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1. Communication and ethical considerations for fertility preservation for patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Anderson, Richard A, Barnbrock, Anke, Beck, Joern D, Bos, Annelies M E, Calaminus, Gabriele, Constine, Louis S, Demeestere, Isabelle, Denzer, Christian, Grabow, Desiree, di Iorgi, Natascia, Hoefgen, Holly R, Jahnukainen, Kirsi, Kaatsch, Peter, Kebudi, Rejin, Lambalk, Cornelis, Langer, Thorsten, Loonen, Jacqueline, Lorenzo, Armando, Meacham, Lillian R, Meissner, Andreas, Mitchell, Rod T, Nahata, Leena, Ranft, Andreas, Dinkelman-Smit, Marij, Stern, Catharyn, Stutz-Grunder, Eveline, Tournaye, Herman, van Dorp, Wendy, van Pelt, Ans M M, de Vries, Andrica, Yu, Richard, Mulder, Renée L, Font-Gonzalez, Anna, van Dulmen-den Broeder, Eline, Quinn, Gwendolyn P, Ginsberg, Jill P, Loeffen, Erik A H, Hudson, Melissa M, Burns, Karen C, van Santen, Hanneke M, Berger, Claire, Diesch, Tamara, Dirksen, Uta, Giwercman, Aleksander, Gracia, Clarisa, Hunter, Sarah E, Kelvin, Joanne F, Klosky, James L, Laven, Joop S E, Lockart, Barbara A, Neggers, Sebastian J C M M, Peate, Michelle, Phillips, Bob, Reed, Damon R, Tinner, Eva Maria E, Byrne, Julianne, Veening, Margreet, van de Berg, Marleen, Verhaak, Chris M, Anazodo, Antoinette, Rodriguez-Wallberg, Kenny, van den Heuvel-Eibrink, Marry M, Asogwa, Ogechukwu A, Brownsdon, Alexandra, Wallace, W Hamish, Green, Daniel M, Skinner, Roderick, Haupt, Riccardo, Kenney, Lisa B, Levine, Jennifer, van de Wetering, Marianne D, Tissing, Wim J E, Paul, Norbert W, Kremer, Leontien C M, and Inthorn, Julia

Published
2021
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2. Fertility preservation for female patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Berger, Claire, Diesch, Tamara, Dirksen, Uta, Ginsberg, Jill, Giwercman, Aleksander, Grabow, Desiree, Gracia, Clarisa, Hunter, Sarah E, Inthorn, Julia, Kaatsch, Peter, Kelvin, Joanne F, Klosky, James L, Laven, Joop S E, Lockart, Barbara A, Neggers, Sebastian JCMM, Paul, Norbert W, Peate, Michelle, Phillips, Bob, Reed, Damon R, Tinner, Eva Maria E, van den Berg, Marleen, Verhaak, Chris, Mulder, Renée L, Font-Gonzalez, Anna, Hudson, Melissa M, van Santen, Hanneke M, Loeffen, Erik A H, Burns, Karen C, Quinn, Gwendolyn P, van Dulmen-den Broeder, Eline, Byrne, Julianne, Haupt, Riccardo, Wallace, W Hamish, van den Heuvel-Eibrink, Marry M, Anazodo, Antoinette, Anderson, Richard A, Barnbrock, Anke, Beck, Joern D, Bos, Annelies M E, Demeestere, Isabelle, Denzer, Christian, Di Iorgi, Natascia, Hoefgen, Holly R, Kebudi, Rejin, Lambalk, Cornelis, Langer, Thorsten, Meacham, Lillian R, Rodriguez-Wallberg, Kenny, Stern, Catharyn, Stutz-Grunder, Eveline, van Dorp, Wendy, Veening, Margreet, Veldkamp, Saskia, van der Meulen, Eline, Constine, Louis S, Kenney, Lisa B, van de Wetering, Marianne D, Kremer, Leontien C M, Levine, Jennifer, and Tissing, Wim J E

Published
2021
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3. Counseling and surveillance of obstetrical risks for female childhood, adolescent, and young adult cancer survivors: recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

van der Kooi, Anne-Lotte Lolkje Femke, Mulder, Renee L., Hudson, Melissa M., Kremer, Leontien C.M., Skinner, Rod, Constine, Louis S., van Dorp, Wendy, van Dulmen-den Broeder, Eline, Falck-Winther, Jeanette, Wallace, W. Hamish, Waugh, Jason, Woodruff, Teresa K., Anderson, Richard A., Armenian, Saro H., Bloemenkamp, Kitty W.M., Critchley, Hilary O.D., Demoor-Goldschmidt, Charlotte, Ehrhardt, Matthew J., Green, Daniel M., Grobman, William A., Iwahata, Yuriko, Krishna, Iris, Laven, Joop S.E., Levitt, Gill, Meacham, Lillian R., Miller, Emily S., Mulders, Annemarie, Polanco, Angela, Ronckers, Cécile M., Samuel, Amber, Walwyn, Tom, Levine, Jennifer M., and van den Heuvel-Eibrink, Marry M.

Published
2021
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5. The prevalence of thyroid dysfunction and hyperprolactinemia in women with PCOS

Author

van der Ham, Kim, Stekelenburg, Karlijn J., Louwers, Yvonne V., van Dorp, Wendy, Schreurs, Marco W.J., van der Wal, Ronald, Steegers-Theunissen, Régine P.M., Laven, Joop S.E., van der Ham, Kim, Stekelenburg, Karlijn J., Louwers, Yvonne V., van Dorp, Wendy, Schreurs, Marco W.J., van der Wal, Ronald, Steegers-Theunissen, Régine P.M., and Laven, Joop S.E.

Abstract

Introduction: Ovulatory dysfunction is usually caused by an endocrine disorder, of which polycystic ovary syndrome (PCOS) is the most common cause. PCOS is usually associated with estrogen levels within the normal range and can be characterized by oligo-/anovulation resulting in decreased progesterone levels. It is suggested that decreased progesterone levels may lead to more autoimmune diseases in women with PCOS. In addition, it is often claimed that there is an association between hyperprolactinemia and PCOS. In this large well-phenotyped cohort of women with PCOS, we have studied the prevalence of thyroid dysfunction and hyperprolactinemia compared to controls, and compared this between the four PCOS phenotypes. Methods: This retrospective cross-sectional study contains data of 1429 women with PCOS and 299 women without PCOS. Main outcome measures included thyroid stimulating hormone (TSH), Free Thyroxine (FT4), and anti-thyroid peroxidase antibodies (TPOab) levels in serum, the prevalence of thyroid diseases and hyperprolactinemia. Results: The prevalence of thyroid disease in PCOS women was similar to that of controls (1.9% versus 2.7%; P = 0.39 for hypothyroidism and 0.5% versus 0%; P = 0.99 for hyperthyroidism). TSH levels were also similar (1.55 mIU/L versus 1.48 mIU/L; P = 0.54). FT4 levels were slightly elevated in the PCOS group, although within the normal range (18.1 pmol/L versus 17.7 pmol/L; P < 0.05). The prevalence of positive TPOab was similar in both groups (5.7% versus 8.7%; P = 0.12). The prevalence of hyperprolactinemia was similarly not increased in women with PCOS (1.3%% versus 3%; P = 0.05). In a subanalysis of 235 women with PCOS and 235 age- and BMI-matched controls, we found no differences in thyroid dysfunction or hyperprolactinemia. In according to differences between PCOS phenotypes, only the prevalence of subclinical hypothyroidism was significantly higher in phenotype B (6

Published
2023

8. Oncofertility Perspectives for Girls with Cancer

Author

van der Perk, M.E. Madeleine, primary, van der Kooi, Anne-Lotte L.F., additional, Bos, Annelies M.E., additional, Broer, Simone L., additional, Veening, Margreet A., additional, van Leeuwen, Jeanette, additional, van Santen, Hanneke M., additional, van Dorp, Wendy, additional, and van den Heuvel-Eibrink, Marry M., additional

Published
2022
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10. Comparison of lichen sclerosus in boys and girls:A systematic literature review of epidemiology, symptoms, genetic background, risk factors, treatment, and prognosis

Author

Kumar, Kajal S., Morrel, Beth, van Hees, Colette L.M., van der Toorn, Fred, van Dorp, Wendy, Mendels, Elodie J., Kumar, Kajal S., Morrel, Beth, van Hees, Colette L.M., van der Toorn, Fred, van Dorp, Wendy, and Mendels, Elodie J.

Abstract

Background: Studies concerning pediatric lichen sclerosus are limited, and, to date, there have been no studies comparing the course of lichen sclerosus in boys and girls. We sought to examine all publications on boys and girls with lichen sclerosus and assess and compare epidemiology, symptoms and signs, genetic background, risk factors, treatment, and prognosis. Methods: A systematic search was performed in the Embase, Medline, Cochrane, and Web of Science databases. Inclusion criteria were information on children ages 0–18 years and a clinical or histologic diagnosis of lichen sclerosus. Literature from 1985 to 2021 was reviewed. Results: A total of 1780 articles were retrieved from the search, of which 90 articles were eligible for inclusion. Boys and girls present similarly on many aspects; nonetheless, treatment and follow-up are approached differently. Conclusions: Though the clinical approach is often different, lichen sclerosus in boys and girls demonstrates many similarities. More research is needed, especially on follow-up, to gain a better understanding of the course of lichen sclerosus and establish an advanced management plan for children.

Published
2022

11. Oncofertility Perspectives for Girls with Cancer

Author

MS VPG/Gynaecologie, Cancer, Child Health, Endocrinologie patientenzorg, Brain, Speerpunt, Zorg en O&O, van der Perk, M. E.Madeleine, van der Kooi, Anne Lotte L.F., Bos, Annelies M.E., Broer, Simone L., Veening, Margreet A., van Leeuwen, Jeanette, van Santen, Hanneke M., van Dorp, Wendy, van den Heuvel-Eibrink, Marry M., MS VPG/Gynaecologie, Cancer, Child Health, Endocrinologie patientenzorg, Brain, Speerpunt, Zorg en O&O, van der Perk, M. E.Madeleine, van der Kooi, Anne Lotte L.F., Bos, Annelies M.E., Broer, Simone L., Veening, Margreet A., van Leeuwen, Jeanette, van Santen, Hanneke M., van Dorp, Wendy, and van den Heuvel-Eibrink, Marry M.

Published
2022

13. Fertility preservation for female patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Mulder, Renée L, Font-Gonzalez, Anna, Hudson, Melissa M, van Santen, Hanneke M, Loeffen, Erik A H, Burns, Karen C, Quinn, Gwendolyn P, van Dulmen-den Broeder, Eline, Byrne, Julianne, Haupt, Riccardo, Wallace, W Hamish, van den Heuvel-Eibrink, Marry M, Anazodo, Antoinette, Anderson, Richard A, Barnbrock, Anke, Beck, Joern D, Bos, Annelies M E, Demeestere, Isabelle, Denzer, Christian, Di Iorgi, Natascia, Hoefgen, Holly R, Kebudi, Rejin, Lambalk, Cornelis, Langer, Thorsten, Meacham, Lillian R, Rodriguez-Wallberg, Kenny, Stern, Catharyn, Stutz-Grunder, Eveline, van Dorp, Wendy, Veening, Margreet, et al, University of Zurich, and Mulder, Renée L

Subjects
10036 Medical Clinic, 610 Medicine & health, 2730 Oncology
Published
2021
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14. Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer 1 Fertility preservation for female patients with childhood , adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Mulder, RL, Font-Gonzalez, A, Hudson, MM, Santen, HMV, Loeffen, EAH, Burns, KC, Quinn, GP, Broeder, EVD, Byrne, J, Haupt, R, Wallace, WH, Van den Heuvel - Eibrink, Marry, Anazodo, A, Anderson, RA, Barnbrock, A, Beck, JD, Bos, AME, Demeestere, I, Denzer, C, Iorgi, ND, Hoefgen, HR, Kebudi, R, Lambalk, C, Langer, T, Meacham, LR, Rodriguez-Wallberg, K, Stern, C, Stutz-Grunder, E, Dorp, Wendy, Veening, M, Veldkamp, S, Meulen, EV, Constine, LS, Kenney, LB, de Wetering, MDV, Kremer, LCM (Leontien), Levine, J, Tissing, WJE, Pediatrics, and Erasmus MC other

Subjects
SDG 3 - Good Health and Well-being
Published
2021

15. Counseling and surveillance of obstetrical risks for female childhood, adolescent, and young adult cancer survivors: recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

van der Kooi, Anne-Lotte, Mulder, RL, Hudson, MM, Kremer, LC, Skinner, R, Constine, LS, Dorp, Wendy, van Dulmen-Den Broeder, E, Falck-Winther, J, Wallace, WH, Waugh, J, Woodruff, TK, Anderson, RA, Armenian, SH, Bloemenkamp, KW, Critchley, HOD, Demoor-Goldschmidt, C, Ehrhardt, MJ, Green, DM, Grobman, WA, Iwahata, Y, Krishna, I, Laven, Joop, Levitt, G, Meacham, LR, Miller, ES, Mulders, Annemarie, Polanco, A, Ronckers, CM, Samuel, A, Walwyn, T, Levine, JM, van den Heuvel-Eibrink, M, van der Kooi, Anne-Lotte, Mulder, RL, Hudson, MM, Kremer, LC, Skinner, R, Constine, LS, Dorp, Wendy, van Dulmen-Den Broeder, E, Falck-Winther, J, Wallace, WH, Waugh, J, Woodruff, TK, Anderson, RA, Armenian, SH, Bloemenkamp, KW, Critchley, HOD, Demoor-Goldschmidt, C, Ehrhardt, MJ, Green, DM, Grobman, WA, Iwahata, Y, Krishna, I, Laven, Joop, Levitt, G, Meacham, LR, Miller, ES, Mulders, Annemarie, Polanco, A, Ronckers, CM, Samuel, A, Walwyn, T, Levine, JM, and van den Heuvel-Eibrink, M

Abstract

Female childhood, adolescent, and young adult cancer survivors have an increased risk of adverse pregnancy outcomes related to their cancer- or treatment-associated sequelae. Optimal care for childhood, adolescent, and young adult cancer survivors can be facilitated by clinical practice guidelines that identify specific adverse pregnancy outcomes and the clinical characteristics of at-risk subgroups. However, national guidelines are scarce and vary in content. Here, the International Late Effects of Childhood Cancer Guideline Harmonization Group offers recommendations for the counseling and surveillance of obstetrical risks of childhood, adolescent, and young adult survivors. A systematic literature search in MEDLINE database (through PubMed) to identify all available evidence published between January 1990 and December 2018. Published articles on pregnancy and perinatal or congenital risks in female cancer survivors were screened for eligibility. Study designs with a sample size larger than 40 pregnancies in childhood, adolescent, and young adult cancer survivors (diagnosed before the age of 25 years, not pregnant at that time) were eligible. This guideline from the International Late Effects of Childhood Cancer Guideline Harmonization Group systematically appraised the quality of available evidence for adverse obstetrical outcomes in childhood, adolescent, and young adult cancer survivors using Grading of Recommendations Assessment, Development, and Evaluation methodology and formulated recommendations to enhance evidence-based obstetrical care and preconception counseling of female childhood, adolescent, and young adult cancer survivors. Healthcare providers should discuss the risk of adverse obstetrical outcomes based on cancer treatment exposures with all female childhood, adolescent, and young adult cancer survivors of reproductive age, before conception. Healthcare providers should be aware that there is no evidence to support an increased risk of giving b

Published
2021

16. Counseling and surveillance of obstetrical risks for female childhood, adolescent, and young adult cancer survivors: recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

MS VPG/Gynaecologie, Geboortecentrum voorzitterschap, Child Health, Klinische Fysica RT, Speerpunt, Zorg en O&O, van der Kooi, Anne Lotte Lolkje Femke, Mulder, Renee L., Hudson, Melissa M., Kremer, Leontien C.M., Skinner, Rod, Constine, Louis S., van Dorp, Wendy, van Dulmen-den Broeder, Eline, Falck-Winther, Jeanette, Wallace, W. Hamish, Waugh, Jason, Woodruff, Teresa K., Anderson, Richard A., Armenian, Saro H., Bloemenkamp, Kitty W.M., Critchley, Hilary O.D., Demoor-Goldschmidt, Charlotte, Ehrhardt, Matthew J., Green, Daniel M., Grobman, William A., Iwahata, Yuriko, Krishna, Iris, Laven, Joop S.E., Levitt, Gill, Meacham, Lillian R., Miller, Emily S., Mulders, Annemarie, Polanco, Angela, Ronckers, Cécile M., Samuel, Amber, Walwyn, Tom, Levine, Jennifer M., van den Heuvel-Eibrink, Marry M., MS VPG/Gynaecologie, Geboortecentrum voorzitterschap, Child Health, Klinische Fysica RT, Speerpunt, Zorg en O&O, van der Kooi, Anne Lotte Lolkje Femke, Mulder, Renee L., Hudson, Melissa M., Kremer, Leontien C.M., Skinner, Rod, Constine, Louis S., van Dorp, Wendy, van Dulmen-den Broeder, Eline, Falck-Winther, Jeanette, Wallace, W. Hamish, Waugh, Jason, Woodruff, Teresa K., Anderson, Richard A., Armenian, Saro H., Bloemenkamp, Kitty W.M., Critchley, Hilary O.D., Demoor-Goldschmidt, Charlotte, Ehrhardt, Matthew J., Green, Daniel M., Grobman, William A., Iwahata, Yuriko, Krishna, Iris, Laven, Joop S.E., Levitt, Gill, Meacham, Lillian R., Miller, Emily S., Mulders, Annemarie, Polanco, Angela, Ronckers, Cécile M., Samuel, Amber, Walwyn, Tom, Levine, Jennifer M., and van den Heuvel-Eibrink, Marry M.

Published
2021

18. Fertility preservation for female patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Mulder, Renée L, primary, Font-Gonzalez, Anna, additional, Hudson, Melissa M, additional, van Santen, Hanneke M, additional, Loeffen, Erik A H, additional, Burns, Karen C, additional, Quinn, Gwendolyn P, additional, van Dulmen-den Broeder, Eline, additional, Byrne, Julianne, additional, Haupt, Riccardo, additional, Wallace, W Hamish, additional, van den Heuvel-Eibrink, Marry M, additional, Anazodo, Antoinette, additional, Anderson, Richard A, additional, Barnbrock, Anke, additional, Beck, Joern D, additional, Bos, Annelies M E, additional, Demeestere, Isabelle, additional, Denzer, Christian, additional, Di Iorgi, Natascia, additional, Hoefgen, Holly R, additional, Kebudi, Rejin, additional, Lambalk, Cornelis, additional, Langer, Thorsten, additional, Meacham, Lillian R, additional, Rodriguez-Wallberg, Kenny, additional, Stern, Catharyn, additional, Stutz-Grunder, Eveline, additional, van Dorp, Wendy, additional, Veening, Margreet, additional, Veldkamp, Saskia, additional, van der Meulen, Eline, additional, Constine, Louis S, additional, Kenney, Lisa B, additional, van de Wetering, Marianne D, additional, Kremer, Leontien C M, additional, Levine, Jennifer, additional, Tissing, Wim J E, additional, Berger, Claire, additional, Diesch, Tamara, additional, Dirksen, Uta, additional, Ginsberg, Jill, additional, Giwercman, Aleksander, additional, Grabow, Desiree, additional, Gracia, Clarisa, additional, Hunter, Sarah E, additional, Inthorn, Julia, additional, Kaatsch, Peter, additional, Kelvin, Joanne F, additional, Klosky, James L, additional, Laven, Joop S E, additional, Lockart, Barbara A, additional, Neggers, Sebastian JCMM, additional, Paul, Norbert W, additional, Peate, Michelle, additional, Phillips, Bob, additional, Reed, Damon R, additional, Tinner, Eva Maria E, additional, van den Berg, Marleen, additional, and Verhaak, Chris, additional

Published
2021
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19. Communication and ethical considerations for fertility preservation for patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Mulder, Renée L, primary, Font-Gonzalez, Anna, additional, van Dulmen-den Broeder, Eline, additional, Quinn, Gwendolyn P, additional, Ginsberg, Jill P, additional, Loeffen, Erik A H, additional, Hudson, Melissa M, additional, Burns, Karen C, additional, van Santen, Hanneke M, additional, Berger, Claire, additional, Diesch, Tamara, additional, Dirksen, Uta, additional, Giwercman, Aleksander, additional, Gracia, Clarisa, additional, Hunter, Sarah E, additional, Kelvin, Joanne F, additional, Klosky, James L, additional, Laven, Joop S E, additional, Lockart, Barbara A, additional, Neggers, Sebastian J C M M, additional, Peate, Michelle, additional, Phillips, Bob, additional, Reed, Damon R, additional, Tinner, Eva Maria E, additional, Byrne, Julianne, additional, Veening, Margreet, additional, van de Berg, Marleen, additional, Verhaak, Chris M, additional, Anazodo, Antoinette, additional, Rodriguez-Wallberg, Kenny, additional, van den Heuvel-Eibrink, Marry M, additional, Asogwa, Ogechukwu A, additional, Brownsdon, Alexandra, additional, Wallace, W Hamish, additional, Green, Daniel M, additional, Skinner, Roderick, additional, Haupt, Riccardo, additional, Kenney, Lisa B, additional, Levine, Jennifer, additional, van de Wetering, Marianne D, additional, Tissing, Wim J E, additional, Paul, Norbert W, additional, Kremer, Leontien C M, additional, Inthorn, Julia, additional, Anderson, Richard A, additional, Barnbrock, Anke, additional, Beck, Joern D, additional, Bos, Annelies M E, additional, Calaminus, Gabriele, additional, Constine, Louis S, additional, Demeestere, Isabelle, additional, Denzer, Christian, additional, Grabow, Desiree, additional, di Iorgi, Natascia, additional, Hoefgen, Holly R, additional, Jahnukainen, Kirsi, additional, Kaatsch, Peter, additional, Kebudi, Rejin, additional, Lambalk, Cornelis, additional, Langer, Thorsten, additional, Loonen, Jacqueline, additional, Lorenzo, Armando, additional, Meacham, Lillian R, additional, Meissner, Andreas, additional, Mitchell, Rod T, additional, Nahata, Leena, additional, Ranft, Andreas, additional, Dinkelman-Smit, Marij, additional, Stern, Catharyn, additional, Stutz-Grunder, Eveline, additional, Tournaye, Herman, additional, van Dorp, Wendy, additional, van Pelt, Ans M M, additional, de Vries, Andrica, additional, and Yu, Richard, additional

Published
2021
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21. Reproductive Function and Outcomes in Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Review

Author

van Dorp, Wendy, primary, Haupt, Riccardo, additional, Anderson, Richard A., additional, Mulder, Renee L., additional, van den Heuvel-Eibrink, Marry M., additional, van Dulmen-den Broeder, Eline, additional, Su, H. Irene, additional, Winther, Jeanette F., additional, Hudson, Melissa M., additional, Levine, Jennifer M., additional, and Wallace, W. Hamish, additional

Published
2018
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22. Reduced trigeminovascular cyclicity in patients with menstrually related migraine

Author

Ibrahimi, K, van Oosterhout, WPJ, Dorp, Wendy, Danser, Jan, Van den Berg - Garrelds, Ingrid, Kushner, Steven, Lesaffre, Emmanuel, Terwindt, GM, Ferrari, MD, van den Meiracker, Ton, Maassen van den Brink, Antoinette, Internal Medicine, Obstetrics & Gynecology, Psychiatry, and Epidemiology

Subjects
integumentary system
Abstract

Objective: A case-control study to investigate the effect of the menstrual cycle on trigeminal nerve-induced vasodilation in healthy women and patients with menstrually related migraine (MRM). Methods: Using a laser-Doppler imager, we compared the vasodilator effects of capsaicin application and electrical stimulation (ES) on the forehead skin, a trigeminal nerve-innervated dermatome, in premenopausal patients with MRM (n = 22), healthy controls (n = 20), and postmenopausal women without migraine (n = 22). Blood samples were collected for female sex hormone measurements. Results: Dermal blood flow(DBF) responses to capsaicin were higher in controls during days 1-2 than during days 19-21 of their menstruation cycle (mean E-max +/- SEM: 203 +/- 28 AU vs 156 +/- 27 AU [p = 0.031] for 0.06 mg/mL capsaicin and 497 +/- 25 AU vs 456 +/- 24 AU [p = 0.009] for 6.0 mg/mL capsaicin). In contrast, patients with MRM demonstrated DBF responses without significant cycle-dependent variability (days 1-2 vs days 19-21: E-max 148 +/- 20 AU vs 154 +/- 20 AU [p = 0.788] for 0.06 mg/mL capsaicin and 470 +/- 17 AU vs 465 +/- 20 AU [p = 0.679] for 6.0 mg/mL capsaicin). DBF responses to ES were not different between either patients with MRM or controls, at either occasion. Estradiol levels on days 19-21 of the menstrual cycle were higher in healthy controls (mean +/- SEM: 75 +/- 8 pg/mL) than in patients with MRM (52 +/- 4 pg/mL, p = 0.014). In postmenopausal women, DBF responses to capsaicin and ES, as well as estradiol levels at both visits, were all significantly reduced compared to patients with MRM and controls (in all cases, p < 0.05). Conclusions: Our study provides evidence for a reduced menstrual cyclicity of both estradiol levels and the trigeminovascular vasodilator system in patients with MRM.

Published
2015

23. Gonadal function in boys with newly diagnosed cancer before the start of treatment

Author

Wigny, Kiki M G J, van Dorp, Wendy, van der Kooi, Anne-Lotte L F, de Rijke, Yolanda B, de Vries, Andrica C H, Smit, Marij, Pluijm, Saskia M F, van den Akker, Erica L T, Pieters, Rob, Laven, Joop S E, van den Heuvel-Eibrink, Marry M, Wigny, Kiki M G J, van Dorp, Wendy, van der Kooi, Anne-Lotte L F, de Rijke, Yolanda B, de Vries, Andrica C H, Smit, Marij, Pluijm, Saskia M F, van den Akker, Erica L T, Pieters, Rob, Laven, Joop S E, and van den Heuvel-Eibrink, Marry M

Published
2016

24. Recommendations for Premature Ovarian Insufficiency Surveillance for Female Survivors of Childhood, Adolescent, and Young Adult Cancer : A Report From the International Late Effects of Childhood Cancer Guideline Harmonization Group in Collaboration With the PanCareSurFup Consortium

Author

van Dorp, Wendy, Mulder, Renée L, Kremer, Leontien C M, Hudson, Melissa M, van den Heuvel-Eibrink, Marry M, van den Berg, Marleen H, Levine, Jennifer M, van Dulmen-den Broeder, Eline, di Iorgi, Natascia, Albanese, Assunta, Armenian, Saro H, Bhatia, Smita, Constine, Louis S, Corrias, Andreas, Deans, Rebecca, Dirksen, Uta, Gracia, Clarisa R, Hjorth, Lars, Kroon, Leah, Lambalk, Cornelis B, Landier, Wendy, Levitt, Gill, Leiper, Alison, Meacham, Lillian, Mussa, Alesandro, Neggers, Sebastian J, Oeffinger, Kevin C, Revelli, Alberto, van Santen, Hanneke M, Skinner, Roderick, Toogood, Andrew, Wallace, William H, Haupt, Riccardo, van Dorp, Wendy, Mulder, Renée L, Kremer, Leontien C M, Hudson, Melissa M, van den Heuvel-Eibrink, Marry M, van den Berg, Marleen H, Levine, Jennifer M, van Dulmen-den Broeder, Eline, di Iorgi, Natascia, Albanese, Assunta, Armenian, Saro H, Bhatia, Smita, Constine, Louis S, Corrias, Andreas, Deans, Rebecca, Dirksen, Uta, Gracia, Clarisa R, Hjorth, Lars, Kroon, Leah, Lambalk, Cornelis B, Landier, Wendy, Levitt, Gill, Leiper, Alison, Meacham, Lillian, Mussa, Alesandro, Neggers, Sebastian J, Oeffinger, Kevin C, Revelli, Alberto, van Santen, Hanneke M, Skinner, Roderick, Toogood, Andrew, Wallace, William H, and Haupt, Riccardo

Published
2016

25. Gonadal function in boys with newly diagnosed cancer before the start of treatment

Author

PMC Research, PMC Medisch specialisten, Child Health, Zorg en O&O, Wigny, Kiki M G J, van Dorp, Wendy, van der Kooi, Anne-Lotte L F, de Rijke, Yolanda B, de Vries, Andrica C H, Smit, Marij, Pluijm, Saskia M F, van den Akker, Erica L T, Pieters, Rob, Laven, Joop S E, van den Heuvel-Eibrink, Marry M, PMC Research, PMC Medisch specialisten, Child Health, Zorg en O&O, Wigny, Kiki M G J, van Dorp, Wendy, van der Kooi, Anne-Lotte L F, de Rijke, Yolanda B, de Vries, Andrica C H, Smit, Marij, Pluijm, Saskia M F, van den Akker, Erica L T, Pieters, Rob, Laven, Joop S E, and van den Heuvel-Eibrink, Marry M

Published
2016

26. Recommendations for Premature Ovarian Insufficiency Surveillance for Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Report From the International Late Effects of Childhood Cancer Guideline Harmonization Group in Collaboration With the PanCareSurFup Consortium

Author

Zorg en O&O, Endocrinologie patientenzorg, Child Health, van Dorp, Wendy, Mulder, Renée L, Kremer, Leontien C M, Hudson, Melissa M, van den Heuvel-Eibrink, Marry M, van den Berg, Marleen H, Levine, Jennifer M, van Dulmen-den Broeder, Eline, di Iorgi, Natascia, Albanese, Assunta, Armenian, Saro H, Bhatia, Smita, Constine, Louis S, Corrias, Andreas, Deans, Rebecca, Dirksen, Uta, Gracia, Clarisa R, Hjorth, Lars, Kroon, Leah, Lambalk, Cornelis B, Landier, Wendy, Levitt, Gill, Leiper, Alison, Meacham, Lillian, Mussa, Alesandro, Neggers, Sebastian J, Oeffinger, Kevin C, Revelli, Alberto, van Santen, Hanneke M, Skinner, Roderick, Toogood, Andrew, Wallace, William H, Haupt, Riccardo, Zorg en O&O, Endocrinologie patientenzorg, Child Health, van Dorp, Wendy, Mulder, Renée L, Kremer, Leontien C M, Hudson, Melissa M, van den Heuvel-Eibrink, Marry M, van den Berg, Marleen H, Levine, Jennifer M, van Dulmen-den Broeder, Eline, di Iorgi, Natascia, Albanese, Assunta, Armenian, Saro H, Bhatia, Smita, Constine, Louis S, Corrias, Andreas, Deans, Rebecca, Dirksen, Uta, Gracia, Clarisa R, Hjorth, Lars, Kroon, Leah, Lambalk, Cornelis B, Landier, Wendy, Levitt, Gill, Leiper, Alison, Meacham, Lillian, Mussa, Alesandro, Neggers, Sebastian J, Oeffinger, Kevin C, Revelli, Alberto, van Santen, Hanneke M, Skinner, Roderick, Toogood, Andrew, Wallace, William H, and Haupt, Riccardo

Published
2016

27. Recommendations for Premature Ovarian Insufficiency Surveillance for Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Report From the International Late Effects of Childhood Cancer Guideline Harmonization Group in Collaboration With the PanCareSurFup Consortium

Author

van Dorp, Wendy, primary, Mulder, Renée L., additional, Kremer, Leontien C.M., additional, Hudson, Melissa M., additional, van den Heuvel-Eibrink, Marry M., additional, van den Berg, Marleen H., additional, Levine, Jennifer M., additional, van Dulmen-den Broeder, Eline, additional, di Iorgi, Natascia, additional, Albanese, Assunta, additional, Armenian, Saro H., additional, Bhatia, Smita, additional, Constine, Louis S., additional, Corrias, Andreas, additional, Deans, Rebecca, additional, Dirksen, Uta, additional, Gracia, Clarisa R., additional, Hjorth, Lars, additional, Kroon, Leah, additional, Lambalk, Cornelis B., additional, Landier, Wendy, additional, Levitt, Gill, additional, Leiper, Alison, additional, Meacham, Lillian, additional, Mussa, Alesandro, additional, Neggers, Sebastian J., additional, Oeffinger, Kevin C., additional, Revelli, Alberto, additional, van Santen, Hanneke M., additional, Skinner, Roderick, additional, Toogood, Andrew, additional, Wallace, William H., additional, and Haupt, Riccardo, additional

Published
2016
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28. Gonadal function in boys with newly diagnosed cancer before the start of treatment

Author

Wigny, Kiki M.G.J., primary, van Dorp, Wendy, additional, van der Kooi, Anne-Lotte L.F., additional, de Rijke, Yolanda B., additional, de Vries, Andrica C.H., additional, Smit, Marij, additional, Pluijm, Saskia M.F., additional, van den Akker, Erica L.T., additional, Pieters, Rob, additional, Laven, Joop S.E., additional, and van den Heuvel-Eibrink, Marry M., additional

Published
2016
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33. Characteristics and Outcome of Pediatric Non-Hodgkin Lymphoma Patients With Ovarian Infiltration at Presentation

Author

Dorp, Wendy, Owusuaa, C, Laven, Joop, Van den Heuvel - Eibrink, Marry, Beishuizen, Auke, Obstetrics & Gynecology, and Pediatrics

Subjects
SDG 3 - Good Health and Well-being, hemic and lymphatic diseases
Abstract

BackgroundOvarian infiltration in pediatric non-Hodgkin lymphoma (NHL) at presentation is rare and information on outcome is scarce and mainly based on case reports and small series. ProcedureEvaluation of clinical characteristics and outcome of ovarian infiltrated pediatric NHL cases of a single center, and an extensive review of the all cases reported so far in literature. ResultsAt presentation, 6/60 female NHL cases of our center had ovarian infiltration, and combining these cases with earlier case reports, a total of 42 cases were identified. Median age at presentation was 10.9 years (range 0-18), and all but one had a B-cell immunophenotype, with 32/42 cases being classified as Burkitt. Bilateral involvement was reported in 26/41 cases, of which 22 were bilaterally ovariectomized as first treatment. All cases were treated with chemotherapy. Relapses were repor ConclusionsWe conclude that in case of ovarian tumors with negative markers, NHL should be considered in order to avoid unnecessary surgery. Pediatr Blood Cancer 2013;60:2054-2059. (c) 2013 Wiley Periodicals, Inc.

Published
2013

36. Determinants of Low Bone Mineral Density after Childhood Cancer

Author

den Hoed, Marissa, primary, Klap, Bibi C., additional, Te Winkel, Mariël L., additional, Stolk, Lisette, additional, Pieters, Rob, additional, van Waas, Marjolein, additional, Neggers, Sebastian J.C.M.M., additional, Blijdorp, Karin, additional, van Dorp, Wendy, additional, Boot, A.M., additional, Pluijm, S.M.F., additional, and van den Heuvel-Eibrink, Marry M., additional

Published
2014
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40. Emotional Distress in 652 Dutch Very Long-term Survivors of Childhood Cancer, Using the Hospital Anxiety and Depression Scale (HADS)

Author

Geest, Ivana M.M. van der, Dorp, Wendy van, Hop, Wim C.J., Neggers, Sebastian J.C.M.M., Vries, Andrica C.H. de, Pieters, Rob, Aarsen, Femke K., and Heuvel-Eibrink, Marry M. van den

Abstract

After a more successful treatment of pediatric cancer, the number of childhood cancer survivors is progressively increasing. Consequently, awareness of psychological late sequelae is important.

Published
2013
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41. Reduced trigeminovascular cyclicity in patients with menstrually related migraine.

Author

Ibrahimi K, van Oosterhout WP, van Dorp W, Danser AH, Garrelds IM, Kushner SA, Lesaffre EM, Terwindt GM, Ferrari MD, van den Meiracker AH, and MaassenVanDenBrink A

Subjects
Adult, Aged, Case-Control Studies, Estrogens blood, Female, Forehead, Humans, Middle Aged, Progesterone blood, Young Adult, Capsaicin pharmacology, Electric Stimulation, Menstruation Disturbances physiopathology, Migraine Disorders physiopathology, Periodicity, Sensory System Agents pharmacology, Skin blood supply, Trigeminal Nerve drug effects, Vasodilation drug effects
Abstract

Objective: A case-control study to investigate the effect of the menstrual cycle on trigeminal nerve-induced vasodilation in healthy women and patients with menstrually related migraine (MRM)., Methods: Using a laser-Doppler imager, we compared the vasodilator effects of capsaicin application and electrical stimulation (ES) on the forehead skin, a trigeminal nerve-innervated dermatome, in premenopausal patients with MRM (n = 22), healthy controls (n = 20), and postmenopausal women without migraine (n = 22). Blood samples were collected for female sex hormone measurements., Results: Dermal blood flow (DBF) responses to capsaicin were higher in controls during days 1-2 than during days 19-21 of their menstruation cycle (mean Emax ± SEM: 203 ± 28 AU vs 156 ± 27 AU [p = 0.031] for 0.06 mg/mL capsaicin and 497 ± 25 AU vs 456 ± 24 AU [p = 0.009] for 6.0 mg/mL capsaicin). In contrast, patients with MRM demonstrated DBF responses without significant cycle-dependent variability (days 1-2 vs days 19-21: Emax 148 ± 20 AU vs 154 ± 20 AU [p = 0.788] for 0.06 mg/mL capsaicin and 470 ± 17 AU vs 465 ± 20 AU [p = 0.679] for 6.0 mg/mL capsaicin). DBF responses to ES were not different between either patients with MRM or controls, at either occasion. Estradiol levels on days 19-21 of the menstrual cycle were higher in healthy controls (mean ± SEM: 75 ± 8 pg/mL) than in patients with MRM (52 ± 4 pg/mL, p = 0.014). In postmenopausal women, DBF responses to capsaicin and ES, as well as estradiol levels at both visits, were all significantly reduced compared to patients with MRM and controls (in all cases, p < 0.05)., Conclusions: Our study provides evidence for a reduced menstrual cyclicity of both estradiol levels and the trigeminovascular vasodilator system in patients with MRM., (© 2014 American Academy of Neurology.)

Published
2015
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42. Obesity independently influences gonadal function in very long-term adult male survivors of childhood cancer.

Author

Blijdorp K, van Dorp W, Laven JS, Pieters R, de Jong FH, Pluijm SM, van der Lely AJ, van den Heuvel-Eibrink MM, and Neggers SJ

Subjects
Adolescent, Adult, Body Composition, Body Mass Index, Case-Control Studies, Child, Child, Preschool, Follicle Stimulating Hormone blood, Humans, Infant, Inhibins blood, Male, Middle Aged, Retrospective Studies, Sex Hormone-Binding Globulin metabolism, Survivors, Testosterone blood, Waist Circumference, Waist-Hip Ratio, Young Adult, Neoplasms complications, Obesity complications, Testis physiopathology
Abstract

Objective: Although obesity is associated with gonadal dysfunction in the general population, gonadotoxic treatment might diminish the impact of obesity in childhood cancer survivors (CCS). The aim was to evaluate whether altered body composition is associated with gonadal dysfunction in male CCS, independent of gonadotoxic cancer treatment., Methods: Three hundred fifty-one male CCS were included. Median age at diagnosis was 5.9 years (0-17.8) and median age at follow-up 25.6 years (18.0-45.8). Total and non-SHBG-bound testosterone, sex hormone-binding globulin, inhibin B, and follicle-stimulating hormone (FSH) were studied. Potential determinants were BMI, waist circumference, waist-hip ratio, and body composition measures (dual energy X-ray absorptiometry)., Results: Non-SHBG-bound testosterone was significantly decreased in survivors with BMI ≥ 30 kg/m(2) (adjusted mean 9.1 nmol/L vs. 10.2 nmol/L, P = 0.015), high fat percentage (10.0 vs. 11.2, P = 0.004), and high waist circumference (>102 cm) (9.0 vs. 11.0, P = 0.020). Survivors with high fat percentage (≥25%) had significantly lower inhibin B/FSH ratios (inhibin B/FSH ratio: β -34%, P = 0.041)., Conclusion: Obesity is associated with gonadal dysfunction in male CCS, independent of the irreversible effect of previous cancer treatment. Randomized controlled trials are required to evaluate whether weight normalization could improve gonadal function, especially in obese survivors with potential other mechanisms than lifestyle causing their obesity., (Copyright © 2014 The Obesity Society.)

Published
2014
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43. [Resuscitation of a pregnant patient--don't hesitate to perform a perimortem caesarean section].

Author

van Dorp W, Maissan IM, Hapa LR, Creemers JW, and van Muyden-Martens JE

Subjects
Adult, Disseminated Intravascular Coagulation etiology, Embolism, Amniotic Fluid etiology, Embolism, Amniotic Fluid therapy, Female, Humans, Infant, Newborn, Pregnancy, Treatment Outcome, Cardiopulmonary Resuscitation, Cesarean Section, Disseminated Intravascular Coagulation therapy, Heart Arrest therapy, Pregnancy Complications, Cardiovascular therapy
Abstract

Cardiac arrest is a rare and life-threatening complication during pregnancy. We present the case of a 26-year-old patient in her first pregnancy who during induction of labour at 41 weeks had a cardiac arrest caused by an amniotic fluid embolism. As part of the resuscitation procedure, a perimortem caesarean section was performed in the delivery room within five minutes. Following the caesarean section, she developed diffuse intravascular coagulation and massive, life-threatening haemorrhage which necessitated supravaginal uterus amputation. Afterwards mother and son recovered well and were discharged from hospital in good condition after 13 days. Pregnancy-induced changes in anatomy and physiology warrant a different approach during resuscitation. All medical personnel involved in the care of pregnant women should be trained to act promptly in acute situations. Training should increase knowledge of the aforementioned changes and stress the importance of performing a perimortem caesarean section, when necessary, on site and without hesitation.

Published
2010

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