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1. Asthma Management in Obesity

Author

Dixon, Anne E., Nyenhuis, Sharmilee M., Rounds, Sharon I. S., Series Editor, Dixon, Anne E., Series Editor, Schnapp, Lynn M., Series Editor, and Forno, Erick, editor

Published
2024
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4. Variation in Sedative and Analgesic Use During the COVID-19 Pandemic and Associated Outcomes

Author

Mesland, Jean-Baptiste, Henin, Pierre, Petre, Hélène, Buelens, Isabelle, Gerard, Anne-Catherine, Markotić, Dragana, Bošnjak, Ivana, Garza, Ruben, Chu, Eric, Chan, Victoria, Gavidia, Oscar Y., Pachon, Felipe, El Kassas, Mohamed, Tawheed, Ahmed, Matsuda, Wataru, Itagaki, Yuki, Kodate, Akira, Suzuki, Reina, Takahashi, Yuki, Moriki, Koyo, Amer, Marwa Ridha, Bawazeer, Mohammed Abdullah, Dahhan, Talal I., Kseibi, Eiad, Butt, Abid Shahzad, Khurshid, Syed Moazzum, Rabee, Muath, Abujazar, Mohammed, Alghunaim, Razan, Abualkhair, Maal, AlFirm, Abeer Turki, Almazyad, Mohammed A., Alarifi, Mohammed I., Macarambon, Jara M., Bukhari, Ahmad Abdullah, Albahrani, Hussain A., Asfina, Kazi N., Aldossary, Kaltham M., Bojicic, Jovana, Kovacevic, Bojan, Predrag, Stevanovic, Stojakov, Dejan S., Ignjatovic, Duska K., Bojic, Suzana C., Bobos, Marina M., Nenadic, Irina B., Zaric, Milica S., Djuric, Marko D., Djukic, Vladimir R., Teruel, Santiago Y., Martin, Belen C., Kharbanda, Anmol, Jhajhria, Sunil, Fyffe, Zachary, Capizzi, Stephen, Alicie, Bethany, Green, Martha, Crockarell, Lori, Drennan, Amelia, Dubuque, Kathleen, Fambrough, Tonya, Gasaway, Nikole, Krantz, Briana, Nebi, Peiman, Orga, Jan, Serfass, Margaret, Simion, Alina, Warren, Kimberly, Wheeler, Cassie, Woolman, C.J., Christie, Amy B., Ashley, Dennis W., Adiga, Rajani, Newsome, Andrea Sikora, Forehand, Christy C., Bruning, Rebecca, Jones, Timothy W., Walkey, Allan J., Waikar, Sushrut S., Garcia, Michael A., Colona, Mia, Kibbelaar, Zoe, Leong, Michael, Wallman, Daniel, Soni, Kanupriya, Maccarone, Jennifer, Gilman, Joshua, Devis, Ycar, Chung, Joseph, Paracha, Munizay, Lumelsky, David N., DiLorenzo, Madeline, Abdurrahman, Najla, Johnson, Shelsey, Tirupathi, Raghavendra, Tang, Alymer, Safi, Arshad, Green, Cindy, Newell, Jackie, Ramani, Naga, Ganti, Bhavani Harika, Daugherty, Steven K., Atkinson, Sam, Shrimpton, Kelly, Smalls, Norma, Reilkoff, Ronald A., Heneghan, Julia A., Eichen, Sarah, Goertzen, Lexie, Rajala, Scott, Feussom, Ghislaine, Tang, Ben, Cartin-Ceba, Rodrigo, Sen, Ayan, Talaei, Fahimeh, Kashyap, Rahul, Domecq, Juan Pablo, Gajic, Ognjen, Bansal, Vikas, Tekin, Aysun, Lal, Amos, O'Horo, John C., Deo, Neha N., Sharma, Mayank, Qamar, Shahraz, Singh, Romil, Valencia Morales, Diana J., Sharma, Nikhil, Khan, Syed Anjum, Jain, Nitesh Kumar, Koritala, Thoyaja, Khedr, Anwar M., Mushtaq, Hisham A., Jama, Abbas B., Venkata, Chakradhar, Engemann, Miriam, Mantese, Annamarie, Aulakh, Bhagat S., Tripathi, Sandeep, Bandy, Jennifer A., Kreps, Lisa M., Bollinger, Dawn R., Stienecker, Roger Scott, Melendez, Andre G., Brunner, Tressa A., Budzon, Sue M., Heffernan, Jessica L., Souder, Janelle M., Miller, Tracy L., Maisonneuve, Andrea G., Vilella, Antonia L., Kutner, Sara B., Clark, Kacie, Moore, Danielle, Zaren, Howard A., Smith, Stephanie J., Lewis, Grant C., Seames, Lauren, Farlow, Cheryl, Miller, Judy, Broadstreet, Gloria, Martinez, Anthony, Allison, Micheal, Mittal, Aniket, Ruiz, Rafael, Skaanland, Aleta, Ross, Robert, Bernstein, Michael A., Goff, Ian K., Naftilan, Matthew, Mathew, Amal, Williams, Deborah, Murdock, Sue, Ducey, Maryanne, Nelson, Kerianne, Gupta, Neha, Jones, Tracy L., Ayers, Shonda C., Harrell, Amy B., Brown, Brent R., Malone, Kassidy, Sinko, Lauren A., Settle, Lisa M., Sears, Taylor J., McGonagill, Patrick W., Galet, Colette, Hubbard, Janice, Wang, David, Allan, Lauren, Badheka, Aditya, Chegondi, Madhuradhar, Stapleton, Renee D., Dixon, Anne E., Johnson, Olivia, Ardren, Sara S., Burns, Stephanie, Raymond, Anna, Gonyaw, Erika, Hodgdon, Kevin, Housenger, Chloe, Lin, Benjamin, McQuesten, Karen, Pecott-Grimm, Heidi, Sweet, Julie, Ventrone, Sebastian, Khanna, Ashish K., Harris, Lynnette, Cusson, Bruce, Reeves, Brandon, Fanelli, Jessica, Disher, Nataya, Samant, Anusha, DeGroot, Chritian, Youshock, Evan, Ligon, R. Miller, McCartney, Katherine, Garcia, Julio, Iloabachie, Chidi, Flores, Kelsey, VanEenenaam, David, Sands, Lauren, Robinson, Samuel, Sweatt, Nia, Fowler, Jacob, Fram, Madeline, Howard, Easton, Johnson, Kathleen, Udoh, Imoh, Nosow, Lillian, Howard, Lucy Winesett, Minh Pham, Quan Duc, Irfanullah, Aman, Ong, Tiffany, Enwezor, Chukwunyelu Henry, Dabagian, Hannah, Mendoza, Rafael, Rucci, Justin M., Law, Anica C., Bolesta, Scott, Quinn, Emily K., Boman, Karen, Yus, Santiago, Goodspeed, Valerie M., and Kumar, Vishakha

Published
2024
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7. Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers

Author

Nakada, Emily M, Bhakta, Nirav R, Korwin-Mihavics, Bethany R, Kumar, Amit, Chamberlain, Nicolas, Bruno, Sierra R, Chapman, David G, Hoffman, Sidra M, Daphtary, Nirav, Aliyeva, Minara, Irvin, Charles G, Dixon, Anne E, Woodruff, Prescott G, Amin, Shantu, Poynter, Matthew E, Desai, Dhimant H, and Anathy, Vikas

Subjects
Asthma, Lung, Health Effects of Indoor Air Pollution, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Respiratory, Allergens, Animals, Bile Acids and Salts, Chemokines, Cytokines, Female, Humans, Hypersensitivity, Inflammation, Metaplasia, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Proteostasis Deficiencies, Pyroglyphidae, Receptors, G-Protein-Coupled, Respiratory Hypersensitivity, Taurochenodeoxycholic Acid, Unfolded Protein Response, Allergy, Protein misfolding, Pulmonology
Abstract

Conjugated bile acids (CBAs), such as tauroursodeoxycholic acid (TUDCA), are known to resolve the inflammatory and unfolded protein response (UPR) in inflammatory diseases, such as asthma. Whether CBAs exert their beneficial effects on allergic airway responses via 1 arm or several arms of the UPR, or alternatively through the signaling pathways for conserved bile acid receptor, remains largely unknown. We used a house dust mite-induced (HDM-induced) murine model of asthma to evaluate and compare the effects of 5 CBAs and 1 unconjugated bile acid in attenuating allergen-induced UPR and airway responses. Expression of UPR-associated transcripts was assessed in airway brushings from human patients with asthma and healthy subjects. Here we show that CBAs, such as alanyl β-muricholic acid (AβM) and TUDCA, significantly decreased inflammatory, immune, and cytokine responses; mucus metaplasia; and airway hyperresponsiveness, as compared with other CBAs in a model of allergic airway disease. CBAs predominantly bind to activating transcription factor 6α (ATF6α) compared with the other canonical transducers of the UPR, subsequently decreasing allergen-induced UPR activation and resolving allergic airway disease, without significant activation of the bile acid receptors. TUDCA and AβM also attenuated other HDM-induced ER stress markers in the lungs of allergic mice. Quantitative mRNA analysis of airway epithelial brushings from human subjects demonstrated that several ATF6α-related transcripts were significantly upregulated in patients with asthma compared with healthy subjects. Collectively, these results demonstrate that CBA-based therapy potently inhibits the allergen-induced UPR and allergic airway disease in mice via preferential binding of the canonical transducer of the UPR, ATF6α. These results potentially suggest a novel avenue to treat allergic asthma using select CBAs.

Published
2019

10. Implementation of a remote behavioral intervention for older adults with asthma – a pilot study.

Author

Baptist, Alan P., Krishnan, Jerry A., Gerald, Lynn B., Maye, Melissa, Feldman, Jonathan M., and Dixon, Anne E.

Abstract

Objective: Older adults with asthma (OAA) have elevated asthma morbidity rates. A six-session intervention based on self-regulation theory was shown to improve outcomes. However, wide-spread implementation was difficult due to the in-person design. Our objective was to determine the feasibility and acceptability of an updated intervention for OAA that is completely remote, includes a physician component, and utilizes shared decision-making (SDM). Methods: A pilot study of 12 OAA with uncontrolled asthma and their asthma providers was conducted at three health centers. The remote intervention (titled SOAR) consisted of 4 sessions (2 groups and 2 individual). Asthma providers (both specialists and primary care) were sent updates of progress along with information on how to incorporate SDM into the visit. Implementation (feasibility, acceptability, and appropriateness) and clinical (asthma control, asthma quality of life, perceived control, depression, and self-confidence) outcomes were measured. Results: SOAR was found to be feasible, acceptable, and appropriate, with values on validated implementation scales similar to those of in-person behavioral interventions. Asthma providers found the program helpful and intended to change care based on the updates. Asthma control scores improved significantly from baseline (14.2 to 16.8, p = 0.04), as did asthma quality of life (4.2 to 4.9, p = 0.03) and self-confidence to manage asthma (7.1 to 8.5, p = 0.02). There was no change in depression nor perceived control scores. Conclusion: A remote behavioral intervention appeared feasible and acceptable for OAA and their health care providers, and can improve outcomes. Larger scale implementation trials are warranted. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Magnitude of obesity alone does not alter the alveolar lipidome.

Author

Tharp, William G., Morris, Carolyn R., Santos-Ortega, Yulica, Vary, Calvin P., Bender, S. Patrick, and Dixon, Anne E.

Subjects
BODY mass index, LIPID metabolism, IONS, PULMONARY surfactant, LUNG diseases, MECONIUM aspiration syndrome
Abstract

Obesity may lead to pulmonary dysfunction through complex and incompletely understood cellular and biochemical effects. Altered lung lipid metabolism has been identified as a potential mechanism of lung dysfunction in obesity. Although murine models of obesity demonstrate changes in pulmonary surfactant phospholipid composition and function, data in humans are lacking. We measured untargeted shotgun lipidomes in two bronchoalveolar lavages (BALs) from apical and anteromedial pulmonary subsegments of 14 adult subjects (7 males and 7 females) with body mass indexes (BMIs) ranging from 24.3 to 50.9 kg/m2. The lipidome composition was characterized at the class, species, and fatty acyl/alkyl level using total lipid molecular ion signal intensities normalized to BAL protein concentration and epithelial lining fluid volumes. Multivariate analyses were conducted to identify potential changes with increasing BMI. The alveolar lipidomes contained the expected composition of surfactant-associated phospholipids, sphingolipids, and sterols in addition to cardiolipin and intracellular signaling lipid species. No significant differences in lipidomes were detected between the two BAL regions. Though a small number of lipid species were associated with BMI in multivariate analyses, no robust differences in lipidome composition or specific lipid species were identified over the range of body habitus. The magnitude of obesity alone does not substantially alter the alveolar lipidome in patients without lung disease. Differences in lung function in patients with obesity and no lung disease are unlikely related to changes in alveolar lipid composition. NEW & NOTEWORTHY: Altered lung lipid metabolism has been identified as a potential mechanism of lung dysfunction in obesity, but data in humans are lacking. We measured the alveolar lipidome in bronchoalveolar lavages from subjects with healthy lungs with a wide range of body mass index. There were no differences in lipidome composition in association with the magnitude of obesity. In patients with healthy lungs, obesity alone does not alter the alveolar lipidome. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Test Performance Characteristics of the AIR, GAD-7 and HADS-Anxiety Screening Questionnaires for Anxiety in Chronic Obstructive Pulmonary Disease

Author

Baker, Anna M, Holbrook, Janet T, Yohannes, Abebaw M, Eakin, Michelle N, Sugar, Elizabeth A, Henderson, Robert J, Casper, Anne S, Kaminsky, David A, Rea, Alexis L, Mathews, Anne M, Que, Loretta G, Ramsdell, Joe W, Gerald, Lynn B, Wise, Robert A, Hanania, Nicola A, Hanania, Nicola, Sockrider, Marianna, Bertrand, Laura, Atik, Mustafa, Lopez, Blanca A, Reibman, Joan, DiMango, Emily, Rogers, Linda, Carapetyan, Karen, Rivera, Kristina, Scheuerman, Melissa, Fiorino, Elizabeth, Bryce-Robinson, Newel, Green, Deanna, Noveck, Robert, Foss, Catherine, Ghidorzi, Jessica, Wang, Zongyao, Pangborn, Elise, Robertson, V Susan, Eberlein, Nicholas, Stiles, Jane, Land, Michael, Vickery, Brian, Wu, Eveline, Jaggers, Denise, Allen, Stephanie, Mervin-Blake, Sabrena, Smith, Lewis, Kalhan, Ravi, Moy, James, Naureckas, Edward, Hixon, Jenny, Gonsalves, Zenobia, Zagaja, Virginia, Kustwin, Jennifer, Xu, Ben, Matthews, Thomas, Robinson, Lucius, Singh, Noopur, Happel, Kyle, Sandi, Marie C, Graham, Jennifer M, Sullivan, Katelyn, Poretta, Elizabeth, Katial, Rohit, Hoyte, Flavia, Rojas, Maria, Castro, Mario, Bacharier, Leonard B, Sumino, Kaharu, Yusen, Roger D, Tarsi, Jaime J, Patterson, Brenda, Montgomery, Terri, Busk, Michael, Weiss, Debra, Sundblad, Kimberly, Irvin, Charles, Dixon, Anne E, Teneback, Charlotte, Kanagalingam, Jothi, Burns, Stephanie M, Dwinell, Kathleen, Goodwin, James L, Brown, Mark A, Carr, Tara F, Berry, Cristine E, Bime, Christian, Goforth, Mark A, Ryan, Elizabeth A, Wences, Jesus A, Lopez, Silvia L, Priefert, Janette C, Provencio-Dean, Natalie S, Ogas, Destinee R, Bloss, Valerie R, Wasserman, Stephen I, Soler, Xavier T, Kinninger, Katie H, and Martineau, Amber J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Mental Health, Brain Disorders, Chronic Obstructive Pulmonary Disease, Clinical Research, Mental health, Respiratory, Good Health and Well Being, test anxiety scale, chronic obstructive pulmonary disease, anxiety, psychometric properties, American Lung Association Airways Clinical Research Centers, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Rationale: Anxiety is a common comorbidity of chronic obstructive pulmonary disease (COPD) that is associated with higher morbidity and mortality. We evaluated three anxiety screening questionnaires: the Generalized Anxiety Disorder 7-Item Scale (GAD-7), the Hospital Anxiety and Depression Scale Anxiety subscale (HADS-A), and the Anxiety Inventory for Respiratory Disease (AIR).Objectives: To evaluate and compare the test performance characteristics of three anxiety screening questionnaires, using the Mini-International Neuropsychiatric Interview (MINI), version 7.0, as the "gold standard."Methods: Individuals with COPD were recruited at 16 centers. The MINI and questionnaires were administered by trained research coordinators at an in-person visit and readministered by telephone 2-4 weeks later. A composite score for the presence of any Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-V) anxiety disorder was computed, based on the MINI as the gold standard, compared with a participant screening positive on self-report measures for these analyses.Results: Two hundred and twenty eligible individuals with COPD were enrolled; 219 completed the study. Eleven percent were identified as having a DSM-V anxiety disorder, based on the MINI. Elevated anxiety symptoms based on questionnaires were 38% for the AIR, 30% for the GAD-7, and 20% for the HADS-A. Area under the receiver operating characteristic curve (AUC) was highest for the GAD-7 (0.78; 95% confidence interval [CI], 0.69-0.87), followed by the HADS-A (0.74; 95% CI, 0.64-0.84) and the AIR (0.66; 95% CI, 0.56-0.76). The AUC for the GAD-7 was significantly greater than for the AIR (P = 0.014). Sensitivity was not statistically different among the questionnaires: 77% for the GAD-7, 63% for the HADS-A, and 66% for the AIR. The HADS-A had the highest specificity, 85%, which was significantly higher than that of the GAD-7 (77%; P

Published
2018

15. Variation in Sedative and Analgesic Use During the COVID-19 Pandemic and Associated Outcomes

Author

Rucci, Justin M., primary, Law, Anica C., additional, Bolesta, Scott, additional, Quinn, Emily K., additional, Garcia, Michael A., additional, Gajic, Ognjen, additional, Boman, Karen, additional, Yus, Santiago, additional, Goodspeed, Valerie M., additional, Kumar, Vishakha, additional, Kashyap, Rahul, additional, Walkey, Allan J., additional, Mesland, Jean-Baptiste, additional, Henin, Pierre, additional, Petre, Hélène, additional, Buelens, Isabelle, additional, Gerard, Anne-Catherine, additional, Markotić, Dragana, additional, Bošnjak, Ivana, additional, Garza, Ruben, additional, Chu, Eric, additional, Chan, Victoria, additional, Gavidia, Oscar Y., additional, Pachon, Felipe, additional, El Kassas, Mohamed, additional, Tawheed, Ahmed, additional, Matsuda, Wataru, additional, Itagaki, Yuki, additional, Kodate, Akira, additional, Suzuki, Reina, additional, Takahashi, Yuki, additional, Moriki, Koyo, additional, Amer, Marwa Ridha, additional, Bawazeer, Mohammed Abdullah, additional, Dahhan, Talal I., additional, Kseibi, Eiad, additional, Butt, Abid Shahzad, additional, Khurshid, Syed Moazzum, additional, Rabee, Muath, additional, Abujazar, Mohammed, additional, Alghunaim, Razan, additional, Abualkhair, Maal, additional, AlFirm, Abeer Turki, additional, Almazyad, Mohammed A., additional, Alarifi, Mohammed I., additional, Macarambon, Jara M., additional, Bukhari, Ahmad Abdullah, additional, Albahrani, Hussain A., additional, Asfina, Kazi N., additional, Aldossary, Kaltham M., additional, Bojicic, Jovana, additional, Kovacevic, Bojan, additional, Predrag, Stevanovic, additional, Stojakov, Dejan S., additional, Ignjatovic, Duska K., additional, Bojic, Suzana C., additional, Bobos, Marina M., additional, Nenadic, Irina B., additional, Zaric, Milica S., additional, Djuric, Marko D., additional, Djukic, Vladimir R., additional, Teruel, Santiago Y., additional, Martin, Belen C., additional, Kharbanda, Anmol, additional, Jhajhria, Sunil, additional, Fyffe, Zachary, additional, Capizzi, Stephen, additional, Alicie, Bethany, additional, Green, Martha, additional, Crockarell, Lori, additional, Drennan, Amelia, additional, Dubuque, Kathleen, additional, Fambrough, Tonya, additional, Gasaway, Nikole, additional, Krantz, Briana, additional, Nebi, Peiman, additional, Orga, Jan, additional, Serfass, Margaret, additional, Simion, Alina, additional, Warren, Kimberly, additional, Wheeler, Cassie, additional, Woolman, C.J., additional, Christie, Amy B., additional, Ashley, Dennis W., additional, Adiga, Rajani, additional, Newsome, Andrea Sikora, additional, Forehand, Christy C., additional, Bruning, Rebecca, additional, Jones, Timothy W., additional, Waikar, Sushrut S., additional, Colona, Mia, additional, Kibbelaar, Zoe, additional, Leong, Michael, additional, Wallman, Daniel, additional, Soni, Kanupriya, additional, Maccarone, Jennifer, additional, Gilman, Joshua, additional, Devis, Ycar, additional, Chung, Joseph, additional, Paracha, Munizay, additional, Lumelsky, David N., additional, DiLorenzo, Madeline, additional, Abdurrahman, Najla, additional, Johnson, Shelsey, additional, Tirupathi, Raghavendra, additional, Tang, Alymer, additional, Safi, Arshad, additional, Green, Cindy, additional, Newell, Jackie, additional, Ramani, Naga, additional, Ganti, Bhavani Harika, additional, Daugherty, Steven K., additional, Atkinson, Sam, additional, Shrimpton, Kelly, additional, Smalls, Norma, additional, Reilkoff, Ronald A., additional, Heneghan, Julia A., additional, Eichen, Sarah, additional, Goertzen, Lexie, additional, Rajala, Scott, additional, Feussom, Ghislaine, additional, Tang, Ben, additional, Cartin-Ceba, Rodrigo, additional, Sen, Ayan, additional, Talaei, Fahimeh, additional, Domecq, Juan Pablo, additional, Bansal, Vikas, additional, Tekin, Aysun, additional, Lal, Amos, additional, O'Horo, John C., additional, Deo, Neha N., additional, Sharma, Mayank, additional, Qamar, Shahraz, additional, Singh, Romil, additional, Valencia Morales, Diana J., additional, Sharma, Nikhil, additional, Khan, Syed Anjum, additional, Jain, Nitesh Kumar, additional, Koritala, Thoyaja, additional, Khedr, Anwar M., additional, Mushtaq, Hisham A., additional, Jama, Abbas B., additional, Venkata, Chakradhar, additional, Engemann, Miriam, additional, Mantese, Annamarie, additional, Aulakh, Bhagat S., additional, Tripathi, Sandeep, additional, Bandy, Jennifer A., additional, Kreps, Lisa M., additional, Bollinger, Dawn R., additional, Stienecker, Roger Scott, additional, Melendez, Andre G., additional, Brunner, Tressa A., additional, Budzon, Sue M., additional, Heffernan, Jessica L., additional, Souder, Janelle M., additional, Miller, Tracy L., additional, Maisonneuve, Andrea G., additional, Vilella, Antonia L., additional, Kutner, Sara B., additional, Clark, Kacie, additional, Moore, Danielle, additional, Zaren, Howard A., additional, Smith, Stephanie J., additional, Lewis, Grant C., additional, Seames, Lauren, additional, Farlow, Cheryl, additional, Miller, Judy, additional, Broadstreet, Gloria, additional, Martinez, Anthony, additional, Allison, Micheal, additional, Mittal, Aniket, additional, Ruiz, Rafael, additional, Skaanland, Aleta, additional, Ross, Robert, additional, Bernstein, Michael A., additional, Goff, Ian K., additional, Naftilan, Matthew, additional, Mathew, Amal, additional, Williams, Deborah, additional, Murdock, Sue, additional, Ducey, Maryanne, additional, Nelson, Kerianne, additional, Gupta, Neha, additional, Jones, Tracy L., additional, Ayers, Shonda C., additional, Harrell, Amy B., additional, Brown, Brent R., additional, Malone, Kassidy, additional, Sinko, Lauren A., additional, Settle, Lisa M., additional, Sears, Taylor J., additional, McGonagill, Patrick W., additional, Galet, Colette, additional, Hubbard, Janice, additional, Wang, David, additional, Allan, Lauren, additional, Badheka, Aditya, additional, Chegondi, Madhuradhar, additional, Stapleton, Renee D., additional, Dixon, Anne E., additional, Johnson, Olivia, additional, Ardren, Sara S., additional, Burns, Stephanie, additional, Raymond, Anna, additional, Gonyaw, Erika, additional, Hodgdon, Kevin, additional, Housenger, Chloe, additional, Lin, Benjamin, additional, McQuesten, Karen, additional, Pecott-Grimm, Heidi, additional, Sweet, Julie, additional, Ventrone, Sebastian, additional, Khanna, Ashish K., additional, Harris, Lynnette, additional, Cusson, Bruce, additional, Reeves, Brandon, additional, Fanelli, Jessica, additional, Disher, Nataya, additional, Samant, Anusha, additional, DeGroot, Chritian, additional, Youshock, Evan, additional, Ligon, R. Miller, additional, McCartney, Katherine, additional, Garcia, Julio, additional, Iloabachie, Chidi, additional, Flores, Kelsey, additional, VanEenenaam, David, additional, Sands, Lauren, additional, Robinson, Samuel, additional, Sweatt, Nia, additional, Fowler, Jacob, additional, Fram, Madeline, additional, Howard, Easton, additional, Johnson, Kathleen, additional, Udoh, Imoh, additional, Nosow, Lillian, additional, Howard, Lucy Winesett, additional, Minh Pham, Quan Duc, additional, Irfanullah, Aman, additional, Ong, Tiffany, additional, Enwezor, Chukwunyelu Henry, additional, Dabagian, Hannah, additional, and Mendoza, Rafael, additional

Published
2024
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16. Protein disulfide isomerase–endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness

Author

Hoffman, Sidra M, Chapman, David G, Lahue, Karolyn G, Cahoon, Jonathon M, Rattu, Gurkiranjit K, Daphtary, Nirav, Aliyeva, Minara, Fortner, Karen A, Erzurum, Serpil C, Comhair, Suzy AA, Woodruff, Prescott G, Bhakta, Nirav, Dixon, Anne E, Irvin, Charles G, Janssen-Heininger, Yvonne MW, Poynter, Matthew E, and Anathy, Vikas

Subjects
Biomedical and Clinical Sciences, Immunology, Clinical Research, Health Effects of Indoor Air Pollution, Lung, Asthma, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Respiratory, Allergens, Animals, B-Lymphocytes, Biopsy, Caspase 3, Cytokines, Disease Models, Animal, Female, Fibrosis, Gene Expression, Humans, Male, Mice, Mice, Transgenic, Protein Disulfide-Isomerases, Respiratory Hypersensitivity, Respiratory Mucosa, T-Lymphocytes, bcl-2 Homologous Antagonist-Killer Protein, Unfolded protein response, endoplasmic reticulum stress, asthma, house dust mite, protein disulfide isomerase, endoplasmic reticulum protein 57, recombination-activating gene 1, epithelium, airways hyperresponsiveness, Allergy
Abstract

BackgroundEvidence for association between asthma and the unfolded protein response is emerging. Endoplasmic reticulum resident protein 57 (ERp57) is an endoplasmic reticulum-localized redox chaperone involved in folding and secretion of glycoproteins. We have previously demonstrated that ERp57 is upregulated in allergen-challenged human and murine lung epithelial cells. However, the role of ERp57 in asthma pathophysiology is unknown.ObjectivesHere we sought to examine the contribution of airway epithelium-specific ERp57 in the pathogenesis of allergic asthma.MethodsWe examined the expression of ERp57 in human asthmatic airway epithelium and used murine models of allergic asthma to evaluate the relevance of epithelium-specific ERp57.ResultsLung biopsy specimens from asthmatic and nonasthmatic patients revealed a predominant increase in ERp57 levels in epithelium of asthmatic patients. Deletion of ERp57 resulted in a significant decrease in inflammatory cell counts and airways resistance in a murine model of allergic asthma. Furthermore, we observed that disulfide bridges in eotaxin, epidermal growth factor, and periostin were also decreased in the lungs of house dust mite-challenged ERp57-deleted mice. Fibrotic markers, such as collagen and α smooth muscle actin, were also significantly decreased in the lungs of ERp57-deleted mice. Furthermore, adaptive immune responses were dispensable for house dust mite-induced endoplasmic reticulum stress and airways fibrosis.ConclusionsHere we show that ERp57 levels are increased in the airway epithelium of asthmatic patients and in mice with allergic airways disease. The ERp57 level increase is associated with redox modification of proinflammatory, apoptotic, and fibrotic mediators and contributes to airways hyperresponsiveness. The strategies to inhibit ERp57 specifically within the airways epithelium might provide an opportunity to alleviate the allergic asthma phenotype.

Published
2016

19. Hospital Variation in Management and Outcomes of Acute Respiratory Distress Syndrome Due to COVID-19

Author

Johnson, Shelsey W., Garcia, Michael A., Sisson, Emily K. Q., Sheldrick, Christopher R., Kumar, Vishakha K., Boman, Karen, Bolesta, Scott, Bansal, Vikas, Lal, Amos, Domecq, J. P., Melamed, Roman R., Christie, Amy B., Husain, Abdurrahman, Yus, Santiago, Gajic, Ognjen, Kashyap, Rahul, Walkey, Allan J., Gavidia, Oscar Y., Pachon, Felipe, Sanchez, Yeimy A., Kassas, Mohamed El, Badr, Mohamed, Tawheed, Ahmed, Tawheed, Ahmed, Yahia, Hend, Matsuda, Wataru, Suzuki, Reina, Suzuki, Reina, Sanui, Masamitsu, Horikita, Sho, Itagaki, Yuki, Kodate, Akira, Suzuki, Reina, Kodate, Akira, Takahashi, Yuki, Moriki, Koyo, Sohaib, Muhammad, Syed, Asghar Mashaal, Anosh, Syed, Naqvi, Ali, Zabolotskikh, Borisovich, Zybin, Konstantin Dmitrievich, Sinkov, Sergey Vasilevich, Musaeva, Tatiana Sergeevna, Almazyad, Mohammed A., Alarifi, Mohammed I., Macarambon, Jara M., Bukhari, Ahmad Abdullah, Albahrani, Hussain A., Asfina, Kazi N., Aldossary, Kaltham M., Zdravkovic, Marija, Todorovic, Zoran, Popadic, Viseslav, Klasnja, Slobodan, Stevanovic, Predrag D., Stojakov, Dejan S., Ignjatovic, Duska K., Bojic, Suzana C., Bobos, Marina M., Nenadic, Irina B., Zaric, Milica S., Djuric, Marko D., Djukic, Vladimir R., Yus, Santiago, Martin, Belen C., Sili, Uluhan, Bilgin, Huseyin, Ay, Pinar, Melamed, Roman R., Tierney, David M., Patel, Love A., Raj, Vino S., Dawud, Barite U., Mazumder, Narayana, Sidebottom, Abbey, Guenther, Alena M., Krehbiel, Benjamin D., Schmitz, Nova J., Jepsen, Stacy L., Sipsey, Lynn, Schulte, Anna, Wunderlich, Whitney, Hoyt, Cecely, Dodd, Kenneth W., Goodmanson, Nicholas, Hesse, Kathleen, Bird, Paige, Weinert, Chauncey, Schoenrade, Nathan, Altaher, Abdulrahman, Mayar, Esmael, Aronson, Matthew, Cooper, Tyler, Logan, Monica, Miner, Brianna, Papo, Gisele, Al-Fares, Abdulrahman, Kharbanda, Anmol, Jhajhria, Sunil, Fyffe, Zachary, Christie, Amy B., Ashley, Dennis W., Adiga, Rajani, Newsome, Andrea Sikora, Forehand, Christy C., Bruning, Rebecca, Jones, Timothy W., Sabov, Moldovan, Zaidi, Fatema, Tissavirasingham, Fiona, Malipeddi, Dhatri, Banner-Goodspeed, Valerie M., Bose, Somnath, Kelly, Lauren E., Joseph, Melisa, McGourty, Marie, Capers, Krystal, Hoenig, Benjamin, Karamourtopoulos, Maria C., Law, Anica C., Baedorf Kassis, Elias N., Walkey, Allan J., Waikar, Sushrut S., Garcia, Michael A., Colona, Mia, Kibbelaar, Zoe, Leong, Michael, Wallman, Daniel, Soni, Kanupriya, Maccarone, Jennifer, Gilman, Joshua, Devis, Ycar, Chung, Joseph, Paracha, Munizay, Lumelsky, David N., DiLorenzo, Madeline, Abdurrahman, Najla, Johnson, Shelsey, Zammit, Kimberly, McGrath, Patrick J., Loeffler, William, Chilbert, Maya R., Mesland, Jean-Baptiste, Henin, Pierre, Petre, Hélène, Buelens, Isabelle, Gerard, Anne-Catherine, Ihle, Rayan E., Martin, Shelda A., Davis, Elaine A., Surani, Salim, White, Joshua, Khan, Aftab, Dhahwal, Rahul, Cheruku, Sreekanth, Ahmed, Farzin, Deonarine, Christopher, Jones, Ashley, Shaikh, Mohammad-Ali, Preston, David, Chin, Jeanette, Daugherty, Steven K., Atkinson, Sam, Shrimpton, Kelly, Bartz, Raquel R., Krishnamoorthy, Vijay, Kraft, Bryan, Pulsipher, Aaron, Friedman, Eugene, Mehta, Sachin, Yamane, David P., Benjenk, Ivy, Prasanna, Nivedita, Nault, Katharine, Reilkoff, Ronald A., Heneghan, Julia A., Eichen, Sarah, Goertzen, Lexie, Rajala, Scott, Feussom, Ghislaine, Tang, Ben, Arizona, Mayo Clinic, Cartin-Ceba, Rodrigo, Sen, Ayan, Palacios, Amanda, Mahdi, Giyth M., Kashyap, Rahul, Gajic, Ognjen, Bansal, Vikas, Tekin, Aysun, Lal, Amos, O’Horo, John C., Deo, Neha N., Sharma, Mayank, Qamar, Shahraz, Domecq, Juan Pablo, Singh, Romil, Niven, Alex, Clinic, Mayo, Claire, Eau, La Nou, Abigail T., Bogojevic, Marija, Mullen, Barbara, Sanghavi, Devang, Guru, Pramod, Franco, Pablo Moreno, Gnanapandithan, Karthik, Saunders, Hollie, Fleissner, Zachary, Garcia, Juan, Yu Lee Mateus, Alejandra, Yarrarapu, Siva Naga, Kaur, Nirmaljot, Giri, Abhisekh, Khan, Syed Anjum, Jain, Nitesh Kumar, Koritala, Thoyaja, Venkata, Chakradhar, Engemann, Miriam, Mantese, Annamarie, Tarabichi, Yasir, Perzynski, Adam, Wang, Christine, Kotekal, Dhatri, Aulakh, Bhagat S., Tripathi, Sandeep, Bandy, Jennifer A., Kreps, Lisa M., Bollinger, Dawn R., Bandy, Jennifer A., Stienecker, Roger Scott, Melendez, Andre G., Brunner, Tressa A., Budzon, Sue M., Heffernan, Jessica L., Souder, Janelle M., Miller, Tracy L., Maisonneuve, Andrea G., Vilella, Antonia L., Kutner, Sara B., Clark, Kacie, Moore, Danielle, Anderson, Harry L., III, Rajkumar, Dixy, Abunayla, Ali, Heiter, Jerrilyn, Zaren, Howard A., Smith, Stephanie J., Lewis, Grant C., Seames, Lauren, Farlow, Cheryl, Miller, Judy, Broadstreet, Gloria, Martinez, Anthony, Allison, Micheal, Mittal, Aniket, Ruiz, Rafael, Skaanland, Aleta, Ross, Robert, Gupta, Neha, Jones, Tracy L., Ayers, Shonda C., Harrell, Amy B., Brown, Dr. Brent R., Husain, Abdurrahman, Malhotra, Atul, Zawaydeh, Qais, Markotić, Dragana, Bošnjak, Ivana, Vail, Emily A., Nicholson, Susannah, Jonas, Rachelle B., Dement, AnnaRose E., Tang, William, DeRosa, Mark, Villarreal, Robert E., McGonagill, Patrick W., Galet, Colette, Hubbard, Janice, Wang, David, Allan, Lauren, Badheka, Aditya, Chegondi, Madhuradhar, Alvarez, Roger A., Alarcon-Calderon, Amarilys, Sosa, Marie Anne, Mahabir, Sunita K., Patel, Mausam J., Shah, Faraaz Ali, Chuan, Byron, Rawal, Sagar L., Piracha, Manal, Tonna, Joseph E., Levin, Nicholas M., Suslavich, Kayte, Tsolinas, Rachel, Fica, Zachary T., Skidmore, Chloe R., Stapleton, Renee D., Dixon, Anne E., Johnson, Olivia, Ardren, Sara S., Burns, Stephanie, Raymond, Anna, Gonyaw, Erika, Hodgdon, Kevin, Housenger, Chloe, Lin, Benjamin, McQuesten, Karen, Pecott-Grimm, Heidi, Sweet, Julie, Ventrone, Sebastian, Akhter, Murtaza, Rahman, Rania Abdul, Mulrow, Mary, Khanna, Ashish K., Harris, Lynne, Cusson, Bruce, Fowler, Jacob, Vaneenenaam, David, McKinney, Glen, Udoh, Imoh, Johnson, Kathleen, Pattan, Vishwanath, Papke, Jessica, Jimada, Ismail, Mhid, Nida, and Chakola, Samuel

Published
2022
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24. Bariatric surgery decreases the capacity of plasma from obese asthmatic subjects to augment airway epithelial cell proinflammatory cytokine production.

Author

Pena-García, Paola E., Fastiggi, V. Amanda, Mank, Madeleine M., Ather, Jennifer L., Garrow, Olivia J., Anathy, Vikas, Dixon, Anne E., and Poynter, Matthew E.

Subjects
BARIATRIC surgery, WEIGHT loss, EPITHELIAL cells, OBESITY, AIRWAY (Anatomy), ABDOMINAL surgery, SMOOTH muscle, FAT cells
Abstract

Obesity is a risk factor for asthma. Individuals with asthma and obesity often have poor asthma control and do not respond as well to therapies such as inhaled corticosteroids and long-acting bronchodilators. Weight loss improves asthma control, with a 5%–10% loss in body mass necessary and sufficient to lead to clinically relevant improvements. Preclinical studies have demonstrated the pathogenic contribution of adipocytes from obese mice to the augmented production of proinflammatory cytokines from airway epithelial cells and the salutary effects of diet-induced weight loss to decrease these consequences. However, the effects of adipocyte-derived products on airway epithelial function in human obesity remain incompletely understood. We utilized samples collected from a 12-mo longitudinal study of subjects with obesity undergoing weight loss (bariatric) surgery including controls without asthma and subjects with allergic and nonallergic obese asthma. Visceral adipose tissue (VAT) samples were collected during bariatric surgery and from recruited normal weight controls without asthma undergoing elective abdominal surgery. Human bronchial epithelial (HBEC3-KT) cells were exposed to plasma or conditioned media from cultured VAT adipocytes with or without agonists. Human bronchial smooth muscle (HBSM) cells were similarly exposed to adipocyte-conditioned media. Proinflammatory cytokines were augmented in supernatants from HBEC3-KT cells exposed to plasma as compared with subsequent visits. Whereas exposure to obese adipocyte-conditioned media induced proinflammatory responses, there were no differences between groups in both HBEC3-KT and HBSM cells. These data show that bariatric surgery and subsequent weight loss beneficially change the circulating factors that augment human airway epithelial and bronchial smooth muscle cell proinflammatory responses. NEW & NOTEWORTHY This longitudinal study following subjects with asthma and obesity reveals that weight loss following bariatric surgery decreases the capacity for plasma to augment proinflammatory cytokine secretion by human bronchial epithelial cells, implicating that circulating but not adipocyte-derived factors are important modulators in obese asthma. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Contributors

Author

Agrawal, Anurag, primary, Antkowiak, Maryellen C., additional, Beck, Melinda A., additional, Bhatia, Sapna, additional, Blaak, Ellen E., additional, Channick, Richard N., additional, Chapman, David, additional, Chaudhuri, Rituparna, additional, De Rosa, Veronica, additional, Dixon, Anne E., additional, Figueroa, Debbie M., additional, Forno, Erick, additional, Goossens, Gijs H., additional, Gordon, Elizabeth M., additional, Green, William D., additional, Gu, Chenjuan, additional, Johnston, Richard A., additional, Jun, Jonathan C., additional, Karlsson, Erik A., additional, King, Gregory, additional, Levine, Stewart J., additional, Marsland, Benjamin J., additional, Matarese, Giuseppe, additional, Milner, J. Justin, additional, Pabelick, Christina, additional, Perna, Francesco, additional, Polotsky, Vsevolod Y., additional, Prakash, Y.S., additional, Procaccini, Claudio, additional, Rastogi, Deepa, additional, Rathore, Aman, additional, Rebeles, Jennifer, additional, Schultz-Cherry, Stacey, additional, Shore, Stephanie A., additional, Sood, Akshay, additional, Stapleton, Renee D., additional, Suratt, Benjamin T., additional, Thompson, Michael A., additional, Ubags, Niki D.J., additional, van Meijel, Rens L.J., additional, Yao, Xianglan, additional, and Younas, Haris, additional

Published
2019
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31. Effect of Obesity, Pneumoperitoneum, and Body Position on Mechanical Power of Intraoperative Ventilation: An Observational Study

Author

Tharp, William G., primary, Neilson, Maegan R., additional, Breidenstein, Max W., additional, Harned, Ryan G., additional, Chatfield, Sydney, additional, Friend, Alexander F., additional, Nunez, Denis, additional, Abnet, Kevin R., additional, Farhang, Borzoo, additional, Klick, John C., additional, Horn, Nathan, additional, Bender, S. Patrick, additional, Bates, Jason H.T., additional, and Dixon, Anne E., additional

Published
2023
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34. A Call for the United States to Accelerate the Implementation of Reliever Combination Inhaled Corticosteroid–Formoterol Inhalers in Asthma

Author

Krings, James G., primary, Gerald, Joe K., additional, Blake, Kathryn V., additional, Krishnan, Jerry A., additional, Reddel, Helen K., additional, Bacharier, Leonard B., additional, Dixon, Anne E., additional, Sumino, Kaharu, additional, Gerald, Lynn B., additional, Brownson, Ross C., additional, Persell, Stephen D., additional, Clemens, Conrad J., additional, Hiller, Katherine M., additional, Castro, Mario, additional, and Martinez, Fernando D., additional

Published
2023
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36. Diet-induced obesity worsens allergen-induced type 2/type 17 inflammation in airways by enhancing DUOX1 activation

Author

Habibovic, Aida, primary, Hristova, Milena, additional, Morris, Carolyn R., additional, Lin, Miao-Chong Joy, additional, Cruz, Litiele C., additional, Ather, Jennifer L., additional, Geiszt, Miklós, additional, Anathy, Vikas, additional, Janssen-Heininger, Yvonne M. W., additional, Poynter, Matthew E., additional, Dixon, Anne E., additional, and van der Vliet, Albert, additional

Published
2023
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37. Mitoquinone mesylate attenuates pathological features of lean and obese allergic asthma in mice

Author

Chandrasekaran, Ravishankar, primary, Bruno, Sierra R., additional, Mark, Zoe F., additional, Walzer, Joseph, additional, Caffry, Sarah, additional, Gold, Clarissa, additional, Kumar, Amit, additional, Chamberlain, Nicolas, additional, Butzirus, Isabella M., additional, Morris, Carolyn R., additional, Daphtary, Nirav, additional, Aliyeva, Minara, additional, Lam, Ying-Wai, additional, van der Vliet, Albert, additional, Janssen-Heininger, Yvonne, additional, Poynter, Matthew E., additional, Dixon, Anne E., additional, and Anathy, Vikas, additional

Published
2023
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38. Roflumilast May Increase Risk of Exacerbations When Used to Treat Poorly Controlled Asthma in People with Obesity

Author

Dixon, Anne E., primary, Que, Loretta G., additional, Kalhan, Ravi, additional, Dransfield, Mark T., additional, Rogers, Linda, additional, Gerald, Lynn B., additional, Kraft, Monica, additional, Krishnan, Jerry A., additional, Johnson, Olivia, additional, Hazucha, Heather, additional, Roy, Gem, additional, Holbrook, Janet T., additional, and Wise, Robert A., additional

Published
2023
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46. Microbiome, Metabolism, and Immunoregulation of Asthma: An American Thoracic Society and National Institute of Allergy and Infectious Diseases Workshop Report

Author

Kozik, Ariangela J., primary, Holguin, Fernando, additional, Segal, Leopoldo N., additional, Chatila, Talal A., additional, Dixon, Anne E., additional, Gern, James E., additional, Lozupone, Catherine, additional, Lukacs, Nicholas, additional, Lumeng, Carey, additional, Molyneaux, Philip L., additional, Reisdorph, Nichole, additional, Vujkovic-Cvijin, Ivan, additional, Togias, Alkis, additional, and Huang, Yvonne J., additional

Published
2022
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