360 results on '"Dong, Aiping"'
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2. The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition
3. A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors
4. A chemical probe to modulate human GID4 Pro/N-degron interactions
5. A resource to enable chemical biology and drug discovery of WDR Proteins
6. Structure–Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials
7. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization
8. Discovery of a Novel DCAF1 Ligand Using a Drug–Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets.
9. Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex
10. Early Embryonic Establishment of Constitutive Heterochromatin Involves H3K14ac-mediated Recruitment of Eggless/SetDB1
11. Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning
12. Chemical Tools for the Gid4 Subunit of the Human E3 Ligase C-terminal to LisH (CTLH) Degradation Complex
13. Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen
14. Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory Neurons
15. Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X
16. Probing the mechanism of Cbl-b inhibition by a small-molecule inhibitor
17. Structure-activity relationship studies of G9a-like protein (GLP) inhibitors
18. Discovery of Nanomolar DCAF1 Small Molecule Ligands
19. From study abroad to study at home: Spontaneous neuronal activity predicts depressive symptoms in overseas students during the COVID-19 pandemic
20. Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complexElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00633f
21. Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4
22. Caltubin regulates microtubule stability via Ca2+-dependent mechanisms favouring neurite regrowth
23. A chemical probe to modulate human GID4 Pro/N-degron interactions
24. Structural and functional consequences of the STAT5BN642H driver mutation
25. Discovery of a Novel DCAF1 Ligand Using a Drug–Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets.
26. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells
27. Defining efficient enzyme–cofactor pairs for bioorthogonal profiling of protein methylation
28. Biochemical and Structural Studies of Conserved Maf Proteins Revealed Nucleotide Pyrophosphatases with a Preference for Modified Nucleotides
29. Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory Neurons
30. Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III
31. Survival‑related DLEU1 is associated with HPV infection status and serves as a biomarker in HPV‑infected cervical cancer
32. Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)
33. Correction to “Structure–Activity Relationship of USP5 Inhibitors”
34. Structural basis for the recognition of the S2, S5‐phosphorylated RNA polymerase II CTD by the mRNA anti‐terminator protein hSCAF4
35. Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status
36. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization
37. The human pseudouridine synthase PUS7 recognizes RNA with an extended multi-domain binding surface
38. Structure–Activity Relationship of USP5 Inhibitors
39. Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1
40. Histone and DNA binding ability studies of the NSD subfamily of PWWP domains
41. Structure and Function of a G-actin Sequestering Protein with a Vital Role in Malaria Oocyst Development inside the Mosquito Vector
42. Development of LM98, a Small‐Molecule TEAD Inhibitor Derived from Flufenamic Acid
43. Structure Activity Relationship of USP5 Allosteric Inhibitors
44. Structural basis for RNA 3′-end recognition by the PIWIL2 PAZ domain
45. Salvage or Recovery of Failed Targets by In Situ Proteolysis
46. Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization
47. Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains
48. A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6
49. Correction: A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion
50. Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19
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