1. Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia
- Author
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Manzoni, Claudia, Kia, Demis A, Ferrari, Raffaele, Leonenko, Ganna, Costa, Beatrice, Saba, Valentina, Jabbari, Edwin, Tan, Manuela MX, Albani, Diego, Alvarez, Victoria, Alvarez, Ignacio, Andreassen, Ole A, Angiolillo, Antonella, Arighi, Andrea, Baker, Matt, Benussi, Luisa, Bessi, Valentina, Binetti, Giuliano, Blackburn, Daniel J, Boada, Merce, Boeve, Bradley F, Borrego-Ecija, Sergi, Borroni, Barbara, Bråthen, Geir, Brooks, William S, Bruni, Amalia C, Caroppo, Paola, Bandres-Ciga, Sara, Clarimon, Jordi, Colao, Rosanna, Cruchaga, Carlos, Danek, Adrian, de Boer, Sterre CM, de Rojas, Itziar, di Costanzo, Alfonso, Dickson, Dennis W, Diehl-Schmid, Janine, Dobson-Stone, Carol, Dols-Icardo, Oriol, Donizetti, Aldo, Dopper, Elise, Durante, Elisabetta, Ferrari, Camilla, Forloni, Gianluigi, Frangipane, Francesca, Fratiglioni, Laura, Kramberger, Milica G, Galimberti, Daniela, Gallucci, Maurizio, García-González, Pablo, Ghidoni, Roberta, Giaccone, Giorgio, Graff, Caroline, Graff-Radford, Neill R, Grafman, Jordan, Halliday, Glenda M, Hernandez, Dena G, Hjermind, Lena E, Hodges, John R, Holloway, Guy, Huey, Edward D, Illán-Gala, Ignacio, Josephs, Keith A, Knopman, David S, Kristiansen, Mark, Kwok, John B, Leber, Isabelle, Leonard, Hampton L, Libri, Ilenia, Lleo, Alberto, Mackenzie, Ian R, Madhan, Gaganjit K, Maletta, Raffaele, Marquié, Marta, Maver, Ales, Menendez-Gonzalez, Manuel, Milan, Graziella, Miller, Bruce L, Morris, Christopher M, Morris, Huw R, Nacmias, Benedetta, Newton, Judith, Nielsen, Jørgen E, Nilsson, Christer, Novelli, Valeria, Padovani, Alessandro, Pal, Suvankar, Pasquier, Florence, Pastor, Pau, Perneczky, Robert, Peterlin, Borut, Petersen, Ronald C, Piguet, Olivier, AL. Pijnenburg, Yolande, Puca, Annibale A, Rademakers, Rosa, Rainero, Innocenzo, Reus, Lianne M, Richardson, Anna MT, and Riemenschneider, Matthias
- Subjects
Biological Sciences ,Health Sciences ,Genetics ,Neurosciences ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Alzheimer's Disease ,Acquired Cognitive Impairment ,Parkinson's Disease ,Brain Disorders ,Neurodegenerative ,Alzheimer's Disease Related Dementias (ADRD) ,Dementia ,Human Genome ,Rare Diseases ,Aging ,Frontotemporal Dementia (FTD) ,2.1 Biological and endogenous factors ,Neurological ,Humans ,Frontotemporal Dementia ,tau Proteins ,Genome-Wide Association Study ,Apolipoproteins E ,Male ,Female ,Genetic Predisposition to Disease ,Aged ,Polymorphism ,Single Nucleotide ,Genetic Loci ,Middle Aged ,Case-Control Studies ,Myelin Proteins ,Medical and Health Sciences ,Genetics & Heredity ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia after Alzheimer disease (AD). Efforts in the field mainly focus on familial forms of disease (fFTDs), while studies of the genetic etiology of sporadic FTD (sFTD) have been less common. In the current work, we analyzed 4,685 sFTD cases and 15,308 controls looking for common genetic determinants for sFTD. We found a cluster of variants at the MAPT (rs199443; p = 2.5 × 10-12, OR = 1.27) and APOE (rs6857; p = 1.31 × 10-12, OR = 1.27) loci and a candidate locus on chromosome 3 (rs1009966; p = 2.41 × 10-8, OR = 1.16) in the intergenic region between RPSA and MOBP, contributing to increased risk for sFTD through effects on expression and/or splicing in brain cortex of functionally relevant in-cis genes at the MAPT and RPSA-MOBP loci. The association with the MAPT (H1c clade) and RPSA-MOBP loci may suggest common genetic pleiotropy across FTD and progressive supranuclear palsy (PSP) (MAPT and RPSA-MOBP loci) and across FTD, AD, Parkinson disease (PD), and cortico-basal degeneration (CBD) (MAPT locus). Our data also suggest population specificity of the risk signals, with MAPT and APOE loci associations mainly driven by Central/Nordic and Mediterranean Europeans, respectively. This study lays the foundations for future work aimed at further characterizing population-specific features of potential FTD-discriminant APOE haplotype(s) and the functional involvement and contribution of the MAPT H1c haplotype and RPSA-MOBP loci to pathogenesis of sporadic forms of FTD in brain cortex.
- Published
- 2024