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2 results on '"Donatella Calvani"'

1. Operationalizing mild cognitive impairment criteria in small vessel disease: The VMCI-Tuscany Study

Author

Antonio Giorgio, Stefano Magnolfi, Guido Gori, Laura Stromillo, Enza Zicari, Renato Galli, Patrizia Formichi, Emilia Salvadori, Francesca Cesari, Stefania Brotini, Roberto Marconi, Rossana Tassi, Alessandro Rossi, Luca Massacesi, Marco Vista, Serena Nannucci, Maria Boddi, Anna Maria Gori, Francesca Pescini, Veronica Caleri, Gloria Tognoni, Nicola De Stefano, Carlo Biagini, Renzo Cisbani, Sandro Marini, Stefania Boschi, Antonella Notarelli, Claudia Pozzi, Paola Vanni, Claudia Gambetti, Paolo Zolo, Carla Giorgi, Laura Bracco, Stefania Mugnai, Giovanni Pracucci, Tiziano Borgogni, Filippo Baldacci, Sandro Sorbi, Giuseppe Meucci, Domenico Inzitari, Giovanni Orlandi, Giovanna Bellini, Leonardo Pantoni, Ilaria Di Donato, Rosanna Abbate, Luciano Gabrielli, Laura Ciolli, Francesca Rossi, Francesco Pinto, Carlo Valente, Alberto Chiti, Ubaldo Bonuccelli, Cristina Frittelli, Gabriele Siciliano, Mario Mancuso, Massimo Cadelo, Antonio Federico, Gaetano Zaccara, Raffaella Valenti, Pasquale Palumbo, Stefano Bartolini, Paolo Cecchi, Stefano Diciotti, Andrea Ginestroni, Mario Mascalchi, Monica Mazzoni, Donatella Calvani, Luciano Gabbani, Anna Poggesi, Leonello Guidi, Maria Lombardi, Maristella Piccininni, Marco Paganini, Marco Pasi, Enrico Mossello, Alessandro Tiezzi, Mirco Cosottini, Mirella Coppo, Maria Teresa Dotti, E Bertini, Betti Giusti, Lorella Lambertucci, G Gambaccini, Cristina Pagni, Alessandra Del Bene, Salvadori, Emilia, Poggesi, Anna, Valenti, Raffaella, Pracucci, Giovanni, Pescini, Francesca, Pasi, Marco, Nannucci, Serena, Marini, Sandro, Del Bene, Alessandra, Ciolli, Laura, Ginestroni, Andrea, Diciotti, Stefano, Orlandi, Giovanni, Di Donato, Ilaria, De Stefano, Nicola, Cosottini, Mirco, Chiti, Alberto, Federico, Antonio, Dotti, Maria Teresa, Bonuccelli, Ubaldo, Inzitari, Domenico, and Pantoni, Leonardo

Subjects
Male, Epidemiology, Cerebrovascular disease, Cognitive aging, Mild cognitive impairment, Neuropsychology, Vascular dementia, Health Policy, Developmental Neuroscience, Geriatrics and Gerontology, Neurology (clinical), Cellular and Molecular Neuroscience, Psychiatry and Mental Health, Neuropsychological Tests, 0302 clinical medicine, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, medicine.diagnostic_test, Magnetic Resonance Imaging, White Matter, Temporal Lobe, medicine.anatomical_structure, Italy, Disease Progression, Cardiology, Female, Psychology, medicine.medical_specialty, Prodromal Symptoms, behavioral disciplines and activities, Temporal lobe, White matter, 03 medical and health sciences, Atrophy, Neuroimaging, Internal medicine, mental disorders, medicine, Humans, Cognitive Dysfunction, Psychiatry, Aged, Magnetic resonance imaging, medicine.disease, nervous system diseases, Cerebrovascular Disorders, human activities, 030217 neurology & neurosurgery
Abstract

Introduction Mild cognitive impairment (MCI) prodromic of vascular dementia is expected to have a multidomain profile. Methods In a sample of cerebral small vessel disease (SVD) patients, we assessed MCI subtypes distributions according to different operationalization of Winblad criteria and compared the neuroimaging features of single versus multidomain MCI. We applied three MCI diagnostic scenarios in which the cutoffs for objective impairment and the number of considered neuropsychological tests varied. Results Passing from a liberal to more conservative diagnostic scenarios, of 153 patients, 5% were no longer classified as MCI, amnestic multidomain frequency decreased, and nonamnestic single domain increased. Considering neuroimaging features, severe medial temporal lobe atrophy was more frequent in multidomain compared with single domain. Discussion Operationalizing MCI criteria changes the relative frequency of MCI subtypes. Nonamnestic single domain MCI may be a previously nonrecognized type of MCI associated with SVD.

Published
2016

2. Disease Severity and Health-Related Quality of Life Across Different Chronic Conditions

Author

Walter De Alfieri, Samuele Baldasseroni, Stefania Bandinelli, Alessandro Cartei, Giulio Masotti, Donatella Calvani, Niccolò Marchionni, Luigi Ferrucci, and Alessio Baldini

Subjects
Male, medicine.medical_specialty, Coronary Disease, Comorbidity, macromolecular substances, Disease, Severity of Illness Index, Quality of life, Rating scale, Sickness Impact Profile, Severity of illness, medicine, Humans, Outpatient clinic, Geriatric Assessment, Stroke, Aged, Vascular disease, business.industry, Parkinson Disease, medicine.disease, Chronic Disease, Linear Models, Quality of Life, Physical therapy, Female, Geriatrics and Gerontology, business
Abstract

OBJECTIVES Measurements of health-related quality of life (HRQL) are an essential component in overall assessment of health status, particularly in older patients. Nevertheless, how measures of HRQL relate to measures of disease severity is largely unexplored. This study was carried out to explore the relationship between a measure of HRQL and measures of severity of ischemic stroke, Parkinson's diseases (PD), or chronic coronary heart disease (CHD). DESIGN AND SETTING Cross-sectional analysis of three groups (54 subjects each) of patients aged > or = 65 years consecutively referred to outpatient clinics for stroke, PD, or CHD, excluding those with cognitive impairment and severe comorbidity. MEASUREMENTS Severity of stroke, PD, and CHD assessed by Fugl-Meyer Scale (FMS), Webster Rating Scale (WBRS), and total work capacity (TWC, from graded exercise test), respectively. HRQL was determined by the Sickness Impact Profile (SIP). RESULTS In PD, WBRS correlated linearly with SIP global score, whereas a significant linear relationship between measures of disease severity and SIP score was limited to the least severely diseased stroke (FMS score>160) and the most severely diseased CHD (TWC

Published
2000

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