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20 results on '"Dong, Zhaoru"'

5. Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer

Author

Wu, Di, Hu, Di, Chen, Hao, Shi, Guoming, Fetahu, Irfete S., Wu, Feizhen, Rabidou, Kimberlie, Fang, Rui, Tan, Li, Xu, Shuyun, Liu, Hang, Argueta, Christian, Zhang, Lei, Mao, Fei, Yan, Guoquan, Chen, Jiajia, Dong, Zhaoru, Lv, Ruitu, Xu, Yufei, Wang, Mei, Ye, Yong, Zhang, Shike, Duquette, Danielle, Geng, Songmei, Yin, Clark, Lian, Christine Guo, Murphy, George F., Adler, Gail K., Garg, Rajesh, Lynch, Lydia, Yang, Pengyuan, Li, Yiming, Lan, Fei, Fan, Jia, Shi, Yang, and Shi, Yujiang Geno

Published
2018
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7. Table S2 from Canonical Wnt Signaling Remodels Lipid Metabolism in Zebrafish Hepatocytes following Ras Oncogenic Insult

Author

Yao, Yuxiao, primary, Sun, Shaoyang, primary, Wang, Jingjing, primary, Fei, Fei, primary, Dong, Zhaoru, primary, Ke, Ai-Wu, primary, He, Ruoyu, primary, Wang, Lei, primary, Zhang, Lili, primary, Ji, Min-Biao, primary, Li, Qiang, primary, Yu, Min, primary, Shi, Guo-Ming, primary, Fan, Jia, primary, Gong, Zhiyuan, primary, and Wang, Xu, primary

Published
2023
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8. Data from Canonical Wnt Signaling Remodels Lipid Metabolism in Zebrafish Hepatocytes following Ras Oncogenic Insult

Author

Yao, Yuxiao, primary, Sun, Shaoyang, primary, Wang, Jingjing, primary, Fei, Fei, primary, Dong, Zhaoru, primary, Ke, Ai-Wu, primary, He, Ruoyu, primary, Wang, Lei, primary, Zhang, Lili, primary, Ji, Min-Biao, primary, Li, Qiang, primary, Yu, Min, primary, Shi, Guo-Ming, primary, Fan, Jia, primary, Gong, Zhiyuan, primary, and Wang, Xu, primary

Published
2023
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9. Supplementary Figures and methods from Canonical Wnt Signaling Remodels Lipid Metabolism in Zebrafish Hepatocytes following Ras Oncogenic Insult

Author

Yao, Yuxiao, primary, Sun, Shaoyang, primary, Wang, Jingjing, primary, Fei, Fei, primary, Dong, Zhaoru, primary, Ke, Ai-Wu, primary, He, Ruoyu, primary, Wang, Lei, primary, Zhang, Lili, primary, Ji, Min-Biao, primary, Li, Qiang, primary, Yu, Min, primary, Shi, Guo-Ming, primary, Fan, Jia, primary, Gong, Zhiyuan, primary, and Wang, Xu, primary

Published
2023
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10. NAD + salvage governs mitochondrial metabolism, invigorating natural killer cell antitumor immunity

Author

Guo, Xiaowei, primary, Tan, Siyu, additional, Wang, Tixiao, additional, Sun, Renhui, additional, Li, Shuangjie, additional, Tian, Panpan, additional, Li, Mengzhen, additional, Wang, Yuzhen, additional, Zhang, Yankun, additional, Yan, Yuchuan, additional, Dong, Zhaoru, additional, Yan, Lunjie, additional, Yue, Xuetian, additional, Wu, Zhuanchang, additional, Li, Chunyang, additional, Yamagata, Kazuya, additional, Gao, Lifen, additional, Ma, Chunhong, additional, Li, Tao, additional, and Liang, Xiaohong, additional

Published
2022
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18. Canonical Wnt Signaling Remodels Lipid Metabolism in Zebrafish Hepatocytes following Ras Oncogenic Insult

Author

Yao, Yuxiao, primary, Sun, Shaoyang, additional, Wang, Jingjing, additional, Fei, Fei, additional, Dong, Zhaoru, additional, Ke, Ai-Wu, additional, He, Ruoyu, additional, Wang, Lei, additional, Zhang, Lili, additional, Ji, Min-Biao, additional, Li, Qiang, additional, Yu, Min, additional, Shi, Guo-Ming, additional, Fan, Jia, additional, Gong, Zhiyuan, additional, and Wang, Xu, additional

Published
2018
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20. NAD + salvage governs mitochondrial metabolism, invigorating natural killer cell antitumor immunity.

Author

Guo X, Tan S, Wang T, Sun R, Li S, Tian P, Li M, Wang Y, Zhang Y, Yan Y, Dong Z, Yan L, Yue X, Wu Z, Li C, Yamagata K, Gao L, Ma C, Li T, and Liang X

Subjects
Humans, Mice, Animals, NAD metabolism, Nicotinamide Mononucleotide metabolism, Cytokines metabolism, Killer Cells, Natural metabolism, Tumor Microenvironment, Carcinoma, Hepatocellular, Liver Neoplasms
Abstract

Background and Aims: Natural killer (NK) cells are key players in tumor immunosurveillance, and metabolic adaptation manipulates their fate and functional state. The nicotinamide adenine dinucleotide (NAD + ) has emerged as a vital factor to link cellular metabolism and signaling transduction. Here, we identified NAD + metabolism as a central hub to determine the homeostasis and function of NK cells., Approach and Results: NAD + level was elevated in activated NK cells. NAD + supplementation not only enhanced cytokine production and cytotoxicity but also improved the proliferation and viability of NK cells. Intriguingly, the salvage pathway was involved in maintaining NAD + homeostasis in activated NK cells. Genetic ablation or pharmacological blockade of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD + salvage pathway, markedly destroyed the viability and function of NK cells. Mechanistically, NAD + salvage dictated the mitochondrial homeostasis and oxidative phosphorylation activity to support the optimal function of NK cells. However, in human HCC tissues, NAMPT expression and NAD + level were significantly down-regulated in tumor-infiltrating NK cells, which negatively correlated with patient survival. And lactate accumulation in the tumor microenvironment was at least partially responsible for the transcriptional repression of NAMPT in NK cells. Further, deficiency of Nampt in NK cells accelerated the growth of HCC and melanoma. Supplementation of the NAD + precursor nicotinamide mononucleotide (NMN) significantly improved NK antitumor response in both mouse and human cell-derived xenografts., Conclusions: These findings reveal NAD + salvage as an essential factor for NK-cell homeostasis and function, suggesting a potential strategy for invigorating NK cell-based immunotherapy., (Copyright © 2023 American Association for the Study of Liver Diseases.)

Published
2023
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