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146 results on '"Dong, Lipeng"'

48. A Generation Framework of Multiple Evasions on IDS

Author

Dong Lipeng, Chen Xing-yuan, Tang Huilin, and Shi Wang

Subjects
Engineering, business.industry, Evasion (network security), Intrusion detection system, Computer security, computer.software_genre, Probability of success, Intrusion, Encoding (memory), Code (cryptography), business, computer, Host (network), Computer network
Abstract

Intrusion detection technology aimed at identifying hidden illegal intrusion by the analysis of network traffic. To an attacker, if he wants to send malicious code to a protected host in the internal network, he has to firstly evade the detection of the intrusion detection system (IDS). The IDS evasion techniques enable IDS produce omission or misstatement, can greatly increase the probability of success attacks. But after years of the contest between evasion and anti-evasion, individual evasions and random combined evasions is difficult to implement and also inefficient. This paper is committed to providing a systematic and scientific generation method for multiple evasions. Using this framework, we are able to design a complete system for IDS anti-evasion testing, and provide recommendations for giving IDS policies.

Published
2013
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49. Parthenolide Is Neuroprotective in Rat Experimental Stroke Model: Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability

Author

Dong, Lipeng, Qiao, Huimin, Zhang, Xiangjian, Zhang, Xiaolin, Wang, Chaohui, Wang, Lina, Cui, Lili, Zhao, Jingru, Xing, Yinxue, Li, Yanhua, Liu, Zongjie, and Zhu, Chunhua

Subjects
Male, Article Subject, Anti-Inflammatory Agents, Non-Steroidal, Caspase 1, NF-kappa B, Brain Edema, Infarction, Middle Cerebral Artery, Immunohistochemistry, p38 Mitogen-Activated Protein Kinases, Gene Expression Regulation, Enzymologic, Permeability, Brain Ischemia, Rats, Rats, Sprague-Dawley, Stroke, Disease Models, Animal, Blood-Brain Barrier, lcsh:Pathology, Animals, Claudin-5, Phosphorylation, Sesquiterpenes, Research Article, lcsh:RB1-214
Abstract

Inflammatory damage plays an important role in cerebral ischemic pathogenesis and may represent a target for treatment. Parthenolide (PN) has been proved to elicit a wide range of biological activities through its anti-inflammatory action in the treatment of migraine, arthritis, and atherosclerosis. To decide whether this effect applies to ischemic injury in brain, we therefore investigate the potential neuroprotective role of PN and the underlying mechanisms. Male Sprague-Dawley rats were randomly divided into Saline, Vehicle, and PN groups and a permanent middle cerebral artery occlusion (MCAO) model was used. PN administered intraperitoneally immediately after cerebral ischemia and once daily on the following days. At time points after MCAO, neurological deficit, infarct volume, and brain water content were measured. Immunohistochemistry, western blot and RT-PCR were used to analyze the expression of NF-κB and caspase-1 in ischemic brain tissue. Phospho-p38MAPK and claudin-5 were detected by western blot. The results indicated that PN dramatically ameliorated neurological deficit, brain water content, and infarct volume, downregulated NF-κB, phospho-p38MAPK, and caspase-1 expressions, and upregulated claudin-5 expression in ischemic brain tissue. Conclusions. PN protected the brain from damage caused by MCAO; this effect may be through downregulating NF-κB, phosho-p38MAPK, and caspase-1 expressions and ameliorating BBB permeability.

Published
2013

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