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13 results on '"Dobbertin‐Welsch, Josefine"'

1. Tolerance induction through non-avoidance to prevent persistent food allergy (TINA) in children and adults with peanut or tree nut allergy: rationale, study design and methods of a randomized controlled trial and observational cohort study

Author

Trendelenburg, Valérie, Dölle-Bierke, Sabine, Unterleider, Nathalie, Alexiou, Aikaterina, Kalb, Birgit, Meixner, Lara, Heller, Stephanie, Lau, Susanne, Lee, Young- Ae, Fauchère, Florent, Braun, Julian, Babina, Magda, Altrichter, Sabine, Birkner, Till, Roll, Stephanie, Dobbertin-Welsch, Josefine, Worm, Margitta, and Beyer, Kirsten

Published
2022
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2. Tolerance induction through early feeding to prevent food allergy in infants with eczema (TEFFA): rationale, study design, and methods of a randomized controlled trial

Author

Kalb, Birgit, Meixner, Lara, Trendelenburg, Valérie, Unterleider, Nathalie, Dobbertin-Welsch, Josefine, Heller, Stephanie, Dölle-Bierke, Sabine, Roll, Stephanie, Lau, Susanne, Lee, Young-Ae, Fauchère, Florent, Braun, Julian, Babina, Magda, Altrichter, Sabine, Birkner, Till, Worm, Margitta, and Beyer, Kirsten

Published
2022
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4. An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium

Author

Worm, Margitta, primary, Alexiou, Aikaterina, additional, Höfer, Veronika, additional, Birkner, Till, additional, Jeanrenaud, Alexander C. S. N., additional, Fauchère, Florent, additional, Pazur, Kristijan, additional, Steinert, Carolin, additional, Arnau‐Soler, Aleix, additional, Banerjee, Priyanka, additional, Diefenbach, Andreas, additional, Dobbertin‐Welsch, Josefine, additional, Dölle‐Bierke, Sabine, additional, Francuzik, Wojciech, additional, Ghauri, Ahla, additional, Heller, Stephanie, additional, Kalb, Birgit, additional, Löber, Ulrike, additional, Marenholz, Ingo, additional, Markó, Lajos, additional, Scheffel, Jörg, additional, Potapenko, Olena, additional, Roll, Stephanie, additional, Lau, Susanne, additional, Lee, Young‐Ae, additional, Braun, Julian, additional, Thiel, Andreas, additional, Babina, Magda, additional, Altrichter, Sabine, additional, Forslund, Sofia Kirke, additional, and Beyer, Kirsten, additional

Published
2022
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5. An interdisciplinary approach to characterize peanut-allergic patients - first data from the FOOD@ consortium

Author

Worm, Margitta M., Alexiou, Aikaterina, Höfer, Veronika, Birkner, Till, Jeanrenaud, Alexander C.S.N., Fauchère, Florent, Pažur, Kristijan, Steinert, Carolin, Arnau-Soler, Aleix, Banerjee, Priyanka, Diefenbach, Andreas, Dobbertin-Welsch, Josefine, Dölle-Bierke, Sabine, Francuzik, W., Ghauri, Ahla, Heller, Stephanie, Kalb, Birgit, Löber, Ulrike, Marenholz, Ingo, Markó, Lajos, Scheffel, Jörg, Potapenko, Olena, Roll, Stephanie, Lau, Susanne, Lee, Young-ae, Braun, Julian, Thiel, Andreas, Babina, Magda, Altrichter, Sabine, Forslund, Sofia Kirke, Beyer, Kirsten, and Publica

Subjects
food allergy, epigenetics, Cardiovascular and Metabolic Diseases, biomarker, microbiome, peanut allergy
Abstract

Background: Peanut allergy is a frequent cause of food allergy and potentially life-threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non-allergic controls. Methods: Biosamples were studied regarding DNA methylation signatures, gut microbiome, adaptive and innate immune cell populations, soluble signaling molecules and allergen-reactive antibody specificities. We applied a scalable systems medicine computational workflow to the assembled data. Results: We identified combined cellular and soluble biomarker signatures that stratify donors into peanut-allergic and non-allergic with high specificity. DNA methylation profiling revealed various genes of interest and stool microbiota differences in bacteria abundances. Conclusion: By extending our findings to a larger set of patients (e.g., children vs. adults), we will establish predictors for food allergy and tolerance and translate these as for example, indicators for interventional studies.

Published
2022

6. Organ‐specific symptom patterns during oral food challenge in children with peanut and tree nut allergy

Author

Dobbertin‐Welsch, Josefine, primary, Staudacher, Olga, additional, Yürek, Songül, additional, Trendelenburg, Valérie, additional, Tschirner, Sebastian, additional, Ziegert, Mandy, additional, Ahrens, Frank, additional, Millner‐Uhlemann, Martina, additional, Büsing, Susanne, additional, Striegel, Anne, additional, Ott, Hagen, additional, Arens, Alisa, additional, Gappa, Monica, additional, Lange, Lars, additional, Gernert, Sunhild, additional, Niggemann, Bodo, additional, and Beyer, Kirsten, additional

Published
2022
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7. Additional file 3 of Tolerance induction through non-avoidance to prevent persistent food allergy (TINA) in children and adults with peanut or tree nut allergy: rationale, study design and methods of a randomized controlled trial and observational cohort study

Author

Trendelenburg, Valérie, Dölle-Bierke, Sabine, Unterleider, Nathalie, Alexiou, Aikaterina, Kalb, Birgit, Meixner, Lara, Heller, Stephanie, Lau, Susanne, Lee, Young- Ae, Fauchère, Florent, Braun, Julian, Babina, Magda, Altrichter, Sabine, Birkner, Till, Roll, Stephanie, Dobbertin-Welsch, Josefine, Worm, Margitta, and Beyer, Kirsten

Abstract

Additional file 3. Consent Form (in German).

Published
2022
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8. Additional file 1 of Tolerance induction through early feeding to prevent food allergy in infants with eczema (TEFFA): rationale, study design, and methods of a randomized controlled trial

Author

Kalb, Birgit, Meixner, Lara, Trendelenburg, Val��rie, Unterleider, Nathalie, Dobbertin-Welsch, Josefine, Heller, Stephanie, D��lle-Bierke, Sabine, Roll, Stephanie, Lau, Susanne, Lee, Young-Ae, Fauch��re, Florent, Braun, Julian, Babina, Magda, Altrichter, Sabine, Birkner, Till, Worm, Margitta, and Beyer, Kirsten

Abstract

Additional file 1. The SPIRIT Checklist

Published
2022
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9. Additional file 1 of Tolerance induction through non-avoidance to prevent persistent food allergy (TINA) in children and adults with peanut or tree nut allergy: rationale, study design and methods of a randomized controlled trial and observational cohort study

Author

Trendelenburg, Valérie, Dölle-Bierke, Sabine, Unterleider, Nathalie, Alexiou, Aikaterina, Kalb, Birgit, Meixner, Lara, Heller, Stephanie, Lau, Susanne, Lee, Young- Ae, Fauchère, Florent, Braun, Julian, Babina, Magda, Altrichter, Sabine, Birkner, Till, Roll, Stephanie, Dobbertin-Welsch, Josefine, Worm, Margitta, and Beyer, Kirsten

Abstract

Additional file 1. The SPIRIT Checklist.

Published
2022
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11. „CHildhood Allergy and tolerance: bioMarkers and Predictors (CHAMP) and quality of life”

Author

Eckert, Jana, primary, Kahle, Julia, additional, Böck, Andreas, additional, Zeber, Kathrin, additional, Urner, Kathrin, additional, Greiner, Wolfgang, additional, Kreimeier, Simone, additional, BEYER, Kirsten, additional, Dobbertin-Welsch, Josefine, additional, Hamelmann, Eckard, additional, Gellhaus, Ines, additional, Schorlemer, Christina, additional, Kabesch, Michael, additional, Kheiroddin, Parastoo, additional, Mutius, Erika von, additional, Depner, Martin, additional, Walter, Daniel, additional, Hansen, Gesine, additional, DeStefano, Stephanie, additional, Schnadt, Sabine, additional, and Schaub, Bianca, additional

Published
2021
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12. „CHildhood Allergy and tolerance: bioMarkers and Predictors” (CHAMP) -A call for prediction and quality of life

Author

Eckert, Jana, primary, Kahle, Julia, additional, Böck, Andreas, additional, Zeber, Kathrin, additional, Urner, Kathrin, additional, Greiner, Wolfgang, additional, Kreimeier, Simone, additional, BEYER, Kirsten, additional, Dobbertin-Welsch, Josefine, additional, Hamelmann, Eckard, additional, Gellhaus, Ines, additional, Schorlemer, Christina, additional, Kabesch, Michael, additional, Kheiroddin, Parastoo, additional, Mutius, Erika von, additional, Depner, Martin, additional, Walter, Daniel, additional, Hansen, Gesine, additional, DeStefano, Stephanie, additional, Schnadt, Sabine, additional, and Schaub, Bianca, additional

Published
2021
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13. CHildhood Allergy and tolerance: Biomarkers and Predictors (CHAMP) and quality of life.

Author

Eckert, Jana Kristin, Kahle, Julia, Böck, Andreas, Zeber, Kathrin, Urner, Kathrin, Greiner, Wolfgang, Kreimeier, Simone, Beyer, Kirsten, Dobbertin‐Welsch, Josefine, Hamelmann, Eckard, Gellhaus, Ines, Schorlemer, Christina, Kabesch, Michael, Kheiroddin, Parastoo, von Mutius, Erika, Depner, Martin, Walter, Daniel, Hansen, Gesine, DeStefano, Stephanie, and Schnadt, Sabine

Subjects
ALLERGIC conjunctivitis, WHEEZE, QUALITY of life, ALLERGIES, BIOMARKERS, MEDICAL personnel
Abstract

Interest of families with allergic children in the prediction of (A) course of current allergic disease or developing a further allergic disease (left) and if the answer is yes/not sure, which allergic disease are you interested in (right); (B) What probability of your child to develop an additional allergic disease do you count as reliable; (C) How important do you consider certain fields of action and research in health? Keywords: allergy; biomarker; childhood; cohorts; health-related quality of life; prediction; survey EN allergy biomarker childhood cohorts health-related quality of life prediction survey 1 6 6 01/05/22 20220101 NES 220101 ACKNOWLEDGEMENTS We would like to thank all participating families. CHAMP is a novel multicentre German allergy consortium, which investigates the critical needs of children with allergic diseases, namely prediction of allergic diseases and improvement of health-related quality of life (HrQoL). When asked about the importance of distinct research priorities and fields of action (Figure 1C), doctor's training was ranked as most important (86.9%), allergy prevention as second (73.8%), followed by research into care (65.9%), new drug therapy (63.6%) and a better understanding of allergy in general (65.5%). [Extracted from the article]

Published
2022
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