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4. Implication of hsa_circ_0028007 in reinforcing migration, invasion, and chemo‐tolerance of nasopharyngeal carcinoma cells

Author

Hao Yalin, Shao Yiting, Zhao Hui, Jin Xiao-jie, Dong Qiongna, Zhou Chuan, He Ping, Zhao Miaomiao, and Zhang Jiafeng

Subjects
Male, 0301 basic medicine, Microbiology (medical), Paclitaxel, Clinical Biochemistry, Antineoplastic Agents, Nose, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Movement, Cell Line, Tumor, otorhinolaryngologic diseases, medicine, Humans, Immunology and Allergy, Gene silencing, Neoplasm Invasiveness, MTT assay, Cisplatin, Nasopharyngeal Carcinoma, Biochemistry (medical), Public Health, Environmental and Occupational Health, Nasopharyngeal Neoplasms, Cell migration, Hematology, Transfection, Middle Aged, medicine.disease, MicroRNAs, stomatognathic diseases, Medical Laboratory Technology, 030104 developmental biology, chemistry, Nasopharyngeal carcinoma, Drug Resistance, Neoplasm, Cell culture, 030220 oncology & carcinogenesis, Cancer research, Female, medicine.drug
Abstract

BACKGROUND Given the reliability of circRNAs in symbolizing cancer progression, this investigation was designed to expound the involvement of hsa_circ_0028007 in regulating chemosensitivity of nasopharyngeal carcinoma (NPC) cells. METHODS Altogether, 241 pairs of NPC tissues and para-cancerous normal tissues were collected to identify NPC-symbolic circRNAs, which have been screened by circRNA microarray in advance. Expressions of the circRNAs were determined by means of real-time polymerase chain reaction (PCR). Besides, human NPC cell lines (ie, CNE2 and HONE1) were transfected by si-hsa_circ_0028007 and si-NC. Scratch assay, transwell assay, and MTT assay were performed to assess migration, invasion, and paclitaxel/cisplatin-resistance of NPC cell lines. RESULTS Hsa_circ_0028007 expression was abnormally heightened within NPC tissues in comparison with matched non-tumor tissues (P

Published
2020

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