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14 results on '"Dolby, Vivien A."'

1. Variants in the fetal genome near FLT1 are associated with risk of preeclampsia

Author

McGinnis, Ralph, Steinthorsdottir, Valgerdur, Williams, Nicholas O, Thorleifsson, Gudmar, Shooter, Scott, Hjartardottir, Sigrun, Bumpstead, Suzannah, Stefansdottir, Lilja, Hildyard, Lucy, Sigurdsson, Jon K, Kemp, John P, Silva, Gabriela B, Thomsen, Liv Cecilie V, Jääskeläinen, Tiina, Kajantie, Eero, Chappell, Sally, Kalsheker, Noor, Moffett, Ashley, Hiby, Susan, Lee, Wai Kwong, Padmanabhan, Sandosh, Simpson, Nigel A B, Dolby, Vivien A, Staines-Urias, Eleonora, Engel, Stephanie M, Haugan, Anita, Trogstad, Lill, Svyatova, Gulnara, Zakhidova, Nodira, Najmutdinova, Dilbar, Dominiczak, Anna F, Gjessing, Håkon K, Casas, Juan P, Dudbridge, Frank, Walker, James J, Pipkin, Fiona Broughton, Thorsteinsdottir, Unnur, Geirsson, Reynir T, Lawlor, Debbie A, Iversen, Ann-Charlotte, Magnus, Per, Laivuori, Hannele, Stefansson, Kari, and Morgan, Linda

Published
2017
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3. Sources of excess steroid prescriptions and clinical adverse outcomes associated with steroid excess in patients with inflammatory bowel disease: The Leeds IBD Steroids study

Author

Rosiou, Konstantina, Carbonell, Jenelyn, Dolby, Vivien, Monfared, Niloufar, Raine, Tim, Selinger, Christian P, Selinger, Christian P [0000-0003-2022-5859], and Apollo - University of Cambridge Repository

Subjects
Adrenal Cortex Hormones, Humans, Steroids, Inflammatory Bowel Diseases, Drug Prescriptions, Anti-Bacterial Agents
Abstract

BACKGROUND: Corticosteroids remain important for managing inflammatory bowel disease (IBD) flares. Steroid excess, however, may be a marker of poor care. Patients access steroid prescriptions from primary (General Practitioners [GP]) or secondary care (hospital-based). Sources of prescriptions and associated outcomes are not well described. METHODS: Patients attending IBD clinics with linked primary care information were included. We examined appropriateness and timeliness of treatment escalation and avoidability of steroid excess in relation to prescription sources. RESULTS: Of 2246 patients, 33% were exposed to steroids over 2 years. Primary care issued 28% of prescriptions. Secondary care prescriptions were more often of appropriate dose and duration (85% vs 41%, p < 0.001). Further flares occurred in 50% of patients prescribed steroids from primary care (vs 39%; p = 0.003). Steroid excess was observed in 15%. Patients with steroid excess who received prescriptions from primary care that were not communicated to secondary care less often received timely treatment escalation (49% vs 66%, p = 0.042) and steroid excess was more often avoidable (73% vs 56%, p = 0.022). Patients with steroid excess had higher risks of hospitalisation for IBD (OR = 12.33, 95% CI [8.89-17.11]), hospitalisation for infections (OR = 2.89, 95% CI [1.82-4.61]) and GP prescribed antibiotics (OR = 1.41, 95% CI [1.07-1.86]). CONCLUSION: Patients commonly access steroids through primary care, but doses and durations are frequently inappropriate with patients more likely to flare. Steroid excess was associated with IBD admissions, admissions for infections and antibiotic prescriptions. Improved liaison between primary and secondary care is required to reduce steroid excess.

Published
2022
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4. Caffeine intake during pregnancy, late miscarriage and stillbirth

Author

Greenwood, Darren C., Alwan, Nisreen, Boylan, Sinead, Cade, Janet E., Charvill, Jim, Chipps, Karen C., Cooke, Marcus S., Dolby, Vivien A., Hay, Alastair W. M., Kassam, Shabira, Kirk, Sara F. L., Konje, Justin C., Potdar, Neelam, Shires, Susan, Simpson, Nigel, Taub, Nicholas, Thomas, James D., Walker, James, White, Kay L. M., and Wild, Christopher P.

Published
2010

6. A propensity score‐matched, real‐world comparison of ustekinumab vs vedolizumab as a second‐line treatment for Crohn’s disease. The Cross Pennine study II

Author

Lenti, Marco Vincenzo, primary, Dolby, Vivien, additional, Clark, Tanya, additional, Hall, Veronica, additional, Tattersall, Suzanne, additional, Fairhurst, Francesca, additional, Kenneth, Catherine, additional, Walker, Rachael, additional, Kemp, Karen, additional, Borg‐Bartolo, Simon, additional, Limdi, Jimmy K., additional, Taylor, Jo, additional, Townsend, Tristan, additional, Subramanian, Sree, additional, Storey, Daniel, additional, Assadsangabi, Arash, additional, Stansfield, Catherine, additional, Smith, Paul, additional, Byrne, Debra, additional, De Silvestri, Annalisa, additional, and Selinger, Christian P., additional

Published
2021
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7. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Author

Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, MariaCarolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Broughton Pipkin, Fiona, Poston, Lucilla, Prescott, Gordon, Saevarsdottir, Saedis, Salimbayeva, Damilya, Juliet Scaife, Paula, Skotte, Line, Staines-Urias, Eleonora, Stefansson, Olafur A., Cecilie Vestrheim Thomsen, Liv, Tragante, Vinicius, Trogstad, Lill, Simpson, Nigel A.B., FINNPEC Consortium, GOPEC Consortium, Aripova, Tamara, Casas, Juan P., Dominiczak, Anna F., Walker, James J., Thorsteinsdottir, Unnur, Iversen, Ann-Charlotte, Feenstra, Bjarke, Lawlor, Deborah A., Boyd, Heather Allison, Magnus, Per, Laivuori, Hannele, Zakhidova, Nodira, Svyatova, Gulnara, Stefansson, Kari, and Morgan, Linda

Subjects
General Physics and Astronomy, General Chemistry, General Biochemistry, Genetics and Molecular Biology
Published
2020

8. P147 Safety and efficacy of ustekinumab for Crohn’s disease (CD): the cross pennine experience

Author

Dolby, Vivien, primary, Clark, Tanya, additional, Hall, Veronica, additional, Tattersall, Suzanne, additional, Fairhurst, Francesca, additional, Kenneth, Catherine, additional, Walker, Rachael, additional, Kemp, Karen, additional, Borg-Bartolo, Simon, additional, Limdi, Jimmy, additional, Taylor, Jo, additional, Townsend, Tristan, additional, Subramanian, Sree, additional, Storey, Daniel, additional, Assadsangabi, Arash, additional, Stansfield, Catherine, additional, Smith, Paul, additional, Byrne, Debra, additional, Lenti, Marco, additional, and Selinger, Christian, additional

Published
2021
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9. A propensity score‐matched, real‐world comparison of ustekinumab vs vedolizumab as a second‐line treatment for Crohn's disease. The Cross Pennine study II.

Author

Lenti, Marco Vincenzo, Dolby, Vivien, Clark, Tanya, Hall, Veronica, Tattersall, Suzanne, Fairhurst, Francesca, Kenneth, Catherine, Walker, Rachael, Kemp, Karen, Borg‐Bartolo, Simon, Limdi, Jimmy K., Taylor, Jo, Townsend, Tristan, Subramanian, Sree, Storey, Daniel, Assadsangabi, Arash, Stansfield, Catherine, Smith, Paul, Byrne, Debra, and De Silvestri, Annalisa

Subjects
*CROHN'S disease, *VEDOLIZUMAB, *ISOLATION perfusion, *DISEASE remission, *INFLAMMATORY bowel diseases
Abstract

Summary: Background: The optimal choice of biological agents after failure of anti‐tumour‐necrosis‐factor‐(TNF)α agent in Crohn's disease (CD) is yet to be defined. Aims: To assess the effectiveness and safety of ustekinumab compared to vedolizumab as second‐line treatment in CD patients who failed anti‐TNFα therapy. Methods: Retrospective analysis of clinical response and remission at 14 and 52 weeks to ustekinumab by physician global assessment (PGA). A propensity score‐matched analysis with a cohort treated with vedolizumab was performed. Results: Of 282 patients (mean age 40 ± 15, F:M ratio 1.7:1) treated with ustekinumab, clinical response or remission was reached by 200/282 patients (70.9%) at 14 weeks, and 162/259 patients (62.5%) at 52 weeks. Overall, 74 adverse events occurred, of which 26 were labelled as serious (8.3 per 100 person‐year). After exclusion of patients without prior anti‐TNFα exposure and patients previously exposed to vedolizumab or ustekinumab, we analysed 275/282 patients (97.5%) on ustekinumab and 118/135 patients (87.4%) on vedolizumab. Propensity score analysis revealed that at 14 weeks, patients treated with ustekinumab were 38% (95% CI 25%‐50%; P < 0.001) more likely to achieve clinical remission, while at 52 weeks, the difference of 9% (95% CI −15% to 33%; P = 0.462) was not significant. Conclusions: Ustekinumab was effective and well tolerated in this real‐world cohort. While ustekinumab proved more effective at 14‐weeks, we found no statistically significant differences at 52 weeks compared to vedolizumab. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Caffeine Intake During Pregnancy, Late Miscarriage, and Stillbirth

Author

Greenwood, Darren C., primary, Alwan, Nisreen, additional, Boylan, Sinead, additional, Cade, Janet E., additional, Charvill, Jim, additional, Chipps, Karen C., additional, Cooke, Marcus S., additional, Dolby, Vivien A., additional, Hay, Alastair W. M., additional, Kassam, Shabira, additional, Kirk, Sara F. L., additional, Konje, Justin C., additional, Potdar, Neelam, additional, Shires, Susan, additional, Simpson, Nigel, additional, Taub, Nicholas, additional, Thomas, James D., additional, Walker, James, additional, and White, Kay L. M., additional

Published
2010
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11. Variants in the fetal genome near FLT1 are associated with risk of preeclampsia

Author

Williams, Nicholas O., Hildyard, Lucy, Casas, Juan P., McGinnis, Ralph, Lee, Wai Kwong, Pipkin, Fiona Broughton, Hjartardottir, Sigrun, Simpson, Nigel A.B., Kemp, John P., Silva, Gabriela B., Kalsheker, Noor, Zakhidova, Nodira, Chappell, Sally, Staines-Urias, Eleonora, Bumpstead, Suzannah, Stefansdottir, Lilja, Thorleifsson, Gudmar, Walker, James J., Moffett, Ashley, Padmanabhan, Sandosh, Lawlor, Debbie A., Morgan, Linda, Trogstad, Lill, Gjessing, Håkon K., Thomsen, Liv Cecilie V., Iversen, Ann-Charlotte, Geirsson, Reynir T., Kajantie, Eero, Laivuori, Hannele, Steinthorsdottir, Valgerdur, Magnus, Per, Svyatova, Gulnara, Stefansson, Kari, Jääskeläinen, Tiina, Engel, Stephanie M., Dudbridge, Frank, Najmutdinova, Dilbar, Sigurdsson, Jon K., Haugan, Anita, Dominiczak, Anna F., Thorsteinsdottir, Unnur, Dolby, Vivien A., Hiby, Susan, and Shooter, Scott

Subjects
embryonic structures, female genital diseases and pregnancy complications, reproductive and urinary physiology, 3. Good health
Abstract

Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets. We report the first GWAS of offspring from preeclamptic pregnancies and discovery of the first genome-wide significant susceptibility locus (rs4769613; P = 5.4 × 10(-11)) in 4,380 cases and 310,238 controls. This locus is near the FLT1 gene encoding Fms-like tyrosine kinase 1, providing biological support, as a placental isoform of this protein (sFlt-1) is implicated in the pathology of preeclampsia. The association was strongest in offspring from pregnancies in which preeclampsia developed during late gestation and offspring birth weights exceeded the tenth centile. An additional nearby variant, rs12050029, associated with preeclampsia independently of rs4769613. The newly discovered locus may enhance understanding of the pathophysiology of preeclampsia and its subtypes.

12. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Author

Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria-Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Poston, Lucilla, Prescott, Gordon, Saevarsdottir, Saedis, Salimbayeva, Damilya, Scaife, Paula Juliet, Skotte, Line, Staines-Urias, Eleonora, Stefansson, Olafur A., Sørensen, Karina Meden, Thomsen, Liv Cecilie Vestrheim, Tragante, Vinicius, Trogstad, Lill, Simpson, Nigel A. B., Aripova, Tamara, Casas, Juan P., Thorsteinsdottir, Unnur, Iversen, Ann-Charlotte, Feenstra, Bjarke, Lawlor, Deborah A., Boyd, Heather Allison, Magnus, Per, Zakhidova, Nodira, Svyatova, Gulnara, Stefansson, Kari, Laivuori, Hannele, Heinonen, Seppo, Kajantie, Eero, Kere, Juha, Kivinen, Katja, Pouta, Anneli, Morgan, Linda, Pipkin, Fiona Broughton, Walker, James J., Macphail, Sheila, Kilby, Mark, Habiba, Marwan, Williamson, Catherine, O’Shaughnessy, Kevin, O’Brien, Shaughn, Cameron, Alan, Redman, Christopher W. G., Farrall, Martin, Caulfield, Mark, and Dominiczak, Anna F.

Subjects
2. Zero hunger, 45, 692/699/75/243, 631/208/205/2138, 45/43, article, 692/699/2732, 3. Good health
Abstract

Funder: EC | EC Seventh Framework Programm | FP7 Health (FP7-HEALTH - Specific Programme "Cooperation": Health); doi: https://doi.org/10.13039/100011272; Grant(s): 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, Funder: EC | EC Seventh Framework Programm | FP7 Health (FP7-HEALTH - Specific Programme "Cooperation": Health), Funder: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.

13. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Author

Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O, Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K, Auro, Kirsi M, Berezina, Galina, Borges, Maria-Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A, Dudbridge, Frank, Engel, Stephanie M, Franklin, Christopher S, Frigge, Michael L, Frisbaek, Yr, Geirsson, Reynir T, Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F, Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P, Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K, Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Poston, Lucilla, Prescott, Gordon, Saevarsdottir, Saedis, Salimbayeva, Damilya, Scaife, Paula Juliet, Skotte, Line, Staines-Urias, Eleonora, Stefansson, Olafur A, Sørensen, Karina Meden, Thomsen, Liv Cecilie Vestrheim, Tragante, Vinicius, Trogstad, Lill, Simpson, Nigel AB, FINNPEC Consortium, GOPEC Consortium, Aripova, Tamara, Casas, Juan P, Dominiczak, Anna F, Walker, James J, Thorsteinsdottir, Unnur, Iversen, Ann-Charlotte, Feenstra, Bjarke, Lawlor, Deborah A, Boyd, Heather Allison, Magnus, Per, Laivuori, Hannele, Zakhidova, Nodira, Svyatova, Gulnara, Stefansson, Kari, and Morgan, Linda

Subjects
Adult, Multifactorial Inheritance, Fibroblast Growth Factor 5, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Datasets as Topic, Blood Pressure, Pre-Eclampsia, Pregnancy, Humans, Genetic Predisposition to Disease, Prospective Studies, reproductive and urinary physiology, Adaptor Proteins, Signal Transducing, Aged, 2. Zero hunger, Hypertension, Pregnancy-Induced, Middle Aged, female genital diseases and pregnancy complications, MDS1 and EVI1 Complex Locus Protein, 3. Good health, Europe, Genetic Loci, Case-Control Studies, embryonic structures, Asia, Central, Female, Genome-Wide Association Study
Abstract

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.

14. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.

Author

Steinthorsdottir V, McGinnis R, Williams NO, Stefansdottir L, Thorleifsson G, Shooter S, Fadista J, Sigurdsson JK, Auro KM, Berezina G, Borges MC, Bumpstead S, Bybjerg-Grauholm J, Colgiu I, Dolby VA, Dudbridge F, Engel SM, Franklin CS, Frigge ML, Frisbaek Y, Geirsson RT, Geller F, Gretarsdottir S, Gudbjartsson DF, Harmon Q, Hougaard DM, Hegay T, Helgadottir A, Hjartardottir S, Jääskeläinen T, Johannsdottir H, Jonsdottir I, Juliusdottir T, Kalsheker N, Kasimov A, Kemp JP, Kivinen K, Klungsøyr K, Lee WK, Melbye M, Miedzybrodska Z, Moffett A, Najmutdinova D, Nishanova F, Olafsdottir T, Perola M, Pipkin FB, Poston L, Prescott G, Saevarsdottir S, Salimbayeva D, Scaife PJ, Skotte L, Staines-Urias E, Stefansson OA, Sørensen KM, Thomsen LCV, Tragante V, Trogstad L, Simpson NAB, Aripova T, Casas JP, Dominiczak AF, Walker JJ, Thorsteinsdottir U, Iversen AC, Feenstra B, Lawlor DA, Boyd HA, Magnus P, Laivuori H, Zakhidova N, Svyatova G, Stefansson K, and Morgan L

Subjects
Adaptor Proteins, Signal Transducing genetics, Adult, Aged, Alpha-Ketoglutarate-Dependent Dioxygenase FTO genetics, Asia, Central epidemiology, Blood Pressure genetics, Case-Control Studies, Datasets as Topic, Europe epidemiology, Female, Fibroblast Growth Factor 5 genetics, Genetic Loci genetics, Genome-Wide Association Study, Humans, Hypertension, Pregnancy-Induced epidemiology, MDS1 and EVI1 Complex Locus Protein genetics, Middle Aged, Pre-Eclampsia epidemiology, Pregnancy, Prospective Studies, Genetic Predisposition to Disease, Hypertension, Pregnancy-Induced genetics, Multifactorial Inheritance, Pre-Eclampsia genetics
Abstract

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.

Published
2020
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