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Abstract Water security is not only an ecological environmental issue but also a bearing on national security and development. The study of water resources carrying capacity is the basis for future socioeconomic development and is the driving force for social progress. Therefore, it is important to investigate the influence factors of regional and national water resources carrying capacity (WRCC) and predict the future trend development. In view of the regional water resources data of the past 10 years in Anhui province, China, the Driving force Pressure State Impact Response Management (DPSIRM) model framework is constructed and the entropy weight method and variable weight theory can be used to make a comprehensive evaluation of the WRCC. Based on the comprehensive evaluation value, a modified Grey-Markov combination forecast can be introduced to predict the local WRCC in the coming years. The study on account of the Anhui Statistical Yearbook, the Water Resources Bulletin, and the water resources data of the Forestry Bureau for the past 10 years shows that the WRCC of Anhui Province is weak from 2010 to 2013 and gradually strengthens from 2014 to 2019; the WRCC of Anhui Province is mainly correlated with the impact subsystem, the management subsystem, and the state subsystem. The combined projections reflect that the future WRCC of Anhui Province is in good condition. It is recommended that the Anhui provincial government should strengthen water security and management, improve water resources utilization techniques, and construct complete and effective management tools and measures to fundamentally safeguard the province's water resources security and improve the WRCC.

Objective To investigate the expression of folate receptor 1(FOLR1) and mesothelin (MSLN) in epithelial ovarian cancer(EOC) and explore their clinical significance. Methods The data of clinical samples and transcriptome sequencing expression matrix of EOC were obtained from TCGA and GEO database(Ovarian Cancer TCGA, Provisional; GSE6008; GSE66957; GSE49997) to analyze the expressions of FOLR1 and MSLN in different tissues and their association with tumor staging and the prognosis of EOC. We also collected paraffin-embedded tissue samples of EOC(105 cases), ovarian borderline tumor(11 cases), and normal ovarian tissue(30 cases) from patients undergoing surgeries in our hospital between 2018 and 2019. The expression levels of FOLR1 and MSLN were detected by immunohistochemistry and their correlation with the clinicopathological characteristics of the patients was analyzed. Results Analysis of TCGA and GEO databases showed that the mRNA levels of FOLR1 and MSLN were significantly higher in EOC tissues than in normal ovarian tissues(P < 0.05), and was also higher in stage Ⅲ~Ⅳ than in stage Ⅰ~Ⅱ EOC(P < 0.05). Survival analysis showed that the patients with a high expression of FOLR1 had significantly longer overall survival(P < 0.05) and disease-free survival(P < 0.05), while the patients with a high expression of MSLN had significantly shortened overall survival(P < 0.05) and disease-free survival(P < 0.05). Immunohistochemical analysis showed that FOLR1 and MSLN proteins were lowly expressed in normal ovarian tissues, and their expressions increased moderately in borderline ovarian tumor and significantly in EOC tissues. The positive expression rates of FOLR1 and MSLN in EOC were 80.95% and 53.33%, respectively. The levels were of FOLR1 and MSLN differed significantly in different tissue types(P < 0.001), and their positive rates were significantly higher in stage Ⅲ~Ⅳ than in stage Ⅰ~Ⅱ EOC(P < 0.05). The positive rate of MSLN was significantly increased in patients with lymph node metastasis(P < 0.05). Subgroup survival analysis of TCGA database showed that patients with a low MSLN expression and a high FOLR1 expression(MLFH) at the mRNA level had the best prognosis, while those with a high MSLN expression and a low FOLR1 expression(MHFL) had the worst prognosis(median survival time 70.57 vs 25.85 months, P < 0.000 1); compared with the MLFL patients, the MHFL patients in the early stage(< 50 months) had a better prognosis, while beyond 50 months, the survival rate of the patients decreased, but the difference was not statistically significant. Conclusion In patients with EOC, a high expression of FOLR1 indicates a more favorable prognosis while a high expression of MSLN is associated with a poor prognosis. These 2 proteins may participate in the process of EOC, and their combined detection may help in prognostic evaluation of EOC.

Abstract This paper analyzes current cloud computing, cloud rendering industry, and related businesses. In this field, cloud system performance lacks unified evaluation criterion. A novel analysis method and a related measure of cloud rendering system performance are presented in this paper. The main paper investigates the number of system concurrent users and average response delay about user access, average frame speed, system operation speed, and average response about user browsing system. This paper makes a theoretical analysis of a core business process about cloud rendering system, multi-task rendering processes especially. This paper analyzes the efficiency, average frame rate, rendering performance bottleneck of the cloud rendering system, and put forward a unique parameter adjustment strategy to improve system performance, by optimizing related server and rendering machine configuration. This paper puts forward a method to reduce the bottleneck of the system and prevent system performance deterioration in the new scheme. This paper puts forward a set of system optimization strategies to improve system performance. This is a new cloud rendering system performance optimization configuration scheme and optimization strategy.

The structural health monitoring system has made great development nowadays, especially on bridge structures. Meanwhile, most SHM systems reported were designed, integrated, and installed into large-scale infrastructures by professionals and equipped with expensive sensors, data acquisition devices, data transfer systems, and so forth. And it is impossible to install SHM system for every civilian building. For this status, a kind of new idea for structural health monitoring using smartphone is introduced in this paper. A smartphone, with embedded responding SHM software and inner sensors or external sensors, can be used not only as a single wireless sensor node but also as a mini-SHM system. The method is described in detail, and then the swing test, cable force test in laboratory, and cable force test on an actual bridge based on the iPhone were conducted to validate the proposed method. The experimental results show that Mobile-SHM using smartphone is feasible. The realization of Mobile-SHM method using smartphones may be considered as a milestone in making SHM popular in the lives of people.

In wireless sensor networks, self-healing key-distribution schemes are used to ensure that, even if the message packets that are broadcast in some sessions get lost, the group nodes can still recover the lost session keys simply by using their personal secret keys and broadcast messages that have been received without requesting additional transmissions from the group manager. These schemes reduce network traffic, decrease the group manager's workload, and lower the risk of node exposure through traffic analysis. However, most existing schemes have many deficiencies, such as high overhead for storage and communication and collusion attacks. In this paper, we have proposed a modified, self-healing, key-distribution scheme based on one-way key chains and secret sharing. Our scheme has the properties of constant storage, lower communication overhead, long lifespan, forward secrecy, backward secrecy, and resistance to collusion attacks.

Aquaponics is a system coordinating fish production and vegetable cultivation in a sustainable way. In order to study the differences in the fish intestinal microbiota between the aquaponic pattern and the traditional farming pattern, this work crossly coupled crucian carps (Carassius auratus auratus) or goldfish (Carassius auratus var. Japonicus simplex) with lettuce (Lactuca sativa L.) or water spinach (Ipomoea aquatica Forsk) to set up four types of aquaponic systems based on hydroponic floating bed. The corresponding traditional farming systems of each fish species were also built as control groups. After six weeks of culturing, the intestinal microbiota of each system was investigated through 16 S sequencing technology and bioinformatics analysis methods. The most abundant bacterial phylum was Proteobacteria, and its abundance in aquaponics was higher in the aquaponic groups than in the corresponding traditional farming groups (P = 0.019 in goldfish; ANOVA). Lactobacillaceae were enriched in traditional farming samples compared with aquaponic samples. The probiotics like Streptomyces and Rhizobium were identified as biomarkers in the water spinach aquaponic samples, and Buttiauxella was significantly more abundant in the lettuce aquaponic samples. A certain number of plant growth promoting bacteria were found in the intestinal microbiota under aquaponics. Aquaponics may improve some probiotics in the fish gut by regulating the water quality; functional prediction of microbiota revealed that aquaponics affected the catabolism and environmental information processing capabilities of fish. There was no growth performance difference between the three farming patterns, neither in goldfish nor in crucian carps. However, the survival rate of goldfish in two types of aquaponics was higher than that in traditional patterns (P = 0.027; ANOVA). In conclusion, the aquaponic systems could change the structure and function of the fish intestinal microbiota, and could make contributions to enhancing the survival rate, which should receive more attention.

IntroductionMinimal manifestation (MM) or better was recommended as the treatment goal for myasthenia gravis (MG). The sustainability of this status has not been described quantitatively in patients who had attained or are close to it.MethodsPatients who were with no or slight impact on daily living were recruited and followed at baseline and 3, 6, and 12 months. The included patients were classified into 3 post-intervention status (PIS) categories: remission (R), MM, and slight impact (SI). The proportion of patients belonging to real-time (not considering the intervals between assessments) and sustained (considering the intervals between assessments) PIS categories was compared at each follow-up. A sensitivity analysis (SA) cohort was established by including patients with PIS categories in all four follow-ups. The QMGS, MG-ADL, and MG-QOL15 scores in patients belonging to each PIS category at each follow-up were compared. The sustainability of the R/MM status was examined and correlated with real-time R/MM status at follow-ups.ResultsAt baseline, 376 patients could be classified, including 55 as R (14.2%), 209 as MM (54.0%), and 112 as SI (28.9%). In the whole cohort, 68.8–89.7%, 71–76.7% and 19.8–77.1% of the patients classified into real-time R, MM, and SI categories remained unchanged in each follow-up compared with the previous follow-up. The proportion of patients belonging to each real-time or sustained R/MM status at the three follow-ups was 89.7–92.1 or 60.8–67. In the SA cohort, at least 86.4% of the baseline R/MM patients remained in R/MM status till 12 months. There were no differences in keeping real-time R/MM status at 6 or 12 months between patients with and without sustained R/MM status at 3 and 6 months. There were differences in the QMGS, MG-ADL, and MG-QOL15 scores among patients belonging to each real-time category at baseline and follow-ups, ranking as R < MM < SI. The same trend was observed in patients belonging to each sustained PIS category with smaller scores than the same items of real-time categories.ConclusionThe sustainability of the R/MM status was confirmed. The R/MM status indicated a stable state of MG. The QMGS, MG-ADL, and MG-QOL15 scores may provide a quantitative reference for these PIS.

Nickel titanate (NiTiO3) semiconductors and graphitic carbon nitride (g-C3N4) have attracted great attention as photocatalysts in the degradation of environmental pollutants because of their visible-light-driven activity. But the utilizations of both semiconductors are limited by their low specific surface area. In this study, a nano-NiTiO3/g-C3N4 photocatalyst was successfully synthesized by optimizing the preparation method of photocatalyst precursors. Compared with the bulk g-C3N4 and bulk NiTiO3/g-C3N4 composite photocatalysts, the nano-NiTiO3/g-C3N4 composite catalyst displayed a larger specific surface area, a more abundant pore size structure, and superior carrier separation capabilities. According to the pseudo-first-order, the degradation rate of MB was more than 2.5–19.7 times higher than that of previous studies. The superoxide radicals (·O2−) and holes (h+) played significant roles in the photocatalytic reaction of MB. This study provides a new idea for the synthesis of photocatalysts and the improvement in photocatalytic performance. [ABSTRACT FROM AUTHOR]

Ochratoxin A (OTA) is one of the mycotoxins that poses a serious threat to human and animal health. Curcumin (CUR) is a major bioactive component of turmeric that provides multiple health benefits. CUR can reduce the toxicities induced by mycotoxins, but the underlying molecular mechanisms remain largely unknown. To explore the effects of CUR on OTA toxicity and identify the key regulators and metabolites involved in the biological processes, we performed metabolomic and transcriptomic analyses of livers from OTA-exposed mice. We found that CUR can alleviate the toxic effects of OTA on body growth and liver functions. In addition, CUR supplementation significantly affects the expressions of 1584 genes and 97 metabolites. Integrated analyses of transcriptomic and metabolomic data showed that the pathways including Arachidonic acid metabolism, Purine metabolism, and Cholesterol metabolism were significantly enriched. Pantothenic acid (PA) was identified as a key metabolite, the exogenous supplementation of which was observed to significantly alleviate the OTA-induced accumulation of reactive oxygen species and cell apoptosis. Further mechanistical analyses revealed that PA can downregulate the expression level of proapoptotic protein BAX, enhance the expression level of apoptosis inhibitory protein BCL2, and decrease the level of phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2). This study demonstrated that CUR can alleviate the adverse effects of OTA by influencing the transcriptomic and metabolomic profiles of livers, which may contribute to the application of CUR in food and feed products for the prevention of OTA toxicity. [ABSTRACT FROM AUTHOR]