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342 results on '"Dominguez, Pablo"'

1. A Fixed-Mass multifractal approach for unweighted complex networks

Author

Pavón-Domínguez, Pablo and Moreno-Pulido, Soledad

Subjects
Physics - Physics and Society, Physics - Data Analysis, Statistics and Probability
Abstract

Complex networks have been studied in recent years due to their relevance in biological, social and technical real systems, such as the world wide web, social networks and biochemical interactions. One of the most current features of complex networks is the presence of (multi-)fractal properties. In spite of the amount of contributions that have been developed in fractal and multifractal analysis, all of them have focused on the adaptation of Fixed size algorithms (FSA) to complex networks, mostly box-counting and sandbox procedures. In this manuscript, a Fixed-mass algorithm (FMA) is adapted to explore the (multi-)fractality of unweighted complex networks is first proposed on the basis on a box-counting procedure. Thus, the aim of this work is to explore the applicability of a FMA to study fractal and multifractal characteristics of unweighted complex networks. After describing the proposed FMA for complex networks, it is tested in several kinds of complex networks such as deterministic, synthetic and real ones. Results suggest that FMA is able to adequately reproduce the fractal and multifractal properties of synthetic complex networks (scale-free, small-world and random). In addition, the algorithm is used for the multifractal description of real complex networks. The main advantage of FMA over FSA is that the minimum configuration of boxes (ideal) for completely covering the network is known. Therefore, results are quite precise when a reasonable covering configuration is obtained, allowing the reconstruction of the Mass exponent, {\tau} , and the Dimension function, D(q), with proper goodness-fits.

Published
2024
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5. International time transfer between precise timing facilities secured with a quantum key distribution network

Author

Picciariello, Francesco, Vedovato, Francesco, Orsucci, Davide, Dominguez, Pablo Nahuel, Zechel, Thomas, Avesani, Marco, Padovan, Matteo, Foletto, Giulio, Calderaro, Luca, Dequal, Daniele, Shrestha, Amita, Blumel, Ludwig, Furthner, Johann, Vallone, Giuseppe, Villoresi, Paolo, Schmidt, Tobias D., and Moll, Florian

Subjects
Quantum Physics
Abstract

Global Navigation Satellite Systems (GNSSs), such as GPS and Galileo, provide precise time and space coordinates globally and constitute part of the critical infrastructure of modern society. To reliably operate GNSS, a highly accurate and stable system time is required, such as the one provided by several independent clocks hosted in Precise Timing Facilities (PTFs) around the world. Periodically, the relative clock offset between PTFs is measured to have a fallback system to synchronize the GNSS satellite clocks. The security and integrity of the communication between PTFs is of paramount importance: if compromised, it could lead to disruptions to the GNSS service. Therefore, it is a compelling use-case for protection via Quantum Key Distribution (QKD), since this technology provides information-theoretic security. We have performed a field trial demonstration of such use-case by sharing encrypted time synchronization information between two PTFs, one located in Oberpfaffenhofen (Germany) and one in Matera (Italy) - more than 900km apart as the crow flies. To bridge this large distance, a satellite-QKD system is required, plus a "last-mile" terrestrial link to connect the optical ground station (OGS) to the actual location of the PTF. In our demonstration we have deployed two full QKD systems to protect the last-mile connection at both the locations and have shown via simulation that upcoming QKD satellites will be able to distribute keys between Oberpfaffenhofen and Matera exploiting already existing OGSs.

Published
2023
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6. Effect of Age and Technology on the Perception of Obsolescence: Case Study of Domestic Vacuum Cleaning Appliances

Author

Camacho-Magriñán, Patricia, Pardo-Vicente, Miguel-Angel, Pavón-Domínguez, Pablo, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Manchado del Val, Cristina, editor, Suffo Pino, Miguel, editor, Miralbes Buil, Ramón, editor, Moreno Sánchez, Daniel, editor, and Moreno Nieto, Daniel, editor

Published
2024
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7. Geometric Characterization of the SOFC Electrodes Microporosity Using Fractal and Multifractal Analysis

Author

Díaz-Jiménez, Marina, Pavón-Domínguez, Pablo, Castro-García, Miguel, Marín-Rueda, Juan Ramón, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Manchado del Val, Cristina, editor, Suffo Pino, Miguel, editor, Miralbes Buil, Ramón, editor, Moreno Sánchez, Daniel, editor, and Moreno Nieto, Daniel, editor

Published
2024
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8. Optimizing quantification of MK6240 tau PET in unimpaired older adults

Author

Harrison, Theresa M, Ward, Tyler J, Murphy, Alice, Baker, Suzanne L, Dominguez, Pablo A, Koeppe, Robert, Vemuri, Prashanthi, Lockhart, Samuel N, Jung, Youngkyoo, Harvey, Danielle J, Lovato, Laura, Toga, Arthur W, Masdeu, Joseph, Oh, Hwamee, Gitelman, Darren R, Aggarwal, Neelum, Snyder, Heather M, Baker, Laura D, DeCarli, Charles, Jagust, William J, Landau, Susan M, and Group, US POINTER Study

Subjects
Health Sciences, Dementia, Biomedical Imaging, Aging, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Behavioral and Social Science, Alzheimer's Disease, Neurodegenerative, Clinical Research, Prevention, Brain Disorders, Clinical Trials and Supportive Activities, Neurosciences, 2.1 Biological and endogenous factors, Neurological, Aged, Humans, Alzheimer Disease, Amyloid beta-Peptides, Brain, Cognitive Dysfunction, Positron-Emission Tomography, tau Proteins, Middle Aged, PET, Tau, Amyloid, Alzheimer's disease, off-target signal, meninges, U.S. POINTER Study Group, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences, Health sciences
Abstract

Accurate measurement of Alzheimer's disease (AD) pathology in older adults without significant clinical impairment is critical to assessing intervention strategies aimed at slowing AD-related cognitive decline. The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (POINTER) is a 2-year randomized controlled trial to evaluate the effect of multicomponent risk reduction strategies in older adults (60-79 years) who are cognitively unimpaired but at increased risk for cognitive decline/dementia due to factors such as cardiovascular disease and family history. The POINTER Imaging ancillary study is collecting tau-PET ([18F]MK6240), beta-amyloid (Aβ)-PET ([18F]florbetaben [FBB]) and MRI data to evaluate neuroimaging biomarkers of AD and cerebrovascular pathophysiology in this at-risk sample. Here 481 participants (70.0±5.0; 66% F) with baseline MK6240, FBB and structural MRI scans were included. PET scans were coregistered to the structural MRI which was used to create FreeSurfer-defined reference regions and target regions of interest (ROIs). We also created off-target signal (OTS) ROIs to examine the magnitude and distribution of MK6240 OTS across the brain as well as relationships between OTS and age, sex, and race. OTS was unimodally distributed, highly correlated across OTS ROIs and related to younger age and sex but not race. Aiming to identify an optimal processing approach for MK6240 that would reduce the influence of OTS, we compared our previously validated MRI-guided standard PET processing and 6 alternative approaches. The alternate approaches included combinations of reference region erosion and meningeal OTS masking before spatial smoothing as well as partial volume correction. To compare processing approaches we examined relationships between target ROIs (entorhinal cortex (ERC), hippocampus or a temporal meta-ROI (MetaROI)) SUVR and age, sex, race, Aβ and a general cognitive status measure, the Modified Telephone Interview for Cognitive Status (TICSm). Overall, the processing approaches performed similarly, and none showed a meaningful improvement over standard processing. Across processing approaches we observed previously reported relationships with MK6240 target ROIs including positive associations with age, an Aβ+> Aβ- effect and negative associations with cognition. In sum, we demonstrated that different methods for minimizing effects of OTS, which is highly correlated across the brain within subject, produced no substantive change in our performance metrics. This is likely because OTS contaminates both reference and target regions and this contamination largely cancels out in SUVR data. Caution should be used when efforts to reduce OTS focus on target or reference regions in isolation as this may exacerbate OTS contamination in SUVR data.

Published
2023

9. Quantitative diffusion-weighted MRI response assessment in rhabdomyosarcoma: an international retrospective study on behalf of the European paediatric Soft tissue sarcoma Study Group Imaging Committee

Author

van Ewijk, Roelof, Chatziantoniou, Cyrano, Adams, Madeleine, Bertolini, Patrizia, Bisogno, Gianni, Bouhamama, Amine, Caro-Dominguez, Pablo, Charon, Valerie, Coma, Ana, Dandis, Rana, Devalck, Christine, De Donno, Giulia, Ferrari, Andrea, Fiocco, Marta, Gallego, Soledad, Giraudo, Chiara, Glosli, Heidi, ter Horst, Simone A. J., Jenney, Meriel, Klein, Willemijn M., Leemans, Alexander, Leseur, Julie, Mandeville, Henry C., McHugh, Kieran, Merks, Johannes H. M., Minard-Colin, Veronique, Moalla, Salma, Morosi, Carlo, Orbach, Daniel, Ording Muller, Lil-Sofie, Pace, Erika, Di Paolo, Pier Luigi, Perruccio, Katia, Quaglietta, Lucia, Renard, Marleen, van Rijn, Rick R., Ruggiero, Antonio, Sirvent, Sara I., De Luca, Alberto, and Schoot, Reineke A.

Published
2023
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15. Dimensioning Method for 3D Modelling

Author

Castro-Cañas, Luis, Pavón-Domínguez, Pablo, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Haddar, Mohamed, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Marín Granados, Manuel D., editor, Mirálbes Buil, Ramón, editor, and de-Cózar-Macías, Oscar D., editor

Published
2023
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17. Ultraviolet Dual Comb Spectroscopy: A Roadmap

Author

Schuster, Vittoria, Liu, Chang, Klas, Robert, Dominguez, Pablo, Rothhardt, Jan, Limpert, Jens, and Bernhardt, Birgitta

Subjects
Physics - Optics
Abstract

Dual Comb Spectroscopy proved its versatile capabilities in molecular fingerprinting in different spectral regions, but not yet in the ultraviolet (UV). Unlocking this spectral window would expand fingerprinting to the electronic energy structure of matter.This will access the prime triggers of photo-chemical reactions with unprecedented spectral resolution. In this research article, we discuss the milestones marking the way to the first UV dual comb spectrometer. We present experimental and simulated studies towards UV dual comb spectroscopy, directly applied to planned absorption measurements of formaldehyde (centered at 343 nm, 3.6 eV) and argon (80 nm, 16 eV). This will enable an unparalleled relative resolution of up to $10^{-9}$ - with a table-top UV source surpassing any synchrotron linked spectrometer by at least two and any grating-based UV spectrometer by up to six orders of magnitude.

Published
2020
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21. Gamification Resources Applied to Reading Comprehension: Projects of Connection with Society Case Study

Author

Páez-Quinde, Cristina, Iza-Pazmiño, Sarah, Morocho-Lara, Daniel, Hernández-Domínguez, Pablo, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Garcia, Marcelo V., editor, Fernández-Peña, Félix, editor, and Gordón-Gallegos, Carlos, editor

Published
2022
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22. Conceptual Design Using Virtual Reality: Case Study with Portable Light

Author

Rodríguez-Parada, Lucía, Pardo-Vicente, Miguel-Ángel, Sánchez-calle, Alejandro, Pavón-Domínguez, Pablo, Cavas-Martínez, Francisco, Series Editor, Chaari, Fakher, Series Editor, di Mare, Francesca, Series Editor, Gherardini, Francesco, Series Editor, Haddar, Mohamed, Series Editor, Ivanov, Vitalii, Series Editor, Kwon, Young W., Series Editor, Trojanowska, Justyna, Series Editor, Cavas Martínez, Francisco, editor, Peris-Fajarnes, Guillermo, editor, Morer Camo, Paz, editor, Lengua Lengua, Ismael, editor, and Defez García, Beatriz, editor

Published
2022
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23. Optimizing quantification of MK6240 tau PET in unimpaired older adults

Author

Harrison, Theresa M., Ward, Tyler J., Murphy, Alice, Baker, Suzanne L., Dominguez, Pablo A., Koeppe, Robert, Vemuri, Prashanthi, Lockhart, Samuel N., Jung, Youngkyoo, Harvey, Danielle J., Lovato, Laura, Toga, Arthur W., Masdeu, Joseph, Oh, Hwamee, Gitelman, Darren R., Aggarwal, Neelum, Snyder, Heather M., Baker, Laura D., DeCarli, Charles, Jagust, William J., and Landau, Susan M.

Published
2023
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30. Lifetime Stressful Events Associated with Alzheimer's Pathologies, Neuroinflammation and Brain Structure in a Risk Enriched Cohort.

Author

Palpatzis, Eleni, Akinci, Muge, Aguilar‐Dominguez, Pablo, Garcia‐Prat, Marina, Blennow, Kaj, Zetterberg, Henrik, Carboni, Margherita, Kollmorgen, Gwendlyn, Wild, Norbert, Fauria, Karine, Falcon, Carles, Gispert, Juan Domingo, Suárez‐Calvet, Marc, Grau‐Rivera, Oriol, Sánchez‐Benavides, Gonzalo, Arenaza‐Urquijo, Eider M., Peña‐Gómez, Cleofé, Anastasi, Federica, Beteta, Annabella, and Brugulat‐Serrat, Anna

Subjects
ALZHEIMER'S disease, BRAIN anatomy, LIFE change events, NEUROINFLAMMATION, MAGNETIC resonance imaging
Abstract

Objective: Along with the known effects of stress on brain structure and inflammatory processes, increasing evidence suggest a role of chronic stress in the pathogenesis of Alzheimer's disease (AD). We investigated the association of accumulated stressful life events (SLEs) with AD pathologies, neuroinflammation, and gray matter (GM) volume among cognitively unimpaired (CU) individuals at heightened risk of AD. Methods: This cross‐sectional cohort study included 1,290 CU participants (aged 48–77) from the ALFA cohort with SLE, lumbar puncture (n = 393), and/or structural magnetic resonance imaging (n = 1,234) assessments. Using multiple regression analyses, we examined the associations of total SLEs with cerebrospinal fluid (1) phosphorylated (p)‐tau181 and Aβ1–42/1–40 ratio, (2) interleukin 6 (IL‐6), and (3) GM volumes voxel‐wise. Further, we performed stratified and interaction analyses with sex, history of psychiatric disease, and evaluated SLEs during specific life periods. Results: Within the whole sample, only childhood and midlife SLEs, but not total SLEs, were associated with AD pathophysiology and neuroinflammation. Among those with a history of psychiatric disease SLEs were associated with higher p‐tau181 and IL‐6. Participants with history of psychiatric disease and men, showed lower Aβ1–42/1–40 with higher SLEs. Participants with history of psychiatric disease and women showed reduced GM volumes in somatic regions and prefrontal and limbic regions, respectively. Interpretation: We did not find evidence supporting the association of total SLEs with AD, neuroinflammation, and atrophy pathways. Instead, the associations appear to be contingent on events occurring during early and midlife, sex and history of psychiatric disease. ANN NEUROL 2024;95:1058–1068 [ABSTRACT FROM AUTHOR]

Published
2024
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35. Quantum-secured time transfer between precise timing facilities: a field trial with simulated satellite links

Author

Picciariello, Francesco, primary, Vedovato, Francesco, additional, Orsucci, Davide, additional, Dominguez, Pablo Nahuel, additional, Zechel, Thomas, additional, Avesani, Marco, additional, Padovan, Matteo, additional, Foletto, Giulio, additional, Calderaro, Luca, additional, Dequal, Daniele, additional, Shrestha, Amita, additional, Blümel, Ludwig, additional, Furthner, Johann, additional, Vallone, Giuseppe, additional, Villoresi, Paolo, additional, Schmidt, Tobias D., additional, and Moll, Florian, additional

Published
2023
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