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9 results on '"Dong, Liqian"'

3. LncRNA Hnf4αos exacerbates liver ischemia/reperfusion injury in mice via Hnf4αos/Hnf4α duplex-mediated PGC1α suppression

Author

Wang, Chaoqun, primary, Yu, Hongjun, additional, Lu, Shounan, additional, Ke, Shanjia, additional, Xu, Yanan, additional, Feng, Zhigang, additional, Qian, Baolin, additional, Bai, Miaoyu, additional, Yin, Bing, additional, Li, Xinglong, additional, Hua, Yongliang, additional, Dong, Liqian, additional, Li, Yao, additional, Zhang, Bao, additional, Li, Zhongyu, additional, Chen, Dong, additional, Chen, Bangliang, additional, Zhou, Yongzhi, additional, Pan, Shangha, additional, Fu, Yao, additional, Jiang, Hongchi, additional, Wang, Dawei, additional, and Ma, Yong, additional

Published
2022
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6. PGC-1α Protects against Hepatic Ischemia Reperfusion Injury by Activating PPARα and PPARγ and Regulating ROS Production

Author

Wang, Chaoqun, primary, Li, Zihao, additional, Zhao, Baolei, additional, Wu, Yaohua, additional, Fu, Yao, additional, Kang, Kai, additional, Li, Yao, additional, Dong, Liqian, additional, Li, Xiaozhuang, additional, Zhang, Bao, additional, Wu, Huibo, additional, Shen, Benqiang, additional, Xu, Yanan, additional, Pan, Shangha, additional, Jiang, Hongchi, additional, Wang, Dawei, additional, and Ma, Yong, additional

Published
2021
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7. The PGC1α/NRF1-MPC1 axis suppresses tumor progression and enhances the sensitivity to sorafenib/doxorubicin treatment in hepatocellular carcinoma

Author

Wang, Chaoqun, primary, Dong, Liqian, additional, Li, Xiaozhuang, additional, Li, Yao, additional, Zhang, Bao, additional, Wu, Huibo, additional, Shen, Benqiang, additional, Ma, Panfei, additional, Li, Zuoyu, additional, Xu, Yang, additional, Chen, Bangliang, additional, Pan, Shangha, additional, Fu, Yao, additional, Huo, Zhongqi, additional, Jiang, Hongchi, additional, Wu, Yaohua, additional, and Ma, Yong, additional

Published
2021
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9. PGC-1 α Protects against Hepatic Ischemia Reperfusion Injury by Activating PPAR α and PPAR γ and Regulating ROS Production.

Author

Wang C, Li Z, Zhao B, Wu Y, Fu Y, Kang K, Li Y, Dong L, Li X, Zhang B, Wu H, Shen B, Xu Y, Pan S, Jiang H, Wang D, and Ma Y

Subjects
Animals, Humans, Male, Mice, Reactive Oxygen Species metabolism, Reperfusion Injury, Liver Diseases metabolism, PPAR alpha metabolism, PPAR gamma metabolism, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha metabolism
Abstract

Peroxisome proliferator-activated receptors (PPARs) α and γ have been shown to be protective in hepatic ischemia/reperfusion (I/R) injury. However, the precise role of PPAR γ coactivator-1 α (PGC-1 α ), which can coactivate both of these receptors, in hepatic I/R injury, remains largely unknown. This study was designed to test our hypothesis that PGC-1 α is protective during hepatic I/R injury in vitro and in vivo. Our results show that endogenous PGC-1 α is basally expressed in normal livers and is moderately increased by I/R. Ectopic PGC-1 α protects against hepatic I/R and hepatocyte anoxia/reoxygenation (A/R) injuries, whereas knockdown of endogenous PGC-1 α aggravates such injuries, as evidenced by assessment of the levels of serum aminotransferases and inflammatory cytokines, necrosis, apoptosis, cell viability, and histological examination. The EMSA assay shows that the activation of PPAR α and PPAR γ is increased or decreased by the overexpression or knockdown of PGC-1 α , respectively, during hepatic I/R and hepatocyte A/R injuries. In addition, the administration of specific antagonists of either PPAR α (MK886) or PPAR γ (GW9662) can effectively decrease the protective effect of PGC-1 α against hepatic I/R and hepatocyte A/R injuries. We also demonstrate an important regulatory role of PGC-1 α in reactive oxygen species (ROS) metabolism during hepatic I/R, which is correlated with the induction of ROS-detoxifying enzymes and is also dependent on the activations of PPAR α and PPAR γ . These data demonstrate that PGC-1 α protects against hepatic I/R injury, mainly by regulating the activation of PPAR α and PPAR γ . Thus, PGC-1 α may be a promising therapeutic target for the protection of the liver against I/R injury., Competing Interests: The authors declare no competing financial interests., (Copyright © 2021 Chaoqun Wang et al.)

Published
2021
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