Search

Your search keyword '"Downing, S. S."' showing total 3 results
Start Over Author "Downing, S. S."
3 results on '"Downing, S. S."'

1. Reduction of the ordered-magnetic moment and its relationship to Kondo coherence in Ce$_{1-x}$La$_{x}$Cu$_{2}$Ge$_{2}$

Author

Ueland, B. G., Jo, N. H., Sapkota, A., Tian, W., Masters, M., Hodovanets, H., Downing, S. S., Schmidt, C., McQueeney, R. J., Bud`ko, S. L., Kreyssig, A., Canfield, P. C., and Goldman, A. I.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

The microscopic details of the suppression of antiferromagnetic order in the Kondo-lattice series Ce$_{1-x}$La$_{x}$Cu$_{2}$Ge$_{2}$ due to nonmagnetic dilution by La are revealed through neutron diffraction results for $x=0.20$, $0.40$, $0.75$, and $0.85$. Magnetic Bragg peaks are found for $0.20\le x\le0.75$, and both the N\'{e}el temperature, $T_{\textrm{N}}$, and the ordered magnetic moment per Ce, $\mu$, linearly decrease with increasing $x$. The reduction in $\mu$ points to strong hybridization of the increasingly diluted Ce $4f$ electrons, and we find a remarkable quadratic dependence of $\mu$ on the Kondo-coherence temperature. We discuss our results in terms of local-moment- versus itinerant-type magnetism and mean-field theory, and show that Ce$_{1-x}$La$_{x}$Cu$_{2}$Ge$_{2}$ provides an exceptional opportunity to quantitatively study competing magnetic interactions in a Kondo lattice., Comment: Supplementary material included

Published
2017
Full Text
View/download PDF

3. Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the consortium of investigators of modifiers of BRCA1/BRCA2

Author

Osorio, A. (Ana), Milne, R.L. (Roger), Pallás-Alonso, C.R. (Carmen), Pita, G. (Guillermo), Peterlongo, P. (Paolo), Teulé, A. (A.), Nathanson, K.L. (Katherine), Domchek, S.M. (Susan), Rebbeck, R. (Timothy), Lasa, A. (Adriana), Konstantopoulou, I. (I.), Hogervorst, F.B.L. (Frans), Verhoef, S. (Senno), Dooren, M.F. (Marieke) van, Jager, A. (Agnes), Ausems, M.G.E.M. (Margreet), Aalfs, C.M. (Cora), Asperen, C.J. (Christi) van, Vreeswijk, M.P. (Maaike), Waisfisz, Q. (Quinten), Roozendaal, C.E.P. (Cornelis) van, Ligtenberg, M.J. (Marjolijn), Easton, D.F. (Douglas), Peock, S. (Susan), Cook, M.S. (Matthew), Oliver, C.T. (C. T.), Frost, D. (Debra), Curzon, B. (B.), Evans, D.G. (Gareth), Lalloo, F. (Fiona), Eeles, R. (Rosalind), Izatt, L. (Louise), Davidson, R. (Rosemarie), Adlard, J.W. (Julian), Eccles, D. (Diana), Ong, K.-R. (Kai-Ren), Douglas, F. (Fiona), Downing, S. (S.), Brewer, C. (C.), Walker, L.J. (Lisa), Nevanlinna, H. (Heli), Aittomäki, K. (Kristiina), Couch, F.J. (Fergus), Fredericksen, Z. (Zachary), Lindor, N.M. (Noralane), Godwin, A.K. (Andrew), Isaacs, C. (Claudine), Caligo, M.A. (Maria), Loman, N. (Niklas), Jernström, H. (H.), Barbany-Bustinza, G. (Gisela), Liljegren, A. (Annelie), Ehrencrona, H. (Hans), Stenmark-Askmalm, M. (M.), Feliubadaló, L. (L.), Manoukian, S. (Siranoush), Peissel, B. (Bernard), Zaffaroni, D. (D.), Bonnani, B. (Bernardo), Fortuzzi, S. (S.), Johannson, O.T. (Oskar), Chenevix-Trench, G. (Georgia), Chen, X.C. (X. C.), Beesley, J. (Jonathan), Spurdle, A.B. (Amanda), Sinilnikova, O. (Olga), Healey, S. (Sue), McGuffog, L. (Lesley), Antoniou, A.C. (Antonis), Brunet, J. (Joan), Radice, P. (Paolo), Benítez, J. (Javier), Osorio, A. (Ana), Milne, R.L. (Roger), Pallás-Alonso, C.R. (Carmen), Pita, G. (Guillermo), Peterlongo, P. (Paolo), Teulé, A. (A.), Nathanson, K.L. (Katherine), Domchek, S.M. (Susan), Rebbeck, R. (Timothy), Lasa, A. (Adriana), Konstantopoulou, I. (I.), Hogervorst, F.B.L. (Frans), Verhoef, S. (Senno), Dooren, M.F. (Marieke) van, Jager, A. (Agnes), Ausems, M.G.E.M. (Margreet), Aalfs, C.M. (Cora), Asperen, C.J. (Christi) van, Vreeswijk, M.P. (Maaike), Waisfisz, Q. (Quinten), Roozendaal, C.E.P. (Cornelis) van, Ligtenberg, M.J. (Marjolijn), Easton, D.F. (Douglas), Peock, S. (Susan), Cook, M.S. (Matthew), Oliver, C.T. (C. T.), Frost, D. (Debra), Curzon, B. (B.), Evans, D.G. (Gareth), Lalloo, F. (Fiona), Eeles, R. (Rosalind), Izatt, L. (Louise), Davidson, R. (Rosemarie), Adlard, J.W. (Julian), Eccles, D. (Diana), Ong, K.-R. (Kai-Ren), Douglas, F. (Fiona), Downing, S. (S.), Brewer, C. (C.), Walker, L.J. (Lisa), Nevanlinna, H. (Heli), Aittomäki, K. (Kristiina), Couch, F.J. (Fergus), Fredericksen, Z. (Zachary), Lindor, N.M. (Noralane), Godwin, A.K. (Andrew), Isaacs, C. (Claudine), Caligo, M.A. (Maria), Loman, N. (Niklas), Jernström, H. (H.), Barbany-Bustinza, G. (Gisela), Liljegren, A. (Annelie), Ehrencrona, H. (Hans), Stenmark-Askmalm, M. (M.), Feliubadaló, L. (L.), Manoukian, S. (Siranoush), Peissel, B. (Bernard), Zaffaroni, D. (D.), Bonnani, B. (Bernardo), Fortuzzi, S. (S.), Johannson, O.T. (Oskar), Chenevix-Trench, G. (Georgia), Chen, X.C. (X. C.), Beesley, J. (Jonathan), Spurdle, A.B. (Amanda), Sinilnikova, O. (Olga), Healey, S. (Sue), McGuffog, L. (Lesley), Antoniou, A.C. (Antonis), Brunet, J. (Joan), Radice, P. (Paolo), and Benítez, J. (Javier)

Abstract

Background: Single-nucleotide polymorphisms (SNPs) in genes involved in DNA repair are good candidates to be tested as phenotypic modifiers for carriers of mutations in the high-risk susceptibility genes BRCA1 and BRCA2. The base excision repair (BER) pathway could be particularly interesting given the relation of synthetic lethality that exists between one of the components of the pathway, PARP1, and both BRCA1 and BRCA2. In this study, we have evaluated the XRCC1 gene that participates in the BER pathway, as phenotypic modifier of BRCA1 and BRCA2. Methods: Three common SNPs in the gene, c.-77C>T (rs3213245) p.Arg280His (rs25489) and p.Gln399Arg (rs25487) were analysed in a series of 701 BRCA1 and 576 BRCA2 mutation carriers. Results: An association was observed between p.Arg280His-rs25489 and breast cancer risk for BRCA2 mutation carriers, with rare homozygotes at increased risk relative to common homozygotes (hazard ratio: 22.3, 95% confidence interval: 14.3-34, P<0.001). This association was further tested in a second series of 4480 BRCA1 and 3016 BRCA2 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1 and BRCA2.Conclusions and inteNo evidence of association was found when the larger series was analysed which lead us to conclude that none of the three SNPs are significant modifiers of breast cancer risk for mutation carriers.

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results