314 results on '"Doggett J"'
Search Results
2. 3-Position Biaryl Endochin-like Quinolones with Enhanced Antimalarial Performance
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Pou, Sovitj, primary, Winter, Rolf W., additional, Dodean, Rozalia A., additional, Liebman, Katherine, additional, Li, Yuexin, additional, Mather, Michael W., additional, Nepal, Binod, additional, Nilsen, Aaron, additional, Handford, Mason J., additional, Riscoe, Teresa M., additional, Laxson, Sydney, additional, Kirtley, Payton J., additional, Aleshnick, Maya, additional, Zakharov, Lev N., additional, Kelly, Jane X., additional, Smilkstein, Martin J., additional, Wilder, Brandon K., additional, Kortagere, Sandhya, additional, Vaidya, Akhil B., additional, Alday, P. Holland, additional, Doggett, J. Stone, additional, and Riscoe, Michael K., additional
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- 2024
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3. Don't Dream It, B It: DEI policies add up to belonging
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Doggett, J. Maija
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Workplace multiculturalism -- Management -- Forecasts and trends ,Company business management ,Market trend/market analysis ,Business ,Business, regional - Abstract
By now, you've seen the initialism DEI, and you know that the letter 'D' stands for diversity, the letter 'E' stands for equity, and the letter 'I' stands for inclusion. [...]
- Published
- 2023
4. Utilizing sentiment analysis of X data to document the evolution of colorectal surgical innovations: The case of transanal total mesorectal excision.
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Weltermann, T., Eltyeb, H., Doggett, J., and Brady, R. R. W.
- Abstract
Aim: The evolution of the utility of medical social media and its global reach has led to a much greater speed of dissemination of medical innovation, such as transanal total mesorectal excision (TaTME). The acceptability and discussions surrounding such innovations can be followed online. Here, we sought to determine if online discussions over time could match known models of innovation evolution using the example of TaTME since its initial description in 2010. Methods: Data on using the X hashtag #TaTME were analysed using the social media analytics tool Brandwatch. Trends in mentions, impressions and reach were highlighted over 13 years (1 May 2010 to 31 July 2023). Each mention's sentiment and emotional connotations were analysed using Brandwatch's natural language processing approach. Results: We identified 18 525 mentions of #TaTME by healthcare professionals, reaching over 30.6 million X users. A Gartner's hype‐cycle‐like pattern was identified for mention volume and emotional connotation over time. The majority of mentions had a neutral (84%; n = 15 341) or positive connotation (15%, n = 2675). A peak of negatively connotated mentions was identified surrounding the temporary suspension of TaTME in 2019. Conclusion: This study presents a novel method of monitoring online discussions surrounding new surgical innovations by healthcare professionals based on sentiment analysis of public social media data. Mention volume and emotional connotation were the most accurate parameters closely resembling Gartner's hype cycle. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Emphysematous Cholecystitis
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Doggett, J. Stone, Wong, Brian, Poretsky, Leonid, Series Editor, Loriaux, Lynn, editor, and Vanek, Chaim, editor
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- 2021
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6. Emphysematous Pyelonephritis
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Doggett, J. Stone, Wong, Brian, Poretsky, Leonid, Series Editor, Loriaux, Lynn, editor, and Vanek, Chaim, editor
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- 2021
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7. Malignant (Necrotizing) Otitis Externa
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Doggett, J. Stone, Wong, Brian, Poretsky, Leonid, Series Editor, Loriaux, Lynn, editor, and Vanek, Chaim, editor
- Published
- 2021
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8. Mucormycosis
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Doggett, J. Stone, Wong, Brian, Poretsky, Leonid, Series Editor, Loriaux, Lynn, editor, and Vanek, Chaim, editor
- Published
- 2021
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9. Necrotizing Soft Tissue Infections
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Doggett, J. Stone, Wong, Brian, Poretsky, Leonid, Series Editor, Loriaux, Lynn, editor, and Vanek, Chaim, editor
- Published
- 2021
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10. Acute Suppurative Thyroiditis
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Doggett, J. Stone, Wong, Brian, Poretsky, Leonid, Series Editor, Loriaux, Lynn, editor, and Vanek, Chaim, editor
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- 2021
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11. Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo
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Anghel, Nicoleta, Imhof, Dennis, Winzer, Pablo, Balmer, Vreni, Ramseier, Jessica, Haenggeli, Kai, Choi, Ryan, Hulverson, Matthew A., Whitman, Grant R., Arnold, Samuel L.M., Ojo, Kayode K., Van Voorhis, Wesley C., Doggett, J. Stone, Ortega-Mora, Luis M., and Hemphill, Andrew
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- 2021
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12. Comparative efficacy of buparvaquone and imidocarb in inhibiting the in vitro growth of Babesia bovis
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Cardillo, Natalia M., primary, Lacy, Paul A., additional, Villarino, Nicolas F., additional, Doggett, J. Stone, additional, Riscoe, Michael K., additional, Bastos, Reginaldo G., additional, Laughery, Jacob M., additional, Ueti, Massaro W., additional, and Suarez, Carlos E., additional
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- 2024
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13. Synthesis of Deuterated Endochin‐Like Quinolones
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Pou, Sovitj, primary, Winter, Rolf W., additional, Liebman, Katherine M., additional, Dodean, Rosie A., additional, Nilsen, Aaron, additional, DeBarber, Andrea, additional, Doggett, J. Stone, additional, and Riscoe, Michael K., additional
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- 2024
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14. Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis
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Vydyam, Pratap, primary, Chand, Meenal, additional, Pou, Sovitj, additional, Winter, Rolf W., additional, Liebman, Katherine M., additional, Nilsen, Aaron, additional, Doggett, J. Stone, additional, Riscoe, Michael K., additional, and Ben Mamoun, Choukri, additional
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- 2024
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15. Verifying Sincerity: A human resources perspective on vaccine mandates
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Doggett, J. Maija
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United States. Occupational Safety and Health Administration ,Vaccines ,Business ,Business, regional - Abstract
You can say I am a card-carrying, dyed-in-the-wool, devoted human resources professional. I got my bachelor's degree in business management, with an emphasis in human resource management, from UAA in [...]
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- 2022
16. In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma gondii oocysts
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Imhof, Dennis, Anghel, Nicoleta, Winzer, Pablo, Balmer, Vreni, Ramseier, Jessica, Hänggeli, Kai, Choi, Ryan, Hulverson, Matthew A., Whitman, Grant R., Arnold, Samuel L.M., Ojo, Kayode K., Van Voorhis, Wesley C., Doggett, J. Stone, Ortega-Mora, Luis M., and Hemphill, Andrew
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- 2021
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17. Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned
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Choi, Ryan, Hulverson, Matthew A., Huang, Wenlin, Vidadala, Rama S.R., Whitman, Grant R., Barrett, Lynn K., Schaefer, Deborah A., Betzer, Dana P., Riggs, Michael W., Doggett, J. Stone, Hemphill, Andrew, Ortega-Mora, Luis Miguel, McCloskey, Molly C., Arnold, Samuel L.M., Hackman, Robert C., Marsh, Kennan C., Lynch, James J., Freiberg, Gail M., Leroy, Bruce E., Kempf, Dale J., Choy, Robert K.M., de Hostos, Eugenio L., Maly, Dustin J., Fan, Erkang, Ojo, Kayode K., and Van Voorhis, Wesley C.
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- 2020
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18. Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance
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Kirkman, Laura A., Zhan, Wenhu, Visone, Joseph, Dziedziech, Alexis, Singh, Pradeep K., Fan, Hao, Tong, Xinran, Bruzual, Igor, Hara, Ryoma, Kawasaki, Masanori, Imaeda, Toshihiro, Okamoto, Rei, Sato, Kenjiro, Michino, Mayako, Alvaro, Elena Fernandez, Guiang, Liselle F., Sanz, Laura, Mota, Daniel J., Govindasamy, Kavitha, Wang, Rong, Ling, Yan, Tumwebaze, Patrick K., Sukenick, George, Shi, Lei, Vendome, Jeremie, Bhanot, Purnima, Rosenthal, Philip J., Aso, Kazuyoshi, Foley, Michael A., Cooper, Roland A., Kafsack, Bjorn, Doggett, J. Stone, Nathan, Carl F., and Lin, Gang
- Published
- 2018
19. Endochin-like quinolone-300 and ELQ-316 inhibit Babesia bovis, B. bigemina, B. caballi and Theileria equi
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Silva, Marta G., Bastos, Reginaldo G., Stone Doggett, J., Riscoe, Michael K., Pou, Sovitj, Winter, Rolf, Dodean, Rozalia A., Nilsen, Aaron, and Suarez, Carlos E.
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- 2020
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20. Genome Sequence of the Enterobacterial Phytopathogen Erwinia carotovora Subsp. atroseptica and Characterization of Virulence Factors
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Bell, K. S., Sebaihia, M., Pritchard, L., Holden, M. T. G., Hyman, L. J., Holeva, M. C., Thomson, N. R., Bentley, S. D., Churcher, L. J. C., Mungall, K., Atkin, R., Bason, N., Brooks, K., Chillingworth, T., Clark, K., Doggett, J., Fraser, A., Hance, Z., Hauser, H., Jagels, K., Moule, S., Norbertczak, H., Ormond, D., Price, C., Quail, M. A., Sanders, M., Walker, D., Whitehead, S., Salmond, G. P. C., Birch, P. R. J., Parkhill, J., Toth, I. K., and Haselkorn, Robert
- Published
- 2004
21. Photoswitchable Inhibitors to Optically Control Specific Kinase Activity
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Aguirre, Tim, primary, Teichmann, Ellen, additional, Römpp, Florian Q., additional, Vivier, Ruthey, additional, Bryant, Cole, additional, Hulverson, Matthew A., additional, Van Voorhis, Wesley C., additional, Ojo, Kayode K., additional, Doggett, J. Stone, additional, Fiedler, Dorothea, additional, and Hecht, Stefan, additional
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- 2023
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22. Quinolone-3-amidoalkanol: A New Class of Potent and Broad-Spectrum Antimicrobial Agent
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Dube, Phelelisiwe S., primary, Angula, Klaudia T., additional, Legoabe, Lesetja J., additional, Jordaan, Audrey, additional, Boitz Zarella, Jan M., additional, Warner, Digby F., additional, Doggett, J. Stone, additional, and Beteck, Richard M., additional
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- 2023
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23. Emphysematous Cholecystitis
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Doggett, J. Stone, Wong, Brian, Conn, P. Michael, Series editor, and Loriaux, Lynn, editor
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- 2014
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24. Emphysematous Pyelonephritis
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Wong, Brian, Doggett, J. Stone, Conn, P. Michael, Series editor, and Loriaux, Lynn, editor
- Published
- 2014
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25. Necrotizing Soft Tissue Infections
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Doggett, J. Stone, Wong, Brian, Conn, P. Michael, Series editor, and Loriaux, Lynn, editor
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- 2014
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26. Mucormycosis
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Doggett, J. Stone, Wong, Brian, Conn, P. Michael, Series editor, and Loriaux, Lynn, editor
- Published
- 2014
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27. Malignant (Necrotizing) Otitis Externa
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Doggett, J. Stone, Wong, Brian, Conn, P. Michael, Series editor, and Loriaux, Lynn, editor
- Published
- 2014
- Full Text
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28. Acute Suppurative Thyroiditis
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Doggett, J. Stone, Wong, Brian, Conn, P. Michael, Series editor, and Loriaux, Lynn, editor
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- 2014
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29. Structure-activity relationships of Toxoplasma gondii cytochrome bc1 inhibitors
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Alday, P. Holland, primary, Nilsen, Aaron, additional, and Doggett, J. Stone, additional
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- 2022
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30. Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis
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Doggett, J. Stone, Nilsen, Aaron, Forquer, Isaac, Wegmann, Keith W., Jones-Brando, Lorraine, Yolken, Robert H., Bordón, Claudia, Charman, Susan A., Katneni, Kasiram, Schultz, Tracey, Burrows, Jeremy N., Hinrichs, David J., Meunier, Brigitte, Carruthers, Vern B., and Riscoe, Michael K.
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- 2012
31. Babesia duncani as a Model Organism to Study the Development, Virulence, and Drug Susceptibility of Intraerythrocytic Parasites In Vitro and In Vivo
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Pal, Anasuya C, primary, Renard, Isaline, additional, Singh, Pallavi, additional, Vydyam, Pratap, additional, Chiu, Joy E, additional, Pou, Sovitj, additional, Winter, Rolf W, additional, Dodean, Rozalia, additional, Frueh, Lisa, additional, Nilsen, Aaron C, additional, Riscoe, Michael K, additional, Doggett, J Stone, additional, and Ben Mamoun, Choukri, additional
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- 2022
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32. Babesia duncani as a model organism to study the development, virulence and drug susceptibility of intraerythrocytic parasites in vitro and in vivo
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Pal, Anasuya C., primary, Renard, Isaline, additional, Singh, Pallavi, additional, Vydyam, Pratap, additional, Chiu, Joy E., additional, Pou, Sovitj, additional, Winter, Rolf W., additional, Dodean, Rozalia, additional, Frueh, Lisa, additional, Nilsen, Aaron C., additional, Riscoe, Michael K., additional, Doggett, J. Stone, additional, and Mamoun, Choukri Ben, additional
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- 2021
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33. Transitions of Care in Nutrition: Implications of Creating a Care Pathway from Inpatient to Outpatient.
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Doggett, J., Fraser, A., and Roberts, T.
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MEDICAL protocols , *OUTPATIENT services in hospitals , *CONFERENCES & conventions , *TRANSITIONAL care , *NUTRITION services - Published
- 2024
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34. A New Scalable Synthesis of ELQ-300, ELQ-316, and other Antiparasitic Quinolones
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Pou, Sovitj, Dodean, Rozalia A., Frueh, Lisa, Liebman, Katherine M., Gallagher, Rory T., Jin, Haihong, Jacobs, Robert T., Nilsen, Aaron, Stuart, David R., Doggett, J. Stone, Riscoe, Michael K., and Winter, Rolf W.
- Subjects
Article - Abstract
The Endochin-Like Quinolone (ELQ) compound class may yield effective, safe treatments for a range of important human and animal afflictions. However, to access the public health potential of this compound series, a synthetic route needed to be devised that lowers costs and is amenable to large scale production. In the new synthetic route described here, a substituted β-keto ester, formed by an Ullmann reaction and subsequent acylation, is reacted with an aniline via a Conrad-Limpach reaction to produce 3-substituted 4(1H)-quinolones such as ELQ-300 and ELQ-316. This synthetic route, the first described to be truly amenable to industrial scale production, is relatively short (5 reaction steps), does not require palladium, chromatographic separation or protecting group chemistry, and may be performed without high vacuum distillation.
- Published
- 2021
35. Effective Therapy Targeting Cytochrome bc 1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection
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Chiu, Joy E., primary, Renard, Isaline, additional, Pal, Anasuya C., additional, Singh, Pallavi, additional, Vydyam, Pratap, additional, Thekkiniath, Jose, additional, Kumar, Madelyn, additional, Gihaz, Shalev, additional, Pou, Sovitj, additional, Winter, Rolf W., additional, Dodean, Rozalia, additional, Frueh, Lisa, additional, Nilsen, Aaron C., additional, Riscoe, Michael K., additional, Doggett, J. Stone, additional, and Mamoun, Choukri Ben, additional
- Published
- 2021
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36. New Scalable Synthetic Routes to ELQ-300, ELQ-316, and Other Antiparasitic Quinolones
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Pou, Sovitj, primary, Dodean, Rozalia A., additional, Frueh, Lisa, additional, Liebman, Katherine M., additional, Gallagher, Rory T., additional, Jin, Haihong, additional, Jacobs, Robert T., additional, Nilsen, Aaron, additional, Stuart, David R., additional, Doggett, J. Stone, additional, Riscoe, Michael K., additional, and Winter, Rolf W., additional
- Published
- 2021
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37. Cytochrome b Drug Resistance Mutation Decreases Babesia Fitness in the Tick Stages But Not the Mammalian Erythrocytic Cycle
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Chiu, Joy E, primary, Renard, Isaline, additional, George, Santosh, additional, Pal, Anasuya C, additional, Alday, P Holland, additional, Narasimhan, Sukanya, additional, Riscoe, Michael K, additional, Doggett, J Stone, additional, and Ben Mamoun, Choukri, additional
- Published
- 2021
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38. GSC 1.2 — A Subplate Reduction of the GSC
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Bucciarelli, B., Doggett, J. B., Sturch, C. R., Lasker, B. M., Mclean, B. J., Lattanzi, M. G., Taff, L. G., MacGillivray, H. T., editor, Thomson, E. B., editor, Lasker, B. M., editor, Reid, I. N., editor, Malin, D. F., editor, West, R. M., editor, and Lorenz, H., editor
- Published
- 1994
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39. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
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Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ, Novo S, Krum H, Varigos J, Siostrzonek P, Sinnaeve P, Gotcheva N, Yong H, Urina-Triana M, Milicic D, Vettus R, Manolis AJ, Wyss F, Sigurdsson A, Fucili A, Veze I, Petrauskiene B, Salvador L, Klemsdal TO, Medina F, Budaj A, Otasevic P, Lainscak M, Seung KB, Commerford P, Donath M, Hwang JJ, Kultursay H, Bilazarian S, East C, Forgosh L, Harris B, Ligueros M, Bohula E, Charmarthi B, Cheng S, Chou S, Danik J, McMahon G, Maron B, Ning M, Olenchock B, Pande R, Perlstein T, Pradhan A, Rost N, Singhal A, Taqueti V, Wei N, Burris H, Cioffi A, Dalseg AM, Ghosh N, Gralow J, Mayer T, Rugo H, Fowler V, Limaye AP, Cosgrove S, Levine D, Lopes R, Scott J, Hilkert R, Tamesby G, Mickel C, Manning B, Woelcke J, Tan M, Manfreda S, Ponce T, Kam J, Saini R, Banker K, Salko T, Nandy P, Tawfik R, O’Neil G, Manne S, Jirvankar P, Lal S, Nema D, Jose J, Collins R, Bailey K, Blumenthal R, Colhoun H, Gersh B, Abreu M, Actis MV, Aiub J, Aiub F, Albisu J, Alvarisqueta A, Avalos V, Barreto M, Berli MA, Blumberg C, Bocanera M, Botta C, Bowen L, Budassi N, Buhlman S, Westberg JC, Carabajal T, Caruso G, Casala J, Cendali G, Coloma G, Berra FC, Cuneo C, Degennaro N, Dellasa M, Diaz M, Dos Santos P, Espinosa V, Facello A, Facello M, Farias E, Fernandez AA, Ferrari V, Pacora FF, Flores GS, Franco M, Gabito A, Viola HG, Garcia F, Garcia Duran R, Garcia Pinna J, Glenny J, Godoy Sanchez M, Grosse A, Guzman P, Hasbani E, Hominal M, Ibañez J, Jure H, Jure D, Vico ML, Liniado G, Luciardi H, Luquez H, Maehara G, Maffei L, Majul C, Mallagray M, Marinaro S, Martinez J, Massaccesi R, De Los Milagros Had M, Azize GM, Montana O, Montenegro E, Morell Y, Muntaner J, Navarrete S, Olmedo M, Paganini M, Paz S, Perez Manghi F, Piskorz D, Polato C, Recoaro R, Romano A, Salinger M, Sanchez A, Saravia MA, Sarjanovich R, Scaro G, Schiavi LB, Soler J, Tinnirello V, Tomassi A, Valle M, Vallejo MA, Venturini C, Marcela Wenetz LM, Yossen M, Zaidman C, Zalazar L, Zangroniz P, Amerena J, Brady L, Colquhoun D, Eccleston D, Ferreira-Jardim A, French J, Jayasinghe R, Mcintosh C, Ord M, Plotz M, Purnell P, Roberts-Thomson P, Schultz C, Shanahan T, Tan R, Taverner P, Turner F, Vibert J, Vorster M, William M, Youssef G, Bergler-Klein J, Brath H, Brodmann M, Fliesser-Goerzer E, Haider K, Heeren G, Hiden C, Mandic L, Paulweber B, Ploechl A, Prenner A, Steringer-Mascherbauer R, Strohner-Kaestenbauer H, Barbato E, Bouvy C, Briké C, Charlier F, Cools F, De Knijf K, De Wolf L, Delforge M, Deweerdt N, Gits F, Goffinet C, Hermans K, Hollanders G, Mestdagh I, Pirenne B, Servaes V, Simons N, Tahon S, Theunissen E, Van Genechten G, Vervoort G, Vissers C, Vranckx P, Vrolix M, Abib E Jr, Abrantes J, Araujo Fonseca M, Barbosa E, Barroso W, Barroso A, Bodanese L, Botelho R, Costa Amorim R, Da Costa F, Da Silva A, Da Silva O Jr, Da Silva D Jr, Ferreira Dos Santos T, Dos Santos F, Dos Santos A, Duda N, Feitosa G, Felario Junior GA, Ferraz R, Filho P, Fonseca A, Wanderley FF, Freitas E, Fucci F, Marengo Garcia De Carvalho L, Hernandez M, Hettwer Magedanz E, Julião K, Kormann A, Lameira A, Lima F, Lino E, Maia L, Manenti E, Marchi AL, Fischer SM, Michalaros Y, Moraes J Jr, Moreira L, Pagnan M, Pesce F, Pinheiro L, Rassi S, Reis G, Reis H, Resende I, Roel A, Ruschel K, Saporito W, Saraiva JF, Seroqui M, Silva R, Unterkircher B, Vicente C, Vieira N, Xavier JP, Zucchetti C, Angelova I, Dimitrov G, Genova D, Gospodinov K, Goudev A, Grigorova V, Hristova K, Makedonska JJ, Katova T, Kostov K, Lazov P, Manov E, Manukov I, Manukov D, Milanova M, Kabakchieva VM, Petrov D, Petrusheva T, Pramatarova I, Raev D, Runev N, Sirakova-Taseva A, Tisheva-Gospodinova S, Todorova A, Tzekova M, Yakovova S, Yanev T, 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M., Everett, B. M., Thuren, T., Macfadyen, J. G., Chang, W. H., Ballantyne, C., FONSECA E PIRES, CARLOS EDUARDO, Nicolau, J., Koenig, W., Anker, S. D., Kastelein, J. J. P., Cornel, J. H., Pais, P., Pella, D., Genest, J., Cifkova, R., Lorenzatti, A., Forster, T., Kobalava, Z., Vida-Simiti, L., Flather, M., Shimokawa, H., Ogawa, H., Dellborg, M., Rossi, P. R. F., Troquay, R. P. T., Libby, P., Glynn R., J, CANTOS Trial, Group, Perrone, Filardi, P, ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, and ACS - Atherosclerosis & ischemic syndromes
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0301 basic medicine ,030204 cardiovascular system & hematology ,law.invention ,0302 clinical medicine ,c-reactive protein ,Randomized controlled trial ,law ,Cardiovascular Disease ,middle aged ,double-blind method ,antibodies ,Myocardial infarction ,humans ,Stroke ,interleukin-1beta ,biology ,Antibodies, Monoclonal ,drug ,General Medicine ,Lipid ,Aged ,anti-inflammatory agents ,monoclonal ,humanized ,atherosclerosis ,cardiovascular diseases ,dose-response relationship ,female ,incidence ,infections ,lipids ,male ,myocardial infarction ,neutropenia ,secondary prevention ,stroke ,Anti-Inflammatory Agent ,aged ,Editorial ,Atherosclerosi ,Monoclonal ,Human ,medicine.drug ,medicine.medical_specialty ,Neutropenia ,Antibodies, Monoclonal, Humanized ,Infections ,Placebo ,antibodies, monoclonal ,dose-response relationship, drug ,infection ,medicine (all) ,03 medical and health sciences ,Internal medicine ,medicine ,Dose-Response Relationship, Drug ,business.industry ,Antiinflammatory Therapy, Canakinumab, for Atherosclerotic Disease ,C-reactive protein ,medicine.disease ,Surgery ,Canakinumab ,030104 developmental biology ,biology.protein ,business - Abstract
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.)
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- 2017
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40. Effective Therapy Targeting Cytochrome bc1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection
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Chiu, Joy E., primary, Renard, Isaline, additional, Pal, Anasuya C., additional, Singh, Pallavi, additional, Vydyam, Pratap, additional, Thekkiniath, Jose, additional, Kumar, Madelyn, additional, Gihaz, Shalev, additional, Pou, Sovitj, additional, Winter, Rolf W., additional, Dodean, Rozalia, additional, Nilsen, Aaron C., additional, Riscoe, Michael K., additional, Doggett, J. Stone, additional, and Mamoun, Choukri Ben, additional
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- 2021
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41. Acridones Are Highly Potent Inhibitors of Toxoplasma gondii Tachyzoites
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Alday, P. Holland, primary, McConnell, Erin V., additional, Boitz Zarella, Jan M., additional, Dodean, Rozalia A., additional, Kancharla, Papireddy, additional, Kelly, Jane X., additional, and Doggett, J. Stone, additional
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- 2021
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42. Additional file 2 of Endochin-like quinolone-300 and ELQ-316 inhibit Babesia bovis, B. bigemina, B. caballi and Theileria equi
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Silva, Marta G., Bastos, Reginaldo G., Stone Doggett, J., Riscoe, Michael K., Pou, Sovitj, Winter, Rolf, Dodean, Rozalia A., Nilsen, Aaron, and Suarez, Carlos E.
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animal diseases ,parasitic diseases ,bacterial infections and mycoses - Abstract
Additional file 2: Table S1. IC50 calculated for different compounds tested against in vitro in B. bovis, B. bigemina, B. caballi and T. equi cultures. Table S2. Amino acid percentage identity of cytochrome bc1 complex (Cytb) of Babesia bovis, B. bigemina, B. caballi, and Theileria equi in comparison to B. microti.
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- 2020
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43. Necrotizing Soft Tissue Infections
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Doggett, J. Stone, primary and Wong, Brian, additional
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- 2013
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44. Acute Suppurative Thyroiditis
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Doggett, J. Stone, primary and Wong, Brian, additional
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- 2013
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45. Malignant (Necrotizing) Otitis Externa
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Doggett, J. Stone, primary and Wong, Brian, additional
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- 2013
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46. Mucormycosis
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Doggett, J. Stone, primary and Wong, Brian, additional
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- 2013
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47. Emphysematous Pyelonephritis
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Wong, Brian, primary and Doggett, J. Stone, additional
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- 2013
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48. Emphysematous Cholecystitis
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Doggett, J. Stone, primary and Wong, Brian, additional
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- 2013
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49. One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases
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Van Voorhis, Wesley C., primary, Hulverson, Matthew A., additional, Choi, Ryan, additional, Huang, Wenlin, additional, Arnold, Samuel L.M., additional, Schaefer, Deborah A., additional, Betzer, Dana P., additional, Vidadala, Rama S.R., additional, Lee, Sangun, additional, Whitman, Grant R., additional, Barrett, Lynn K., additional, Maly, Dustin J., additional, Riggs, Michael W., additional, Fan, Erkang, additional, Kennedy, Thomas J., additional, Tzipori, Saul, additional, Doggett, J. Stone, additional, Winzer, Pablo, additional, Anghel, Nicoleta, additional, Imhof, Dennis, additional, Müller, Joachim, additional, Hemphill, Andrew, additional, Ferre, Ignacio, additional, Sanchez-Sanchez, Roberto, additional, Ortega-Mora, Luis Miguel, additional, and Ojo, Kayode K., additional
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- 2021
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50. The Need for Antiviral Drugs for Pandemic Coronaviruses From a Global Health Perspective
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Villamagna, Angela Holly, primary, Gore, Sara J., additional, Lewis, James S., additional, and Doggett, J. Stone, additional
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- 2020
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