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2. Fibroblast Activation Protein-Targeted Photodynamic Therapy of Cancer-Associated Fibroblasts in Murine Models for Pancreatic Ductal Adenocarcinoma

Author

Dorst, Daphne N., primary, Smeets, Esther M. M., additional, Klein, Christian, additional, Frielink, Cathelijne, additional, Geijs, Daan, additional, Trajkovic-Arsic, Marija, additional, Cheung, Phyllis F. Y., additional, Stommel, Martijn W. J., additional, Gotthardt, Martin, additional, Siveke, Jens T., additional, Aarntzen, Erik H. J. G., additional, and van Lith, Sanne A. M., additional

Published
2023
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3. Fibroblast Activation Protein-Targeting Minibody-IRDye700DX for Ablation of the Cancer-Associated Fibroblast with Photodynamic Therapy

Author

Smeets, Esther M. M., primary, Dorst, Daphne N., additional, Franssen, Gerben M., additional, van Essen, Merijn S., additional, Frielink, Cathelijne, additional, Stommel, Martijn W. J., additional, Trajkovic-Arsic, Marija, additional, Cheung, Phyllis F., additional, Siveke, Jens T., additional, Wilson, Ian, additional, Mascioni, Alessandro, additional, Aarntzen, Erik H. J. G., additional, and van Lith, Sanne A. M., additional

Published
2023
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6. Fibroblast Activation Protein Targeted Photodynamic Therapy Selectively Kills Activated Skin Fibroblasts from Systemic Sclerosis Patients and Prevents Tissue Contraction

Author

Dorst, Daphne N., primary, van Caam, Arjan P. M., additional, Vitters, Elly L., additional, Walgreen, Birgitte, additional, Helsen, Monique M. A., additional, Klein, Christian, additional, Gudi, Shreya, additional, Wubs, Tirza, additional, Kumari, Jyoti, additional, Vonk, Madelon C., additional, van der Kraan, Peter M., additional, and Koenders, Marije I., additional

Published
2021
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7. Photodynamic Therapy Targeting Macrophages Using IRDye700DX-Liposomes Decreases Experimental Arthritis Development

Author

Dorst, Daphne N., primary, Boss, Marti, additional, Rijpkema, Mark, additional, Walgreen, Birgitte, additional, Helsen, Monique M. A., additional, Bos, Desirée L., additional, van Bloois, Louis, additional, Storm, Gerrit, additional, Brom, Maarten, additional, Laverman, Peter, additional, van der Kraan, Peter M., additional, Buitinga, Mijke, additional, Koenders, Marije I., additional, and Gotthardt, Martin, additional

Published
2021
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8. Targeting of fibroblast activation protein in rheumatoid arthritis patients: imaging and ex vivo photodynamic therapy

Author

Dorst, Daphne N, primary, Rijpkema, Mark, additional, Buitinga, Mijke, additional, Walgreen, Birgitte, additional, Helsen, Monique M A, additional, Brennan, Evan, additional, Klein, Christian, additional, Laverman, Peter, additional, Ramming, Andreas, additional, Schmidkonz, Christian, additional, Kuwert, Torsten, additional, Schett, Georg, additional, van der Kraan, Peter M, additional, Gotthardt, Martin, additional, and Koenders, Marije I, additional

Published
2021
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9. Targeting of fibroblast activation protein in rheumatoid arthritis patients: imaging and ex vivo photodynamic therapy.

Author

Dorst, Daphne N, Rijpkema, Mark, Buitinga, Mijke, Walgreen, Birgitte, Helsen, Monique M A, Brennan, Evan, Klein, Christian, Laverman, Peter, Ramming, Andreas, Schmidkonz, Christian, Kuwert, Torsten, Schett, Georg, Kraan, Peter M van der, Gotthardt, Martin, and Koenders, Marije I

Subjects
*PROTEIN metabolism, *IN vitro studies, *FLOW cytometry, *FIBROBLASTS, *SYNOVIAL membranes, *CELL culture, *MACROPHAGES, *DIAGNOSTIC imaging, *CELL survival, *RHEUMATOID arthritis, *POSITRON emission tomography, *PHOTOCHEMOTHERAPY, *COMPUTED tomography, *CELL death
Abstract

Objective Activated synovial fibroblasts are key effector cells in RA. Selectively depleting these based upon their expression of fibroblast activation protein (FAP) is an attractive therapeutic approach. Here we introduce FAP imaging of inflamed joints using 68Ga-FAPI-04 in a RA patient, and aim to assess feasibility of anti-FAP targeted photodynamic therapy (FAP-tPDT) ex vivo using 28H1-IRDye700DX on RA synovial explants. Methods Remnant synovial tissue from RA patients was processed into 6 mm biopsies and, from several patients, into primary fibroblast cell cultures. Both were treated using FAP-tPDT. Cell viability was measured in fibroblast cultures and biopsies were evaluated for histological markers of cell damage. Selectivity of the effect of FAP-tPDT was assessed using flow cytometry on primary fibroblasts and co-cultured macrophages. Additionally, one RA patient intravenously received 68Ga-FAPI-04 and was scanned using PET/CT imaging. Results In the RA patient, FAPI-04 PET imaging showed high accumulation of the tracer in arthritic joints with very low background signal. In vitro , FAP-tPDT induced cell death in primary RA synovial fibroblasts in a light dose-dependent manner. An upregulation of cell damage markers was observed in the synovial biopsies after FAP-tPDT. No significant effects of FAP-tPDT were noted on macrophages after FAP-tPDT of neighbouring fibroblasts. Conclusion In this study the feasibility of selective FAP-tPDT in synovium of rheumatoid arthritis patients ex vivo is demonstrated. Furthermore, this study provides the first indication that FAP-targeted PET/CT can be used to image arthritic joints, an important step towards application of FAP-tPDT as a targeted locoregional therapy for RA. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Targeted photodynamic therapy selectively kills activated fibroblasts in experimental arthritis

Author

Dorst, Daphne N, primary, Rijpkema, Mark, additional, Boss, Marti, additional, Walgreen, Birgitte, additional, Helsen, Monique M A, additional, Bos, Desirée L, additional, Brom, Maarten, additional, Klein, Christian, additional, Laverman, Peter, additional, van der Kraan, Peter M, additional, Gotthardt, Martin, additional, Koenders, Marije I, additional, and Buitinga, Mijke, additional

Published
2020
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