1. Refractive Growth of the Crystalline Lens in the Infant Aphakia Treatment Study
- Author
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Thaddeus S. McClatchey, MD, Scott R. Lambert, MD, David G. Morrison, MD, Stacey J. Kruger, MD, Lorri B. Wilson, MD, Scott K. McClatchey, MD, Scott R. Lambert, MD (Study Chair), Lindreth DuBois, MEd, MMSc, CO, COMT (National Coordinator), Azhar Nizam, MS (Director), Qi Long, PhD (former Director), Michael J. Lynn, MS (former Director), Betsy Bridgman, BS, Marianne Celano, PhD, Julia Cleveland, MS, George Cotsonis, MS, Carey Drews-Botsch, PhD, Nana Freret, MSN, Lu Lu, MS, Seegar Swanson, Thandeka Tutu-Gxashe, MPH, E. Eugenie Hartmann, PhD (Director), Anna K. Carrigan, MPH, Clara Edwards, Claudio Busettini, PhD, Samuel Hayley, Eleanor Lewis, Alicia Kindred Joost Felius, PhD, Edward G. Buckley, MD, David A. Plager, MD, M. Edward Wilson, MD, Lindreth DuBois, MEd, MMSc, Carolyn Drews-Botsch, PhD, E. Eugenie Hartmann, PhD, Donald F. Everett, MA, Michael J. Lynn, MS, Qi Long, PhD, Azhar Nizam, MS, Joost Felius, PhD, Margaret Bozic, CCRC, COA, Ann Holleschau, BA, Buddy Russell, COMT, Michael Ward, Carol Bradham, COA, Deborah K. Vanderveen, MD, Theresa A. Mansfield, RN, Kathryn Bisceglia Miller, OD, Tamar Winter, RN, Stephen P. Christiansen, MD, Erick D. Bothun, MD, Jason Jedlicka, OD, Patricia Winters, OD, Jacob Lang, OD, Jill S. Anderson, MD, Elias I. Traboulsi, MD, Susan Crowe, BS, COT, Heather Hasley Cimino, OD, Faruk Orge, MD, Megin Kwiatkowski, Beth Colon, Angela Meador, COA, MHA, Kimberly G. Yen, MD, Maria Castanes, MPH, Alma Sanchez, COA, Shirley York, OD, Stacy Malone, COA, Margaret Olfson, Gihan Romany, MBChB, COMT, CCRC, David T. Wheeler, MD, Ann U. Stout, MD, Paula Rauch, OT, CRC, Kimberly Beaudet, CO, COMT, Pam Berg, CO, COMT, Lorri Wilson, MD, Amy K. Hutchinson, MD, Lindreth Dubois, MEd, MMSc, CO, COMT, Rachel Robb, MMSc, CO, COMT, Marla J. Shainberg, CO, Sharon F. Freedman, MD, Lois Duncan, BS, CO, COMT, B.W. Phillips, FCLSA, John T. Petrowski, OD, Sarah Jones, MS, David Morrison, MD, Sandy Owings, COA, CCRP, Ron Biernacki, CO, COMT, Christine Franklin, COT, Scott Ruark, Daniel E. Neely, MD, Michele Whitaker, COMT, CCRP, Donna Bates, COA, Dana Donaldson, OD, Stacey Kruger, MD, Charlotte Tibi, CO, Susan Vega, David R. Weakley, MD, David R. Stager, Jr., M.D., Clare Dias, CO, Debra L. Sager, Todd Brantley, OD, Bonnie Miller, PhD, Eva Lutz, CO, Lisa Davis, Robert Hardy, PHD (Chair), Eileen Birch, PhD, Ken Cheng, MD, Richard Hertle, MD, Craig Kollman, PhD, Marshalyn Yeargin-Allsopp, MD (resigned), Cyd McDowell, and Allen Beck, MD
- Subjects
IATS ,Ocular development ,Pediatric cataract surgery ,RRG3 ,Ophthalmology ,RE1-994 - Abstract
Objective: To compare the rate of refractive growth (RRG3) of the crystalline lens (“lens”) versus the eye excluding the lens (“globe”) for the fellow, noncataractous eyes of participants in the Infant Aphakia Treatment Study. Design: Retrospective cohort study. Subjects: A total of 114 children who had unilateral cataract surgery as infants were recruited. Biometric and refraction data were obtained from the normal eyes at surgery and at 1, 5, and 10 years. Subjects were included if complete data (axial length [AL], corneal power, and refraction) were available at surgery and at 10 years of age. Methods: At surgery and at 1, 5, and 10 years, AL, corneal power, and cycloplegic refraction were measured in the normal eyes. For each eye, the RRG3 was defined by linear regression of refraction at the intraocular lens (IOL) plane against log10 (age + 0.6 years). The RRG3 for the globe was based on IOL power for emmetropia; the RRG3 for the lens was based on IOL power calculated to give the observed refractions. Intraocular lens powers were calculated with the Holladay 1 formula. The means were compared with a paired 2-tailed t test, and linear regression was used to look for a correlation between RRG3 of the lens globe. Main Outcome Measures: The RRG3 of the lens and globe. Results: Complete data were available for 107 normal eyes. The mean RRG3 of the lenses was −12.0 ± 2.5 diopters (D) and the mean RRG3 of the globes was −14.1 ± 2.7 D (P < 0.001). The RRG3 of the lens correlated with the RRG3 of the globe (R2 = 0.25, P < 0.001). Conclusions: The RRG3 was 2 D more negative in globes compared with lenses in normal eyes. Globes with a greater rate of growth tended to have lenses with a greater rate of growth.
- Published
- 2022
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