105 results on '"Domagala, John M."'
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2. Bacterial Two-Component Signalling as a Therapeutic Target in Drug Design : Inhibition of NRII by the Diphenolic Methanes (Bisphenols)
3. NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin.
4. Structure-Activity Relationships of the Quinolone Antibacterials in the New Millennium: Some Things Change and Some Do Not
5. HIV protease inhibitors possessing a novel, high-affinity, and achiral P1'/P2' ligand with a unique pattern of in vitro resistance. Importance of a conformationally-restricted template in the design of enzyme inhibitors
6. Bacterial Two-Component Signalling as a Therapeutic Target in Drug Design
7. Chapter 11. New Approaches and Agents to Overcome Bacterial Resistance
8. Chapter 13. Antibacterial Agents, Targets and Approaches
9. Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390: a lead HIV protease inhibitor
10. Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing a novel and achiral 3-(2- t-butyl-5-methyl-4-sulfamate)phenylthio moiety
11. Nonpeptidic HIV protease inhibitors: 6-alkyl-5, 6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxamide-2- t-butyl, 5-methylphenyl thio) moiety: Antiviral activities and pharmacokinetic properties
12. Novel series of achiral, low molecular weight, and potent HIV-1 protease inhibitors
13. Structure–activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors
14. 3-Aminoquinazolinediones as a New Class of Antibacterial Agents Demonstrating Excellent Antibacterial Activity Against Wild-Type and Multidrug Resistant Organisms
15. Synthesis and Structural—Activity Relationships of 3‐Hydroxyquinazoline‐2,4‐dione Antibacterial Agents.
16. Chapter 1: Structure-Activity Relationships of the Quinolone Antibacterials in the New Millennium: Some Things Change and Some Do Not.
17. Synthesis of the novel antibacterial 6,8-dihydroxy-7-propyl-9H-pyrrolo[1,2-b][1,3]-benzoxazin-9-one
18. 5,6-Dihydropyran-2-ones Possessing Various Sulfonyl Functionalities: Potent Nonpeptidic Inhibitors of HIV Protease
19. 2,2′-dithiobisbenzamides derived from α-, β- and γ-amino acids possessing anti-HIV activities: synthesis and structure–activity relationship
20. Synthesis of 5,6-Dihydro-4-hydroxy-2- pyrones as HIV-1 Protease Inhibitors: The Profound Effect of Polarity on Antiviral Activity
21. A new class of anti-HIV-1 agents targeted toward the nucleocapsid protein NCp7: The 2,2′-dithiobisbenzamides
22. Discovery and optimization of nonpeptide HIV-1 protease inhibitors
23. The synthesis of 3-bromo-2,4,5-trifluorobenzoic acid and its conversion to 8-bromoquinolonecarboxylic acids
24. Nonpeptidic HIV Protease Inhibitors: 4-Hydroxy-pyran-2-one Inhibitors with Functional Tethers to P1Phenyl Ring to Reach S3Pocket of the Enzyme
25. Structure−Activity Relationships of the Quinolone Antibacterials against Mycobacteria: Effect of Structural Changes at N-1 and C-7
26. Synthesis and structural–activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents
27. The Synthesis, Structure-Activity, and Structure-Side Effect Relationships of a Series of 8-Alkoxy- and 5-Amino-8-alkoxyquinolone Antibacterial Agents
28. Effect of Lipophilicity at N-1 on Activity of Fluoroquinolones against Mycobacteria
29. A Novel Nonpeptide HIV-1 Protease Inhibitor: Elucidation of the Binding Mode and Its Application in the Design of Related Analogs
30. Synthesis and antibacterial activity of new quinolones containing a 7-[3-(1-amino-1-methylethyl)-1-pyrrolidinyl] moiety. Gram-positive agents with excellent oral activity and low side-effect potential
31. Structure-activity and structure-side-effect relationships for the quinolone antibacterials
32. Synthesis and antimicrobial evaluation of a series of 7-[3-amino (or aminomethyl)-4-aryl (or cyclopropyl)-1-pyrrolidinyl]-4-quinolone and -1,8-naphthyridone-3-carboxylic acids
33. Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1-pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy
34. Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity and antimicrobial activity
35. Synthesis of the four stereoisomers of several 3-(1-aminoethyl)pyrrolidines. Important intermediates in the preparation of quinolone antibacterials
36. Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity
37. Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship
38. Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids
39. Synthesis of 5-methyl-4-oxo-quinolinecarboxylic acids
40. New quinolone antibacterial agents. Synthesis and biological activity of 7-(3,3- or 3,4-disubstituted-1-pyrrolidinyl)quinoline-3-carboxylic acids
41. New 7-substituted quinolone antibacterial agents. II. The synthesis of 1-ethyl-1,4-dihydro-4-oxo-7-(pyrazolyl, isoxazolyl, and pyrimidinyl)-1,8-naphthyridine and quinolone-3-carboxylic acids.
42. New 7-substituted quinolone antibacterial agents. The synthesis of 1-ethyl-1,4-dihydro-4-oxo-7-(2-thiazolyl and 4-thiazolyl)-3-quinolinecarboxylic acids.
43. Functionalization of substituted 2(1 H)- and 4(1 H)-pyridones. III. The preparation of substituted 6-Vinyl-1,2-dihydro-2-oxo- and 1,4-dihydro-4-oxo-3-pyridinecarboxylic acids through the chemistry of pyridone dianions.
44. Functionalization of substituted 2-(1 H)pyridones. II. Synthetic pathways to c-6 modified 3-cyano- and 3-carboxy-2-(1 H)pyridones from a common precursor.
45. Synthesis of the novel antibacterial 6,8-dihydroxy-7-propyl-9 H-pyrrolo[1,2- b][1,3]-benzoxazin-9-one
46. Functionalization of substituted 2(1H)‐ and 4(1H)‐pyridones. III. The preparation of substituted 6‐Vinyl‐1,2‐dihydro‐2‐oxo‐ and 1,4‐dihydro‐4‐oxo‐3‐pyridinecarboxylic acids through the chemistry of pyridone dianions
47. Functionalization of substituted 2(1 H)-pyridones. V. The synthesis of 1,2-dihydro-2-oxo-3,5-pyridinedicarboxylic acid derivatives through a novel dianion route.
48. Thermal rearrangement of trans-2,3-epoxy-1,3-diphenylbutan-1-one. A concerted 1,2-carbonyl migration.
49. Semisynthetic cephalosporins with .ALPHA.-oximino acid side chains. The preparation and coupling of 4-acylamino-.ALPHA.-oximinobenzeneacetic acids and 1,2-dihydro-6-methyl-.ALPHA.-oximino-2-oxo-3-pyridineacetic acid to 7-aminocephalosporanic acid.
50. ChemInform Abstract: REARRANGEMENT OF OPTICALLY ACTIVE ETHYL (E)-3-METHYL-3-PHENYLGLYCIDATE. EVIDENCE FOR CONCERTED CARBETHOXY MIGRATION
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