Search

Indices for approximate nearest neighbor search (ANNS) are a basic component for information retrieval and widely used in database, search, recommendation and RAG systems. In these scenarios, documents or other objects are inserted into and deleted from the working set at a high rate, requiring a stream of updates to the vector index. Algorithms based on proximity graph indices are the most efficient indices for ANNS, winning many benchmark competitions. However, it is challenging to update such graph index at a high rate, while supporting stable recall after many updates. Since the graph is singly-linked, deletions are hard because there is no fast way to find in-neighbors of a deleted vertex. Therefore, to update the graph, state-of-the-art algorithms such as FreshDiskANN accumulate deletions in a batch and periodically consolidate, removing edges to deleted vertices and modifying the graph to ensure recall stability. In this paper, we present IP-DiskANN (InPlaceUpdate-DiskANN), the first algorithm to avoid batch consolidation by efficiently processing each insertion and deletion in-place. Our experiments using standard benchmarks show that IP-DiskANN has stable recall over various lengthy update patterns in both high-recall and low-recall regimes. Further, its query throughput and update speed are better than using the batch consolidation algorithm and HNSW.

Retrieving points based on proximity in a high-dimensional vector space is a crucial step in information retrieval applications. The approximate nearest neighbor search (ANNS) problem, which identifies the $k$ nearest neighbors for a query (approximately, since exactly is hard), has been extensively studied in recent years. However, comparatively little attention has been paid to the related problem of finding all points within a given distance of a query, the range retrieval problem, despite its applications in areas such as duplicate detection, plagiarism checking, and facial recognition. In this paper, we present a set of algorithms for range retrieval on graph-based vector indices, which are known to achieve excellent performance on ANNS queries. Since a range query may have anywhere from no matching results to thousands of matching results in the database, we introduce a set of range retrieval algorithms based on modifications of the standard graph search that adapt to terminate quickly on queries in the former group, and to put more resources into finding results for the latter group. Due to the lack of existing benchmarks for range retrieval, we also undertake a comprehensive study of range characteristics of existing embedding datasets, and select a suitable range retrieval radius for eight existing datasets with up to 100 million points in addition to the one existing benchmark. We test our algorithms on these datasets, and find up to 100x improvement in query throughput over a naive baseline approach, with 5-10x improvement on average, and strong performance up to 100 million data points.

One of the defining features of complex networks is the connectivity properties that we observe emerging from local interactions. Recently, hypergraphs have emerged as a versatile tool to model networks with non-dyadic, higher-order interactions. Nevertheless, the connectivity properties of real-world hypergraphs remain largely understudied. In this work we introduce path size as a measure to characterise higher-order connectivity and quantify the relevance of non-dyadic ties for efficient shortest paths in a diverse set of empirical networks with and without temporal information. By comparing our results with simple randomised null models, our analysis presents a nuanced picture, suggesting that non-dyadic ties are often central and are vital for system connectivity, while dyadic edges remain essential to connect more peripheral nodes, an effect which is particularly pronounced for time-varying systems. Our work contributes to a better understanding of the structural organisation of systems with higher-order interactions., Comment: Pre-submission version, 10 pages and 7 figures. Fixed small typos in Figure 1 & 6

The spectrum of nonabelian gauge theories cannot be described in terms of elementary particles, and so must be constructed from gauge-invariant composite operators, even in the presence of a Brout--Englert--Higgs effect. This leads to qualitative discrepancies in the prediction of the spectrum between perturbation theory and a full non-perturbative treatment in many theories. This is especially noticeable for GUTs. We present results corroborating this general statement using lattice simulations for a ''GUT-like'' toy theory, $\mathrm{SU}(3)$ Yang--Mills theory coupled to a Higgs field in the fundamental representation. Despite the apparent simplicity of the model, we find a rich spectrum with some previously unseen features. We also outline the next steps required to generate a large operator basis to extend this investigation to more realistic GUTs.

This study introduces RelCAT (Relation Concept Annotation Toolkit), an interactive tool, library, and workflow designed to classify relations between entities extracted from clinical narratives. Building upon the CogStack MedCAT framework, RelCAT addresses the challenge of capturing complete clinical relations dispersed within text. The toolkit implements state-of-the-art machine learning models such as BERT and Llama along with proven evaluation and training methods. We demonstrate a dataset annotation tool (built within MedCATTrainer), model training, and evaluate our methodology on both openly available gold-standard and real-world UK National Health Service (NHS) hospital clinical datasets. We perform extensive experimentation and a comparative analysis of the various publicly available models with varied approaches selected for model fine-tuning. Finally, we achieve macro F1-scores of 0.977 on the gold-standard n2c2, surpassing the previous state-of-the-art performance, and achieve performance of >=0.93 F1 on our NHS gathered datasets.

Transmission utilities routinely collect detailed outage data, including resilience events in which outages bunch up due to weather. The resilience events and their resilience metrics can readily be extracted from this historical outage data. Improvements such as grid hardening or investments in restoration lead to reduced outages or faster restoration. We show how to rerun this history with the effects of the reduced outages or faster restoration included to find the resulting improvement in resilience metrics, thus quantifying the benefits of these investments. This is demonstrated with case studies for specific events (a derecho and a hurricane), and all large events or large thunderstorms in the Midwest USA. Instead of predicting future extreme events with models, which is very challenging, the historical rerun readily quantifies the benefits that a resilience investment would have had if it had been made in the past. The historical rerun is particularly vivid in making the case for resilience investments to stakeholders because it quantifies the benefits for events actually experienced by those stakeholders, rather than for future events predicted with uncertainty.

The electric distribution system is a cornerstone of modern life, playing a critical role in the daily activities and well-being of individuals. As the world transitions toward a decarbonized future, where even mobility relies on electricity, ensuring the resilience of the grid becomes paramount. This paper introduces novel resilience metrics designed to equip utilities and stakeholders with actionable tools to assess performance during storm events. The metrics focus on emergency storm response and the resources required to improve customer service. The practical calculation of the metrics from historical utility data is demonstrated for multiple storm events. Additionally, the metrics' improvement with added crews is estimated by "rerunning history" with faster restoration. By applying this resilience framework, utilities can enhance their restoration strategies and unlock potential cost savings, benefiting both providers and customers in an era of heightened energy dependency., Comment: to appear in IEEE Power and Energy Society General Meeting Austin TX USA July 2025

The electrocaloric effect refers to the temperature change in a material when an electric field is applied or removed. Significant breakthroughs revealed its potential for solid-state cooling technologies in past decades. These devices offer a sustainable alternative to traditional vapor compression refrigeration, with advantages such as compactness, silent operation, and the absence of moving parts or refrigerants. Electrocaloric effects are typically studied using indirect methods using polarization data, and which suffer from inaccuracies related to assumptions about heat capacity. Direct methods, although more precise, require device fabrication and face challenges in studying meso- or nanoscale systems, like 2D materials, and materials with non-uniform polarization textures where high spatial resolution is required. In this study, a novel technique, Scanning Electrocaloric Thermometry, is introduced for characterizing the local electrocaloric effect in nanomaterials. This approach achieves high spatial resolution by locally applying electric fields and by simultaneously measuring the resulting temperature change. By employing AC excitation, the measurement sensitivity is further enhanced and the electrocaloric effect is disentangled from other heating mechanisms such as Joule heating and dielectric losses. The effectiveness of the method is demonstrated by examining electrocaloric and heat dissipation phenomena in two-dimensional In${}_2$Se${}_3$ micrometer-sized flakes.

Foresight 2 (FS2) is a large language model fine-tuned on hospital data for modelling patient timelines (GitHub 'removed for anon'). It can understand patients' clinical notes and predict SNOMED codes for a wide range of biomedical use cases, including diagnosis suggestions, risk forecasting, and procedure and medication recommendations. FS2 is trained on the free text portion of the MIMIC-III dataset, firstly through extracting biomedical concepts and then creating contextualised patient timelines, upon which the model is then fine-tuned. The results show significant improvement over the previous state-of-the-art for the next new biomedical concept prediction (P/R - 0.73/0.66 vs 0.52/0.32) and a similar improvement specifically for the next new disorder prediction (P/R - 0.69/0.62 vs 0.46/0.25). Finally, on the task of risk forecast, we compare our model to GPT-4-turbo (and a range of open-source biomedical LLMs) and show that FS2 performs significantly better on such tasks (P@5 - 0.90 vs 0.65). This highlights the need to incorporate hospital data into LLMs and shows that small models outperform much larger ones when fine-tuned on high-quality, specialised data.

We report on a search for millicharged particles (mCPs) produced in cosmic ray proton atmospheric interactions using data collected during the first science run of the LUX-ZEPLIN experiment. The mCPs produced by two processes -- meson decay and proton bremsstrahlung -- are considered in this study. This search utilized a novel signature unique to liquid xenon (LXe) time projection chambers (TPCs), allowing sensitivity to mCPs with masses ranging from 10 to 1000 MeV/c$^2$ and fractional charges between 0.001 and 0.02 of the electron charge e. With an exposure of 60 live days and a 5.5 tonne fiducial mass, we observed no significant excess over background. This represents the first experimental search for atmospheric mCPs and the first search for mCPs using an underground LXe experiment.

Let $G$ be a group. The BCI problem asks whether two Haar graphs of $G$ are isomorphic if and only if they are isomorphic by an element of an explicit list of isomorphisms. We first generalize this problem in a natural way and give a theoretical way to solve the isomorphism problem for the natural generalization. We then restrict our attention to abelian groups and, with an exception, reduce the problem to the isomorphism problem for a related quotient, component, or corresponding Cayley digraph. For Haar graphs of an abelian group of odd order with connection sets $S$ those of Cayley graphs (i.e. $S = -S$), the exception does not exist. For Haar graphs of cyclic groups of odd order with connection sets those of a Cayley graph, among others, we solve the isomorphism problem.

Objective: A proof-of-concept study aimed at designing and implementing VIEWER, a versatile toolkit for visual analytics of clinical data, and systematically evaluating its effectiveness across various clinical applications while gathering feedback for iterative improvements. Materials and Methods: VIEWER is an open-source and extensible toolkit that employs natural language processing and interactive visualisation techniques to facilitate the rapid design, development, and deployment of clinical information retrieval, analysis, and visualisation at the point of care. Through an iterative and collaborative participatory design approach, VIEWER was designed and implemented in one of the UK's largest NHS mental health Trusts, where its clinical utility and effectiveness were assessed using both quantitative and qualitative methods. Results: VIEWER provides interactive, problem-focused, and comprehensive views of longitudinal patient data (n=409,870) from a combination of structured clinical data and unstructured clinical notes. Despite a relatively short adoption period and users' initial unfamiliarity, VIEWER significantly improved performance and task completion speed compared to the standard clinical information system. More than 1,000 users and partners in the hospital tested and used VIEWER, reporting high satisfaction and expressed strong interest in incorporating VIEWER into their daily practice. Conclusion: VIEWER was developed to improve data accessibility and representation across various aspects of healthcare delivery, including population health management and patient monitoring. The deployment of VIEWER highlights the benefits of collaborative refinement in optimizing health informatics solutions for enhanced patient care.

We study the connections between ordinary differential equations and optimization algorithms in a non-Euclidean setting. We propose a novel accelerated algorithm for minimising convex functions over a convex constrained set. This algorithm is a natural generalization of Nesterov's accelerated gradient descent method to the non-Euclidean setting and can be interpreted as an additive Runge-Kutta algorithm. The algorithm can also be derived as a numerical discretization of the ODE appearing in Krichene et al. (2015a). We use Lyapunov functions to establish convergence rates for the ODE and show that the discretizations considered achieve acceleration beyond the setting studied in Krichene et al. (2015a). Finally, we discuss how the proposed algorithm connects to various equations and algorithms in the literature., Comment: 25 pages, 5 figures

The XLZD collaboration is developing a two-phase xenon time projection chamber with an active mass of 60 to 80 t capable of probing the remaining WIMP-nucleon interaction parameter space down to the so-called neutrino fog. In this work we show that, based on the performance of currently operating detectors using the same technology and a realistic reduction of radioactivity in detector materials, such an experiment will also be able to competitively search for neutrinoless double beta decay in $^{136}$Xe using a natural-abundance xenon target. XLZD can reach a 3$\sigma$ discovery potential half-life of 5.7$\times$10$^{27}$ yr (and a 90% CL exclusion of 1.3$\times$10$^{28}$ yr) with 10 years of data taking, corresponding to a Majorana mass range of 7.3-31.3 meV (4.8-20.5 meV). XLZD will thus exclude the inverted neutrino mass ordering parameter space and will start to probe the normal ordering region for most of the nuclear matrix elements commonly considered by the community., Comment: 29 pages, 7 figures

We introduce KANICE (Kolmogorov-Arnold Networks with Interactive Convolutional Elements), a novel neural architecture that combines Convolutional Neural Networks (CNNs) with Kolmogorov-Arnold Network (KAN) principles. KANICE integrates Interactive Convolutional Blocks (ICBs) and KAN linear layers into a CNN framework. This leverages KANs' universal approximation capabilities and ICBs' adaptive feature learning. KANICE captures complex, non-linear data relationships while enabling dynamic, context-dependent feature extraction based on the Kolmogorov-Arnold representation theorem. We evaluated KANICE on four datasets: MNIST, Fashion-MNIST, EMNIST, and SVHN, comparing it against standard CNNs, CNN-KAN hybrids, and ICB variants. KANICE consistently outperformed baseline models, achieving 99.35% accuracy on MNIST and 90.05% on the SVHN dataset. Furthermore, we introduce KANICE-mini, a compact variant designed for efficiency. A comprehensive ablation study demonstrates that KANICE-mini achieves comparable performance to KANICE with significantly fewer parameters. KANICE-mini reached 90.00% accuracy on SVHN with 2,337,828 parameters, compared to KANICE's 25,432,000. This study highlights the potential of KAN-based architectures in balancing performance and computational efficiency in image classification tasks. Our work contributes to research in adaptive neural networks, integrates mathematical theorems into deep learning architectures, and explores the trade-offs between model complexity and performance, advancing computer vision and pattern recognition. The source code for this paper is publicly accessible through our GitHub repository (https://github.com/m-ferdaus/kanice).

This report describes the experimental strategy and technologies for a next-generation xenon observatory sensitive to dark matter and neutrino physics. The detector will have an active liquid xenon target mass of 60-80 tonnes and is proposed by the XENON-LUX-ZEPLIN-DARWIN (XLZD) collaboration. The design is based on the mature liquid xenon time projection chamber technology of the current-generation experiments, LZ and XENONnT. A baseline design and opportunities for further optimization of the individual detector components are discussed. The experiment envisaged here has the capability to explore parameter space for Weakly Interacting Massive Particle (WIMP) dark matter down to the neutrino fog, with a 3$\sigma$ evidence potential for the spin-independent WIMP-nucleon cross sections as low as $3\times10^{-49}\rm cm^2$ (at 40 GeV/c$^2$ WIMP mass). The observatory is also projected to have a 3$\sigma$ observation potential of neutrinoless double-beta decay of $^{136}$Xe at a half-life of up to $5.7\times 10^{27}$ years. Additionally, it is sensitive to astrophysical neutrinos from the atmosphere, sun, and galactic supernovae., Comment: 32 pages, 14 figures

We report results of a search for nuclear recoils induced by weakly interacting massive particle (WIMP) dark matter using the LUX-ZEPLIN (LZ) two-phase xenon time projection chamber. This analysis uses a total exposure of $4.2\pm0.1$ tonne-years from 280 live days of LZ operation, of which $3.3\pm0.1$ tonne-years and 220 live days are new. A technique to actively tag background electronic recoils from $^{214}$Pb $\beta$ decays is featured for the first time. Enhanced electron-ion recombination is observed in two-neutrino double electron capture decays of $^{124}$Xe, representing a noteworthy new background. After removal of artificial signal-like events injected into the data set to mitigate analyzer bias, we find no evidence for an excess over expected backgrounds. World-leading constraints are placed on spin-independent (SI) and spin-dependent WIMP-nucleon cross sections for masses $\geq$9 GeV/$c^2$. The strongest SI exclusion set is $2.1\times10^{-48}$ cm$^{2}$ at the 90% confidence level at a mass of 36 GeV/$c^2$, and the best SI median sensitivity achieved is $5.0\times10^{-48}$ cm$^{2}$ for a mass of 40 GeV/$c^2$., Comment: 9 pages, 7 figures. See https://www.hepdata.net/record/155182 for a data release related to this paper

We utilize serendipitous observations from the Asteroid Terrestrial-impact Last Alert System (ATLAS) and the Zwicky Transient Facility (ZTF) in addition to targeted follow-up observations from the Las Cumbres Observatory (LCO) and Liverpool Telescope to analyze the first observed instance of cometary activity by the newly-discovered Jupiter-family comet C/2023 RN3 (ATLAS), whose orbital dynamics place it close to residing on a Centaur-like orbit. Across our 7-month baseline, we observe an epoch of cometary activity commencing in August 2023 with an increase in brightness of >5.4 mag. The lightcurve of 2023 RN3 indicates the presence of continuous cometary activity across our observations, suggesting the onset of a new period of sustained activity. We find no evidence of any outbursts on top of the observed brightening, nor do we find any significant color evolution across our observations. 2023 RN3 is visibly extended in LCO and Liverpool Telescope observations, indicating the presence of a spatially-extended coma. Numerical integration of 2023 RN3's orbit reveals the comet to have recently undergone a slight increase in semimajor axis due to a planetary encounter with Jupiter, however whether this orbital change could trigger 2023 RN3's cometary activity is unclear. Our estimate for the maximum dust production metric of Afrho ~400 cm is consistent with previous measurements for the Jupiter-family comet and Centaur populations., Comment: 20 pages, 9 figures

The 2023 Big ANN Challenge, held at NeurIPS 2023, focused on advancing the state-of-the-art in indexing data structures and search algorithms for practical variants of Approximate Nearest Neighbor (ANN) search that reflect the growing complexity and diversity of workloads. Unlike prior challenges that emphasized scaling up classical ANN search ~\cite{DBLP:conf/nips/SimhadriWADBBCH21}, this competition addressed filtered search, out-of-distribution data, sparse and streaming variants of ANNS. Participants developed and submitted innovative solutions that were evaluated on new standard datasets with constrained computational resources. The results showcased significant improvements in search accuracy and efficiency over industry-standard baselines, with notable contributions from both academic and industrial teams. This paper summarizes the competition tracks, datasets, evaluation metrics, and the innovative approaches of the top-performing submissions, providing insights into the current advancements and future directions in the field of approximate nearest neighbor search., Comment: Code: https://github.com/harsha-simhadri/big-ann-benchmarks/releases/tag/v0.3.0

Digital phenotyping offers a novel and cost-efficient approach for managing depression and anxiety. Previous studies, often limited to small-to-medium or specific populations, may lack generalizability. We conducted a cross-sectional analysis of data from 10,129 participants recruited from a UK-based general population between June 2020 and August 2022. Participants shared wearable (Fitbit) data and self-reported questionnaires on depression (PHQ-8), anxiety (GAD-7), and mood via a study app. We first examined the correlations between PHQ-8/GAD-7 scores and wearable-derived features, demographics, health data, and mood assessments. Subsequently, unsupervised clustering was used to identify behavioural patterns associated with depression or anxiety. Finally, we employed separate XGBoost models to predict depression and anxiety and compared the results using different subsets of features. We observed significant associations between the severity of depression and anxiety with several factors, including mood, age, gender, BMI, sleep patterns, physical activity, and heart rate. Clustering analysis revealed that participants simultaneously exhibiting lower physical activity levels and higher heart rates reported more severe symptoms. Prediction models incorporating all types of variables achieved the best performance ($R^2$=0.41, MAE=3.42 for depression; $R^2$=0.31, MAE=3.50 for anxiety) compared to those using subsets of variables. This study identified potential indicators for depression and anxiety, highlighting the utility of digital phenotyping and machine learning technologies for rapid screening of mental disorders in general populations. These findings provide robust real-world insights for future healthcare applications.

We examine bicoset digraphs and their natural properties from the point of view of symmetry. We then consider connected bicoset digraphs that are $X$-joins with collections of empty graphs, and show that their automorphism groups can be obtained from their natural irreducible quotients. We then show that such digraphs can be recognized from their connection sets., Comment: The work of the second author is supported in part by the Slovenian Research Agency (research program P1-0285 and research projects N1-0140, N1-0160, J1-2451, N1-0208, J1-3001, J1-3003, J1-4008, and J1-50000), while the work of the third author is supported in part by the Slovenian Research Agency (research program P1-0285 and Young Researchers Grant)

Filamentary objects such as nano-wires, nanotubes and DNA are of current interest in physics, nanoscience, chemistry, biology and medicine. They can interact via exceptionally long-ranged many-object van der Waals (vdW, dispersion) forces, causing them to cluster into multi-object bundles. We analyse their vdW interactions quantitatively, predicting $N$-object vdW energy contributions that alternate in sign with increasing $N$. We also provide novel insights permitting these tendencies to be understood simply in terms of electronic screening and anti-screening. Relevant systems include polyelectrolyte double layers, Nafion exclusion zone, endothelial surface layer of cells, microemulsion interfaces and hexagonal phases, salt fingers in Gibbs Marangoni effects, myosin fibres in muscle, multiple nanotubes in the interior of neuronal axons, and carbon fibre materials., Comment: 14 pages, 5 figures

The broad physics reach of the LUX-ZEPLIN (LZ) experiment covers rare phenomena beyond the direct detection of dark matter. We report precise measurements of the extremely rare decay of $^{124}$Xe through the process of two-neutrino double electron capture (2$\nu$2EC), utilizing a $1.39\,\mathrm{kg} \times \mathrm{yr}$ isotopic exposure from the first LZ science run. A half-life of $T_{1/2}^{2\nu2\mathrm{EC}} = (1.09 \pm 0.14_{\text{stat}} \pm 0.05_{\text{sys}}) \times 10^{22}\,\mathrm{yr}$ is observed with a statistical significance of $8.3\,\sigma$, in agreement with literature. First empirical measurements of the KK capture fraction relative to other K-shell modes were conducted, and demonstrate consistency with respect to recent signal models at the $1.4\,\sigma$ level., Comment: 15 pages, 3 figures

Electronic Health Records are large repositories of valuable clinical data, with a significant portion stored in unstructured text format. This textual data includes clinical events (e.g., disorders, symptoms, findings, medications and procedures) in context that if extracted accurately at scale can unlock valuable downstream applications such as disease prediction. Using an existing Named Entity Recognition and Linking methodology, MedCAT, these identified concepts need to be further classified (contextualised) for their relevance to the patient, and their temporal and negated status for example, to be useful downstream. This study performs a comparative analysis of various natural language models for medical text classification. Extensive experimentation reveals the effectiveness of transformer-based language models, particularly BERT. When combined with class imbalance mitigation techniques, BERT outperforms Bi-LSTM models by up to 28% and the baseline BERT model by up to 16% for recall of the minority classes. The method has been implemented as part of CogStack/MedCAT framework and made available to the community for further research.

The Boulby UnderGround Screening (BUGS) facility, located at the Boulby Underground Laboratory, has significantly advanced its material screening capabilities by installing two XIA UltraLo-1800 alpha particle detectors. This study presents a comprehensive evaluation of one of these detectors, operated 1,100 meters underground at the Boulby Underground Laboratory, which provides significant shielding from cosmic radiation and maintains a low ambient radon activity of 2.30 $\pm$ 0.03 Bq/m$^3$. Our evaluation focuses on energy reconstruction accuracy, background radiation rates, and operational stability. The XIA UltraLo-1800 detector demonstrates remarkable stability in energy reconstruction, with less than 0.1 MeV variation over four years. Moreover, the implementation of a graphite-filled PTFE liner in the sample tray resulted in a significant reduction in background radiation levels compared to measurements with the original stainless steel tray, achieving an average activity of 0.15 $\pm$ 0.01 $\alpha$/cm$^2$/khr. Copper sample assays, performed before and after radon exposure, demonstrated the detector's ability to accurately identify and quantify $^{210}$Po contamination. By implementing the robust cleanliness procedures and protocols described in this article, we observed a reduction in $^{210}$Po activity from 0.504 $\pm$ 0.022 mBq to 0.336 $\pm$ 0.013 mBq, highlighting the crucial role of refined cleaning methods in minimizing background for sensitive experiments. Additionally, observations of elevated background activity levels post-high-activity sample measurements illustrate the need for careful management of assay conditions and environment to maintain low background levels. These results highlight the potential of the XIA UltraLo-1800 in enhancing the precision of material assays essential for reducing background interference in rare event experiments.

When there is a fault, the protection system automatically removes one or more transmission lines on a fast time scale of less than one minute. The outaged lines form a pattern in the transmission network. We extract these patterns from utility outage data, determine some key statistics of these patterns, and then show how to generate new patterns consistent with these statistics. The generated patterns provide a new and easily feasible way to model the overall effect of the protection system at the scale of a large transmission system. This new generative modeling of protection is expected to contribute to simulations of disturbances in large grids so that they can better quantify the risk of blackouts. Analysis of the pattern sizes suggests an index that describes how much outages spread in the transmission network at the fast timescale.

Centaurs are small Solar System objects on chaotic orbits in the giant planet region, forming an evolutionary continuum with the Kuiper belt objects and Jupiter-family comets. Some Centaurs are known to exhibit cometary activity, though unlike comets this activity tends not to correlate with heliocentric distance and the mechanism behind it is currently poorly understood. We utilize serendipitous observations from the Asteroid Terrestrial-impact Last Alert System (ATLAS), Zwicky Transient Facility (ZTF), Panoramic Survey Telescope and Rapid Response System (Pan-STARRS), Dark Energy Survey (DES), and Gaia in addition to targeted follow-up observations from the Las Cumbres Observatory, TRAnsiting Planets and PlanetesImals Small Telescope South (TRAPPIST-South), and Gemini North telescope to analyze an unexpected brightening exhibited by the known active Centaur (2060) Chiron in 2021. This is highly indicative of a cometary outburst. As of 2023 February, Chiron has still not returned to its pre-brightening magnitude. We find Chiron's rotational lightcurve, phase curve effects, and possible high-albedo surface features to be unlikely causes of this observed brightening. We consider the most likely cause to be an epoch of either new or increased cometary activity, though we cannot rule out a possible contribution from Chiron's reported ring system, such as a collision of as-yet unseen satellites shepherding the rings. We find no evidence for coma in our Gemini or TRAPPIST-South observations, though this does not preclude the possibility that Chiron is exhibiting a coma that is too faint for observation or constrained to the immediate vicinity of the nucleus., Comment: 39 pages, 14 figures, 14 tables. Has been accepted for publication in PSJ

We focus on large blackouts in electric distribution systems caused by extreme winds. Such events have a large cost and impact on customers. To quantify resilience to these events, we formulate large event risk and show how to calculate it from the historical outage data routinely collected by utilities' outage management systems. Risk is defined using an event cost exceedance curve. The tail of this curve and the large event risk is described by the probability of a large cost event and the slope magnitude of the tail on a log-log plot. Resilience can be improved by planned investments to upgrade system components or speed up restoration. The benefits that these investments would have had if they had been made in the past can be quantified by "rerunning history" with the effects of the investment included, and then recalculating the large event risk to find the improvement in resilience. An example using utility data shows a 12% and 22% reduction in the probability of a large cost event due to 10% wind hardening and 10% faster restoration respectively. This new data-driven approach to quantify resilience and resilience investments is realistic and much easier to apply than complicated approaches based on modeling all the phases of resilience. Moreover, an appeal to improvements to past lived experience may well be persuasive to customers and regulators in making the case for resilience investments.

We present a comprehensive analysis of deep learning approaches for Electronic Health Record (EHR) time-series imputation, examining how architectural and framework biases combine to influence model performance. Our investigation reveals varying capabilities of deep imputers in capturing complex spatiotemporal dependencies within EHRs, and that model effectiveness depends on how its combined biases align with medical time-series characteristics. Our experimental evaluation challenges common assumptions about model complexity, demonstrating that larger models do not necessarily improve performance. Rather, carefully designed architectures can better capture the complex patterns inherent in clinical data. The study highlights the need for imputation approaches that prioritise clinically meaningful data reconstruction over statistical accuracy. Our experiments show imputation performance variations of up to 20\% based on preprocessing and implementation choices, emphasising the need for standardised benchmarking methodologies. Finally, we identify critical gaps between current deep imputation methods and medical requirements, highlighting the importance of integrating clinical insights to achieve more reliable imputation approaches for healthcare applications.

It has long been known that a vertex-transitive graph $\Gamma$ is isomorphic to a double coset graph $\text{Cos}(G,H,S)$ of a transitive group $G\le\text{Aut}(\Gamma)$, a vertex stabilizer $H\le G$, and some subset $S\subseteq G$. We show that the automorphism group of the Cayley graph $\text{Cay}(G,S)$ with connection set $S$ can be obtained from the automorphism group of $\text{Cos}(G,H,S)$ and vice versa. We also show that the isomorphism problem for double coset graphs is equivalent to the isomorphism problem for Cayley graphs provided one knows all groups $G$ for which a fixed Cayley graph is a Cayley graph of $G$. Our main tool is a "recognition theorem", which recognizes when a Cayley graph of a group $G$ is a wreath product of two graphs based upon its connection set., Comment: This work is supported in part by the Slovenian Research Agency (research program P1-0285 and research projects N1-0140, N1-0160, J1-2451, N1-0208, J1-3001, J1-3003, J1-4008, and J1-50000)

Speech and language biomarkers have the potential to be regular, objective assessments of symptom severity in several health conditions, both in-clinic and remotely using mobile devices. However, the complex nature of speech and often subtle changes associated with health mean that findings are highly dependent on methodological and cohort choices. These are often not reported adequately in studies investigating speech-based health assessment, hindering the progress of methodological speech research. Our objectives were to) facilitate replicable speech research by presenting an adaptable speech collection and analytical method and design checklist for other researchers to adapt for their own experiments and develop an exemplar protocol that reduces and controls for confounding factors in repeated recordings of speech, including device choice, speech elicitation task and non-pathological variability. The presented protocol comprises the elicitation of read speech, held vowels and a picture description collected with a freestanding condenser microphone, 3 smartphones and a headset. We extracted a set of 14 exemplar speech features. We collected healthy speech from 28 individuals 3 times in 1 day, repeated at the same times 8-11 weeks later, and from 25 individuals on 3 days in 1 week at fixed times. Participant characteristics collected included sex, age, native language status and voice use habits. Before each recording, we collected information on recent voice use, food and drink intake, and emotional state. The extracted features are presented providing a resource of normative values. Speech data collection, processing, analysis and reporting towards clinical research and practice varies widely. Greater harmonisation of study protocols and consistent reporting are urgently required to translate speech processing into clinical research and practice., Comment: Main manuscript: 37 pages. 3 figures, 8 tables, 1 textbox. Submitted to JMIR Research Methods. Replacement with format changes and copyediting

Weakly interacting massive particles (WIMPs) may interact with a virtual pion that is exchanged between nucleons. This interaction channel is important to consider in models where the spin-independent isoscalar channel is suppressed. Using data from the first science run of the LUX-ZEPLIN dark matter experiment, containing 60 live days of data in a 5.5~tonne fiducial mass of liquid xenon, we report the results on a search for WIMP-pion interactions. We observe no significant excess and set an upper limit of $1.5\times10^{-46}$~cm$^2$ at a 90\% confidence level for a WIMP mass of 33~GeV/c$^2$ for this interaction.