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2. Supplementary Table from Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

Author

Salmon, Jessica M., primary, Todorovski, Izabela, primary, Stanley, Kym L., primary, Bruedigam, Claudia, primary, Kearney, Conor J., primary, Martelotto, Luciano G., primary, Rossello, Fernando, primary, Semple, Timothy, primary, Arnau, Gisela Mir, primary, Zethoven, Magnus, primary, Bots, Michael, primary, Bjelosevic, Stefan, primary, Cluse, Leonie A., primary, Fraser, Peter J., primary, Litalien, Veronique, primary, Vidacs, Eva, primary, McArthur, Kate, primary, Matthews, Antony Y., primary, Gressier, Elise, primary, de Weerd, Nicole A., primary, Lichte, Jens, primary, Kelly, Madison J., primary, Hogg, Simon J., primary, Hertzog, Paul J., primary, Kats, Lev M., primary, Vervoort, Stephin J., primary, De Carvalho, Daniel D., primary, Scheu, Stefanie, primary, Bedoui, Sammy, primary, Kile, Benjamin T., primary, Lane, Steven W., primary, Perkins, Andrew C., primary, Wei, Andrew H., primary, Dominguez, Pilar M., primary, and Johnstone, Ricky W., primary

Published
2023
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3. Data from Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

Author

Salmon, Jessica M., primary, Todorovski, Izabela, primary, Stanley, Kym L., primary, Bruedigam, Claudia, primary, Kearney, Conor J., primary, Martelotto, Luciano G., primary, Rossello, Fernando, primary, Semple, Timothy, primary, Arnau, Gisela Mir, primary, Zethoven, Magnus, primary, Bots, Michael, primary, Bjelosevic, Stefan, primary, Cluse, Leonie A., primary, Fraser, Peter J., primary, Litalien, Veronique, primary, Vidacs, Eva, primary, McArthur, Kate, primary, Matthews, Antony Y., primary, Gressier, Elise, primary, de Weerd, Nicole A., primary, Lichte, Jens, primary, Kelly, Madison J., primary, Hogg, Simon J., primary, Hertzog, Paul J., primary, Kats, Lev M., primary, Vervoort, Stephin J., primary, De Carvalho, Daniel D., primary, Scheu, Stefanie, primary, Bedoui, Sammy, primary, Kile, Benjamin T., primary, Lane, Steven W., primary, Perkins, Andrew C., primary, Wei, Andrew H., primary, Dominguez, Pilar M., primary, and Johnstone, Ricky W., primary

Published
2023
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4. Supplementary Figure from Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

Author

Salmon, Jessica M., primary, Todorovski, Izabela, primary, Stanley, Kym L., primary, Bruedigam, Claudia, primary, Kearney, Conor J., primary, Martelotto, Luciano G., primary, Rossello, Fernando, primary, Semple, Timothy, primary, Arnau, Gisela Mir, primary, Zethoven, Magnus, primary, Bots, Michael, primary, Bjelosevic, Stefan, primary, Cluse, Leonie A., primary, Fraser, Peter J., primary, Litalien, Veronique, primary, Vidacs, Eva, primary, McArthur, Kate, primary, Matthews, Antony Y., primary, Gressier, Elise, primary, de Weerd, Nicole A., primary, Lichte, Jens, primary, Kelly, Madison J., primary, Hogg, Simon J., primary, Hertzog, Paul J., primary, Kats, Lev M., primary, Vervoort, Stephin J., primary, De Carvalho, Daniel D., primary, Scheu, Stefanie, primary, Bedoui, Sammy, primary, Kile, Benjamin T., primary, Lane, Steven W., primary, Perkins, Andrew C., primary, Wei, Andrew H., primary, Dominguez, Pilar M., primary, and Johnstone, Ricky W., primary

Published
2023
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5. Data from CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Author

Lelliott, Emily J., primary, Kong, Isabella Y., primary, Zethoven, Magnus, primary, Ramsbottom, Kelly M., primary, Martelotto, Luciano G., primary, Meyran, Deborah, primary, Zhu, Joe Jiang, primary, Costacurta, Matteo, primary, Kirby, Laura, primary, Sandow, Jarrod J., primary, Lim, Lydia, primary, Dominguez, Pilar M., primary, Todorovski, Izabela, primary, Haynes, Nicole M., primary, Beavis, Paul A., primary, Neeson, Paul J., primary, Hawkins, Edwin D., primary, McArthur, Grant A., primary, Parish, Ian A., primary, Johnstone, Ricky W., primary, Oliaro, Jane, primary, Sheppard, Karen E., primary, Kearney, Conor J., primary, and Vervoort, Stephin J., primary

Published
2023
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6. TableS1.xlsx from CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Author

Lelliott, Emily J., primary, Kong, Isabella Y., primary, Zethoven, Magnus, primary, Ramsbottom, Kelly M., primary, Martelotto, Luciano G., primary, Meyran, Deborah, primary, Zhu, Joe Jiang, primary, Costacurta, Matteo, primary, Kirby, Laura, primary, Sandow, Jarrod J., primary, Lim, Lydia, primary, Dominguez, Pilar M., primary, Todorovski, Izabela, primary, Haynes, Nicole M., primary, Beavis, Paul A., primary, Neeson, Paul J., primary, Hawkins, Edwin D., primary, McArthur, Grant A., primary, Parish, Ian A., primary, Johnstone, Ricky W., primary, Oliaro, Jane, primary, Sheppard, Karen E., primary, Kearney, Conor J., primary, and Vervoort, Stephin J., primary

Published
2023
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7. Supplementary Figures from CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Author

Lelliott, Emily J., primary, Kong, Isabella Y., primary, Zethoven, Magnus, primary, Ramsbottom, Kelly M., primary, Martelotto, Luciano G., primary, Meyran, Deborah, primary, Zhu, Joe Jiang, primary, Costacurta, Matteo, primary, Kirby, Laura, primary, Sandow, Jarrod J., primary, Lim, Lydia, primary, Dominguez, Pilar M., primary, Todorovski, Izabela, primary, Haynes, Nicole M., primary, Beavis, Paul A., primary, Neeson, Paul J., primary, Hawkins, Edwin D., primary, McArthur, Grant A., primary, Parish, Ian A., primary, Johnstone, Ricky W., primary, Oliaro, Jane, primary, Sheppard, Karen E., primary, Kearney, Conor J., primary, and Vervoort, Stephin J., primary

Published
2023
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9. Supplementary Figure 7 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, primary, von Scheidt, Bianca, primary, Dominguez, Pilar M., primary, Harrison, Aaron J., primary, Tantalo, Daniela G.M., primary, Kang, Jian, primary, Oliver, Amanda J., primary, Chan, Jack D., primary, Du, Xin, primary, Bai, Yuchen, primary, Lee, Belinda, primary, Johnstone, Ricky W., primary, Darcy, Phillip K., primary, Kershaw, Michael H., primary, and Slaney, Clare Y., primary

Published
2023
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10. Supplementary Figure 3 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, primary, von Scheidt, Bianca, primary, Dominguez, Pilar M., primary, Harrison, Aaron J., primary, Tantalo, Daniela G.M., primary, Kang, Jian, primary, Oliver, Amanda J., primary, Chan, Jack D., primary, Du, Xin, primary, Bai, Yuchen, primary, Lee, Belinda, primary, Johnstone, Ricky W., primary, Darcy, Phillip K., primary, Kershaw, Michael H., primary, and Slaney, Clare Y., primary

Published
2023
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11. Supplementary Figure 4 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, primary, von Scheidt, Bianca, primary, Dominguez, Pilar M., primary, Harrison, Aaron J., primary, Tantalo, Daniela G.M., primary, Kang, Jian, primary, Oliver, Amanda J., primary, Chan, Jack D., primary, Du, Xin, primary, Bai, Yuchen, primary, Lee, Belinda, primary, Johnstone, Ricky W., primary, Darcy, Phillip K., primary, Kershaw, Michael H., primary, and Slaney, Clare Y., primary

Published
2023
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12. Supplementary Figure 1 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, primary, von Scheidt, Bianca, primary, Dominguez, Pilar M., primary, Harrison, Aaron J., primary, Tantalo, Daniela G.M., primary, Kang, Jian, primary, Oliver, Amanda J., primary, Chan, Jack D., primary, Du, Xin, primary, Bai, Yuchen, primary, Lee, Belinda, primary, Johnstone, Ricky W., primary, Darcy, Phillip K., primary, Kershaw, Michael H., primary, and Slaney, Clare Y., primary

Published
2023
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13. Supplementary Figure 8 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, primary, von Scheidt, Bianca, primary, Dominguez, Pilar M., primary, Harrison, Aaron J., primary, Tantalo, Daniela G.M., primary, Kang, Jian, primary, Oliver, Amanda J., primary, Chan, Jack D., primary, Du, Xin, primary, Bai, Yuchen, primary, Lee, Belinda, primary, Johnstone, Ricky W., primary, Darcy, Phillip K., primary, Kershaw, Michael H., primary, and Slaney, Clare Y., primary

Published
2023
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14. Supplementary Figure 5 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, primary, von Scheidt, Bianca, primary, Dominguez, Pilar M., primary, Harrison, Aaron J., primary, Tantalo, Daniela G.M., primary, Kang, Jian, primary, Oliver, Amanda J., primary, Chan, Jack D., primary, Du, Xin, primary, Bai, Yuchen, primary, Lee, Belinda, primary, Johnstone, Ricky W., primary, Darcy, Phillip K., primary, Kershaw, Michael H., primary, and Slaney, Clare Y., primary

Published
2023
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15. Supplementary Figure 6 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, primary, von Scheidt, Bianca, primary, Dominguez, Pilar M., primary, Harrison, Aaron J., primary, Tantalo, Daniela G.M., primary, Kang, Jian, primary, Oliver, Amanda J., primary, Chan, Jack D., primary, Du, Xin, primary, Bai, Yuchen, primary, Lee, Belinda, primary, Johnstone, Ricky W., primary, Darcy, Phillip K., primary, Kershaw, Michael H., primary, and Slaney, Clare Y., primary

Published
2023
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16. Supplementary Figure 2 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, primary, von Scheidt, Bianca, primary, Dominguez, Pilar M., primary, Harrison, Aaron J., primary, Tantalo, Daniela G.M., primary, Kang, Jian, primary, Oliver, Amanda J., primary, Chan, Jack D., primary, Du, Xin, primary, Bai, Yuchen, primary, Lee, Belinda, primary, Johnstone, Ricky W., primary, Darcy, Phillip K., primary, Kershaw, Michael H., primary, and Slaney, Clare Y., primary

Published
2023
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19. Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

Author

Salmon, Jessica M., primary, Todorovski, Izabela, additional, Stanley, Kym L., additional, Bruedigam, Claudia, additional, Kearney, Conor J., additional, Martelotto, Luciano G., additional, Rossello, Fernando, additional, Semple, Timothy, additional, Arnau, Gisela Mir, additional, Zethoven, Magnus, additional, Bots, Michael, additional, Bjelosevic, Stefan, additional, Cluse, Leonie A., additional, Fraser, Peter J., additional, Litalien, Veronique, additional, Vidacs, Eva, additional, McArthur, Kate, additional, Matthews, Antony Y., additional, Gressier, Elise, additional, de Weerd, Nicole A., additional, Lichte, Jens, additional, Kelly, Madison J., additional, Hogg, Simon J., additional, Hertzog, Paul J., additional, Kats, Lev M., additional, Vervoort, Stephin J., additional, De Carvalho, Daniel D., additional, Scheu, Stefanie, additional, Bedoui, Sammy, additional, Kile, Benjamin T., additional, Lane, Steven W., additional, Perkins, Andrew C., additional, Wei, Andrew H., additional, Dominguez, Pilar M., additional, and Johnstone, Ricky W., additional

Published
2022
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20. A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, additional, von Scheidt, Bianca, additional, Dominguez, Pilar M., additional, Harrison, Aaron J., additional, Tantalo, Daniela G.M., additional, Kang, Jian, additional, Oliver, Amanda J., additional, Chan, Jack D., additional, Du, Xin, additional, Bai, Yuchen, additional, Lee, Belinda, additional, Johnstone, Ricky W., additional, Darcy, Phillip K., additional, Kershaw, Michael H., additional, and Slaney, Clare Y., additional

Published
2021
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21. CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Author

Lelliott, Emily J., primary, Kong, Isabella Y., additional, Zethoven, Magnus, additional, Ramsbottom, Kelly M., additional, Martelotto, Luciano G., additional, Meyran, Deborah, additional, Zhu, Joe Jiang, additional, Costacurta, Matteo, additional, Kirby, Laura, additional, Sandow, Jarrod J., additional, Lim, Lydia, additional, Dominguez, Pilar M., additional, Todorovski, Izabela, additional, Haynes, Nicole M., additional, Beavis, Paul A., additional, Neeson, Paul J., additional, Hawkins, Edwin D., additional, McArthur, Grant A., additional, Parish, Ian A., additional, Johnstone, Ricky W., additional, Oliaro, Jane, additional, Sheppard, Karen E., additional, Kearney, Conor J., additional, and Vervoort, Stephin J., additional

Published
2021
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23. Epigenetic reprogramming of plasmacytoid dendritic cells drives type I interferon-dependent differentiation of acute myeloid leukemias for therapeutic benefit

Author

Salmon, Jessica M., primary, Todorovski, Izabela, additional, Vervoort, Stephin J., additional, Stanley, Kym L., additional, Kearney, Conor J., additional, Martelotto, Luciano, additional, Rossello, Fernando, additional, Semple, Tim, additional, Mir-Arnau, Gisela, additional, Zethoven, Magnus, additional, Bots, Michael, additional, Vidacs, Eva, additional, McArthur, Kate, additional, Gressier, Elise, additional, de Weerd, Nicky, additional, Lichte, Jens, additional, Kelly, Madison J., additional, Cluse, Leonie, additional, Hogg, Simon J., additional, Hertzog, Paul J., additional, Kats, Lev, additional, de Carvalho, Daniel D., additional, Scheu, Stefanie, additional, Bedoui, Sammy, additional, Kile, Benjamin T., additional, Wei, Andrew, additional, Dominguez, Pilar M., additional, and Johnstone, Ricky W., additional

Published
2020
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25. TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis

Author

Dominguez, Pilar M., primary, Ghamlouch, Hussein, additional, Rosikiewicz, Wojciech, additional, Kumar, Parveen, additional, Béguelin, Wendy, additional, Fontán, Lorena, additional, Rivas, Martín A., additional, Pawlikowska, Patrycja, additional, Armand, Marine, additional, Mouly, Enguerran, additional, Torres-Martin, Miguel, additional, Doane, Ashley S., additional, Calvo Fernandez, María T., additional, Durant, Matt, additional, Della-Valle, Veronique, additional, Teater, Matt, additional, Cimmino, Luisa, additional, Droin, Nathalie, additional, Tadros, Saber, additional, Motanagh, Samaneh, additional, Shih, Alan H., additional, Rubin, Mark A., additional, Tam, Wayne, additional, Aifantis, Iannis, additional, Levine, Ross L., additional, Elemento, Olivier, additional, Inghirami, Giorgio, additional, Green, Michael R., additional, Figueroa, Maria E., additional, Bernard, Olivier A., additional, Aoufouchi, Said, additional, Li, Sheng, additional, Shaknovich, Rita, additional, and Melnick, Ari M., additional

Published
2018
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26. AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis

Author

Teater, Matt, primary, Dominguez, Pilar M., additional, Redmond, David, additional, Chen, Zhengming, additional, Ennishi, Daisuke, additional, Scott, David W., additional, Cimmino, Luisa, additional, Ghione, Paola, additional, Chaudhuri, Jayanta, additional, Gascoyne, Randy D., additional, Aifantis, Iannis, additional, Inghirami, Giorgio, additional, Elemento, Olivier, additional, Melnick, Ari, additional, and Shaknovich, Rita, additional

Published
2018
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29. AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis.

Author

Dominguez, Pilar M., Melnick, Ari, Shaknovich, Rita, Teater, Matt, Ghione, Paola, Redmond, David, Elemento, Olivier, Zhengming Chen, Ennishi, Daisuke, Scott, David W., Cimmino, Luisa, Aifantis, Iannis, Chaudhuri, Jayanta, Gascoyne, Randy D., and Inghirami, Giorgio

Subjects
CYTIDINE deaminase, EPIGENETICS, HETEROGENEITY, GERMINAL centers, DIFFUSE large B-cell lymphomas
Abstract

Epigenetic heterogeneity is emerging as a feature of tumors. In diffuse large B-cell lymphoma (DLBCL), increased cytosine methylation heterogeneity is associated with poor clinical outcome, yet the underlying mechanisms remain unclear. Activation-induced cytidine deaminase (AICDA), an enzyme that mediates affinity maturation and facilitates DNA demethylation in germinal center (GC) B cells, is required for DLBCL pathogenesis and linked to inferior outcome. Here we show that AICDA overexpression causes more aggressive disease in BCL2-driven murine lymphomas. This phenotype is associated with increased cytosine methylation heterogeneity, but not with increased AICDA-mediated somatic mutation burden. Reciprocally, the cytosine methylation heterogeneity characteristic of normal GC B cells is lost upon AICDA depletion. These observations are relevant to human patients, since DLBCLs with high AICDA expression manifest increased methylation heterogeneity vs. AICDA-low DLBCLs. Our results identify AICDA as a driver of epigenetic heterogeneity in Bcell lymphomas with potential significance for other tumors with aberrant expression of cytidine deaminases. [ABSTRACT FROM AUTHOR]

Published
2018
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