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9. Novel insights into the BAP1-inactivated melanocytic tumor

Author

Donati, Michele, Martinek, Petr, Steiner, Petr, Grossmann, Petr, Vanecek, Tomas, Kastnerova, Liubov, Kolm, Isabel, Baneckova, Martina, Donati, Pietro, Kletskaya, Irina, Kalmykova, Antonina, Feit, Josef, Blasch, Petr, Szilagyi, Diana, Baldi, Alfonso, Persichetti, Paolo, Crescenzi, Anna, Michal, Michal, and Kazakov, Dmitry V.

Published
2022
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10. Routes to sustainability in public food procurement: An investigation of different models in primary school catering

Author

Tregear, Angela, Aničić, Zorica, Arfini, Filippo, Biasini, Beatrice, Bituh, Martina, Bojović, Ratko, Brečić, Ružica, Brennan, Mary, Colić Barić, Irena, Del Rio, Daniele, Donati, Michele, Filipović, Jelena, Giopp, Francesca, Ilić, Ana, Lanza, Gianluca, Mattas, Konstadinos, Quarrie, Steve, Rosi, Alice, Sayed, Maysara, Scazzina, Francesca, and Tsakiridou, Efthimia

Published
2022
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12. The economic, environmental and social performance of European certified food

Author

Bellassen, Valentin, Drut, Marion, Hilal, Mohamed, Bodini, Antonio, Donati, Michele, de Labarre, Matthieu Duboys, Filipović, Jelena, Gauvrit, Lisa, Gil, José M., Hoang, Viet, Malak-Rawlikowska, Agata, Mattas, Konstadinos, Monier-Dilhan, Sylvette, Muller, Paul, Napasintuwong, Orachos, Peerlings, Jack, Poméon, Thomas, Tomić Maksan, Marina, Török, Áron, Veneziani, Mario, Vittersø, Gunnar, and Arfini, Filippo

Published
2022
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13. Nutritional, environmental and economic implications of children plate waste at school: a comparison between two Italian case studies

Author

Biasini, Beatrice, primary, Donati, Michele, additional, Rosi, Alice, additional, Giopp, Francesca, additional, Colić Barić, Irena, additional, Bituh, Martina, additional, Brečić, Ružica, additional, Brennan, Mary, additional, Ilić, Ana, additional, Quarrie, Steve, additional, Sayed, Maysara, additional, Tregear, Angela, additional, Menozzi, Davide, additional, and Scazzina, Francesca, additional

Published
2024
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14. Common Methods and Sustainability Indicators

Author

Bellassen, Valentin, Antonioli, Federico, Bodini, Antonio, Donati, Michele, Drut, Marion, de Labarre, Matthieu Duboys, Hilal, Mohamed, Monier-Dilhan, Sylvette, Muller, Paul, Poméon, Thomas, Veneziani, Mario, Arfini, Filippo, editor, and Bellassen, Valentin, editor

Published
2019
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17. Conceptual Framework

Author

Arfini, Filippo, Antonioli, Federico, Donati, Michele, Gorton, Matthew, Mancini, Maria Cecilia, Tocco, Barbara, Veneziani, Mario, Arfini, Filippo, editor, and Bellassen, Valentin, editor

Published
2019
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31. Melanocytic Neoplasm With KITand APCMutations: A New Subtype of Melanocytoma?

Author

Donati, Michele, Grossmann, Petr, Mansour, Boulos, and Kazakov, Dmitry V.

Abstract

We report a very unusual case of melanocytic neoplasm appearing clinically as a 0.5-cm dome-shaped pigmented papule on the chest of a 63-year-old man. Microscopically, it was an asymmetric, entirely dermally based neoplasm characterized by a multinodular, vaguely plexiform architecture composed of moderately pleomorphic spindled melanocytes with ample, dusty pigmented cytoplasm and scattered multinucleated cells. The tumor cells were strongly positive for Melan-A, HMB45, S100, and PRAME, whereas p16 showed diffuse nuclear loss. β-catenin presented a strong and diffuse cytoplasmic staining, while nuclei were negative. Despite an increased cellularity, mitotic count was low (1/mm2). Fluorescence in situ hybridization revealed no copy number alteration in melanoma-related genes (CDKN2A, MYB, MYC, CCND1and RREB1). DNA and RNA sequencing identified KITc.2458G>T and APCc.6709C>T mutations. No further genetic alteration was detected including TERT-promoter (TERT-p) hot-spot mutation. A re-excision was performed. A sentinel lymph node biopsy was negative. Clinical investigations revealed no extracutaneous involvement. The patient is disease-free after a follow-up period of 8 months. Given the peculiar morphologic and molecular findings, we hypothesize the lesion may represent a novel subtype of an intermediate grade melanocytic tumor (melanocytoma).

Published
2024
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32. Spitz tumor with SQSTM1::NTRK2 fusion : a clinicopathological study of 5 cases

Author

Mansour, Boulos, Vanecek, Tomas, Kastnerova, Liubov, Nosek, Daniel, Kazakov, Dmitry V., Donati, Michele, Mansour, Boulos, Vanecek, Tomas, Kastnerova, Liubov, Nosek, Daniel, Kazakov, Dmitry V., and Donati, Michele

Abstract

Spitz tumors are melanocytic neoplasms characterized by specific, mutually exclusive driver molecular events, namely genomic rearrangements involving the threonine kinase BRAF and the tyrosine kinase receptors ALK , NTRK1 , NTRK2 , NTRK3 , MET , RET , ROS1 , and MAP3K8 or less commonly, mutations in HRAS or MAP2K1 . We hereby report 5 Spitz tumors with a SQSTM1::NTRK2 fusion. All patients were woman with the ages at diagnosis ranging from 30 to 50 years. Locations included the lower extremity (n = 3), forearm, and back (one each). All the neoplasms were superficial melanocytic proliferation with a flat to dome-shaped silhouette, in which junctional spindled and polygonal dendritic melanocytes were mainly arranged as horizontal nests associated with conspicuous lentiginous involvement of the follicular epithelium. Only one case showed heavily pigmented, vertically oriented melanocytic nests resembling Reed nevus. A superficial intradermal component observed in 2 cases appeared as small nests with a back-to-back configuration. In all lesions, next-generation sequencing analysis identified a SQSTM1::NTRK2 fusion. A single case studied with fluorescence in situ hybridization for copy number changes in melanoma-related genes proved negative. No further molecular alterations were detected, including TERT-p hotspot mutations.

Published
2023
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38. Plaque-type verrucous porokeratosis of the back

Author

Paolino, Giovanni, primary, Mercuri, Santo Raffaele, additional, Mansour, Boulos, additional, Di Nicola, Matteo Riccardo, additional, Carrera, Manuela, additional, Taccogna, Silvia, additional, Bianchi, Vittoria Giulia, additional, Donati, Pietro, additional, and Donati, Michele, additional

Published
2022
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40. Dermatoscopic, Histological and Confocal Microscopic Analysis of a Kissing Nevus of the Penis.

Author

Bianchi, Alexander, Baldi, Alfonso, Farabini, Andrea, Nibid, Lorenzo, Roberti, Vincenzo, Pellacani, Giovanni, Kazakov, Dmitry V., and Donati, Michele

Subjects
MICROSCOPY, PENIS, KISSING, EMBRYOLOGY, CONFOCAL microscopy, NEVUS
Abstract

Kissing nevus is a congenital melanocytic neoplasm arising in those parts of the body that split at some point during embryological development (i.e., eyelid; penis), resulting in two adjacent melanocytic nevi. To date, 23 cases of kissing nevus of the penis have been described, and dermatoscopic and histological findings are available in 4/23 cases. We report a dermatoscopic, histological and confocal microscopic analysis in a new case of the kissing nevus of the penis in a 57 years old man. Dermatoscopic analysis showed large globules in the central area and a peripheral pigment network; the histological examination confirmed the presence of an intradermal melanocytic nevus with minimal junctional component and congenital features. Moreover, we reported, for the first time, confocal microscopy findings in the kissing nevus of the penis, revealing the presence of dendritic cells in correspondence with the epidermis and suggesting a state of cellular activity. Considering the clinicopathological features of the lesion, a conservative approach was adopted, and a clinical follow-up was planned after six months. [ABSTRACT FROM AUTHOR]

Published
2023
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41. The economic, environmental and social performance of European certified food

Author

Universitat Politècnica de Catalunya. Departament d'Enginyeria Agroalimentària i Biotecnologia, Universitat Politècnica de Catalunya. CREDA-UPC-IRTA - Centre de Recerca en Economia i Desenvolupament Agroalimentari UPC-IRTA, Bellassen, Valentin, Bodini, Antonio, Drut, Marion, Hilal, Mohammed, Viet, Hoang Nguyen, Donati, Michele, Duboys de Labarre, Matthieu, Gauvrit, Lisa, Torok, A, Arfini, Filippo, Gil Roig, José María, Universitat Politècnica de Catalunya. Departament d'Enginyeria Agroalimentària i Biotecnologia, Universitat Politècnica de Catalunya. CREDA-UPC-IRTA - Centre de Recerca en Economia i Desenvolupament Agroalimentari UPC-IRTA, Bellassen, Valentin, Bodini, Antonio, Drut, Marion, Hilal, Mohammed, Viet, Hoang Nguyen, Donati, Michele, Duboys de Labarre, Matthieu, Gauvrit, Lisa, Torok, A, Arfini, Filippo, and Gil Roig, José María

Abstract

To identify whether EU certified food – here organic and geographical indications – is more sustainable than a conventional reference, we developed indicators covering the three sustainability pillars. Original data was collected on 52 products at farm, processing and retail levels, allowing the estimation of circa 2,000 indicator values. Most strikingly, we show that, in our sample, certified food outperforms its non-certified reference on most economic and social indicators. On major environmental indicators – carbon and water footprint – their performance is similar., Objectius de Desenvolupament Sostenible::12 - Producció i Consum Responsables, Postprint (updated version)

Published
2022

42. Somatic and germline molecular analysis and morphological aspects of unusual variants of malignant melanomas and uncommon melanocytic neoplasms

Author

Donati, Michele, Skálová, Alena, Baldi, Alfonso, and Paolino, Giovanni

Abstract

Somatic and germline molecular analysis and morphological aspects of unusual variants of malignant melanomas and uncommon melanocytic neoplasms Abstract Background: The histopathological diagnosis of melanocytic tumors represented one of the greatest challenges of pathology. In the last years, the concept of melanoma as a single entity have been questioned. In fact, several subgroups of melanocytic neoplasms have been recognized on the bases of their clinical and histological presentation. The microscopic assessment of these lesions is based upon the detection of a constellation of morphological features, some of which lack interobserver reproducibility. In recent years, thanks to the development of molecular biology, a significant step forward has been made in the diagnosis of melanocytic neoplasms. Considering clinicopathological and genetic data some authors have suggested a stepwise model of evolution of melanocytic neoplasm to melanoma from a conventional nevus. Moreover, in the era of precision medicine, several efforts are being made to identify molecular biomarkers to predict prognosis. These biomarkers can be detected also in germline status of the patients to identify predisposing factors to tumor development. Aims: Primary aim of our projects is to perform of molecular analysis on morphologically...

Published
2022

43. Measuring and comparing the carbon footprints of different procurement models for primary school meals:Analysis of cases across five European countries

Author

Tregear, Angela, Sayed, Maysara, Brennan, Mary, Brečić, Ružica, Barić, Irena Colić, Lučić, Andrea, Bituh, Martina, Ilić, Ana, Sinčić Ćorić, Dubravka, Tsakiridou, Efthimia, Mattas, Konstadinos, Papadopoulos, I., Arfini, Filippo, Biasini, Beatrice, Del Rio, Daniele, Donati, Michele, Giopp, Francesca, Lanza, Gianluca, Rosi, Alice, Scazzina, Francesca, Filipović, Jelena, Aničić, Zorica, Quarrie, Steve, Bojović, Ratko, Swensson, Luana F. J., Hunter, Danny, Schneider, Sergio, and Tartanac, Florence

Abstract

The study presented in this chapter sought to assess the sustainability outcomes of different procurement models for primary school meals services in five European countries. Based on environmental impact analysis, this chapter reports on the size and composition of the carbon footprints of the procurement models and analyses the contributions to overall carbon emissions of the various activities in the supply chains for meals services. It was found that while the transportation of food by suppliers to schools contributed somewhat to overall carbon footprints, other variables have a more significant impact, in particular the amount of meat on the menu and the choice of waste disposal method. The chapter concludes by discussing which actions stakeholders should prioritize to improve the environmental impacts of public food procurement. The research for this chapter was funded under European Union H2020 grant agreement 678024.

Published
2021
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44. Sustainability Performance of Certified and Non-certified Food

Author

Bellassen, Valentin, Arfini, Filippo, Antonioli, Federico, Bodini, Antonio, Boehm, Michael, Brečić, Ružica, Chiussi, Sara, Csillag, Peter, Donati, Michele, Dries, Liesbeth, Drut, Marion, Duboys de Labarre, Matthieu, Ferrer, Hugo, Filipović, Jelena, Gauvrit, Lisa, Gil, José, Gorton, Matthew, Hoàng, Viet, Hilal, Mohamed, Steinnes, Kamilla Knutsen, Lilavanichakul, Apichaya, Malak-Rawlikowska, Agata, Majewski, Edward, Monier-Dilhan, Sylvette, Muller, Paul, Napasintuwong, Orachos, Nikolaou, Kalliroi, Nguyen, Mai, Quỳnh, An Nguyễn, Papadopoulos, Ioannis, Peerlings, Jack, Török, Aron, Poméon, Thomas, Ristic, Bojan, Schaer, Burkhard, Stojanovic, Zaklina, Tocco, Barbara, Maksan, Marina Tomic, Veneziani, Mario, Vitterso, Gunnar, Centre d'Economie et de Sociologie Rurales Appliquées à l'Agriculture et aux Espaces Ruraux (CESAER), AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Parma = Università degli studi di Parma [Parme, Italie], ECOZEPT, Montpellier, France, Faculty of Economics [Zagreb], University of Zagreb, Corvinus University of Budapest, Wageningen University and Research [Wageningen] (WUR), Centre for Agro-Food Economy & Development, UPC-IRTA, Castelldefels, Spain (CREDA), Université polytechnique de Catalogne (UPC), University of Belgrade [Belgrade], Newcastle University [Newcastle], School of Economics, University of Economics Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam, Oslo Metropolitan University (OsloMet), Kasetsart University (KU), Warsaw University of Life Sciences (SGGW), Observatoire des Programmes Communautaires de Développement Rural (US ODR), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Bureau d'Économie Théorique et Appliquée (BETA), Université de Strasbourg (UNISTRA)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Aristotle University of Thessaloniki

Subjects
Protected geographical indication, Organic farming, [SHS.ENVIR]Humanities and Social Sciences/Environmental studies, Protected designation of origin, Certified food, Social performance, Sustainability performance, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Economic performance, Environmental performance
Abstract

International audience; The dataset Sustainability performance of certified and non-certified food (https://www.doi.org/10.15454/OP51SJ) contains 25 indicators of economic, environmental, sustainability performance and social performance, estimated for 27 certified food value chains and their 27 conventional reference products. The indicators are estimated at different levelsof the value chain: farm level, processing level, and retail level. It also contains the raw data based on which the indicators are estimated, its source, and the completed spreadsheet calculators for the following indicators: carbon footprint and food miles. This article describes the common method and indicators used to collect data for the twenty-seven certified products and their conventional counterparts. It presents the assumptions and choices, the process of data collection, and the indicator estimation methods designed to assess the three sustainability dimensions within a reasonable time constraint. That is: three person-months for each food quality scheme and its noncertified reference product. Several prioritisations were set regarding data collection (indicator, variable, value chain level) together with a level of representativeness specific to each variable and product type (country and sector). Technical details on how relatively common variables (e.g., number of animals per hectare) are combined into indicators (e.g., carbon footprint) are provided in the full documentation of the dataset.This is an open access article distributed under the terms of the CC BY 4.0 license.

Published
2021
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45. Sustainability Performance of Certified and Non-certified Food

Author

Bellassen, Valentin, primary, Arfini, Filippo, additional, Antonioli, Federico, additional, Bodini, Antonio, additional, Boehm, Michael, additional, Brečić, Ružica, additional, Chiussi, Sara, additional, Csillag, Peter, additional, Donati, Michele, additional, Dries, Liesbeth, additional, Drut, Marion, additional, de Labarre, Matthieu Duboys, additional, Ferrer, Hugo, additional, Filipović, Jelena, additional, Gauvrit, Lisa, additional, Gil, José M., additional, Gorton, Matthew, additional, Hoàng, Viet, additional, Hilal, Mohamed, additional, Steinnes, Kamilla Knutsen, additional, Lilavanichakul, Apichaya, additional, Malak-Rawlikowska, Agata, additional, Majewski, Edward, additional, Monier-Dilhan, Sylvette, additional, Muller, Paul, additional, Napasintuwong, Orachos, additional, Nikolaou, Kalliroi, additional, Nguyen, Mai, additional, Quỳnh, An Nguyễn, additional, Papadopoulos, Ioannis, additional, Peerlings, Jack, additional, Török, Aron, additional, Poméon, Thomas, additional, Ristic, Bojan, additional, Schaer, Burkhard, additional, Stojanovic, Zaklina, additional, Tocco, Barbara, additional, Maksan, Marina Tomic, additional, Veneziani, Mario, additional, and Vitterso, Gunnar, additional

Published
2021
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47. Basal cell carcinoma thickness evaluated by high-frequency ultrasounds and correlation with dermoscopic features

Author

COPPOLA, Rosa, primary, BARONE, Mauro, additional, ZANFRAMUNDO, Salvatore, additional, DEVIRGILIIS, Valeria, additional, ROBERTI, Vincenzo, additional, PERRELLA, Eleonora, additional, DONATI, Michele, additional, PALESE, Enzo, additional, TENNA, Stefania, additional, PERSICHETTI, Paolo, additional, and PANASITI, Vincenzo, additional

Published
2021
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48. Spitz Tumor With SQSTM1::NTRK2Fusion: A Clinicopathological Study of 5 Cases

Author

Mansour, Boulos, Vanecek, Tomas, Kastnerova, Liubov, Nosek, Daniel, Kazakov, Dmitry V., and Donati, Michele

Abstract

Spitz tumors are melanocytic neoplasms characterized by specific, mutually exclusive driver molecular events, namely genomic rearrangements involving the threonine kinase BRAFand the tyrosine kinase receptors ALK, NTRK1, NTRK2, NTRK3, MET, RET, ROS1, and MAP3K8or less commonly, mutations in HRASor MAP2K1. We hereby report 5 Spitz tumors with a SQSTM1::NTRK2fusion. All patients were woman with the ages at diagnosis ranging from 30 to 50 years. Locations included the lower extremity (n = 3), forearm, and back (one each). All the neoplasms were superficial melanocytic proliferation with a flat to dome-shaped silhouette, in which junctional spindled and polygonal dendritic melanocytes were mainly arranged as horizontal nests associated with conspicuous lentiginous involvement of the follicular epithelium. Only one case showed heavily pigmented, vertically oriented melanocytic nests resembling Reed nevus. A superficial intradermal component observed in 2 cases appeared as small nests with a back-to-back configuration. In all lesions, next-generation sequencing analysis identified a SQSTM1::NTRK2fusion. A single case studied with fluorescence in situ hybridization for copy number changes in melanoma-related genes proved negative. No further molecular alterations were detected, including TERT-photspot mutations.

Published
2023
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50. BAP1-Inactivated Melanoma Arising From BAP1-Inactivated Melanocytic Tumor in a Patient With BAP1Germline Mutation: A Case Report and Review of the Literature

Author

Donati, Michele, Šteiner, Petr, and Kazakov, Dmitry V.

Abstract

BAP1-inactivated melanocytic tumors represent a subset of epithelioid melanocytic neoplasms resulting from biallelic inactivation of the BAP1gene and by a driver mutation that activate the MAP kinase pathway, most commonly BRAFV600E. They occur sporadically or, less common, in the setting of BAP1tumor predisposition syndrome caused by a BAP1germline mutation that predisposes to several malignancies including cutaneous and uveal melanoma. To date, only few cases of BAP1-inactivated melanomas have been reported. We present a case of a 35-year-old woman presented with a melanocytic lesion microscopically composed of 3 distinct melanocytic populations, suggesting a stepwise progression model to melanoma from a conventional nevus through a melanocytoma stage. This progression was also supported from a molecular viewpoint given BRAFV600E, BAP1, and TERT-phot spot mutations detected by targeted mutational analysis. Four atypical melanocytic lesions were removed from the patient's back, and the same A BAP1c.856A>T, p.(Lys286Ter) mutation was detected on either tumoral or normal tissue samples. To the best of our knowledge, this is the first case of BAP1-inactivated melanoma with a documented TERT-phot spot mutation manifesting as the first presentation of BAP1tumor predisposition syndrome.

Published
2023
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