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Background: Growing evidence suggests that depression affects gastroesophageal reflux disease (GERD). But, the relationship between depression and GERD is unclear. To examine the relationship between depression and the risk of GERD, as well as the mediating role of risk factors. Methods: We found genetic variants associated with GERD (N = 78,707) and depression (N = 500,199 (excluding 23 and Me) from the largest genome-wide association study and we applied two-sample Mendelian randomization (MR) to find out if they are related. We further used two-step MR to find the mediating factors. Results: The results found a causal link between depression and GERD, inverse-variance weighted (IVW), risk OR 2.149 (95% CI, 1.910 to 2.418; P <0.001). F-statistics for all instrumental variables (IVs) were greater than 10. Multivariate MR maintained the significance of the depression-GERD link even after adjusting for body mass index (BMI), waist-to-hip ratio (WHR), and educational attainment (EA). Mediation analysis revealed that increased depression is associated with lower EA (OR = 0.94; 95% CI, 0.89 to 0.99; P = 0.03), while EA itself significantly impacts GERD risk (OR = 0.25; 95% CI, 0.18 to 0.34; P = 8.24 × 10-9). Ultimately, EA mediates the effect of depression on GERD (OR = 1.09; 95% CI, 1.01 to 1.18; P = 0.04), accounting for 11.4% of the mediated effect. Conclusions: Depression is associated with an increased risk of developing GERD, with some of the effects mediated by EA. This result may provide important information for the prevention and intervention of depression and GERD. [ABSTRACT FROM AUTHOR]

Soft and hard contact deformation is most common issue of the refrigerator gasket and it has almost been ignored in previous studies. In this paper, the novelty is to propose a thermal-solid coupling simulation to study the effect of assembly states on the heat transfer of gaskets, improving the accuracy of heat transfer simulation analysis. The numerical results indicate that the calculated temperature based on physical model of assembly state is closer to measured temperature. The assembly distance affects the assembly state of the gasket by changing the contact positions and lengths of contact interfaces. As a result, the heat transfer path and condition at the gasket region also changes. As the deformation increases form −1.0 mm to 5.0 mm, the heat leakage load of gasket rises firstly and then falls, in the range of 1.61 ~ 3.33 W•m−1. The heat leakage at the transfer paths of internal cold air, outer shell and cold bridge accounts for over 20%. Thus, it is recommended to reduce the contact interface length of internal cold air, increase the thermal resistance of auxiliary air-bag, reduce the thermal conductivity and thickness of magnetic strip and increase the contact thermal resistance of cold bridge. [ABSTRACT FROM AUTHOR]