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21 results on '"Domínguez ‐ Riscart, Jesús"'

7. Altered Insulin Secretion Dynamics Relates to Oxidative Stress and Inflammasome Activation in Children with Obesity and Insulin Resistance

Author

González-Domínguez, Álvaro, primary, Belmonte, Thalía, additional, Domínguez-Riscart, Jesús, additional, Ruiz-Ocaña, Pablo, additional, Muela-Zarzuela, Inés, additional, Saez-Benito, Ana, additional, Montañez-Martínez, Raúl, additional, Mateos, Rosa M., additional, and Lechuga-Sancho, Alfonso M, additional

Published
2023
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14. Iron Metabolism in Obesity and Metabolic Syndrome

Author

González-Domínguez, Álvaro, Visiedo-García, Francisco M., Domínguez-Riscart, Jesús, González-Domínguez, Raúl, Mateos, Rosa M., Lechuga-Sancho, Alfonso María, [González-Domínguez,A, Visiedo-García,FM, Mateos,RM, Lechuga-Sancho,AM] Inflammation, Nutrition, Metabolism and Oxidative Stress Study Group (INMOX), Biomedical Research and Innovation Institute of Cádiz (INiBICA), Research Unit, Puerta del Mar University Hospital, Cádiz, Spain. [Domínguez-Riscart,J, Lechuga-Sancho,AM] Pediatric Endocrinology, Department of Pediatrics, Puerta del Mar University Hospital, Cádiz, Spain. [González-Domínguez,R] Department of Chemistry, Faculty of Experimental Sciences, University of Huelva, Huelva, Spain. [Mateos,RM] Area of Biochemistry and Molecular Biology, Department of Biomedicine, Biotechnology and Public Health, University of Cádiz, Cádiz, Spain. [Lechuga-Sancho,AM] Area of Pediatrics, Department of Child and Mother Health and Radiology, Medical School, University of Cádiz, Cádiz, Spain., and This research was funded by Spanish Government through the Carlos III Health Institute (Sanitary Research Fund (FIS)), code PI18/01316. A G-D is supported by an intramural grant from the Biomedical Research and Innovation Institute of Cádiz (INiBICA), code LII19/16IN-CO24.

Subjects
Síndrome metabólico, Metabolismo, Iron, Obesidad, Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2 [Medical Subject Headings], Diseases::Digestive System Diseases::Liver Diseases::Fatty Liver [Medical Subject Headings], Anemia, Metabolic syndrome, Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Metabolism, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance [Medical Subject Headings], Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity::Pediatric Obesity [Medical Subject Headings], Obesidad pediátrica, Persons::Persons::Age Groups::Child [Medical Subject Headings], Childhood obesity, Obesity, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Iron Metabolism Disorders [Medical Subject Headings], Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Anemia [Medical Subject Headings], Diseases::Cardiovascular Diseases [Medical Subject Headings], Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation [Medical Subject Headings], Hierro
Abstract

Obesity is an excessive adipose tissue accumulation that may have detrimental effects on health. Particularly, childhood obesity has become one of the main public health problems in the 21st century, since its prevalence has widely increased in recent years. Childhood obesity is intimately related to the development of several comorbidities such as nonalcoholic fatty liver disease, dyslipidemia, type 2 diabetes mellitus, non-congenital cardiovascular disease, chronic inflammation and anemia, among others. Within this tangled interplay between these comorbidities and associated pathological conditions, obesity has been closely linked to important perturbations in iron metabolism. Iron is the second most abundant metal on Earth, but its bioavailability is hampered by its ability to form highly insoluble oxides, with iron deficiency being the most common nutritional disorder. Although every living organism requires iron, it may also cause toxic oxygen damage by generating oxygen free radicals through the Fenton reaction. Thus, iron homeostasis and metabolism must be tightly regulated in humans at every level (i.e., absorption, storage, transport, recycling). Dysregulation of any step involved in iron metabolism may lead to iron deficiencies and, eventually, to the anemic state related to obesity. In this review article, we summarize the existent evidence on the role of the most recently described components of iron metabolism and their alterations in obesity. Yes

Published
2020

15. Iron Metabolism in Obesity and Metabolic Syndrome

Author

González-Domínguez, Álvaro, primary, Visiedo-García, Francisco M., additional, Domínguez-Riscart, Jesús, additional, González-Domínguez, Raúl, additional, Mateos, Rosa M., additional, and Lechuga-Sancho, Alfonso María, additional

Published
2020
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18. ELAC (3,12‐di‐O‐acetyl‐8‐O‐tigloilingol), a plant‐derived lathyrane diterpene, induces subventricular zone neural progenitor cell proliferation through PKCβ activation

Author

Murillo‐Carretero, Maribel, Geribaldi‐Doldán, Noelia, Flores‐Giubi, Eugenia, García‐Bernal, Francisco, Navarro‐Quiroz, Elkin A, Carrasco, Manuel, Macías‐Sánchez, Antonio J, Herrero‐Foncubierta, Pilar, Delgado‐Ariza, Antonio, Verástegui, Cristina, Domínguez‐Riscart, Jesús, Daoubi, Mourad, Hernández‐Galán, Rosario, and Castro, Carmen

Subjects
Research Papers
Published
2017

19. ELAC (3,12-di-O-acetyl-8-O-tigloilingol), a plant-derived lathyrane diterpene, induces subventricular zone neural progenitor cell proliferation through PKCβ activation

Author

Murillo-Carretero, Maribel, primary, Geribaldi-Doldán, Noelia, additional, Flores-Giubi, Eugenia, additional, García-Bernal, Francisco, additional, Navarro-Quiroz, Elkin A, additional, Carrasco, Manuel, additional, Macías-Sánchez, Antonio J, additional, Herrero-Foncubierta, Pilar, additional, Delgado-Ariza, Antonio, additional, Verástegui, Cristina, additional, Domínguez-Riscart, Jesús, additional, Daoubi, Mourad, additional, Hernández-Galán, Rosario, additional, and Castro, Carmen, additional

Published
2017
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20. 12-Deoxyphorbols Promote Adult Neurogenesis by Inducing Neural Progenitor Cell Proliferation via PKC Activation

Author

Geribaldi-Doldán, Noelia, primary, Flores-Giubi, Eugenia, additional, Murillo-Carretero, Maribel, additional, García-Bernal, Francisco, additional, Carrasco, Manuel, additional, Macías-Sánchez, Antonio J., additional, Domínguez-Riscart, Jesús, additional, Verástegui, Cristina, additional, Hernández-Galán, Rosario, additional, and Castro, Carmen, additional

Published
2015
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21. 12-Deoxyphorbols Promote Adult Neurogenesis by Inducing Neural Progenitor Cell Proliferation via PKC Activation.

Author

Geribaldi-Doldán, Noelia, Flores-Giubi, Eugenia, Murillo-Carretero, Maribel, García-Bernal, Francisco, Carrasco, Manuel, Macías-Sánchez, Antonio J., Domínguez-Riscart, Jesús, Verástegui, Cristina, Hernández-Galán, Rosario, and Castro, Carmen

Subjects
PHORBOLS, DEVELOPMENTAL neurobiology, CELL proliferation, NEUROLOGICAL disorders, PROTEIN kinase C
Abstract

Background: Neuropsychiatric and neurological disorders frequently occur after brain insults associated with neuronal loss. Strategies aimed to facilitate neuronal renewal by promoting neurogenesis constitute a promising therapeutic option to treat neuronal death-associated disorders. In the adult brain, generation of new neurons occurs physiologically throughout the entire life controlled by extracellular molecules coupled to intracellular signaling cascades. Proteins participating in these cascades within neurogenic regions constitute potential pharmacological targets to promote neuronal regeneration of injured areas of the central nervous system. Methodology: We have performed in vitro and in vivo approaches to determine neural progenitor cell proliferation to understand whether activation of kinases of the protein kinase C family facilitates neurogenesis in the adult brain. Results: We have demonstrated that protein kinase C activation by phorbol-12-myristate-13-acetate induces neural progenitor cell proliferation in vitro. We also show that the nontumorogenic protein kinase C activator prostratin exerts a proliferative effect on neural progenitor cells in vitro. This effect can be reverted by addition of the protein kinase C inhibitor G06850, demonstrating that the effect of prostratin is mediated by protein kinase C activation. Additionally, we show that prostratin treatment in vivo induces proliferation of neural progenitor cells within the dentate gyrus of the hippocampus and the subventricular zone. Finally, we describe a library of diterpenes with a 12-deoxyphorbol structure similar to that of prostratin that induces a stronger effect than prostratin on neural progenitor cell proliferation both in vitro and in vivo. [ABSTRACT FROM AUTHOR]

Published
2016
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