23 results on '"Dofferhoff, A. S.M."'
Search Results
2. Vitamin K2 Supplementation in Hospitalised COVID-19 Patients: A Randomised Controlled Trial
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Researchgr. Systems Radiology, Cancer, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Visser, Margot P.J., Dofferhoff, Anton S.M., van den Ouweland, Jody M.W., de Jong, Pim A., Zanen, Pieter, van Daal, Henny, Theeuwen, Eline B., Kramers, Cornelis, Janssen, Rob, Walk, Jona, Researchgr. Systems Radiology, Cancer, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Visser, Margot P.J., Dofferhoff, Anton S.M., van den Ouweland, Jody M.W., de Jong, Pim A., Zanen, Pieter, van Daal, Henny, Theeuwen, Eline B., Kramers, Cornelis, Janssen, Rob, and Walk, Jona
- Published
- 2024
3. Bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities: a randomized controlled trial
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Koekenbier, Eva L., primary, Fohse, Konstantin, additional, van de Maat, Josephine S., additional, Oosterheert, Jan Jelrik, additional, van Nieuwkoop, Cees, additional, Hoogerwerf, Jacobien J., additional, Grobusch, Martin P., additional, van den Bosch, Maurice A.A.J., additional, van de Wijgert, Janneke H.H., additional, Netea, Mihai G., additional, Rosendaal, Frits R., additional, Bonten, Marc J.M., additional, Werkhoven, C.H. (Henri) van, additional, Aardenburg-van Huisstede, Astrid, additional, Ammerlaan, Heidi S.M., additional, Boersma, Willem G., additional, Brinkman, Kees, additional, Bruijning-Verhagen, Patricia C.J., additional, van Crevel, Reinout, additional, Delsing, Corine, additional, ten Doesschaten, Thijs, additional, Dofferhoff, Anton S.M., additional, Duijkers, Ruud, additional, Groenwold, Rolf H.H., additional, de Haas, Corine, additional, Hassing, Robert-Jan, additional, de Hoog, Marieke L.A., additional, Huijts, Susanne M., additional, van Hylckama-Vlieg, Astrid, additional, Jong, Eefje, additional, de Jong, Hanna K., additional, Knap, Martijn, additional, Koekenbier, Eva L., additional, Koenders, Michael, additional, Kouijzer, Ilse J.E., additional, Kramer, Henk, additional, van de Laar, Roel, additional, Lalmohamed, Arief, additional, Lensen, Karel-Jan D.F., additional, Lijfering, Willem M., additional, Magdelijns, Fabienne, additional, Meek, Bob, additional, Middelburg, Rutger A., additional, Moeniralam, Hazra S., additional, Mooijaart, Simon P., additional, van Munster, Barbara C., additional, ten Oever, Jaap, additional, Goossens, Marc Padros, additional, Peters, Vincent, additional, Postma, Douwe F., additional, Pouw, Niels, additional, Reesink, Herre J., additional, de Regt, Marieke J.A., additional, van der Reijden, Anneli C.J., additional, Schaakxs, R., additional, Slieker, Kitty, additional, Slingerland, Robbert J., additional, van Sluis, Nicolette L.J., additional, Stehouwer, Coen D.A., additional, van de Veerdonk, Frank, additional, Verbon, Annelies, additional, and van Werkhoven, C.H. (Henri), additional
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- 2023
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4. Sex Differences In The Mortality Of Hospitalized Patients With COVID-19 And Non-ICU Policies In The Netherlands
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Freytag, Astrid, primary, Hoogerwerf, Jacobien, additional, Dofferhoff, Anton S.M., additional, Janssen, Nico, additional, Blaauw, Marc, additional, Hassing, Robert-Jan, additional, Apeldoorn, Marjan van, additional, Kerckhoffs, Angèle, additional, Veerman, Karin, additional, de Maat, Josephine van, additional, and Oertelt-Prigione, Sabine, additional
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- 2022
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5. The netherlands is on track to meet the world health organization hepatitis C elimination targets by 2030
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Van Dijk, Marleen, Brakenhoff, Sylvia M., Isfordink, Cas J., Cheng, Wei‐Han, Blokzijl, Hans, Boland, Greet, Dofferhoff, Anthonius S.M., Van Hoek, Bart, Van Nieuwkoop, Cees, Sonneveld, Milan J., Van Der Valk, Marc, Drenth, Joost P.H., De Knegt, Robert J., Van Dijk, Marleen, Brakenhoff, Sylvia M., Isfordink, Cas J., Cheng, Wei‐Han, Blokzijl, Hans, Boland, Greet, Dofferhoff, Anthonius S.M., Van Hoek, Bart, Van Nieuwkoop, Cees, Sonneveld, Milan J., Van Der Valk, Marc, Drenth, Joost P.H., and De Knegt, Robert J.
- Abstract
Background: The Netherlands strives for hepatitis C virus (HCV) elimination, in accordance with the World Health Organization targets. An accurate estimate when HCV elimination will be reached is elusive. We have embarked on a nationwide HCV elimination project (CELINE) that allowed us to harvest detailed data on the Dutch HCV epidemic. This study aims to provide a well‐supported timeline towards HCV elimination in The Netherlands. Methods: A previously published Markov model was used, adopting published data and unpublished CELINE project data. Two main scenarios were devised. In the Status Quo scenario, 2020 diagnosis and treatment levels remained constant in subsequent years. In the Gradual Decline scenario, an annual decrease of 10% in both diagnoses and treatments was implemented, starting in 2020. WHO incidence target was disregarded, due to low HCV incidence in The Netherlands (≤5 per 100,000). Results: Following the Status Quo and Gradual Decline scenarios, The Netherlands would meet WHO’s elimination targets by 2027 and 2032, respectively. From 2015 to 2030, liver‐related mortality would be reduced by 97% in the Status Quo and 93% in the Gradual Decline scenario. Compared to the Status Quo scenario, the Gradual Decline scenario would result in 12 excess cases of decompensated cirrhosis, 18 excess cases of hepatocellular carcinoma, and 20 excess cases of liverrelated death from 2020-2030. Conclusions: The Netherlands is on track to reach HCV elimination by 2030. However, it is vital that HCV elimination remains high on the agenda to ensure adequate numbers of patients are being diagnosed and treated.
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- 2021
6. Reduced Vitamin K Status as a Potentially Modifiable Risk Factor of Severe Coronavirus Disease 2019
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Researchgr. Systems Radiology, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, Dofferhoff, Anton S.M., Piscaer, Ianthe, Schurgers, Leon J., Visser, Margot P.J., van den Ouweland, Jody M.W., de Jong, Pim A., Gosens, Reinoud, Hackeng, Tilman M., van Daal, Henny, Lux, Petra, Maassen, Cecile, Karssemeijer, Esther G.A., Vermeer, Cees, Wouters, Emiel F.M., Kistemaker, Loes E.M., Walk, Jona, Janssen, Rob, Researchgr. Systems Radiology, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, Dofferhoff, Anton S.M., Piscaer, Ianthe, Schurgers, Leon J., Visser, Margot P.J., van den Ouweland, Jody M.W., de Jong, Pim A., Gosens, Reinoud, Hackeng, Tilman M., van Daal, Henny, Lux, Petra, Maassen, Cecile, Karssemeijer, Esther G.A., Vermeer, Cees, Wouters, Emiel F.M., Kistemaker, Loes E.M., Walk, Jona, and Janssen, Rob
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- 2021
7. The netherlands is on track to meet the world health organization hepatitis C elimination targets by 2030
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MS MDL 1, MMB Staf diagnostiek, Infection & Immunity, Van Dijk, Marleen, Brakenhoff, Sylvia M., Isfordink, Cas J., Cheng, Wei‐Han, Drenth, Joost P.H., De Knegt, Robert J., Blokzijl, Hans, Boland, Greet, Dofferhoff, Anthonius S.M., Van Hoek, Bart, Van Nieuwkoop, Cees, Sonneveld, Milan J., Van Der Valk, Marc, MS MDL 1, MMB Staf diagnostiek, Infection & Immunity, Van Dijk, Marleen, Brakenhoff, Sylvia M., Isfordink, Cas J., Cheng, Wei‐Han, Drenth, Joost P.H., De Knegt, Robert J., Blokzijl, Hans, Boland, Greet, Dofferhoff, Anthonius S.M., Van Hoek, Bart, Van Nieuwkoop, Cees, Sonneveld, Milan J., and Van Der Valk, Marc
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- 2021
8. Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19
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CDL Staf Research, Circulatory Health, CDL Arcadia, Medische Staf Intensive Care, Infection & Immunity, Arts Assistenten Longziekten, Onderzoeksgroep 6, Janssen, Nico A.F., Grondman, Inge, de Nooijer, Aline H., Boahen, Collins K., Koeken, Valerie A.C.M., Matzaraki, Vasiliki, Kumar, Vinod, He, Xuehui, Kox, Matthijs, Koenen, Hans J.P.M., Smeets, Ruben L., Joosten, Irma, Brüggemann, Roger J.M., Kouijzer, Ilse J.E., van der Hoeven, Hans G., Schouten, Jeroen A., Frenzel, Tim, Reijers, Monique H.E., Hoefsloot, Wouter, Dofferhoff, Anton S.M., van Apeldoorn, Marjan J., Blaauw, Marc J.T., Veerman, Karin, Maas, Coen, Schoneveld, Arjan H., Hoefer, Imo E., Derde, Lennie P.G., van Deuren, Marcel, van der Meer, Jos W.M., van Crevel, Reinout, Giamarellos-Bourboulis, Evangelos J., Joosten, Leo A.B., van den Heuvel, Michel M., Hoogerwerf, Jacobien, de Mast, Quirijn, Pickkers, Peter, Netea, Mihai G., van de Veerdonk, Frank L., CDL Staf Research, Circulatory Health, CDL Arcadia, Medische Staf Intensive Care, Infection & Immunity, Arts Assistenten Longziekten, Onderzoeksgroep 6, Janssen, Nico A.F., Grondman, Inge, de Nooijer, Aline H., Boahen, Collins K., Koeken, Valerie A.C.M., Matzaraki, Vasiliki, Kumar, Vinod, He, Xuehui, Kox, Matthijs, Koenen, Hans J.P.M., Smeets, Ruben L., Joosten, Irma, Brüggemann, Roger J.M., Kouijzer, Ilse J.E., van der Hoeven, Hans G., Schouten, Jeroen A., Frenzel, Tim, Reijers, Monique H.E., Hoefsloot, Wouter, Dofferhoff, Anton S.M., van Apeldoorn, Marjan J., Blaauw, Marc J.T., Veerman, Karin, Maas, Coen, Schoneveld, Arjan H., Hoefer, Imo E., Derde, Lennie P.G., van Deuren, Marcel, van der Meer, Jos W.M., van Crevel, Reinout, Giamarellos-Bourboulis, Evangelos J., Joosten, Leo A.B., van den Heuvel, Michel M., Hoogerwerf, Jacobien, de Mast, Quirijn, Pickkers, Peter, Netea, Mihai G., and van de Veerdonk, Frank L.
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- 2021
9. 8 weeks of sofosbuvir/ledipasvir is effective in DAA-naive non-cirrhotic HCV genotype 4 infected patients (HEPNED-001 study)
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Boerekamps, Anne, Vanwolleghem, Thomas, van der Valk, Marc, van den Berk, Guido E., van Kasteren, Marjo, Posthouwer, Dirk, Dofferhoff, Anthonius S.M., van Hoek, Bart, Ramsoekh, Dewkoemar, Koopsen, Jelle, Schinkel, Janke, Florence, Eric, Arends, Joop E., and Rijnders, Bart J.
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- 2019
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10. Vitamin D – contrary to vitamin K – does not associate with clinical outcome in hospitalized COVID-19 patients
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Walk, Jona, primary, Dofferhoff, Anton S.M., additional, van den Ouweland, Jody M.W., additional, van Daal, Henny, additional, and Janssen, Rob, additional
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- 2020
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11. Reduced Vitamin K Status as A Potentially Modifiable Prognostic Risk Factor in COVID-19
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Dofferhoff, Anton S.M., primary, Piscaer, Ianthe, additional, Schurgers, Leon J., additional, Walk, Jona, additional, van den Ouweland, Jody M.W., additional, Hackeng, Tilman M., additional, de Jong, Pim A., additional, Gosens, Reinoud, additional, Lux, Petra, additional, van Daal, Henny, additional, Maassen, Cecile, additional, Maassen, Esther G.A., additional, Kistemaker, Loes E.M., additional, Vermeer, Cees, additional, Wouters, Emiel F.M., additional, and Janssen, Rob, additional
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- 2020
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12. A systems approach to inflammation identifies therapeutic targets in SARS-CoV-2 infection
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van de Veerdonk, Frank L., primary, Janssen, Nico A.F., additional, Grondman, Inge, additional, de Nooijer, Aline H., additional, Koeken, Valerie A.C.M., additional, Matzaraki, Vasiliki, additional, Boahen, Collins K., additional, Kumar, Vinod, additional, Kox, Matthijs, additional, Koenen, Hans J.P.M., additional, Smeets, Ruben L., additional, Joosten, Irma, additional, Brüggemann, Roger J.M., additional, Kouijzer, Ilse J.E., additional, van der Hoeven, Hans G., additional, Schouten, Jeroen A., additional, Frenzel, Tim, additional, Reijers, Monique, additional, Hoefsloot, Wouter, additional, Dofferhoff, Anton S.M., additional, Kerckhoffs, Angèle P.M., additional, Blaauw, Marc J.T., additional, Veerman, Karin, additional, Maas, Coen, additional, Schoneveld, Arjan H., additional, Hoefer, Imo E., additional, Derde, Lennie P.G., additional, Willems, Loek, additional, Toonen, Erik, additional, van Deuren, Marcel, additional, van der Meer, Emeritus Jos W.M., additional, van Crevel, Reinout, additional, Giamarellos-Bourboulis, Evangelos J., additional, Joosten, Leo A.B., additional, van den Heuvel, Michel M., additional, Hoogerwerf, Jacobien, additional, de Mast, Quirijn, additional, Pickkers, Peter, additional, and Netea, Mihai G., additional
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- 2020
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13. A prospective multicenter study on fever of unknown origin: the yield of a structured diagnostic protocol
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Bleeker-Rovers, Chantal P., Vos, Fidel J., Kleijn, Elisabeth M.H.A. de, Mudde, Aart H., Dofferhoff, Ton S.M., Richter, Clemens, Smilde, Tineke J., Krabbe, Paul F.M., Oyen, Wim J.G., and Meer, Jos W.M. van der
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Fever -- Research ,Fever -- Causes of ,Hyperthermia -- Research ,Hyperthermia -- Causes of ,Diagnosis -- Research - Published
- 2007
14. Pharmacokinetics of IV or IM ceftazidime in relation to cytokines in septic neutropenic mice: P1804
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Buijs, J., Dofferhoff, A. S.M., Mouton, J. W., and van der Meer, J. W.M.
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- 2005
15. Melioidosis in travelers: An analysis of Dutch melioidosis registry data 1985–2018
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Birnie, Emma, primary, Savelkoel, Jelmer, additional, Reubsaet, Frans, additional, Roelofs, Joris J.T.H., additional, Soetekouw, Robin, additional, Kolkman, Saskia, additional, Cremers, Anne Lia, additional, Grobusch, Martin P., additional, Notermans, Daan W., additional, Wiersinga, W. Joost, additional, Rozemeijer, Wouter, additional, Rijkeboer, Annemieke, additional, Birnie, Emma, additional, Scholing, Maarten, additional, van Dijk, Karin, additional, Mascini, Ellen M., additional, van der Veen, Henk, additional, van den Bijllaardt, Wouter, additional, de Vries, Maaike, additional, Smeets, Leonard C., additional, Ott, Alewijn, additional, van Krimpen, Kees, additional, Herpers, Bjorn L., additional, Watttel-Louis, G. Hanke, additional, Waar, Karola, additional, Schwandt, Noortje L.Q., additional, Maat, Ianthe, additional, Dofferhoff, Anthonius S.M., additional, Vermeulen, Joost N., additional, van Westreenen, Mireille, additional, de Man, Peter, additional, Hofland, Regina W., additional, van Gorp, Joost, additional, Thijsen, Steven, additional, van der Velden, Lieven B., additional, and Verduin, Cornelis M., additional
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- 2019
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16. Pseudohyperkalemia and Platelet Counts
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Nijsten, M. W.N., de Smet, B. J.G.L., and Dofferhoff, A. S.M.
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- 1991
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17. Factors associated with presenting late or with advanced HIV disease in the Netherlands, 1996-2014: results from a national observational cohort
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Op De Coul, Eline L.M., Van Sighem, Ard, Brinkman, Kees, Van Benthem, Birgit H., Van Der Ende, Marchina E., Geerlings, Suzanne, Reiss, Peter, Prins, J. M., Kuijpers, T. W., Scherpbier, H. J., Van Der Meer, J. T.M., Wit, F.W.N.M., Godfried, M. H., Reiss, P., Van Der Poll, T., Nellen, F. J.B., Geerlings, S. E., Van Vugt, M., Pajkrt, D., Bos, J. C., Wiersinga, W. J., Van Der Valk, M., Goorhuis, A., Hovius, J. W., Van Eden, J., Henderiks, A., Van Hes, A. M.H., Mutschelknauss, M., Nobel, H. E., Pijnappel, F. J.J., Westerman, A. M., Jurriaans, S., Back, N. K.T., Zaaijer, H. L., Berkhout, B., Cornelissen, M. T.E., Schinkel, C. J., Thomas, X. V., De Ruyter Ziekenhuis, Admiraal, Van Den Berge, M., Stegeman, A., Baas, S., De Looff, L. Hage, Versteeg, D., Pronk, M. J.H., Ammerlaan, H. S.M., Korsten-Vorstermans, E. M.H.M., De Munnik, E. S., Tjhie, J., Wegdam, M. C.A., Weijsenfeld, A. M., Van Der Ende, M. E., De Vries-Sluijs, T. E.M.S., Van Gorp, E. C.M., Schurink, C. A.M., Nouwen, J. L., Verbon, A., Rijnders, B. J.A., Bax, H. I., Hassing, R. J., Van Der Feltz, M., Bassant, N., Van Beek, J. E.A., Vriesde, M., Van Zonneveld, L. M., De Oude-Lubbers, A., Van Den Berg-Cameron, H. J., Bruinsma-Broekman, F. B., De Groot, J., De Zeeuw-De Man, M., Broekhoven-Kruijne, M. J., Schutten, M., Osterhaus, A. D.M.E., Boucher, C. A.B., Driessen, G. J.A., Van Rossum, A. M.C., Van Der Knaap, L. C., Visser, E., Branger, J., Duijf-Van De Ven, C. J.H.M., Schippers, E. F., Van Nieuwkoop, C., Brimicombe, R. W., VanJperen, J. M., Van Der Hut, G., Franck, P. F.H., Van Eeden, A., Groot, M., Kwa, I. S., Bouwhuis, J. W., Van Hulzen, A. G.W., Bor, P. C.J., Bloembergen, P., Wolfhagen, M. J.H.M., Ruijs, G. J.H.M., Soetekouw, R., Van Der Prijt, L. M.M., Schoemaker, M., Van Der Reijden, W. A., Jansen, R., Herpers, B. L., Kroon, F. P., Arend, S. M., De Boer, M. G.J., Bauer, M. P., Jolink, H., Vollaard, A. M., Moons, C., Kroes, A. C.M., Pogany, K., Smit, J. V., Smit, E., Van Niekerk, T., Pontesilli, O., Lashof, A. Oude, Posthouwer, D., Schippers, J., Vergoossen, R., Loo, I. H., El Moussaoui, R., Van Twillert, G., Stuart, J. W.T.Cohen, Diederen, B. M.W., Van Truijen-Oud, F. A., Gelinck, L. B.S., Meerkerk, C., Wildenbeest, G. S., Jansen, C. L., Van Houte, D. P.F., Faber, S., Delsing, C. E., Heins, H., Frissen, P. H.J., Blok, W. L., Schouten, W. E.M., Van Den Berk, G. E.L., Brouwer, C. J., Geerders, G. F., Hoeksema, K., Kleene, M. J., Van Der Meché, I. B., Toonen, A. J.M., Wijnands, S., Keuter, M., Van Der Ven, A. J.A.M., Hofstede, Hjm Ter, Dofferhoff, A. S.M., Van Crevel, R., Bosch, M. E.W., Grintjes-Huisman, K. J.T., Zomer, B. J., Van Der Berg, J. P., Gisolf, E. H., Van Bentum, P. H.M., Langebeek, N., Swanink, C. M.A., Lettinga, K. D., Sulman, H., Witte, E., Vrouenraets, S. M.E., Lauw, F. N., Paap, H., Vlasblom, D. J., Rosingh, A. W., Brouwer, A. E., Kuipers, M., Santegoets, R. M.W.J., Van Der Ven, B., Buiting, A. G.M., Kabel, P. J., Sprenger, H. G., Scholvinck, E. H., Van Assen, S., Wilting, K. R., Stienstra, Y., Van Der Meulen, P. A., De Weerd, D. A., Riezebos-Brilman, A., Van Leer-Buter, C. C., Schneider, M. M.E., Mudrikova, T., Ellerbroek, P. M., Oosterheert, J. J., Arends, J. E., Barth, R. E., Wassenberg, M. W.M., Laan, L. M., Van Oers-Hazelzet, E. E.B., Patist, J., Vervoort, S., Frauenfelder, R., Verduyn-Lunel, F., Wensing, A. M.J., Van Agtmael, M. A., Perenboom, R. M., Bomers, M., De Vocht, J., Vandenbroucke-Grauls, C. M.J.E., Ang, C. W., Wolfs, T. F.W., Bont, L. J., Gras, L., Van Sighem, A. I., Smit, C., Hillebregt, M., Kimmel, V., Tong, Y., Van Den Boogaard, R., Hoekstra, P., De Lang, A., Berkhout, M., Grivell, S., Jansen, A., Van Den Akker, M., Bergsma, D., Lodewijk, C., Meijering, R., Peeck, B., Raethke, M., Ree, C., Regtop, R., Ruijs, Y., Schoorl, M., Tuijn, E., Veenenberg, L., Woudstra, T., Bakker, Y., De Jong, A., Broekhoven, M., Claessen, E., Rademaker, M. J., Munjishvili, L., Kruijne, E., Other departments, AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Infectious diseases, Global Health, Paediatric Infectious Diseases / Rheumatology / Immunology, General Internal Medicine, Center of Experimental and Molecular Medicine, Graduate School, Medical Microbiology and Infection Prevention, Gastroenterology and Hepatology, APH - Health Behaviors & Chronic Diseases, Internal Medicine, Virology, Medical Microbiology & Infectious Diseases, Epidemiology, Pediatric Surgery, Pediatrics, Med Microbiol, Infect Dis & Infect Prev, MUMC+: MA Alg Interne Geneeskunde (9), MUMC+: DA MMI Staf (9), RS: CAPHRI - R4 - Health Inequities and Societal Participation, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, MUMC+: DA Medische Microbiologie en Infectieziekten (5), MUMC+: DA MMI Infectieserologie (9), and MUMC+: DA MMI AIOS (9)
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Male ,Pediatrics ,Delayed Diagnosis ,Epidemiology ,General Practice ,Health Behavior ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,HIV Infections ,Logistic regression ,Cohort Studies ,0302 clinical medicine ,Risk Factors ,Ethnicity ,030212 general & internal medicine ,Young adult ,Netherlands ,Transients and Migrants ,Age Factors ,Prenatal Care ,General Medicine ,Middle Aged ,Hospitals ,Cohort ,Disease Progression ,Female ,0305 other medical science ,Sexuality ,Cohort study ,Adult ,medicine.medical_specialty ,Emigrants and Immigrants ,Prenatal care ,03 medical and health sciences ,Young Adult ,Acquired immunodeficiency syndrome (AIDS) ,SDG 3 - Good Health and Well-being ,medicine ,Humans ,Socioeconomic status ,030505 public health ,business.industry ,Research ,medicine.disease ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,business ,Demography - Abstract
Contains fulltext : 172538.pdf (Publisher’s version ) (Open Access) OBJECTIVES: Early testing for HIV and entry into care are crucial to optimise treatment outcomes of HIV-infected patients and to prevent spread of HIV. We examined risk factors for presentation with late or advanced disease in HIV-infected patients in the Netherlands. METHODS: HIV-infected patients registered in care between January 1996 and June 2014 were selected from the ATHENA national observational HIV cohort. Risk factors for late presentation and advanced disease were analysed by multivariable logistic regression. Furthermore, geographical differences and time trends were examined. RESULTS: Of 20 965 patients, 53% presented with late-stage HIV infection, and 35% had advanced disease. Late presentation decreased from 62% (1996) to 42% (2013), while advanced disease decreased from 46% to 26%. Late presentation only declined significantly among men having sex with men (MSM; p /=50 years (1.46; CI 1.33 to 1.60 vs 30-49 years), region of origin (South-East Asia 2.14; 1.80 to 2.54, sub-Saharan Africa 2.11; 1.88 to 2.36, Surinam 1.59; 1.37 to 1.84, Caribbean 1.31; 1.13 to 1.53, Latin America 1.23; 1.04 to 1.46 vs the Netherlands), and location of HIV diagnosis (hospital 3.27; 2.94 to 3.63, general practitioner 1.66; 1.50 to 1.83, antenatal screening 1.76; 1.38 to 2.34 vs sexually transmitted infection clinic). No association was found for socioeconomic status or level of urbanisation. Compared with Amsterdam, 2 regions had higher adjusted odds and 2 regions had lower odds of late presentation. Results were highly similar for advanced disease. CONCLUSIONS: Although the overall rate of late presentation is declining in the Netherlands, targeted programmes to reduce late HIV diagnoses remain needed for all risk groups, but should be prioritised for heterosexual males, migrant populations, people aged >/=50 years and certain regions in the Netherlands.
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- 2016
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18. Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries
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Lodi, Sara, Del Amo, Julia, Moreno, Santiago, Bucher, H. C., Furrer, Hansjakob, Logan, Roger, Sterne, Jonathan, Pérez-Hoyos, Santiago, Jarrín, Inma, Phillips, Andrew, Olson, Ashley, Van Sighem, Ard, Reiss, Peter, Sabin, C., Jose, Sophie, Justice, Amy, Goulet, Joseph, Miró, José M., Ferrer, Elena, Meyer, Laurence, Seng, Rémonie, Vourli, Georgia, Antoniadou, Anastasia, Dabis, Francois, Vandenhede, Mari Anne, Costagliola, Dominique, Abgrall, S., Hernán, Miguel A., Hernan, Miguel, Bansi, L., Hill, T., Dunn, D., Porter, K., Glabay, A., Orkin, C., Thomas, R., Jones, K., Fisher, M., Perry, N., Pullin, A., Churchill, D., Gazzard, B., Nelson, M., Asboe, D., Bulbeck, S., Mandalia, S., Clarke, J., Delpech, V., Anderson, J., Munshi, S., Post, F., Easterbrook, P., Khan, Y., Patel, P., Karim, F., Duffell, S., Gilson, R., Man, S. L., Williams, I., Gompels, M., Dooley, D., Schwenk, A., Ainsworth, J., Johnson, M., Youle, M., Lampe, F., Smith, C., Grabowska, H., Chaloner, C., Ismajani Puradiredja, D., Phillips, A., Walsh, J., Weber, J., Kemble, C., Mackie, N., Winston, A., Leen, C., Wilson, A., Bezemer, D. O., Gras, L. A.J., Kesselring, A. M., Van Sighem, A. I., Zaheri, S., Van Twillert, G., Kortmann, W., Branger, J., Prins, J. M., Kuijpers, T. W., Scherpbier, H. J., Van Der Meer, J. T.M., Wit, F. W.M.N., Godfried, M. H., Reiss, P., Van Der Poll, T., Nellen, F. J.B., Lange, J. M.A., Geerlings, S. E., Van Vugt, M., Pajkrt, D., Bos, J. C., Van Der Valk, M., Grijsen, M. L., Wiersinga, W. J., Brinkman, K., Blok, W. L., Frissen, P. H.J., Schouten, W. E.M., Van Den Berk, G. E.L., Veenstra, J., Lettinga, K. D., Mulder, J. W., Vrouenraets, S. M.E., Lauw, F. N., Van Eeden, A., Verhagen, D. W.M., Van Agtmael, M. A., Perenboom, R. M., Claessen, F. A.P., Bomers, M., Peters, E. J.G., Richter, C., Van Der Berg, J. P., Gisolf, E. H., Schippers, E. F., Van Nieuwkoop, C., Van Elzakker, E. P., Leyten, E. M.S., Gelinck, L. B.S., Pronk, M. J.H., Bravenboer, B., Kootstra, G. J., Delsing, C. E., Sprenger, H. G., Doedens, R., Scholvinck, E. H., Van Assen, S., Bierman, W. F.W., Soetekouw, R., Ten Kate, R. W., Van Vonderen, M. G.A., Van Houte, D. P.F., Kroon, F. P., Van Dissel, J. T., Arend, S. M., De Boer, M. G.J., Jolink, H., Ter Vollaard, H. J.M., Bauer, M. P., Weijer, S., El Moussaoui, R., Lowe, S., Schreij, G., Oude Lashof, A., Posthouwer, D., Koopmans, P. P., Keuter, M., Van Der Ven, A. J.A.M., Ter Hofstede, H. J.M., Dofferhoff, A. S.M., Warris, A., Van Crevel, R., Van Der Ende, M. E., De Vries-Sluijs, T. E.M.S., Schurink, C. A.M., Nouwen, J. L., Nispen Tot Pannerden, M. H., Verbon, A., Rijnders, B. J.A., Van Gorp, E. C.M., Hassing, R. J., Smeulders, A. W.M., Hartwig, N. G., Driessen, G. J.A., Den Hollander, J. G., Pogany, K., Juttmann, J. R., Van Kasteren, M. E.E., Hoepelman, A. I.M., Mudrikova, T., Schneider, M. M.E., Jaspers, C. A.J.J., Ellerbroek, P. M., Oosterheert, J. J., Arends, J. E., Wassenberg, M. W.M., Barth, R. E., Geelen, S. P.M., Wolfs, T. F.W., Bont, L. J., Van Den Berge, M., Stegeman, A., Groeneveld, P. H.P., Alleman, M. A., Bouwhuis, J. W., Barin, F., Burty, C., Duvivier, C., Enel, P., Fredouille-Heripret, L., Gasnault, J., Khuong, M. A., Mahamat, A., Pilorgé, F., Tattevin, P., Salomon, Valérie, Jacquemet, N., Costagliola, D., Grabar, S., Guiguet, M., Lanoy, E., Lièvre, L., Mary-Krause, M., Selinger-Leneman, H., Lacombe, J. M., Potard, V., Bricaire, F., Herson, S., Katlama, C., Simon, A., Desplanque, N., Girard, P. M., Meynard, J. L., Meyohas, M. C., Picard, O., Cadranel, J., Mayaud, C., Pialoux, G., Clauvel, J. P., Decazes, J. M., Gérard, L., Molina, J. M., Diemer, M., Sellier, P., Bentata, M., Honoré, P., Jeantils, V., Tassi, S., Mechali, D., Taverne, B., Bouvet, E., Crickx, B., Ecobichon, J. L., Matheron, S., Picard-Dahan, C., Yeni, P., Berthé, H., Dupont, C., Chandemerle, C., Mortier, E., De Truchis, P., Tisne-Dessus, D., Weiss, L., Salmon, D., Auperin, I., Gilquin, J., Roudière, L., Viard, J. P., Boue, F., Fior, R., Delfraissy, J. F., Goujard, C., Jung, C., Lesprit, Ph, Vittecoq, D., Fraisse, P., Lang, J. M., Rey, D., Beck-Wirth, G., Stahl, J. P., Lecercq, P., Gourdon, F., Laurichesse, H., Fresard, A., Lucht, F., Bazin, C., Verdon, R., Chavanet, P., Arvieux, C., Michelet, C., Choutet, P., Goudeau, A., Maître, M. F., Hoen, B., Eglinger, P., Faller, J. P., Borsa-Lebas, F., Caron, F., Reynes, J., Daures, J. P., May, T., Rabaud, C., Berger, J. L., Rémy, G., Arlet-Suau, E., Cuzin, L., Massip, P., Thiercelin Legrand, M. F., Pontonnier, G., Viget, N., Yasdanpanah, Y., Dellamonica, P., Pradier, C., Pugliese, P., Aleksandrowicz, K., Quinsat, D., Ravaux, I., Tissot-Dupont, H., Delmont, J. P., Moreau, J., Gastaut, J. A., Poizot Martin, I., Retornaz, F., Soubeyrand, J., Galinier, A., Ruiz, J. M., Allegre, T., Blanc, P. A., Bonnet-Montchardon, D., Lepeu, G., Granet-Brunello, P., Esterni, J. P., Pelissier, L., Cohen-Valensi, R., Nezri, M., Chadapaud, S., Laffeuillade, A., Billaud, E., Raffi, F., Boibieux, A., Peyramond, D., Livrozet, J. M., Touraine, J. L., Cotte, L., Trepo, C., Strobel, M., Bissuel, F., Pradinaud, R., Sobesky, M., Cabié, A., Gaud, C., Contant, M., Aubert, V., Barth, J., Battegay, M., Bernasconi, E., Böni, J., Burton-Jeangros, C., Calmy, A., Cavassini, M., Egger, M., Elzi, L., Fehr, J., Fellay, J., Furrer, H., Haerry, D., Fux, C. A., Gorgievski, M., Günthard, H., Hasse, B., Hirsch, H. H., Hösli, I., Kahlert, C., Kaiser, L., Keiser, O., Klimkait, T., Kovari, H., Ledergerber, B., Martinetti, G., Martinez De Tejada, B., Metzner, K., Müller, N., Nadal, D., Pantaleo, G., Rauch, A., Regenass, S., Rickenbach, M., Rudin, C., Schmid, P., Schultze, D., Schöni-Affolter, F., Schüpbach, J., Speck, R., Taffé, P., Tarr, P., Telenti, A., Trkola, A., Vernazza, P., Weber, R., Yerly, S., Casabona, J., Gallois, A., Esteve, A., Podzamczer, D., Murillas, J., Gatell, J. M., Manzardo, C., Tural, C., Clotet, B., Ferrer, E., Riera, M., Segura, F., Navarro, G., Force, L., Vilaró, J., Masabeu, A., García, I., Guadarrama, M., Cifuentes, C., Dalmau, D., Jaen, Agustí, C., Montoliu, A., Pérez, I., Gargoulas, Freyra, Blanco, J. L., Garcia-Alcaide, F., Martínez, E., Mallolas, J., López-Dieguez, M., García-Goez, J. F., Sirera, G., Romeu, J., Jou, A., Negredo, E., Miranda, C., Capitan, M. C., Saumoy, M., Imaz, A., Tiraboschi, J. M., Murillo, O., Bolao, F., Peña, C., Cabellos, C., Masó, M., Vila, A., Sala, M., Cervantes, M., Jose Amengual, Ma, Navarro, M., Penelo, E., Barrufet, P., Bejarano, G., Molina, J., Alvaro, M., Mercadal, J., Fernandez, Juanse, Ospina, Jesus E., Muñoz, M. A., Caro-Murillo, A. M., Sobrino, P., Jarrín, I., Gomez Sirvent, J. L., Rodríguez, P., Aleman, M. R., Alonso, M. M., Lopez, A. M., Hernandez, M. I., Soriano, V., Labarga, P., Barreiro, P., Medrano, J., Rivas, P., Herrero, D., Blanco, F., Vispo, M. E., Martín, L., Ramírez, G., De Diego, M., Rubio, R., Pulido, F., Moreno, V., Cepeda, C., Hervás, Rl, Iribarren, J. A., Arrizabalaga, J., Aramburu, M. J., Camino, X., Rodrí-guez-Arrondo, F., Von Wichmann, M. A., Pascual, L., Goenaga, M. A., Gutierrez, F., Masia, M., Ramos, J. M., Padilla, S., Sanchez-Hellín, V., Bernal, E., Escolano, C., Montolio, F., Peral, Y., Berenguer, J., Lopez, J. C., Miralles, P., Cosín, J., Sanchez, M., Gutierrez, I., Ramírez, M., Padilla, B., Vidal, F., Sanjuan, M., Peraire, J., Veloso, S., Vilades, C., Lopez-Dupla, M., Olona, M., Vargas, M., Aldeguer, J. L., Blanes, M., Lacruz, J., Salavert, M., Montero, M., Cuéllar, S., De Los Santos, I., Sanz, J., Oteo, J. A., Blanco, J. R., Ibarra, V., Metola, L., Sanz, M., Pérez-Martínez, L., Sola, J., Uriz, J., Castiello, J., Reparaz, J., Arriaza, M. J., Irigoyen, C., Moreno, S., Antela, A., Casado, J. L., Dronda, F., Moreno, A., Pérez, M. J., López, D., Gutiérrez, C., Hernández, B., Pumares, M., Martí, P., García, L., Page, C., García, F., Hernández, J., Peña, A., Muñoz, L., Parra, J., Viciana, P., Leal, M., López-Cortés, L. F., Trastoy, M., Mata, R., Justice, A. C., Fiellin, D. A., Rimland, D., Jones-Taylor, C., Oursler, K. A., Titanji, R., Brown, S., Garrison, S., Rodriguez-Barradas, M., Masozera, N., Goetz, M., Leaf, D., Simberkoff, M., Blumenthal, D., Leung, J., Butt, A., Hoffman, E., Gibert, C., Peck, R., Mattocks, K., Braithwaite, S., Brandt, C., Bryant, K., Cook, R., Conigliaro, J., Crothers, K., Chang, J., Crystal, S., Day, N., Erdos, J., Freiberg, M., Kozal, M., Gandhi, N., Gaziano, M., Gerschenson, M., Good, B., Gordon, A., Goulet, J. L., Hernán, M. A., Kraemer, K., Lim, J., Maisto, S., Miller, P., Mole, L., O'Connor, P., Papas, R., Robins, J. M., Rinaldo, C., Roberts, M., Samet, J., Tierney, B., Whittle, J., Babiker, A., Brettle, R., Darbyshire, J., Goldberg, D., Hawkins, D., Jaffe, H., Johnson, A., McLean, K., Pillay, D., Cursley, Adam, Ewings, Fiona, Fairbrother, Keith, Louisa Gnatiuc, S. L., Murphy, Brendan, Douglas, G., Kennedy, N., Pritchard, J., Andrady, U., Rajda, N., Maw, R., McKernan, S., Drake, S., Gilleran, G., White, D., Ross, J., Toomer, S., Hewart, R., Wilding, H., Woodward, R., Dean, G., Heald, L., Horner, P., Glover, S., Bansaal, D., Eduards, S., Carne, C., Browing, M., Das, R., Stanley, B., Estreich, S., Magdy, A., O'Mahony, C., Fraser, P., Hayman, B., Jebakumar, S. P.R., Joshi, U., Ralph, S., Wade, A., Mette, R., Lalik, J., Summerfield, H., El-Dalil, A., France, J. A., White, C., Robertson, R., Gordon, S., McMillan, S., Morris, S., Lean, C., Vithayathil, K., McLean, L., Winter, A., Gale, D., Jacobs, S., Tayal, S., Short, L., Green, S., Williams, G., Sivakumar, K., Bhattacharyya, N. D., Monteiro, E., Minton, J., Dhar, J., Nye, F., De Souza, C. B., Isaksen, A., McDonald, L., Franca, A., William, L., Jendrulek, I., Peters, B., Shaunak, S., El-Gadi, S., Easterbrook, P. J., Mazhude, C., Johnstone, R., Fakoya, A., McHale, J., Waters, A., Kegg, S., Mitchell, S., Byrne, P., Rice, P., Fidler, S., Mullaney, S. A., McCormack, S., David, D., Melville, R., Phillip, K., Balachandran, T., Mabey-Puttock, S., Sukthankar, A., Murphy, C., Wilkins, E., Ahmad, S., Haynes, J., Evans, E., Ong, E., Grey, R., Meaden, J., Bignell, C., Loay, D., Peacock, K., Girgis, M. R., Morgan, B., Palfreeman, A., Wilcox, J., Tobin, J., Tucker, L., Saeed, A. M., Chen, F., Deheragada, A., Williams, O., Lacey, H., Herman, S., Kinghorn, D., Devendra, V. S., Wither, J., Dawson, S., Rowen, D., Harvey, J., Bridgwood, A., Singh, G., Chauhan, M., Kellock, D., Young, S., Dannino, S., Kathir, Y., Rooney, G., Currie, J., FitzGerald, M., Devendra, S., Keane, F., Booth, G., Green, T., Arumainayyagam, J., Chandramani, S., Rajamanoharan, S., Robinson, T., Curless, E., Gokhale, R., Tariq, A., Luzzi, G., Fairley, I., Wallis, F., Smit, E., Ward, F., Loze, B., Morlat, P., Bonarek, M., Bonnet, F., Nouts, C., Louis, I., Reliquet, V., Sauser, F., Biron, C., Mounoury, O., Hue, H., Brosseau, D., Ghosn, J., Rannou, M. T., Bergmann, J. F., Badsi, E., Rami, A., Parrinello, M., Samanon-Bollens, D., Campa, P., Tourneur, M., Desplanques, N., Jeanblanc, F., Chiarello, P., Makhloufi, D., Blanc, A. P., Allègre, T., Baillat, V., Lemoing, V., Merle De Boever, C., Tramoni, C., Sobesky, G., Abel, S., Beaujolais, V., Slama, L., Chakvetadze, C., Berrebi, V., Fournier, I., Gerbe, J., Koffi, K., Augustin-Normand, C., Miailhes, P., Thoirain, V., Brochier, C., Souala, F., Ratajczak, M., Beytoux, J., Jacomet, C., Rouveix, E., Morelon, S., Olivier, C., Lortholary, O., Dupont, B., Maignan, A., Ragnaud, J. M., Raymond, I., Leport, C., Jadand, C., Jestin, C., Longuet, P., Boucherit, S., Sereni, D., Lascoux, C., Prevoteau, F., Sobel, A., Levy, Y., Lelievre, J. D., Lascaux, A. S., Dominguez, S., Dumont, C., Aumâitre, H., Delmas, B., Saada, M., Medus, M., Guillevin, L., Tahi, T., Yazdanpanah, Y., Pavel, S., Marien, M. C., Drenou, B., Beck, C., Benomar, M., Tubiana, R., Ait Mohand, H., Chermak, A., Ben Abdallah, S., Touam, F., Drobacheff, C., Folzer, A., Obadia, M., Prudhomme, L., Bonnet, E., Balzarin, F., Pichard, E., Chennebault, J. M., Fialaire, P., Loison, J., Galanaud, P., Boué, F., Bornarel, D., Six, M., Ferret, P., Batisse, D., Gonzales-Canali, G., Devidas, A., Chevojon, P., Turpault, I., Lafeuillade, A., Cheret, A., Philip, G., Morel, P., Timsit, J., Amirat, N., Brancion, C., Cabane, J., Tredup, J., Stein, A., Ravault, I., Chavanet, C., Buisson, M., Treuvetot, S., Nau, P., Bastides, F., Boyer, L., Wassoumbou, S., Oksenhendeler, E., Bernard, L., Domart, Y., Merrien, D., Greder Belan, A., Gayraud, M., Bodard, L., Meudec, A., Beuscart, C., Daniel, C., Pape, E., Vinceneux, P., Simonpoli, A. M., Zeng, A., Fournier, L., Fuzibet, J. G., Sohn, C., Rosenthal, E., Quaranta, M., Chaillou, S., Sabah, M., Audhuy, B., Schieber, A., Moreau, P., Niault, M., Vaillant, O., Huchon, G., Compagnucci, A., De Lacroix Szmania, I., Richier, L., Lamaury, I., Saint-Dizier, F., Garipuy, D., Drogoul, M. P., Fabre, G., Lambert De Cursay, G., Abraham, B., Perino, C., Lagarde, P., David, F., Roche-Sicot, J., Saraux, J. L., Leprêtre, A., Fampin, B., Uludag, A., Morin, A. S., Bletry, O., Zucman, D., Regnier, A., Girard, J. J., Quinsat, D. T., Heripret, L., Grihon, F., Houlbert, D., Ruel, M., Chemlal, K., Debab, Y., Tremollieres, F., Perronne, V., Slama, B., Perré, P., Miodovski, C., Guermonprez, G., Dulioust, A., Boudon, P., Malbec, D., Patey, O., Semaille, C., Deville, J., Remy, G., Béguinot, I., Chambrin, V., Pignon, C., Estocq, G. A., Levy, A., Duracinsky, M., Le Bras, P., Ngussan, M. S., Peretti, D., Medintzeff, N., Lambert, T., Segeral, O., Lezeau, P., Laurian, Y., Piketty, C., Karmochkine, M., Eliaszewitch, M., Jayle, D., Kazatchkine, M., Colasante, U., Duval, X., Nouaouia, W., Vilde, J. L., Bollens, D., Binet, D., Diallo, B., Fonquernie, L., Lagneau, J. L., Launay, O., Pietrie, M. P., Sicard, D., Stieltjes, N., Michot, J., Bourdillon, F., Obenga, G., Escaut, L., Bolliot, C., Schneider, L., Iguertsira, M., Tomei, C., Dhiver, C., Tissot Dupont, H., Vallon, A., Gallais, J., Gallais, H., Durant, J., Mondain, V., Perbost, I., Cassuto, J. P., Karsenti, J. M., Venti, H., Ceppi, C., Krivitsky, J. A., Bouchaud, O., Honore, P., Delgado, J., Rouzioux, C., Burgard, M., Boufassa, L., Peynet, J., Pérez-Hoyos, S., Del Amo, J., Alvarez, D., Monge, S., Muga, R., Sanvisens, A., Tor, J., Rivas, I., Vallecillo, G., Del Romero, J., Raposo, P., Rodríguez, C., Vera, M., Hurtado, I., Belda, J., Fernandez, E., Alastrue, I., Santos, C., Tasa, T., Juan, A., Trullen, J., Garcia De Olalla, P., Cayla, J., Masdeu, E., Knobel, H., Mirò, J. M., Sambeat, M. A., Guerrero, R., Rivera, E., Marco, A., Quintana, M., Gonzalez, C., Castilla, J., Guevara, M., De Mendoza, C., Zahonero, N., Ortíz, M., Paraskevis, D., Touloumi, G., Pantazis, N., Bakoyannis, G., Gioukari, V., Antoniadou, A., Papadopoulos, A., Petrikkos, G., Daikos, G., Psichogiou, M., Gargalianos-Kakolyris, P., Xylomenos, G., Katsarou, O., Kouramba, A., Ioannidou, P., Kordossis, T., Kontos, A., Lazanas, M., Chini, M., Tsogas, N., Panos, G., Paparizos, V., Leuow, K., Kourkounti, S., Sambatakou, H., Mariolis, I., Skoutelis, A., Papastamopoulos, V., Baraboutis, I., Internal medicine, APH - Aging & Later Life, Pediatric surgery, CCA - Innovative therapy, ICaR - Circulation and metabolism, ICaR - Ischemia and repair, Graduate School, Paediatric Infectious Diseases / Rheumatology / Immunology, Landsteiner Laboratory, AII - Amsterdam institute for Infection and Immunity, Infectious diseases, Global Health, Center of Experimental and Molecular Medicine, APH - Amsterdam Public Health, AII - Inflammatory diseases, and ARD - Amsterdam Reproduction and Development
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Opportunistic infection ,AIDS-Related Opportunistic Infections ,Immunology ,Population ,Retinitis ,HIV Infections ,Article ,17 Psychology And Cognitive Sciences ,Young Adult ,Immune reconstitution inflammatory syndrome ,Antiretroviral Therapy, Highly Active ,Neoplasms ,Virology ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,education ,Inverse probability weighting ,Aged ,education.field_of_study ,business.industry ,Developed Countries ,Incidence ,Progressive multifocal leukoencephalopathy ,Hazard ratio ,HIV ,virus diseases ,11 Medical And Health Sciences ,Middle Aged ,06 Biological Sciences ,medicine.disease ,United States ,Europe ,Infectious Diseases ,Anti-Retroviral Agents ,Unmasking ,Female ,Cytomegalovirus retinitis ,business - Abstract
Background: There is little information on the incidence of AIDS-defining events which have been reported in the literature to be associated with immune reconstitution inflammatory syndrome (IRIS) after combined antiretroviral therapy (cART) initiation. These events include tuberculosis, mycobacterium avium complex (MAC), cytomegalovirus (CMV) retinitis, progressive multifocal leukoencephalopathy (PML), herpes simplex virus (HSV), Kaposi sarcoma, non-Hodgkin lymphoma (NHL), cryptococcosis and candidiasis.Methods: We identified individuals in the HIV-CAUSAL Collaboration, which includes data from six European countries and the US, who were HIV-positive between 1996 and 2013, antiretroviral therapy naive, aged at least 18 years, hadCD4+ cell count and HIV-RNA measurements and had been AIDS-free for at least 1 month between those measurements and the start of follow-up. For each AIDS-defining event, we estimated the hazard ratio for no cART versus less than 3 and at least 3 months since cART initiation, adjusting for time-varying CD4+ cell count and HIV-RNA via inverse probability weighting.Results: Out of 96 562 eligible individuals (78% men) with median (interquantile range) follow-up of 31 [13,65] months, 55 144 initiated cART. The number of cases varied between 898 for tuberculosis and 113 for PML. Compared with non-cART initiation, the hazard ratio (95% confidence intervals) up to 3 months after cART initiation were 1.21 (0.90-1.63) for tuberculosis, 2.61 (1.05-6.49) for MAC, 1.17 (0.34-4.08) for CMV retinitis, 1.18 (0.62-2.26) for PML, 1.21 (0.83-1.75) for HSV, 1.18 (0.87-1.58) for Kaposi sarcoma, 1.56 (0.82-2.95) for NHL, 1.11 (0.56-2.18) for cryptococcosis and 0.77 (0.40-1.49) for candidiasis.Conclusion: With the potential exception of mycobacterial infections, unmasking IRIS does not appear to be a common complication of cART initiation in high-income countries.
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- 2014
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19. Rapid and reliable identification of Streptococcus anginosus group isolates to the species level by real-time PCR and melting curve analysis
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Desar, Ingrid M.E., primary, de Boer, Maaike, additional, Bens, Corina C.P.M., additional, Jacobs, Jan A., additional, Mouton, Johan W., additional, Dofferhoff, Anton S.M., additional, and Klaassen, Corné H.W., additional
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- 2008
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20. Schistosomiasis haematobium as a cause of vulvar hypertrophy
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Laven, Joop S.E, primary, Vleugels, Michel P.H, additional, Dofferhoff, Anthonius S.M, additional, and Bloembergen, Peter, additional
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- 1998
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21. The influence of antibiotic-induced filament formation on the release of endotoxin from Gram-negative bacteria
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Dofferhoff, Anthonius S.M., primary and Buys, Jacqueline, additional
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- 1996
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22. Effects of Imipenem, Cefotaxime and Cotrimoxazole on Aerobic Microbial Colonization of the Digestive Tract
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van der Leur, Joris J.J.P.M., primary, Thunnissen, Peter L.M., additional, Clasener, Henk A.L., additional, Muller, Niels F., additional, and Dofferhoff, Anthonius S.M., additional
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- 1993
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23. The influence of antibiotic-induced filament formation on the release of endotoxin from Gram-negative bacteria.
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Dofferhoff, Anthonius S.M. and Buys, Jacqueline
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- 1996
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