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2. Hydrogen deuterium mass spectrometry in drug discovery

Author

Nino Campobasso and Donald Huddler

Subjects
Hydrogen, Drug discovery, Solution state, Organic Chemistry, Clinical Biochemistry, Analytical chemistry, Deuterium Exchange Measurement, Pharmaceutical Science, chemistry.chemical_element, Amide proton, Mass spectrometry, Biochemistry, Mass Spectrometry, Deuterium, chemistry, Structural biology, Computational chemistry, Drug Discovery, Molecular Medicine, Hydrogen–deuterium exchange, Molecular Biology
Abstract

Hydrogen deuterium exchange mass spectrometry (HDX-MS) has become an increasingly routine technology for probing the solution structure and dynamics of proteins. HDX-MS measures the exchange of deuterium with the amide proton on the protein backbone chain. HDX-MS results can be used to aid in construct design for biophysical studies, to probe protein–ligand interactions and to characterize the dynamics of proteins. This digest highlights recent progress which makes this technology accessible and explores examples of HDX-MS in drug discovery and solution state structural biology.

Published
2015

4. ChemInform Abstract: Hydrogen Deuterium Mass Spectrometry in Drug Discovery

Author

Donald Huddler and Nino Campobasso

Subjects
Structural biology, Hydrogen, Deuterium, Chemistry, Drug discovery, Computational chemistry, Solution state, Amide proton, chemistry.chemical_element, Hydrogen–deuterium exchange, General Medicine, Mass spectrometry
Abstract

Hydrogen deuterium exchange mass spectrometry (HDX-MS) has become an increasingly routine technology for probing the solution structure and dynamics of proteins. HDX-MS measures the exchange of deuterium with the amide proton on the protein backbone chain. HDX-MS results can be used to aid in construct design for biophysical studies, to probe protein–ligand interactions and to characterize the dynamics of proteins. This digest highlights recent progress which makes this technology accessible and explores examples of HDX-MS in drug discovery and solution state structural biology.

Published
2015

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