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2. The circadian clock remains intact, but with dampened hormonal output in heart failure

Author

Crnko, Sandra, Printezi, Markella I., Zwetsloot, Peter-Paul M., Leiteris, Laurynas, Lumley, Andrew I., Zhang, Lu, Ernens, Isabelle, Jansen, Tijn P.J., Homsma, Lilian, Feyen, Dries, van Faassen, Martijn, du Pré, Bastiaan C., Gaillard, Carlo A.J.M., Kemperman, Hans, Oerlemans, Marish I.F.J., Doevendans, Pieter A.F.M., May, Anne M., Zuithoff, Nicolaas P.A., Sluijter, Joost P.G., Devaux, Yvan, and van Laake, Linda W.

Published
2023
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5. The circadian clock remains intact, but with dampened hormonal output in heart failure

Author

Cardiologie, Pathologie Bachelor Research hub, Onderzoek Precision medicine, Arts Assistenten Cardiologie, Cardiologie Arts-onderzoekers, DIGD-Medisch 1, Circulatory Health, CDL Cluster 24/7 centraal laboratorium, Other research (not in main researchprogram), Team Medisch, Regenerative Medicine and Stem Cells, Hart- en Vaatziekten Team A, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Biostatistiek Onderzoek, Onderzoek Cardiovasculair Reg. Med., Crnko, Sandra, Printezi, Markella I., Zwetsloot, Peter Paul M., Leiteris, Laurynas, Lumley, Andrew I., Zhang, Lu, Ernens, Isabelle, Jansen, Tijn P.J., Homsma, Lilian, Feyen, Dries, van Faassen, Martijn, du Pré, Bastiaan C., Gaillard, Carlo A.J.M., Kemperman, Hans, Oerlemans, Marish I.F.J., Doevendans, Pieter A.F.M., May, Anne M., Zuithoff, Nicolaas P.A., Sluijter, Joost P.G., Devaux, Yvan, van Laake, Linda W., Cardiologie, Pathologie Bachelor Research hub, Onderzoek Precision medicine, Arts Assistenten Cardiologie, Cardiologie Arts-onderzoekers, DIGD-Medisch 1, Circulatory Health, CDL Cluster 24/7 centraal laboratorium, Other research (not in main researchprogram), Team Medisch, Regenerative Medicine and Stem Cells, Hart- en Vaatziekten Team A, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Biostatistiek Onderzoek, Onderzoek Cardiovasculair Reg. Med., Crnko, Sandra, Printezi, Markella I., Zwetsloot, Peter Paul M., Leiteris, Laurynas, Lumley, Andrew I., Zhang, Lu, Ernens, Isabelle, Jansen, Tijn P.J., Homsma, Lilian, Feyen, Dries, van Faassen, Martijn, du Pré, Bastiaan C., Gaillard, Carlo A.J.M., Kemperman, Hans, Oerlemans, Marish I.F.J., Doevendans, Pieter A.F.M., May, Anne M., Zuithoff, Nicolaas P.A., Sluijter, Joost P.G., Devaux, Yvan, and van Laake, Linda W.

Published
2023

6. Feasibility of Linear Irreversible Electroporation Ablation in the Coronary Sinus

Author

Cardiologie, Team Onderzoek, Circulatory Health, Team Medisch, Regenerative Medicine and Stem Cells, Buist, Thomas J., Groen, Marijn H.A., Wittkampf, Fred H.M., Loh, Peter, Doevendans, Pieter A.F.M., van Es, René, Elvan, Arif, Cardiologie, Team Onderzoek, Circulatory Health, Team Medisch, Regenerative Medicine and Stem Cells, Buist, Thomas J., Groen, Marijn H.A., Wittkampf, Fred H.M., Loh, Peter, Doevendans, Pieter A.F.M., van Es, René, and Elvan, Arif

Published
2023

11. Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes

Author

Experimentele Afd. Cardiologie 2, Onderzoek Precision medicine, Circulatory Health, Perfusie, Onderzoek CTC, Regenerative Medicine and Stem Cells, Team Medisch, Onderzoek Cardiovasculair Reg. Med., Maas, Renee G.C., Lee, Soah, Harakalova, Magdalena, Snijders Blok, Christian J.B., Goodyer, William R., Hjortnaes, Jesper, Doevendans, Pieter A.F.M., Van Laake, Linda W., van der Velden, Jolanda, Asselbergs, Folkert W., Wu, Joseph C., Sluijter, Joost P.G., Wu, Sean M., Buikema, Jan W., Experimentele Afd. Cardiologie 2, Onderzoek Precision medicine, Circulatory Health, Perfusie, Onderzoek CTC, Regenerative Medicine and Stem Cells, Team Medisch, Onderzoek Cardiovasculair Reg. Med., Maas, Renee G.C., Lee, Soah, Harakalova, Magdalena, Snijders Blok, Christian J.B., Goodyer, William R., Hjortnaes, Jesper, Doevendans, Pieter A.F.M., Van Laake, Linda W., van der Velden, Jolanda, Asselbergs, Folkert W., Wu, Joseph C., Sluijter, Joost P.G., Wu, Sean M., and Buikema, Jan W.

Published
2021

12. Clinical course long after atrial switch: A novel risk score for major clinical events

Author

Team Onderzoek, Team Medisch, Regenerative Medicine and Stem Cells, Circulatory Health, Cardiologie, Woudstra, Odilia I., Zandstra, Tjitske E., Vogel, Rosanne F., van Dijk, Arie P.J., Vliegen, Hubert W., Kiès, Philippine, Jongbloed, Monique R.M., Egorova, Anastasia D., Doevendans, Pieter A.F.M., Konings, Thelma C., Mulder, Barbara J.M., Tanck, Michael W.T., Meijboom, Folkert J., Bouma, Berto J., Team Onderzoek, Team Medisch, Regenerative Medicine and Stem Cells, Circulatory Health, Cardiologie, Woudstra, Odilia I., Zandstra, Tjitske E., Vogel, Rosanne F., van Dijk, Arie P.J., Vliegen, Hubert W., Kiès, Philippine, Jongbloed, Monique R.M., Egorova, Anastasia D., Doevendans, Pieter A.F.M., Konings, Thelma C., Mulder, Barbara J.M., Tanck, Michael W.T., Meijboom, Folkert J., and Bouma, Berto J.

Published
2021

14. Heritable Thoracic Diseases: Syndromal and Isolated (F)TAAD

Author

Mulder, Barbara J. M., van de Laar, Ingrid M. B. H., de Backer, Julie, Baars, Hubert F., Doevendans, Pieter A.F.M., Houweling, Arjan C., van Tintelen, J, Peter, Cardiology, ACS - Heart failure & arrhythmias, APH - Personalized Medicine, and APH - Aging & Later Life

Published
2020

16. Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes

Author

Maas, Renee G.C., primary, Lee, Soah, additional, Harakalova, Magdalena, additional, Snijders Blok, Christian J.B., additional, Goodyer, William R., additional, Hjortnaes, Jesper, additional, Doevendans, Pieter A.F.M., additional, Van Laake, Linda W., additional, van der Velden, Jolanda, additional, Asselbergs, Folkert W., additional, Wu, Joseph C., additional, Sluijter, Joost P.G., additional, Wu, Sean M., additional, and Buikema, Jan W., additional

Published
2021
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20. A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention

Author

Sampietro, M. Lourdes, Trompet, Stella, Verschuren, Jeffrey J.W., Talens, Rudolf P., Deelen, Joris, Heijmans, Bastiaan T., de Winter, Robbert J., Tio, Rene A., Doevendans, Pieter A.F.M., Ganesh, Santhi K., Nabel, Elizabeth G., Westra, Harm-Jan, Franke, Lude, van den Akker, Erik B., Westendorp, Rudi G.J., Zwinderman, Aeilko H., Kastrati, Adnan, Koch, Werner, Slagboom, P.Eline, de Knijff, Peter, and Jukema, J. Wouter

Published
2011
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25. Ex vivo pilot study of cardiac magnetic resonance velocity mapping for quantification of aortic regurgitation in a porcine model in the presence of a transcatheter heart valve

Author

Kooistra, Nynke H.M., Nijhoff, Freek, Abawi, Masieh, Agostoni, Pierfrancesco, Araya Roos, Daniël M., van Tuijl, Sjoerd, Blanken, Niels, Voskuil, Michiel, Doevendans, Pieter A.F.M., Stella, Pieter R., Leiner, Tim, Kooistra, Nynke H.M., Nijhoff, Freek, Abawi, Masieh, Agostoni, Pierfrancesco, Araya Roos, Daniël M., van Tuijl, Sjoerd, Blanken, Niels, Voskuil, Michiel, Doevendans, Pieter A.F.M., Stella, Pieter R., and Leiner, Tim

Abstract

Accuracy of aortic regurgitation (AR) quantification by magnetic resonance (MR) imaging in the presence of a transcatheter heart valve (THV) remains to be established. We evaluated the accuracy of cardiac MR velocity mapping for quantification of antegrade flow (AF) and retrograde flow (RF) across a THV and the optimal slice position to use in cardiac MR imaging. In a systematic and fully controlled laboratory ex vivo setting, two THVs (Edwards SAPIEN XT, Medtronic CoreValve) were tested in a porcine model (n = 1) under steady flow conditions. Results showed a high level of accuracy and precision. For both THVs, AF was best measured at left ventricular outflow tract level, and RF at ascending aorta level. At these levels, MR had an excellent repeatability (ICC > 0.99), with a tendency to overestimate (4.6 ± 2.4% to 9.4 ± 7.0%). Quantification of AR by MR velocity mapping in the presence of a THV was accurate, precise, and repeatable in this pilot study, when corrected for the systematic error and when the best MR slice position was used. Confirmation of these results in future clinical studies would be a step forward in increasing the accuracy of the assessment of paravalvular AR severity.

Published
2019

27. The concept of triple wavefront fusion during biventricular pacing : Using the EGM to produce the best acute hemodynamic improvement in CRT

Author

ter Horst, Iris A.H., Bogaard, Margot D., Tuinenburg, Anton E., Mast, Thomas P., de Boer, Teun P., Doevendans, Pieter A.F.M., and Meine, Mathias

Subjects
fusion, EGM, cardiovascular system, Journal Article, CRT, noninvasive device optimization, cardiovascular diseases, Cardiology and Cardiovascular Medicine
Abstract

Background: Previous reports suggest that biventricular pacing (BiVp) fused with intrinsic conduction (BiVp-fusion, triple wavefront fusion) is associated with improved resynchronization compared to pure-BiVp in cardiac resynchronization therapy (CRT). This study aimed to assess the association between acute hemodynamic benefit of CRT and signs of BiVp-fusion by using a novel electrogram (EGM)-based method. Methods: In 17 patients undergoing CRT implantation, 28 combinations of atrioventricular (AV) and interventricular (VV) delays were applied while invasively measuring acute hemodynamic response based on maximum rate of left ventricular (LV) pressure rise (LV dP/dtmax) to assess optimal BiVp settings. BiVp-fusion was noted if farfield signal (caused by first intrinsic ventricular depolarization) was seen prior to right ventricular (RV) pacing (RVp) artifact on integrated bipolar RV EGM, or QRS morphology changed compared to pure-BiVp (short AV-delay) as seen on electrocardiogram (ECG). Results: Mean optimal RVp timing was at 98 ± 17% of intrinsic right atrial (RA)-RVfarfield (interval from right atrial pace or sense to RV farfield signal) interval, while preactivating the LV at 50 ± 11% of RA-RVsense (interval from right atrial pace or sense to RV sense interval) interval. BiVp-fusion was noted in 16 of 17 (94%) patients on ECG during optimal BiVp. Eight of these patients showed intrinsic farfield signal prior to RVp artifact on RV EGM. In the remaining eight, the RVp was paced just within the RA-RVfarfield interval with a mean of 25 ± 14 ms prior to the onset; therefore, the intrinsic farfield was masked. Conclusion: Optimal hemodynamic BiVp facilitates triple wavefront fusion, by pacing the RV around the onset of intrinsic farfield signal on RV EGM, while preactivating the LV. Aiming at BiVp-fusion could be a target for noninvasive EGM-based CRT device setting optimization.

Published
2017

28. Postoperative Delirium in Individuals Undergoing Transcatheter Aortic Valve Replacement: A Systematic Review and Meta‐Analysis

Author

Abawi, Masieh, primary, Pagnesi, Matteo, additional, Agostoni, Pierfrancesco, additional, Chiarito, Mauro, additional, Jaarsveld, Romy C., additional, Dongen, Charlotte S., additional, Slooter, Arjen J.C., additional, Colombo, Antonio, additional, Kooistra, Nynke H.M., additional, Doevendans, Pieter A.F.M., additional, Latib, Azeem, additional, and Stella, Pieter R., additional

Published
2018
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30. Additional Candidate Genes for Human Atherosclerotic Disease Identified Through Annotation Based on Chromatin Organization

Author

Haitjema, Saskia, Meddens, Claartje A., Van Der Laan, Sander W., Kofink, Daniel, Harakalova, Magdalena, Tragante, Vinicius, Foroughi Asl, Hassan, Van Setten, Jessica, Brandt, Maarten M., Bis, Joshua C., O'Donnell, Christopher, Cheng, Caroline, Hoefer, Imo E., Waltenberger, Johannes, Biessen, Erik A L, Jukema, J. Wouter, Doevendans, Pieter A.F.M., Nieuwenhuis, Edward E.S., Erdmann, Jeanette, Björkegren, Johan L M, Pasterkamp, Gerard, Asselbergs, Folkert W., Den Ruijter, Hester M., Mokry, Michal, Haitjema, Saskia, Meddens, Claartje A., Van Der Laan, Sander W., Kofink, Daniel, Harakalova, Magdalena, Tragante, Vinicius, Foroughi Asl, Hassan, Van Setten, Jessica, Brandt, Maarten M., Bis, Joshua C., O'Donnell, Christopher, Cheng, Caroline, Hoefer, Imo E., Waltenberger, Johannes, Biessen, Erik A L, Jukema, J. Wouter, Doevendans, Pieter A.F.M., Nieuwenhuis, Edward E.S., Erdmann, Jeanette, Björkegren, Johan L M, Pasterkamp, Gerard, Asselbergs, Folkert W., Den Ruijter, Hester M., and Mokry, Michal

Published
2017

31. The concept of triple wavefront fusion during biventricular pacing: Using the EGM to produce the best acute hemodynamic improvement in CRT

Author

Researchbureau DHL, Circulatory Health, Onderzoek Device, Team Medisch, Medische Fysiologie, Regenerative Medicine and Stem Cells, ter Horst, Iris A.H., Bogaard, Margot D., Tuinenburg, Anton E., Mast, Thomas P., de Boer, Teun P., Doevendans, Pieter A.F.M., Meine, Mathias, Researchbureau DHL, Circulatory Health, Onderzoek Device, Team Medisch, Medische Fysiologie, Regenerative Medicine and Stem Cells, ter Horst, Iris A.H., Bogaard, Margot D., Tuinenburg, Anton E., Mast, Thomas P., de Boer, Teun P., Doevendans, Pieter A.F.M., and Meine, Mathias

Published
2017

32. Sudden Death Due to Coronary Artery Lesions Long-term After the Arterial Switch Operation: A Systematic Review.

Author

UMC Utrecht, Cardiologie onderzoek 1, Cardiologie patientenzorg, Child Health, Cardiopulmonale Chirurgie pat. zorg, Onderzoek Molecular Cardiology, Regenerative Medicine and Stem Cells, Circulatory Health, Team Medisch, Cardiologie, van Wijk, Sebastiaan W.H., van der Stelt, Femke, ter Heide, Henriëtte, Schoof, Paul H., Doevendans, Pieter A.F.M., Meijboom, Folkert J., Breur, Johannes M.P.J., UMC Utrecht, Cardiologie onderzoek 1, Cardiologie patientenzorg, Child Health, Cardiopulmonale Chirurgie pat. zorg, Onderzoek Molecular Cardiology, Regenerative Medicine and Stem Cells, Circulatory Health, Team Medisch, Cardiologie, van Wijk, Sebastiaan W.H., van der Stelt, Femke, ter Heide, Henriëtte, Schoof, Paul H., Doevendans, Pieter A.F.M., Meijboom, Folkert J., and Breur, Johannes M.P.J.

Published
2017

33. Additional Candidate Genes for Human Atherosclerotic Disease Identified Through Annotation Based on Chromatin Organization

Author

Experimentele Afd. Cardiologie 1, MDL onderzoek 3, Child Health, Circulatory Health, Onderzoek Precision medicine, Planningssecretariaat HCK, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, CDL Staf Research, CDL Arcadia, Team Medisch, Pathologie Groep Brosens, Zorg en O&O, Infection & Immunity, CDL Cluster Onderzoek en Onderwijs, Haitjema, Saskia, Meddens, Claartje A., Van Der Laan, Sander W., Kofink, Daniel, Harakalova, Magdalena, Tragante, Vinicius, Foroughi Asl, Hassan, Van Setten, Jessica, Brandt, Maarten M., Bis, Joshua C., O'Donnell, Christopher, Cheng, Caroline, Hoefer, Imo E., Waltenberger, Johannes, Biessen, Erik A L, Jukema, J. Wouter, Doevendans, Pieter A.F.M., Nieuwenhuis, Edward E.S., Erdmann, Jeanette, Björkegren, Johan L M, Pasterkamp, Gerard, Asselbergs, Folkert W., Den Ruijter, Hester M., Mokry, Michal, Experimentele Afd. Cardiologie 1, MDL onderzoek 3, Child Health, Circulatory Health, Onderzoek Precision medicine, Planningssecretariaat HCK, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, CDL Staf Research, CDL Arcadia, Team Medisch, Pathologie Groep Brosens, Zorg en O&O, Infection & Immunity, CDL Cluster Onderzoek en Onderwijs, Haitjema, Saskia, Meddens, Claartje A., Van Der Laan, Sander W., Kofink, Daniel, Harakalova, Magdalena, Tragante, Vinicius, Foroughi Asl, Hassan, Van Setten, Jessica, Brandt, Maarten M., Bis, Joshua C., O'Donnell, Christopher, Cheng, Caroline, Hoefer, Imo E., Waltenberger, Johannes, Biessen, Erik A L, Jukema, J. Wouter, Doevendans, Pieter A.F.M., Nieuwenhuis, Edward E.S., Erdmann, Jeanette, Björkegren, Johan L M, Pasterkamp, Gerard, Asselbergs, Folkert W., Den Ruijter, Hester M., and Mokry, Michal

Published
2017

34. Clinical Cardiogenetics: Second Edition

Author

Baars, Hubert F., Doevendans, Pieter A.F.M., Houweling, Arjan C., van Tintelen, J. Peter, Human genetics, and ICaR - Ischemia and repair

Abstract

Clinical management and signs are the focus of this practical cardiogenetic reference for those who are involved in the care for cardiac patients with a genetic disease. With detailed discussion of the basic science of cardiogenetics in order to assist in the clinical understanding of the topic. The genetic causes of various cardiovascular diseases are explained in a concise clinical way that reinforces the current management doctrine in a practical manner. The authors will cover the principles of molecular genetics in general but also specific to cardiac diseases. They will discuss the etiology, pathogenesis, pathophysiology, clinical presentation, clinical diagnosis, molecular diagnosis and treatment of each cardiogenetic disease separately. Therapy advice, ICD indications, indications for and manner of further family investigation will all be covered, while each chapter will also contain take-home messages to reinforce the key points. The chapters reviewing the different diseases will each contain a table describing the genes involved in each. Each chapter will also contain specific illustrations, cumulatively giving a complete, practical review of each cardiogenetic disease separately. Special emphasis will be given to advice on how to diagnose and manage cardiogenetic diseases in clinical practice, which genes should be investigated and why, and the pros and cons of genetic testing. Guidelines for investigation in families with sudden cardiac death at young age will also be include.

Published
2016
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36. Additional Candidate Genes for Human Atherosclerotic Disease Identified Through Annotation Based on Chromatin Organization

Author

Haitjema, Saskia, primary, Meddens, Claartje A., additional, van der Laan, Sander W., additional, Kofink, Daniel, additional, Harakalova, Magdalena, additional, Tragante, Vinicius, additional, Foroughi Asl, Hassan, additional, van Setten, Jessica, additional, Brandt, Maarten M., additional, Bis, Joshua C., additional, O’Donnell, Christopher, additional, Cheng, Caroline, additional, Hoefer, Imo E., additional, Waltenberger, Johannes, additional, Biessen, Erik, additional, Jukema, J. Wouter, additional, Doevendans, Pieter A.F.M., additional, Nieuwenhuis, Edward E.S., additional, Erdmann, Jeanette, additional, Björkegren, Johan L.M., additional, Pasterkamp, Gerard, additional, Asselbergs, Folkert W., additional, den Ruijter, Hester M., additional, and Mokry, Michal, additional

Published
2017
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38. Pulmonary Vein Stenosis After Catheter Ablation

Author

van Driel, Vincent J.H.M., primary, Neven, Kars G.E.J., additional, van Wessel, Harry, additional, du Pré, Bastiaan C., additional, Vink, Aryan, additional, Doevendans, Pieter A.F.M., additional, and Wittkampf, Fred H.M., additional

Published
2014
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40. Toll-like receptor 2 and 4 stimulation elicits an enhanced inflammatory response in human obese patients with atherosclerosis

Author

Scholtes, Vincent P.W., primary, Versteeg, Dik, additional, de Vries, Jean-Paul P.M., additional, Hoefer, Imo E., additional, Schoneveld, Arjan H., additional, Stella, Pieter R., additional, Doevendans, Pieter A.F.M., additional, van Keulen, Karlijn J.K., additional, de Kleijn, Dominique P.V., additional, Moll, Frans L., additional, and Pasterkamp, Gerard, additional

Published
2011
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44. Restenosis after percutaneous coronary intervention is associated with the angiotensin-II type-1 receptor 1166A/C polymorphism but not with polymorphisms of angiotensin-converting enzyme, angiotensin-II receptor, angiotensinogen or heme oxygenase-1

Author

Wijpkema, Jasper S., primary, van Haelst, Paul L., additional, Monraats, Pascalle S., additional, Bruinenberg, Marcel, additional, Zwinderman, Aeilko H., additional, Zijlstra, Felix, additional, van der Steege, Gerrit, additional, de Winter, Rob J., additional, Doevendans, Pieter A.F.M., additional, Waltenberger, Johannes, additional, Wouter Jukema, J., additional, and Tio, René A., additional

Published
2006
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45. Plakophilin-2 Mutations Are the Major Determinant of Familial Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Author

van Tintelen, J.Peter, primary, Entius, Mark M., additional, Bhuiyan, Zahurul A., additional, Jongbloed, Roselie, additional, Wiesfeld, Ans C.P., additional, Wilde, Arthur A.M., additional, van der Smagt, Jasper, additional, Boven, Ludolf G., additional, Mannens, Marcel M.A.M., additional, van Langen, Irene M., additional, Hofstra, Robert M.W., additional, Otterspoor, Luuk C., additional, Doevendans, Pieter A.F.M., additional, Rodriguez, Luz-Maria, additional, van Gelder, Isabelle C., additional, and Hauer, Richard N.W., additional

Published
2006
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46. Pulmonary Vein Stenosis After Catheter Ablation

Author

Driel, Vincent J.H.M. van, Neven, Kars G.E.J., van Wessel, Harry, Pré, Bastiaan C. du, Vink, Aryan, Doevendans, Pieter A.F.M., and Wittkampf, Fred H.M.

Abstract

Radiofrequency ablation inside pulmonary vein (PV) ostia can cause PV stenosis. A novel alternative method of ablation is irreversible electroporation, but the long-term response of PVs to electroporation ablation is unknown.

Published
2014
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48. Metabolic background determines the importance of NOS3 polymorphisms in restenosis after percutaneous coronary intervention: A study in patients with and without the metabolic syndrome.

Author

Pons, Douwe, Monraats, Pascalle S., Zwinderman, Aeilko H., de Maat, Moniek P.M., Doevendans, Pieter A.F.M., de Winter, Robbert J., Tio, René A., Waltenberger, Johannes, and Jukema, J. Wouter

Subjects
*GENETIC polymorphisms, *CORONARY restenosis, *PATIENTS, *METABOLIC syndrome, *ENDOTHELIUM diseases, *MEDICAL care
Abstract

Variation in the NOS3 gene has been related to the development of restenosis. The Glu298Asp polymorphism has previously been investigated for its effect on NO levels and the development of restenosis. However, the variability of findings gave rise to the hypothesis that the functional significance of this polymorphism may only become manifest under conditions of endothelial dysfunction. Since patients with the metabolic syndrome are known to have endothelial dysfunction, we aimed to investigate if the significance of NOS3 polymorphisms may depend on the presence of the metabolic syndrome. We examined the impact of the -949 A/G, the -716 C/T and the Glu298Asp polymorphisms in the NOS3 gene on the risk of clinical restenosis in a previously described subpopulation of the GENDER-study, a multicenter prospective study design that enrolled consecutive patients after successful PCI. This subpopulation consisted of 901 patients of whom sufficient data were available to establish absence or presence of the metabolic syndrome. Of these patients, 448 had the metabolic syndrome. Clinical restenosis, defined as target vessel revascularization (TVR), was the primary endpoint. We demonstrated that the minor -949G, -716T and 298Asp alleles were associated with a significantly increased risk of TVR in patients with the metabolic syndrome (HR: 1.58 [95%CI: 1.04–2.40], HR: 1.95 [95%CI: 1.02–3.70] and HR: 1.67 [95%CI: 1.09–2.54], respectively). In the group without the metabolic syndrome we observed no association between the three polymorphisms and TVR. [ABSTRACT FROM AUTHOR]

Published
2009
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49. Oxygen uptake kinetics in chronic heart failure : clinical and physiological aspects

Author

Kemps, H.M.C., Wijn, Pieter F.F., Doevendans, Pieter A.F.M., Schep, Goof, and Plasma & Materials Processing

Abstract

Chronic heart failure (CHF) is a clinical syndrome characterized by exercise intolerance. Because resting indices of cardiac function and the level of perceived exercise intolerance correlate poorly with the exercise performance of these patients, exercise testing has become an important tool for the evaluation and monitoring of heart failure. Whereas the maximal aerobic capacity (peak VO2) has been shown to be a reliable indicator of the severity and prognosis of heart failure, submaximal exercise parameters may better reflect the ability to perform daily physical activities. Oxygen (O2) uptake kinetics describe the rate of change in oxygen uptake (VO2) during onset or recovery of exercise (O2 onset and recovery kinetics, respectively). Previous studies showed that, compared to healthy individuals, CHF patients have slower O2 onset and recovery kinetics, with the degree of the delay correlating with the functional impairment in these patients. However, it is not well established whether O2 uptake kinetics are sensitive to the effects of therapeutic interventions in CHF patients. Moreover, knowledge is lacking on the pathophysiological background of the delay in O2 uptake kinetics in CHF patients. This thesis addressed the following central questions: 1. Are O2 uptake kinetics useful in clinical practice to quantify and predict the effects of physical training in CHF patients? 2. What are the physiological determinants of O2 uptake kinetics in CHF patients?

Published
2009

50. 1103-195 Genetic predictive factors for restenosis in diabetic patients after percutaneous transluminal coronary angioplasty.

Author

Monraats, Pascalle S, Agema, Willem R.P, Zwinderman, Aeilko H, de Winter, Robbert J, Tio, Rene A, Doevendans, Pieter A.F.M, Crijns, Harry J.G.M, de Maat, Moniek P.M, Atsma, Douwe E, van der Laarse, Arnoud, van der Wall, Ernst E, and Wouter Jukema, J

Subjects
*CORONARY restenosis, *PEOPLE with diabetes, *TRANSLUMINAL angioplasty, *CORONARY artery surgery, *DISEASE progression, *APOLIPOPROTEINS, *THERAPEUTICS, *DISEASES
Published
2004
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