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Your search keyword '"Donde, Nikunj N."' showing total 9 results
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9 results on '"Donde, Nikunj N."'

2. Changing tides: A vascular surgery trainee perspective on the #MedBikini Campaign and a call for action

Author

DiLosa, Kathryn, primary, Drudi, Laura M., additional, DiLosa, Kathryn, additional, Hata, Kai, additional, Devrome, Andrea N., additional, Yang, Yang, additional, Shraga, Sarrina, additional, Blakely, Channa, additional, Zaza, Sarah, additional, Kinio, Anna, additional, Kim, Gloria Y., additional, Andraska, Elizabeth, additional, Phillips, Amanda R., additional, Summers, Kelli, additional, Sethi, Danielle, additional, Kim, Joyce J., additional, Rojas, Elianne, additional, Newhall, Karina, additional, Thayer, Angelyn, additional, MacCallum, Katherine, additional, Lubitz, Andrea L., additional, Liao, Jane, additional, Kochubey, Mariya, additional, Pappas, Georgina M., additional, Concha-Moore, Kirsten, additional, Gonzalez, Kathy, additional, Rea, Jessica Nicole, additional, Grafmuller, Leanne, additional, Ilyas, Sadia, additional, Scully, Rebecca, additional, Jones, Melissa, additional, Boudreau, Catherine, additional, Strauss, Shira, additional, Keller, Melissa R., additional, Story, Lauren, additional, Loh, Sarah, additional, George, Elizabeth L., additional, Ho, Vy Thuy, additional, Brathwaite, Shayna, additional, Jokisch, Christine, additional, Lee Fierro, Allegra, additional, Dunphy, Kaitlyn, additional, Kumar, Shivani, additional, Powell, Chloé, additional, Dufresne, Laurence, additional, Raju, Sneha, additional, Balogun, Yetunde, additional, Minisandram, Aarathi, additional, Lee, Mary, additional, Peng, Kate, additional, Mai, Trinh, additional, Beliveau, Lauren, additional, Kenney, Kevin P., additional, Doonan, R.J., additional, Ayeed, Saad Bin, additional, Schroeder, Andrew C., additional, Fortin, William, additional, Locham, Satinderjit S., additional, Balceniuk, Mark D., additional, Kanna, Sreedharan, additional, Davidson, Anders J., additional, Hanna, Paul, additional, Donde, Nikunj N., additional, Kim, Young, additional, Jacob-Brassard, Jean, additional, Robinson, Scott, additional, Desai, Kash, additional, Braet, Drew, additional, Audu, Chris, additional, Hemingway, Jake, additional, and Nkansah, Reginald, additional

Published
2020
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6. Early development and replacement of the stickleback dentition

Author

Ellis, Nicholas A., Donde, Nikunj N., and Miller, Craig T.

Subjects
stomatognathic diseases, Time Factors, stomatognathic system, Jaw, Animals, Dentition, Gene Expression Regulation, Developmental, Pharynx, Tooth, Article, Smegmamorpha
Abstract

Teeth have long served as a model system to study basic questions about vertebrate organogenesis, morphogenesis, and evolution. In nonmammalian vertebrates, teeth typically regenerate throughout adult life. Fish have evolved a tremendous diversity in dental patterning in both their oral and pharyngeal dentitions, offering numerous opportunities to study how morphology develops, regenerates, and evolves in different lineages. Threespine stickleback fish (Gasterosteus aculeatus) have emerged as a new system to study how morphology evolves, and provide a particularly powerful system to study the development and evolution of dental morphology. Here, we describe the oral and pharyngeal dentitions of stickleback fish, providing additional morphological, histological, and molecular evidence for homology of oral and pharyngeal teeth. Focusing on the ventral pharyngeal dentition in a dense developmental time course of lab-reared fish, we describe the temporal and spatial consensus sequence of early tooth formation. Early in development, this sequence is highly stereotypical and consists of seventeen primary teeth forming the early tooth field, followed by the first tooth replacement event. Comparing this detailed morphological and ontogenetic sequence to that described in other fish reveals that major changes to how dental morphology arises and regenerates have evolved across different fish lineages. J. Morphol. 277:1072-1083, 2016. © 2016 Wiley Periodicals, Inc.

Published
2016

9. Distinct developmental genetic mechanisms underlie convergently evolved tooth gain in sticklebacks.

Author

Ellis, Nicholas A., Glazer, Andrew M., Donde, Nikunj N., Cleves, Phillip A., Agoglia, Rachel M., and Miller, Craig T.

Subjects
DENTITION, GASTEROSTEIFORMES, STICKLEBACKS, GENETICS, EMBRYOLOGY, MESENCHYMAL stem cells
Abstract

Teeth are a classic model system of organogenesis, as repeated and reciprocal epithelial and mesenchymal interactions pattern placode formation and outgrowth. Less is known about the developmental and genetic bases of tooth formation and replacement in polyphyodonts, which are vertebrates with continual tooth replacement. Here, we leverage natural variation in the threespine stickleback fish Gasterosteus aculeatus to investigate the genetic basis of tooth development and replacement. We find that two derived freshwater stickleback populations have both convergently evolved more ventral pharyngeal teeth through heritable genetic changes. In both populations, evolved tooth gain manifests late in development. Using pulse-chase vital dye labeling to mark newly forming teeth in adult fish, we find that both high-toothed freshwater populations have accelerated tooth replacement rates relative to low-toothed ancestral marine fish. Despite the similar evolved phenotype of more teeth and an accelerated adult replacement rate, the timing of tooth number divergence and the spatial patterns of newly formed adult teeth are different in the two populations, suggesting distinct developmental mechanisms. Using genome-wide linkage mapping in marine-freshwater F2 genetic crosses, we find that the genetic basis of evolved tooth gain in the two freshwater populations is largely distinct. Together, our results support a model whereby increased tooth number and an accelerated tooth replacement rate have evolved convergently in two independently derived freshwater stickleback populations using largely distinct developmental and genetic mechanisms. [ABSTRACT FROM AUTHOR]

Published
2015
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