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Your search keyword '"Domenyuk, Valeriy"' showing total 13 results
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13 results on '"Domenyuk, Valeriy"'

1. Validation of a whole exome/whole transcriptome liquid biopsy assay with correction for clonal hematopoiesis.

Author

Perdigones Borderias, Nieves, primary, Abraham, Jim, additional, Radovich, Milan, additional, Oberley, Matthew James, additional, Swensen, Jeffrey, additional, Heath, Elisabeth I., additional, Dietrich, Martin Frederik, additional, Liu, Stephen V., additional, Nabhan, Chadi, additional, Hahn-Lowry, Robert, additional, Lou, Emil, additional, El-Deiry, Wafik S., additional, Shields, Anthony F., additional, Marshall, John, additional, Miglarese, Mark Robert, additional, Antani, Sourabh, additional, Sledge, George W., additional, Halbert, David D., additional, Spetzler, David, additional, and Domenyuk, Valeriy, additional

Published
2023
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2. Tumour mutational burden, microsatellite instability, and actionable alterations in metastatic colorectal cancer: Next-generation sequencing results of TRIBE2 study

Author

Antoniotti, Carlotta, primary, Korn, W. Michael, additional, Marmorino, Federica, additional, Rossini, Daniele, additional, Lonardi, Sara, additional, Masi, Gianluca, additional, Randon, Giovanni, additional, Conca, Veronica, additional, Boccaccino, Alessandra, additional, Tomasello, Gianluca, additional, Passardi, Alessandro, additional, Swensen, Jeff, additional, Ugolini, Clara, additional, Oberley, Matthew, additional, Tamburini, Emiliano, additional, Casagrande, Mariaelena, additional, Domenyuk, Valeriy, additional, Fontanini, Gabriella, additional, Giordano, Mirella, additional, Abraham, Jim, additional, Spetzler, David, additional, Falcone, Alfredo, additional, Lenz, Heinz-Josef, additional, and Cremolini, Chiara, additional

Published
2021
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3. Poly-ligand profiling (PLP) to differentiate pancreatic cancer patients who benefit from gemcitabine+evofosfamide versus gemcitabine+placebo treatment.

Author

Domenyuk, Valeriy, primary, Magee, Daniel, additional, Gatalica, Zoran, additional, Stark, Adam, additional, Kennedy, Patrick, additional, Barker, Anna, additional, Berry, Donald A., additional, Poste, George H., additional, Halbert, David D, additional, Hart, Charles P, additional, Famulok, Michael, additional, Mayer, Gunter, additional, Korn, Michael, additional, Miglarese, Mark Robert, additional, and Spetzler, David, additional

Published
2018
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4. Poly-ligand profiling differentiates trastuzumab-treated breast cancer patients according to their outcomes

Author

Domenyuk, Valeriy, primary, Gatalica, Zoran, additional, Santhanam, Radhika, additional, Wei, Xixi, additional, Stark, Adam, additional, Kennedy, Patrick, additional, Toussaint, Brandon, additional, Levenberg, Symon, additional, Wang, Jie, additional, Xiao, Nianqing, additional, Greil, Richard, additional, Rinnerthaler, Gabriel, additional, Gampenrieder, Simon P., additional, Heimberger, Amy B., additional, Berry, Donald A., additional, Barker, Anna, additional, Quackenbush, John, additional, Marshall, John L., additional, Poste, George, additional, Vacirca, Jeffrey L., additional, Vidal, Gregory A., additional, Schwartzberg, Lee S., additional, Halbert, David D., additional, Voss, Andreas, additional, Magee, Daniel, additional, Miglarese, Mark R., additional, Famulok, Michael, additional, Mayer, Günter, additional, and Spetzler, David, additional

Published
2018
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5. A Simple Platform for the Rapid Development of Antimicrobials

Author

Johnston, Stephen Albert, primary, Domenyuk, Valeriy, additional, Gupta, Nidhi, additional, Batista, Milene Tavares, additional, Lainson, John C., additional, Zhao, Zhan-Gong, additional, Lusk, Joel F., additional, Loskutov, Andrey, additional, Cichacz, Zbigniew, additional, Stafford, Phillip, additional, Legutki, Joseph Barten, additional, and Diehnelt, Chris W., additional

Published
2017
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7. Plasma Exosome Profiling of Cancer Patients by a Next Generation Systems Biology Approach

Author

Domenyuk, Valeriy, primary, Zhong, Zhenyu, additional, Stark, Adam, additional, Xiao, Nianqing, additional, O’Neill, Heather A., additional, Wei, Xixi, additional, Wang, Jie, additional, Tinder, Teresa T., additional, Tonapi, Sonal, additional, Duncan, Janet, additional, Hornung, Tassilo, additional, Hunter, Andrew, additional, Miglarese, Mark R., additional, Schorr, Joachim, additional, Halbert, David D., additional, Quackenbush, John, additional, Poste, George, additional, Berry, Donald A., additional, Mayer, Günter, additional, Famulok, Michael, additional, and Spetzler, David, additional

Published
2017
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10. Adaptive dynamic artificial poly-ligand targeting (ADAPT) of low-abundance exosome-associated proteins in blood plasma.

Author

Domenyuk, Valeriy, primary, Zhong, Zhenyu, additional, Stark, Adam, additional, Wei, Xixi, additional, Kennedy, Patrick, additional, Toussaint, Brandon, additional, Santhanam, Radhika, additional, Levenberg, Symon, additional, O'Neill, Heather A., additional, Tinder, Teresa T., additional, Duncan, Janet E., additional, Hunter, Andrew William, additional, Miglarese, Mark Robert, additional, Halbert, David D, additional, Mayer, Gunter, additional, Famulok, Michael, additional, and Spetzler, David, additional

Published
2016
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11. Adaptive dynamic artificial poly-ligand targeting (ADAPT) of the plasma exosome proteome: A highly multiplexed non-invasive diagnostic discovery platform.

Author

Domenyuk, Valeriy, primary, Zhong, Zhenyu, additional, Wang, Jie, additional, Stark, Adam, additional, Wei, Xixi, additional, Kennedy, Patrick, additional, Toussaint, Brandon, additional, Santhanam, Radhika, additional, Levenberg, Symon, additional, Xiao, Nianqing, additional, Miglarese, Mark Robert, additional, Halbert, David D, additional, Poste, George H., additional, Famulok, Michael, additional, Mayer, Gunter, additional, and Spetzler, David, additional

Published
2016
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13. Plasma Exosome Profiling of Cancer Patients by a Next Generation Systems Biology Approach

Author

Domenyuk, Valeriy, Zhong, Zhenyu, Stark, Adam, Xiao, Nianqing, O’Neill, Heather A., Wei, Xixi, Wang, Jie, Tinder, Teresa T., Tonapi, Sonal, Duncan, Janet, Hornung, Tassilo, Hunter, Andrew, Miglarese, Mark R., Schorr, Joachim, Halbert, David D., Quackenbush, John, Poste, George, Berry, Donald A., Mayer, Günter, Famulok, Michael, and Spetzler, David

Abstract

Technologies capable of characterizing the full breadth of cellular systems need to be able to measure millions of proteins, isoforms, and complexes simultaneously. We describe an approach that fulfils this criterion: Adaptive Dynamic Artificial Poly-ligand Targeting (ADAPT). ADAPT employs an enriched library of single-stranded oligodeoxynucleotides (ssODNs) to profile complex biological samples, thus achieving an unprecedented coverage of system-wide, native biomolecules. We used ADAPT as a highly specific profiling tool that distinguishes women with or without breast cancer based on circulating exosomes in their blood. To develop ADAPT, we enriched a library of ~1011 ssODNs for those associating with exosomes from breast cancer patients or controls. The resulting 106 enriched ssODNs were then profiled against plasma from independent groups of healthy and breast cancer-positive women. ssODN-mediated affinity purification and mass spectrometry identified low-abundance exosome-associated proteins and protein complexes, some with known significance in both normal homeostasis and disease. Sequencing of the recovered ssODNs provided quantitative measures that were used to build highly accurate multi-analyte signatures for patient classification. Probing plasma from 500 subjects with a smaller subset of 2000 resynthesized ssODNs stratified healthy, breast biopsy-negative, and -positive women. An AUC of 0.73 was obtained when comparing healthy donors with biopsy-positive patients.

Published
2017
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