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474 results on '"Dix D"'

16. P2.03-02 Cell-Free DNA (cfDNA) Testing in Lung Adenocarcinoma (LUAC) Patients: Spanish Lung Liquid Versus Invasive Biopsy Program (SLLIP)

Author

Palmero, R., primary, Taus, A., additional, Viteri, S., additional, Majem, M., additional, Carcereny, E., additional, Garde-Noguera, J., additional, Felip, E., additional, Sampayo, M., additional, Gomez, L., additional, Lopez, N., additional, Olsen, S., additional, Jackson, M., additional, Faull, I., additional, Dix, D., additional, Karachaliou, N., additional, and Rosell, R., additional

Published
2018
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17. Homology-directed repair (HDR)-defective lung adenocarcinomas (LUACs) in circulating tumor DNA (ctDNA)

Author

Karachaliou, N., primary, Lefterova, M., additional, Draper, J.F., additional, Molina, M.-A., additional, Chaib, I., additional, Palmero, R., additional, Taus, A., additional, Viteri, S., additional, González Cao, M., additional, Majem Tarruella, M., additional, Carcereny Costa, E., additional, Moran, T., additional, Garde Noguera, J., additional, Felip Font, E., additional, Olsen, S., additional, Jackson, M., additional, Sampayo, M., additional, Faull, I., additional, Dix, D., additional, and Rosell, R., additional

Published
2018
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19. P3.01-046 Longitudinal Analysis of Plasma CtDNA in EGFR-Mutant NSCLC: SWOG S1403 Trial of Afatinib with or Without Cetuximab

Author

Mack, P., primary, Miao, J., additional, Banks, K., additional, Burich, R., additional, Politi, K., additional, Raymond, V., additional, Dix, D., additional, Lanman, R., additional, Moon, J., additional, Melnick, M.A., additional, Truini, A., additional, Redman, M., additional, Goldberg, S., additional, Gandara, D.R., additional, and Kelly, K., additional

Published
2017
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25. The Fe(II) permease Fet4p functions as a low affinity copper transporter and supports normal copper trafficking in Saccharomyces cerevisiae

Author

Hassett, R, Dix, D R, Eide, D J, and Kosman, D J

Subjects
Ions, Saccharomyces cerevisiae Proteins, Dose-Response Relationship, Drug, Transcription, Genetic, Iron, Down-Regulation, Galactose, Membrane Proteins, Membrane Transport Proteins, Biological Transport, Saccharomyces cerevisiae, Enzyme Activation, Kinetics, Glucose, Copper Transport Proteins, Iron-Binding Proteins, Mutation, Carrier Proteins, Cation Transport Proteins, Copper, Research Article, Copper Transporter 1
Abstract

The plasma-membrane of Saccharomyces cerevisiae contains high affinity permeases for Cu(I) and Fe(II). A low affinity Fe(II) permease has also been identified, designated Fet4p. A corresponding low affinity copper permease has not been characterized, although yeast cells that lack high affinity copper uptake do accumulate this metal ion. We demonstrate in the present study that Fet4p can function as a low affinity copper permease. Copper is a non-competitive inhibitor of (55)Fe uptake through Fet4p (K(i)=22 microM). Fet4p-dependent (67)Cu uptake was kinetically characterized, with K(m) and V(max) values of 35 microM and 8 pmol of copper/min per 10(6) cells respectively. A fet4-containing strain exhibited no saturable, low affinity copper uptake indicating that this uptake was attributable to Fet4p. Mutant forms of Fet4p that exhibited decreased efficiency in (55/59)Fe uptake were similarly compromised in (67)Cu uptake, indicating that similar amino acid residues in Fet4p contribute to both uptake processes. The copper taken into the cell by Fet4p was metabolized similarly to the copper taken into the cell by the high affinity permease, Ctr1p. This was shown by the Fet4p-dependence of copper activation of Fet3p, the copper oxidase that supports high affinity iron uptake in yeast. Also, copper-transported by Fet4p down-regulated the copper sensitive transcription factor, Mac1p. Whether supplied by Ctr1p or by Fet4p, an intracellular copper concentration of approx. 10 microM caused a 50% reduction in the transcriptional activity of Mac1p. The data suggest that the initial trafficking of newly arrived copper in the yeast cell is independent of the copper uptake pathway involved, and that this copper may be targeted first to a presumably small 'holding' pool prior to its partitioning within the cell.

Published
2000

26. Plasma Dynamics

Author

Yoshikawa, S., Cooper, L. Y., Brandt, B., Woodson, H. H., Lewis, A. T., Smullin, Louis D., Hall, R. B., Lidsky, Lawrence M., Getty, W. D., Haus, Hermann A., Rothleder, S. D., Dix, D. M., Autler, S. H., Donadieu, L. J., Bekefi, George, Hirshfield, J. L., Yoshikawa, S., Cooper, L. Y., Brandt, B., Woodson, H. H., Lewis, A. T., Smullin, Louis D., Hall, R. B., Lidsky, Lawrence M., Getty, W. D., Haus, Hermann A., Rothleder, S. D., Dix, D. M., Autler, S. H., Donadieu, L. J., Bekefi, George, and Hirshfield, J. L.

Abstract

Contains reports on three research projects., Wright Air Development Division (Contract AF33(616)-3984), United States Atomic Energy Commission (Contract AT(30-1)-1842), National Science Foundation (Grant G-9330), United States Air Force, Air Force Cambridge Research Center (Contract AF19(604)-4551), United States Air Force, Air Force Cambridge Research Center, Air Research and Development Command (Contract AF19(604)-5992)

Published
2010

27. Plasma Dynamics

Author

Bekefi, George, Hall, R. B., Ericson, Magda, Whitehouse, D. R., Harwit, M. O., Getty, W. D., Chorney, P., Gajewski, R., Mawardi, O. K., Dix, D. M., Fay, J. A., Zauderer, B., Bekefi, George, Hall, R. B., Ericson, Magda, Whitehouse, D. R., Harwit, M. O., Getty, W. D., Chorney, P., Gajewski, R., Mawardi, O. K., Dix, D. M., Fay, J. A., and Zauderer, B.

Abstract

Contains reports on three research projects., United States Atomic Energy Commission (Contract AT(30-1)-1842), United States Air Force, Air Force Cambridge Research Center (Contract AF19(604)-5992), United States Air Force, Air Force Cambridge Research Center (Contract AF19(604)-4551), National Science Foundation (Grant G-9930), Office of Naval Research through Project SQUID, Phase III, under contract with Massachusetts Institute of Technology

Published
2010

28. Second Bacteremia During Antibiotic Treatment in Children With Acute Myeloid Leukemia: A Report From the Canadian Infections in Acute Myeloid Leukemia Research Group

Author

Tran, T. H., primary, Yanofsky, R., additional, Johnston, D. L., additional, Dix, D., additional, Gillmeister, B., additional, Ethier, M.-C., additional, Portwine, C., additional, Price, V., additional, Mitchell, D., additional, Cellot, S., additional, Lewis, V., additional, Zelcer, S., additional, Silva, M., additional, Michon, B., additional, Bowes, L., additional, Stobart, K., additional, Brossard, J., additional, Beyene, J., additional, and Sung, L., additional

Published
2014
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32. Response to "Accurate Risk-Based Chemical Screening * Relies on Robust Exposure Estimates"

Author

Wetmore, B. A., primary, Wambaugh, J. F., additional, Ferguson, S. S., additional, Sochaski, M. A., additional, Rotroff, D. M., additional, Freeman, K., additional, Clewell, H. J., additional, Dix, D. J., additional, Andersen, M. E., additional, Houck, K. A., additional, Allen, B., additional, Judson, R. S., additional, Singh, R., additional, Kavlock, R. J., additional, Richard, A. M., additional, and Thomas, R. S., additional

Published
2012
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33. Characteristics of Children with Fractures at Diagnosis of ALL: the Influence of Physical Activity.

Author

Hay, J., Martin, B., Wilson, B., Miettunen, P. M., Jaremko, J. L., Huber, A. M., Houghton, K., Ho, J., Grant8, R., B. Dix, D., Charron8, M., Barr, R., Blydt-Hansen, T., Ma, J., and Ward, L. M.

Subjects
BONE fractures in children, DIAGNOSIS of bone fractures, PHYSICAL activity, THERAPEUTIC use of glucocorticoids, RISK factors of fractures, ANALYSIS of variance, BONES, COMPARATIVE studies, DIET, BONE fractures, LYMPHOBLASTIC leukemia, PAIN, POISSON distribution, PROBABILITY theory, PUBERTY, SPINAL injuries, BONE density
Abstract

Background: A significant percentage of children newly diagnosed with acute lymphoblastic leukemia (ALL) present with vertebral fracture(s). In the pan-Canadian Steroid Induced Osteoporosis in Pediatric Populations (STOPP) study, a longitudinal natural history of ALL, 17% of children presented with at least a single lumbar fracture at diagnosis. Understanding the influences on bone fragility early in the disease process would have significant benefit when coordinating care for children when initiating treatment. Methods: We examined data taken around the time of diagnosis of 188 children (ages 2.5 to 16.9) newly diagnosed with ALL. We compared 29 children with vertebral fractures (mean age 6.49 (4.08)) to those 157 (7.15 (3.85)) without vertebral fractures. Measures included areal BMD (DEXA), fractures (x-ray), Tanner stage, (from pictures), pain (self-report), nutrition (7 day recall) and activity from the HAES. Gluccocorticoid (GC) exposure was derived from clinical records. Results: Analyses of variance found NSD between the two groups in age, gender, Tanner stage, Ca intake or VitD intake (both %RDA), inactive hours, change in activity from pre-illness levels, GC exposure by mass or surface area, ALL risk classification, or duration from symptom onset until diagnosis. The non-fracture group had significantly higher (p<.002) lumbar BMDa z-scores. The fracture group reported significantly more back pain (p<.001) and significantly (p<.02) more somewhat active hours (walking, etc.) in the two weeks prior to assessment. Poisson regression analysis (Likelihood Ratio Chi-Square value = 132.768, p=0.001) demonstrated a significantly elevated risk of fractures with decreased BMDa Z-scores (p<.001) and increased age (p<.02), BMI z-score (p<.001), pain (p<.004), and total weekly somewhat active hours (p<.001). No other variables had significant effects. Discussion: These results suggest that the older children in the STOPP study, with greater mass and greater durations of activity, appear to be at elevated risk of lumbar fractures at diagnosis. For some children, the pathological effects of ALL on bone may lead to rapid increases in bone fragility. As a consequence stress from previously normal activity levels may be sufficient to provoke lumbar fractures. As high intensity activity is often suppressed in illness, attention to lower intensity weight-bearing activity is warranted. [ABSTRACT FROM AUTHOR]

Published
2016

35. Prospects for pilot plants based on the tokamak, spherical tokamak and stellarator

Author

Menard, J.E., primary, Bromberg, L., additional, Brown, T., additional, Burgess, T., additional, Dix, D., additional, El-Guebaly, L., additional, Gerrity, T., additional, Goldston, R.J., additional, Hawryluk, R.J., additional, Kastner, R., additional, Kessel, C., additional, Malang, S., additional, Minervini, J., additional, Neilson, G.H., additional, Neumeyer, C.L., additional, Prager, S., additional, Sawan, M., additional, Sheffield, J., additional, Sternlieb, A., additional, Waganer, L., additional, Whyte, D., additional, and Zarnstorff, M., additional

Published
2011
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