1. The plateau at V˙ O2max is associated with anaerobic alleles
- Author
-
Dan Gordon and Don Keiller
- Subjects
medicine.medical_specialty ,Significant difference ,Physical Therapy, Sports Therapy and Rehabilitation ,030229 sport sciences ,Biology ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Polymorphism (computer science) ,Internal medicine ,Exercise performance ,medicine ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Allele ,Anaerobic capacity ,Literature survey ,Anaerobic exercise ,Allele frequency - Abstract
Objectives This study tests the hypothesis that individuals who achieve a plateau at V ˙ O2max ( V ˙ O2plat) are more likely to possess alleles, associated with anaerobic capacity, than those who do not. Design A literature survey, physiological testing and genetic analysis was used to determine any association between the aerobic and anaerobic polymorphisms of 40 genes and V ˙ O2plat. Methods 34, healthy, Caucasian volunteers, completed an exercise test to determine V ˙ O2max, and V ˙ O2plat. 28 of the volunteers agreed to DNA testing and 26 were successfully genotyped. A literature search was used to determine whether the 40 polymorphisms analysed were associated with aerobic, or anaerobic exercise performance. Results The literature survey enabled classification of the 40 target alleles as aerobic [11], anaerobic [24], or having no apparent association (NAA) [5] with exercise performance. It also found no previous studies linking a genetic component with the ability to achieve V ˙ O2plat. Independent t-tests showed a significant difference (p V ˙ O2plat, but no other measured physiological variable was significantly different. Pearson’s χ2 testing demonstrated a highly significant association (p = 0.008) between anaerobic allele frequency and V ˙ O2plat, but not with V ˙ O2max. There was no association between aerobic alleles and V ˙ O2plat, or V ˙ O2max. Finally there were no significant differences in the allelic frequencies, observed in this study and those expected of Northern and Western European Caucasians. Conclusion These results support the hypothesis that the ability to achieve V ˙ O2plat is associated with alleles linked to anaerobic exercise capacity.
- Published
- 2020