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Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (-79.7 ± 28.7, mean ± standard deviation), taste (-69.0 ± 32.6), and chemesthetic (-37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.

The flavor of the maternal diet is transferred to women's amniotic fluid and breast milk, so that the amniotic fluid and breast milk become natural transmitters of flavor-related information developing babies are exposed to at early stages of development. We aimed to review the available evidence regarding the impact of early exposure to flavor on child vegetable intake, and to discuss for the first time possible effects of availability or unavailability of particular vegetables because of geographic reasons on these exposures, a variable that has been forgotten in the literature. We have focused on studies that have examined the association of prenatal and early postnatal -at breastfeeding- exposures to vegetable-related flavors with vegetable consumption in children. We have identified that this particular kind of exposures may lead to increases in children's acceptance, liking of and preference for the vegetables. Especially novel has been to identify that these effects might be modulated not only by the particular flavor of the vegetable -bitter vs. sweet- and the time of exposure -prenatal vs. breastfeeding- but also by vegetable availability because of geographic reasons of the place of residence of the mother, a variable that should be taken into account in future research. This would give rise to a new research line aimed at solving the mentioned gap. Finally, a theoretical model of cyclical processes that might explain the origin and perpetuation of transmission of particular patterns of vegetable consumption and vegetables-composed dishes over time in a given population is also included here as another new contribution. [ABSTRACT FROM AUTHOR]

Participants in cluster 2 (orange,N= 1724; bottom center) are generally characterized by ratings that reflect smell/taste loss with preserved chemesthesis. Based on the centroid of each cluster, participants in cluster 1 (blue,N= 1767; top left) are generally characterized by significant smell, taste and chemesthesis loss. Loadings for participants in cluster 3 (green,N= 548; right side) are generally characterized by reduced smell and taste loss, and preserved chemesthesis. [Extracted from the article]

The author comments on the impact of flavor exposure on the flavor learning of human beings in the U.S. The author states that the early exposure of individuals to stimuli at early development stages served as imprinting effects later in their lives. Moreover, she said that the said experiences will have lasting changes in their behavior, neural and sensory functions.