne T. and Dix, Richard B.

Subjects
Soldiers -- Equipment and supplies, Logistics services -- Strategic aspects -- Distribution -- Equipment and supplies, Logistics -- Distribution -- Equipment and supplies, Company distribution practices, General interest, Military and naval science
Abstract

The Army Materiel Command (AMC) is evolving to meet the needs of today's warfighter and the requirements of the Modular Force. AMC's Army field support brigades and their battalions are [...]

Published
2007

28. Parthanatos‐associated proteins are stimulated intraocularly during development of experimental murine cytomegalovirus retinitis in mice with retrovirus‐induced immunosuppression.

Author

Oh, Jay J., Carter, Jessica J., Nemeno, Judee Grace E., and Dix, Richard D.

Subjects
HUMAN cytomegalovirus, PATHOLOGY, CELL death, IMMUNOSUPPRESSION, MICE
Abstract

The mechanisms that contribute to retinal tissue destruction during the onset and progression of AIDS‐related human cytomegalovirus (HCMV) retinitis remain unclear. Evidence for the stimulation of multiple cell death pathways including apoptosis, necroptosis, and pyroptosis during the pathogenesis of experimental murine cytomegalovirus (MCMV) retinitis in mice with retrovirus‐induced immunosuppression (MAIDS) has been reported. Parthanatos is a caspase‐independent cell death pathway mediated by rapid overactivation of poly (ADP‐ribose) polymerase‐1 (PARP‐1) and distinct from other cell death pathways. Using the MAIDS model of MCMV retinitis, studies were performed to test the hypothesis that intraocular MCMV infection of mice with MAIDS stimulates parthanatos‐associated messenger RNAs (mRNAs) and proteins within the eye during the development of retinal necrosis that takes place by 10 days after MCMV infection. MCMV‐infected eyes of MAIDS mice exhibited significant stimulation of PARP‐1 mRNA and proteins at 3 days after infection but declined thereafter at 6 and 10 days after infection. Additional studies showed the intraocular stimulation of mRNAs or proteins before MCMV retinitis development for two additional participants in parthanatos, polymer of ADP‐ribose and poly (ADP‐ribose) glycohydrolase. These results provide new evidence for a role for parthanatos during MAIDS‐related MCMV retinitis that may also extend to AIDS‐related HCMV retinitis. Highlight: AIDS‐related human cytomegalovirus (HCMV) retinitis results in vision loss or blindness in up to 30% of AIDS patients who do not have access to combination antiretroviral therapy.Cell death pathways contribute to retinal tissue destruction during the onset and development of AIDS‐related HCMV retinitis.This report provides the first evidence for a role for parthanatos, a caspase‐independent cell death pathway, during the development of retinal disease using an experimental mouse model of AIDS‐related HCMV retinitis. [ABSTRACT FROM AUTHOR]

Published
2020
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34. Viral forensic genomics reveals the relatedness of classic herpes simplex virus strains KOS, KOS63, and KOS79

Author

Bowen, Christopher D., Renner, Daniel W., Shreve, Jacob T., Tafuri, Yolanda, Payne, Kimberly M., Dix, Richard D., Kinchington, Paul R., Gatherer, Derek, Szpara, Moriah L., Bowen, Christopher D., Renner, Daniel W., Shreve, Jacob T., Tafuri, Yolanda, Payne, Kimberly M., Dix, Richard D., Kinchington, Paul R., Gatherer, Derek, and Szpara, Moriah L.

Abstract

Herpes simplex virus 1 (HSV-1) is a widespread global pathogen, of which the strain KOS is one of the most extensively studied. Previous sequence studies revealed that KOS does not cluster with other strains of North American geographic origin, but instead clustered with Asian strains. We sequenced a historical isolate of the original KOS strain, called KOS63, along with a separately isolated strain attributed to the same source individual, termed KOS79. Genomic analyses revealed that KOS63 closely resembled other recently sequenced isolates of KOS and was of Asian origin, but that KOS79 was a genetically unrelated strain that clustered in genetic distance analyses with HSV-1 strains of North American/European origin. These data suggest that the human source of KOS63 and KOS79 could have been infected with two genetically unrelated strains of disparate geographic origins. A PCR RFLP test was developed for rapid identification of these strains.

Published
2016

47. Cavity Aeroacoustics

Author

ARNOLD ENGINEERING DEVELOPMENT CENTER ARNOLD AFS TN, Dix, Richard E., Butler, Carroll, ARNOLD ENGINEERING DEVELOPMENT CENTER ARNOLD AFS TN, Dix, Richard E., and Butler, Carroll

Abstract

Consider the retraction or hiding of items in a cavity that is closed and smooth to the flow over the body. At an appropriate time, doors or panels open as part of a desired operational sequence, and the storage volume, or cavity, together with the contents, are exposed to the external flow. Two important flow phenomena occur with exposure of a cavity in high speed aircraft: (1) development of a shear layer within which transition from the stagnant cavity environment to the active external flow occurs, and (2) the creation of a concomitant fluctuating pressure environment. A program of experiments has been undertaken since 1985 at Arnold AFB, TN to investigate these phenomena which have resulted in a rather large data base describing the aeroacoustic environment associated with cavities of three different length-to-height ratios, equipped with a variety of acoustic suppression devices and doors, and exposed to external flows of subsonic and supersonic speeds. This paper documents that series of experiments and the results therein. Keywords: Flow suppression devices; Shear layer; Aeroacoustic modulation; Store loads; Computational fluid dynamics; Schlieren evidence., Prepared in cooperation with Calspan Corp./AEDC.

Published
1990

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