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1. Short peripheral blood leukocyte telomere length in rheumatoid arthritis-interstitial lung disease.

Author

Doyle, Tracy, Juge, Pierre-Antoine, Peljto, Anna, Lee, Seoyeon, Walts, Avram, Esposito, Anthony, Poli, Sergio, Gill, Ritu, Hatabu, Hiroto, Nishino, Mizuki, Dellaripa, Paul, Weinblatt, Michael, Shadick, Nancy, Demoruelle, M, Sparks, Jeffrey, Rosas, Ivan, Granger, Benjamin, Deane, Kevin, Crestani, Bruno, Wolters, Paul, Dieudé, Philippe, and Lee, Joyce

Subjects
interstitial fibrosis, rheumatoid lung disease, Humans, Telomere Shortening, Telomere, Arthritis, Rheumatoid, Lung Diseases, Interstitial, Smoking
Abstract

Shortened telomere lengths (TLs) can be caused by single nucleotide polymorphisms and loss-of-function mutations in telomere-related genes (TRG), as well as ageing and lifestyle factors such as smoking. Our objective was to determine if shortened TL is associated with interstitial lung disease (ILD) in individuals with rheumatoid arthritis (RA). This is the largest study to demonstrate and replicate that shortened peripheral blood leukocytes-TL is associated with ILD in patients with RA compared with RA without ILD in a multinational cohort, and short PBL-TL was associated with baseline disease severity in RA-ILD as measured by forced vital capacity percent predicted.

Published
2024

2. Forced vital capacity trajectories and risk of lung transplant and ILD-related mortality among patients with rheumatoid arthritis-associated interstitial lung disease

Author

Venkat, Rathnam K., Hayashi, Keigo, Juge, Pierre-Antoine, McDermott, Gregory, Paudel, Misti, Wang, Xiaosong, Vanni, Kathleen M. M., Kowalski, Emily N., Qian, Grace, Bade, Katarina J., Saavedra, Alene A., Mueller, Kevin T., Chang, Sung Hae, Dellaripa, Paul F., Weinblatt, Michael E., Shadick, Nancy A., Doyle, Tracy J., Dieude, Philippe, and Sparks, Jeffrey A.

Published
2024
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3. Systemic sclerosis associated interstitial lung disease: a conceptual framework for subclinical, clinical and progressive disease.

Author

Roofeh, David, Brown, Kevin, Kazerooni, Ella, Tashkin, Donald, Assassi, Shervin, Martinez, Fernando, Wells, Athol, Raghu, Ganesh, Denton, Christopher, Chung, Lorinda, Hoffmann-Vold, Anna-Maria, Distler, Oliver, Johannson, Kerri, Allanore, Yannick, Matteson, Eric, Kawano-Dourado, Leticia, Pauling, John, Seibold, James, Volkmann, Elizabeth, Walsh, Simon, Oddis, Chester, White, Eric, Barratt, Shaney, Bernstein, Elana, Domsic, Robyn, Dellaripa, Paul, Conway, Richard, Rosas, Ivan, Bhatt, Nitin, Hsu, Vivien, Ingegnoli, Francesca, Kahaleh, Bashar, Garcha, Puneet, Gupta, Nishant, Khanna, Surabhi, Korsten, Peter, Lin, Celia, Mathai, Stephen, Strand, Vibeke, Doyle, Tracy, Steen, Virginia, Zoz, Donald, Ovalles-Bonilla, Juan, Rodriguez-Pinto, Ignasi, Shenoy, Padmanabha, Lewandoski, Andrew, Belloli, Elizabeth, Lescoat, Alain, Nagaraja, Vivek, Ye, Wen, Huang, Suiyuan, Maher, Toby, and Khanna, Dinesh

Subjects
connective tissue disease interstitial lung disease, systemic sclerosis associated interstitial lung disease subsets, systemic sclerosis interstitial lung disease, Humans, Lung Diseases, Interstitial, Scleroderma, Systemic, Vital Capacity, Tomography, X-Ray Computed, Severity of Illness Index, Lung
Abstract

OBJECTIVES: To establish a framework by which experts define disease subsets in systemic sclerosis associated interstitial lung disease (SSc-ILD). METHODS: A conceptual framework for subclinical, clinical and progressive ILD was provided to 83 experts, asking them to use the framework and classify actual SSc-ILD patients. Each patient profile was designed to be classified by at least four experts in terms of severity and risk of progression at baseline; progression was based on 1-year follow-up data. A consensus was reached if ≥75% of experts agreed. Experts provided information on which items were important in determining classification. RESULTS: Forty-four experts (53%) completed the survey. Consensus was achieved on the dimensions of severity (75%, 60 of 80 profiles), risk of progression (71%, 57 of 80 profiles) and progressive ILD (60%, 24 of 40 profiles). For profiles achieving consensus, most were classified as clinical ILD (92%), low risk (54%) and stable (71%). Severity and disease progression overlapped in terms of framework items that were most influential in classifying patients (forced vital capacity, extent of lung involvement on high resolution chest CT [HRCT]); risk of progression was influenced primarily by disease duration. CONCLUSIONS: Using our proposed conceptual framework, international experts were able to achieve a consensus on classifying SSc-ILD patients along the dimensions of disease severity, risk of progression and progression over time. Experts rely on similar items when classifying disease severity and progression: a combination of spirometry and gas exchange and quantitative HRCT.

Published
2023

5. MUC5B promoter variant rs35705950 and rheumatoid arthritis associated interstitial lung disease survival and progression

Author

Juge, Pierre-Antoine, Solomon, Joshua J, van Moorsel, Coline HM, Garofoli, Romain, Lee, Joyce S, Louis-Sydney, Fabienne, Rojas-Serrano, Jorge, González-Pérez, Montserrat I, Mejia, Mayra, Buendia-Roldán, Ivette, Falfán-Valencia, Ramcés, Ambrocio-Ortiz, Enrique, Manali, Effrosyni, Papiris, Spyros A, Karageorgas, Theofanis, Boumpas, Dimitrios, Antoniou, Katarina M, Sidiropoulos, Prodromos, Trachalaki, Athina, van der Vis, Joanne J, Jamnitski, Anna, Grutters, Jan C, Kannengiesser, Caroline, Borie, Raphaël, Kawano-Dourado, Leticia, Wemeau-Stervinou, Lidwine, Flipo, René-Marc, Nunes, Hilario, Uzunhan, Yurdagul, Valeyre, Dominique, Saidenberg-Kermanac'h, Nathalie, Boissier, Marie-Christophe, Richez, Christophe, Schaeverbeke, Thierry, Doyle, Tracy, Wolters, Paul J, Debray, Marie-Pierre, Boileau, Catherine, Porcher, Raphaël, Schwartz, David A, Crestani, Bruno, and Dieudé, Philippe

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Genetics, Lung, Autoimmune Disease, Rare Diseases, Arthritis, Inflammatory and immune system, Respiratory, Aged, Arthritis, Rheumatoid, Female, Humans, Idiopathic Pulmonary Fibrosis, Lung Diseases, Interstitial, Mucin-5B, Promoter Regions, Genetic, Rheumatoid Arthritis, Interstitial Lung Disease, MUC5B, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences
Abstract

BackgroundThe major risk factor for idiopathic pulmonary fibrosis (IPF), MUC5B rs35705950, was found to be associated with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Whilst the MUC5B rs35705950 T risk allele has been associated with better survival in IPF, its impact on RA-ILD prognosis remains to be determined. Our objective was to explore the influence of MUC5B rs35705950 on survival and progression in RA-ILD.MethodsThrough an international retrospective observational study, patients with RA-ILD were genotyped for the MUC5B rs35705950 variant and consecutive pulmonary function tests (PFTs) findings were collected. Longitudinal data up to a 10-year follow-up were considered and analyzed using mixed regression models. Proportional hazards and joint proportional hazards models were used to analyze the association of baseline and longitudinal variables with lung transplant-free survival. Significant progression of RA-ILD was defined as at least an absolute or relative 10% decline of forced vital capacity at 2 years from baseline.ResultsOut of 321 registered patients, 261 were included in the study: 139 women (53.3%), median age at RA-ILD diagnosis 65 years (interquartile range [IQR] 57 to 71), 151 ever smokers (59.2%). Median follow-up was 3.5 years (IQR 1.3 to 6.6). Mortality rate was 32% (95%CI 19 to 42) at 10 years. The MUC5B rs35705950 variant did not impact lung transplant-free survival (HR for the T risk allele carriers=1.26; 95%CI 0.61 to 2.62; P=0.53). Decline in pulmonary function at 2 years was not influenced by MUC5B rs35705950 (OR=0.95; 95%CI 0.44 to 2.05; P=0.89), irrespective of the HRCT pattern.ConclusionIn this study, the MUC5B rs35705950 promoter variant did not influence transplant- free survival or decline in pulmonary function in patients with RA-ILD.

Published
2021

7. Autoantibodies against citrullinated and native proteins and prediction of rheumatoid arthritis-associated interstitial lung disease: a nested case–control study

Author

Kronzer, Vanessa L, Hayashi, Keigo, Yoshida, Kazuki, Davis, John M, III, McDermott, Gregory C, Huang, Weixing, Dellaripa, Paul F, Cui, Jing, Feathers, Vivi, Gill, Ritu R, Hatabu, Hiroto, Nishino, Mizuki, Blaustein, Rachel, Crowson, Cynthia S, Robinson, William H, Sokolove, Jeremy, Liao, Katherine P, Weinblatt, Michael E, Shadick, Nancy A, Doyle, Tracy J, and Sparks, Jeffrey A

Published
2023
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8. Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study

Author

Haynes-Harp, Shana, Poli, Fernando, Vidya, Coimbatore Sree, Baron, Rebecca R., Clouser, Timothy, Doyle, Tracy, Maeda, Anthony, Highland, Kristin B., Albayda, Jemima F., Collins, Sarah E., Suresh, Karthik S., Davis, John M., Limper, Andrew H., Amigues, Isabel, Eliopoulos, Kristina, Swigris, Jeffery J., Humphries, Stephen, Huntwork, John C., Glynn, Chris, Duncan, Steve R., Danila, Maria I., Glassberg, Marilyn K., Oberstein, Elana M., Belloli, Elizabeth A., Briggs, Linda, Nagaraja, Vivek, Cholewa, Linda, DiFranco, Donna, Green, Edward, Liffick, Christie, Naik, Tanvi, Montas, Genevieve, Lebiedz-Odrobina, Dorota, Bissell, Reba, Wener, Mark, Lancaster, Lisa H., Crawford, Leslie J., Chan, Karmela, Kaner, Robert J., Morris, Alicia, Wu, Xiaoping, Khalidi, Nader A., Ryerson, Christopher J., Wong, Alyson W., Fell, Charlene D., LeClercq, Sharon A., Hyman, Mark, Shapera, Shane, Mittoo, Shikha, Shaffu, Shireen, Gaffney, Karl, Wilson, Andrew M., Barratt, Shaney, Gunawardena, Harsha, Hoyles, Rachel K., David, Joel, Kewalramani, Namrata, Maher, Toby M., Molyneaux, Philip L., Kokosi, Maria A., Cates, Matthew J., Mandizha, Mandizha, Ashish, Abdul, Chelliah, Gladstone, Parfrey, Helen, Thillai, Muhunthan, Vila, Josephine, Fletcher, Sophie V., Beirne, Paul, Favager, Clair, Brown, Jo, Dawson, Julie K., Ortega, Pilar Rivera, Haque, Sahena, Watson, Pippa, Khoo, Jun K., Symons, Karen, Youssef, Peter, Mackintosh, John A., Solomon, Joshua J, Danoff, Sonye K, Woodhead, Felix A, Hurwitz, Shelley, Maurer, Rie, Glaspole, Ian, Dellaripa, Paul F, Gooptu, Bibek, Vassallo, Robert, Cox, P Gerard, Flaherty, Kevin R, Adamali, Huzaifa I, Gibbons, Michael A, Troy, Lauren, Forrest, Ian A, Lasky, Joseph A, Spencer, Lisa G, Golden, Jeffrey, Scholand, Mary Beth, Chaudhuri, Nazia, Perrella, Mark A, Lynch, David A, Chambers, Daniel C, Kolb, Martin, Spino, Cathie, Raghu, Ganesh, Goldberg, Hilary J, and Rosas, Ivan O

Published
2023
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9. Quantitative Interstitial Abnormality Progression and Outcomes in the Genetic Epidemiology of COPD and Pittsburgh Lung Screening Study Cohorts

Author

Choi, Bina, Adan, Najma, Doyle, Tracy J., San José Estépar, Ruben, Harmouche, Rola, Humphries, Stephen M., Moll, Matthew, Cho, Michael H., Putman, Rachel K., Hunninghake, Gary M., Kalhan, Ravi, Liu, Gabrielle Y., Diaz, Alejandro A., Mason, Stefanie E., Rahaghi, Farbod N., Pistenmaa, Carrie L., Enzer, Nicholas, Poynton, Clare, Sánchez-Ferrero, Gonzalo Vegas, Ross, James C., Lynch, David A., Martinez, Fernando J., Han, MeiLan K., Bowler, Russell P., Wilson, David O., Rosas, Ivan O., Washko, George R., San José Estépar, Raúl, and Ash, Samuel Y.

Published
2023
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10. Rheumatoid arthritis, quantitative parenchymal lung features and mortality among smokers.

Author

McDermott, Gregory C, Hayashi, Keigo, Yoshida, Kazuki, Juge, Pierre-Antoine, Moll, Matthew, Cho, Michael H, Doyle, Tracy J, Kinney, Gregory L, Dellaripa, Paul F, Wallace, Zachary S, Regan, Elizabeth A, Hunninghake, Gary M, Silverman, Edwin K, Ash, Samuel Y, Estepar, Raul San Jose, Washko, George R, and Sparks, Jeffrey A

Abstract

Objectives There have been limited investigations of the prevalence and mortality impact of quantitative CT (QCT) parenchymal lung features in RA. We examined the cross-sectional prevalence and mortality associations of QCT features, comparing RA and non-RA participants. Methods We identified participants with and without RA in COPDGene, a multicentre cohort study of current or former smokers. Using a k -nearest neighbour quantifier, high resolution CT chest scans were scored for percentage of normal lung, interstitial changes and emphysema. We examined associations between QCT features and RA using multivariable linear regression. After dichotomizing participants at the 75th percentile for each QCT feature among non-RA participants, we investigated mortality associations by RA/non-RA status and quartile 4 vs quartiles 1–3 of QCT features using Cox regression. We assessed for statistical interactions between RA and QCT features. Results We identified 82 RA cases and 8820 non-RA comparators. In multivariable linear regression, RA was associated with higher percentage of interstitial changes (β = 1.7 [0.5], P  = 0.0008) but not emphysema (β = 1.3 [1.7], P  = 0.44). Participants with RA and >75th percentile of emphysema had significantly higher mortality than non-RA participants (hazard ratio [HR] 5.86; 95% CI: 3.75, 9.13) as well as RA participants (HR 5.56; 95% CI: 2.71, 11.38) with ≤75th percentile of emphysema. There were statistical interactions between RA and emphysema for mortality (multiplicative P  = 0.014; attributable proportion 0.53; 95% CI: 0.30, 0.70). Conclusion Using machine learning-derived QCT data in a cohort of smokers, RA was associated with higher percentage of interstitial changes. The combination of RA and emphysema conferred >5-fold higher mortality. [ABSTRACT FROM AUTHOR]

Published
2025
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11. MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

Author

Juge, Pierre-Antoine, Lee, Joyce S, Ebstein, Esther, Furukawa, Hiroshi, Dobrinskikh, Evgenia, Gazal, Steven, Kannengiesser, Caroline, Ottaviani, Sébastien, Oka, Shomi, Tohma, Shigeto, Tsuchiya, Naoyuki, Rojas-Serrano, Jorge, González-Pérez, Montserrat I, Mejía, Mayra, Buendía-Roldán, Ivette, Falfán-Valencia, Ramcés, Ambrocio-Ortiz, Enrique, Manali, Effrosyni, Papiris, Spyros A, Karageorgas, Theofanis, Boumpas, Dimitrios, Antoniou, Katarina, van Moorsel, Coline HM, van der Vis, Joanne, de Man, Yaël A, Grutters, Jan C, Wang, Yaping, Borie, Raphaël, Wemeau-Stervinou, Lidwine, Wallaert, Benoît, Flipo, René-Marc, Nunes, Hilario, Valeyre, Dominique, Saidenberg-Kermanac’h, Nathalie, Boissier, Marie-Christophe, Marchand-Adam, Sylvain, Frazier, Aline, Richette, Pascal, Allanore, Yannick, Sibilia, Jean, Dromer, Claire, Richez, Christophe, Schaeverbeke, Thierry, Lioté, Huguette, Thabut, Gabriel, Nathan, Nadia, Amselem, Serge, Soubrier, Martin, Cottin, Vincent, Clément, Annick, Deane, Kevin, Walts, Avram D, Fingerlin, Tasha, Fischer, Aryeh, Ryu, Jay H, Matteson, Eric L, Niewold, Timothy B, Assayag, Deborah, Gross, Andrew, Wolters, Paul, Schwarz, Marvin I, Holers, Michael, Solomon, Joshua J, Doyle, Tracy, Rosas, Ivan O, Blauwendraat, Cornelis, Nalls, Mike A, Debray, Marie-Pierre, Boileau, Catherine, Crestani, Bruno, Schwartz, David A, and Dieudé, Philippe

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Rare Diseases, Arthritis, Lung, Genetics, Autoimmune Disease, Rheumatoid Arthritis, Clinical Research, 2.1 Biological and endogenous factors, Respiratory, Inflammatory and immune system, Aged, Arthritis, Rheumatoid, Female, Gain of Function Mutation, Genetic Predisposition to Disease, Genotype, Humans, Idiopathic Pulmonary Fibrosis, Lung Diseases, Interstitial, Male, Middle Aged, Mucin-5B, Odds Ratio, Promoter Regions, Genetic, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundGiven the phenotypic similarities between rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we hypothesized that the strongest risk factor for the development of idiopathic pulmonary fibrosis, the gain-of-function MUC5B promoter variant rs35705950, would also contribute to the risk of ILD among patients with RA.MethodsUsing a discovery population and multiple validation populations, we tested the association of the MUC5B promoter variant rs35705950 in 620 patients with RA-ILD, 614 patients with RA without ILD, and 5448 unaffected controls.ResultsAnalysis of the discovery population revealed an association of the minor allele of the MUC5B promoter variant with RA-ILD when patients with RA-ILD were compared with unaffected controls (adjusted odds ratio, 3.8; 95% confidence interval [CI], 2.8 to 5.2; P=9.7×10-17). The MUC5B promoter variant was also significantly overrepresented among patients with RA-ILD, as compared with unaffected controls, in an analysis of the multiethnic case series (adjusted odds ratio, 5.5; 95% CI, 4.2 to 7.3; P=4.7×10-35) and in a combined analysis of the discovery population and the multiethnic case series (adjusted odds ratio, 4.7; 95% CI, 3.9 to 5.8; P=1.3×10-49). In addition, the MUC5B promoter variant was associated with an increased risk of ILD among patients with RA (adjusted odds ratio in combined analysis, 3.1; 95% CI, 1.8 to 5.4; P=7.4×10-5), particularly among those with evidence of usual interstitial pneumonia on high-resolution computed tomography (adjusted odds ratio in combined analysis, 6.1; 95% CI, 2.9 to 13.1; P=2.5×10-6). However, no significant association with the MUC5B promoter variant was observed for the diagnosis of RA alone.ConclusionsWe found that the MUC5B promoter variant was associated with RA-ILD and more specifically associated with evidence of usual interstitial pneumonia on imaging. (Funded by Société Française de Rhumatologie and others.).

Published
2018

14. Outcome measurement instrument selection for lung physiology in systemic sclerosis associated interstitial lung disease: A systematic review using the OMERACT filter 2.1 process

Author

Roofeh, David, Barratt, Shaney L., Wells, Athol U, Kawano-Dourado, Leticia, Tashkin, Donald, Strand, Vibeke, Seibold, James, Proudman, Susanna, Brown, Kevin K, Dellaripa, Paul F, Doyle, Tracy, Leonard, Thomas, Matteson, Eric L, Oddis, Chester V, Solomon, Joshua J, Sparks, Jeffrey A, Vassallo, Robert, Maxwell, Lara, Beaton, Dorcas, Christensen, Robin, Townsend, Whitney, and Khanna, Dinesh

Published
2021
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17. Distinguishing Smoking-Related Lung Disease Phenotypes Via Imaging and Molecular Features

Author

Billatos, Ehab, Ash, Samuel Y., Duan, Fenghai, Xu, Ke, Romanoff, Justin, Marques, Helga, Moses, Elizabeth, Han, MeiLan K., Regan, Elizabeth A., Bowler, Russell P., Mason, Stefanie E., Doyle, Tracy J., San José Estépar, Rubén, Rosas, Ivan O., Ross, James C., Xiao, Xiaohui, Liu, Hanqiao, Liu, Gang, Sukumar, Gauthaman, Wilkerson, Matthew, Dalgard, Clifton, Stevenson, Christopher, Whitney, Duncan, Aberle, Denise, Spira, Avrum, San José Estépar, Raúl, Lenburg, Marc E., and Washko, George R.

Published
2021
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19. Relationship between high-resolution computed tomography quantitative imaging analysis and physiological and clinical features in antisynthetase syndrome-related interstitial lung disease.

Author

Bae, Sangmee Sharon, Abtin, Fereidoun, Kim, Grace, Markovic, Daniela, Cato Chan, Moghadam-Kia, Siamak, Oddis, Chester V., Sullivan, Daniel, Marder, Galina, Venuturupalli, Swamy, Dellaripa, Paul F., Doyle, Tracy J., Hunninghake, Gary Matt, Falk, Jeremy, Charles-Schoeman, Christina, Tashkin, Donald P., Goldin, Jonathan, and Aggarwal, Rohit

Published
2024
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24. IgA Antibodies Directed Against Citrullinated Protein Antigens Are Elevated in Patients With Idiopathic Pulmonary Fibrosis

Author

Solomon, Joshua J., Matson, Scott, Kelmenson, Lindsay B., Chung, Jonathan H., Hobbs, Stephen B., Rosas, Ivan O., Dellaripa, Paul F., Doyle, Tracy J., Poli, Sergio, Esposito, Anthony J., Visser, Ashley, Marin, A. Itzam, Amigues, Isabelle, Fernández Pérez, Evans R., Brown, Kevin K., Mahler, Michael, Heinz, David, Cool, Carlyne, Deane, Kevin D., Swigris, Jeffrey J., and Demoruelle, M. Kristen

Published
2020
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25. Agreement between local and central anti-synthetase antibodies detection: results from the Classification Criteria of Anti-Synthetase Syndrome project biobank

Author

Loganathan, Aravinthan, primary, Zanframundo, Giovanni, additional, Yoshida, Akira, additional, Faghihi-Kashani, Sara, additional, Bauer Ventura, Iazsmin, additional, Dourado, Eduardo, additional, Bozan, Francisca, additional, Sambataro, Gianluca, additional, Yamano, Yasuhiko, additional, Bae, Sharon Sangmee, additional, Lim, Darosa, additional, Ceribelli, Angela, additional, Isailovic, Natasa, additional, Selmi, Carlo, additional, Fertig, Noreen, additional, Bravi, Elena, additional, Kaneko, Yuko, additional, Saraiva, André Pinto, additional, Jovani, Vega, additional, Bachiller-Corral, Javier, additional, Cifrian, Jose, additional, Mera-Varela, Antonio, additional, Moghadam-Kia, Siamak, additional, Wolff, Veronica, additional, Campagne, Julien, additional, Meyer, Alain, additional, Giannini, Margherita, additional, Triantafyllias, Konstantinos, additional, Knitza, Johannes, additional, Gupta, Latika, additional, Molad, Yair, additional, Iannone, Florenzo, additional, Cavazzana, Ilaria, additional, Piga, Matteo, additional, De Luca, Giacomo, additional, Tansley, Sarah, additional, Bozzalla-Cassione, Emanuele, additional, Bonella, Francesco, additional, Corte, Tamera J., additional, Doyle, Tracy J., additional, Fiorentino, David, additional, Gonzalez-Gay, Miguel Angel, additional, Hudson, Marie, additional, Kuwana, Masataka, additional, Lundberg, Ingrid E., additional, Mammen, Andrew L., additional, McHugh, Neil John, additional, Miller, Fredrick W., additional, Montecucco, Carlomaurizio, additional, Oddis, Chester V., additional, Rojas-Serrano, Jorge, additional, Schmidt, Jens, additional, Scirè, Carlo Alberto, additional, Selva-O'Callaghan, Albert, additional, Werth, Victoria P., additional, Alpini, Claudia, additional, Bozzini, Sara, additional, Cavagna, Lorenzo, additional, and Aggarwal, Rohit, additional

Published
2024
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26. Utility of peripheral protein biomarkers for the prediction of incident interstitial features: a multicentre retrospective cohort study

Author

Ash, Samuel, primary, Doyle, Tracy J, additional, Choi, Bina, additional, San Jose Estepar, Ruben, additional, Castro, Victor, additional, Enzer, Nicholas, additional, Kalhan, Ravi, additional, Liu, Gabrielle, additional, Bowler, Russell, additional, Wilson, David O, additional, San Jose Estepar, Raul, additional, Rosas, Ivan O, additional, and Washko, George R, additional

Published
2024
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27. RPA3-UMAD1 rs12702634 and rheumatoid arthritis–associated interstitial lung disease in European ancestry

Author

Longziekten, Infection & Immunity, Juge, Pierre Antoine, Sparks, Jeffrey A., Gazal, Steven, Ebstein, Esther, Borie, Raphaël, Debray, Marie Pierre, Kannengiesser, Caroline, McDermott, Gregory C., Cui, Jing, Hayashi, Keigo, Doyle, Tracy J., van Moorsel, Coline H.M., van der Vis, Joanne J., Grutters, Jan C., Knevel, Rachel, Heckert, Sascha L., Vasarmidi, Eirini, Antoniou, Katerina M., van der Helm van Mil, Annette H.M., Boileau, Catherine, Crestani, Bruno, Dieudé, Philippe, Longziekten, Infection & Immunity, Juge, Pierre Antoine, Sparks, Jeffrey A., Gazal, Steven, Ebstein, Esther, Borie, Raphaël, Debray, Marie Pierre, Kannengiesser, Caroline, McDermott, Gregory C., Cui, Jing, Hayashi, Keigo, Doyle, Tracy J., van Moorsel, Coline H.M., van der Vis, Joanne J., Grutters, Jan C., Knevel, Rachel, Heckert, Sascha L., Vasarmidi, Eirini, Antoniou, Katerina M., van der Helm van Mil, Annette H.M., Boileau, Catherine, Crestani, Bruno, and Dieudé, Philippe

Published
2024

28. RPA3-UMAD1 rs12702634 and rheumatoid arthritis-associated interstitial lung disease in European ancestry

Author

Juge, Pierre-Antoine, Sparks, Jeffrey A., Gazal, Steven, Ebstein, Esther, Borie, Raphael, Debray, Marie-Pierre, Kannengiesser, Caroline, Mcdermott, Gregory C., Cui, Jing, Hayashi, Keigo, Doyle, Tracy J., van Moorsel, Coline H. M., van der Vis, Joanne J., Grutters, Jan C., Knevel, Rachel, Heckert, Sascha L., Vasarmidi, Eirini, Antoniou, Katerina M., van Mil, Annette H. M. van der Helm, Boileau, Catherine, Crestani, Bruno, Dieude, Philippe, Juge, Pierre-Antoine, Sparks, Jeffrey A., Gazal, Steven, Ebstein, Esther, Borie, Raphael, Debray, Marie-Pierre, Kannengiesser, Caroline, Mcdermott, Gregory C., Cui, Jing, Hayashi, Keigo, Doyle, Tracy J., van Moorsel, Coline H. M., van der Vis, Joanne J., Grutters, Jan C., Knevel, Rachel, Heckert, Sascha L., Vasarmidi, Eirini, Antoniou, Katerina M., van Mil, Annette H. M. van der Helm, Boileau, Catherine, Crestani, Bruno, and Dieude, Philippe

Abstract

Objective: Recently, a genome-wide association study identified an association between RA-associated interstitial lung disease (ILD) and RPA3-UMAD1 rs12702634 in the Japanese population, especially for patients with a usual interstitial pneumonia (UIP) pattern. We aimed to replicate this association in a European population and test for interaction with MUC5B rs35705950. Methods: In this genetic case–control association study, patients with RA and ILD and controls with RA and no ILD were included from France, the USA and the Netherlands. Only cases and controls from European genetic ancestries determined by principal components analysis were included in the analyses. RA was defined by the 1987 ACR or 2010 ACR/EULAR criteria and ILD by chest high-resolution CT scan, except in the control dataset from the Netherlands, where the absence of ILD was determined by chart review. Patients were genotyped for RPA3-UMAD1 rs12702634 and MUC5B rs35705950. Associations were tested using logistic regression adjusted for sex, age at RA onset, age at ILD onset or at certified absence of ILD, tobacco smoking status and country of origin. Results: Among the 883 patients included, 322 were RA-ILD cases (36.5%). MUC5B rs35705950 was strongly associated with RA-ILD in all datasets fcombined adjusted odds ratio [OR] 2.9 [95% CI 2.1, 3.9], P¼ 1.1 × 10 − 11. No association between RPA3-UMAD1 rs12702634 and RA-ILD was observed [combined OR 1.2 (95% CI 0.8, 1.6), P¼ 0.31. No interaction was found between RPA3-UMAD1 rs12702634 and MUC5B rs35705950 (P¼ 0.70). Conclusion: Our findings did not support a contribution of RPA3-UMAD1 rs12702634 to the overall RA-ILD susceptibility in the European population.

Published
2024

32. RPA3-UMAD1 rs12702634 and rheumatoid arthritis-associated interstitial lung disease in European ancestry

Author

Juge, Pierre-Antoine, primary, Sparks, Jeffrey A, additional, Gazal, Steven, additional, Ebstein, Esther, additional, Borie, Raphaël, additional, Debray, Marie-Pierre, additional, Kannengiesser, Caroline, additional, McDermott, Gregory C, additional, Cui, Jing, additional, Hayashi, Keigo, additional, Doyle, Tracy J, additional, van Moorsel, Coline H M, additional, van der Vis, Joanne J, additional, Grutters, Jan C, additional, Knevel, Rachel, additional, Heckert, Sascha L, additional, Vasarmidi, Eirini, additional, Antoniou, Katerina M, additional, van der Helm van Mil, Annette H M, additional, Boileau, Catherine, additional, Crestani, Bruno, additional, and Dieudé, Philippe, additional

Published
2024
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33. Contribution of Rare Deleterious Variants in Telomere-Related Genes to the Risk of Interstitial Lung Disease in Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis

Author

Juge, Pierre-Antoine, primary, Kawano-Dourado, Leticia, additional, Stockwell, Amy D., additional, Lee, Joyce S., additional, Ebstein, Esther, additional, Gazal, Steven, additional, McDermott, Gregory, additional, Hayashi, Keigo, additional, Cui, Jing, additional, Granger, Benjamin, additional, Kannengiesser, Caroline, additional, Borie, Raphaël, additional, Wemeau, Ludivine, additional, Debray, Marie Pierre, additional, Wolters, Paul J., additional, Marchand-Adam, Sylvain, additional, RICHEZ, Christophe, additional, Nunes, Hilario, additional, Froguel, Philippe, additional, Avouac, Jérôme, additional, Flipo, René-Marc, additional, Cottin, Vincent, additional, Boissier, Marie-Christophe, additional, Schaeverbeke, Thierry, additional, Kermanac’h, Nathalie Saidenberg, additional, Crestani, Bruno, additional, Doyle, Tracy, additional, Raychaudhuri, Soumya, additional, Karlson, Elizabeth W., additional, Yaspan, Brian L., additional, Sparks, Jeffrey A., additional, and Dieudé, Philippe, additional

Published
2024
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34. 2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Treatment of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases.

Author

Johnson, Sindhu R., Bernstein, Elana J., Bolster, Marcy B., Chung, Jonathan H., Danoff, Sonye K., George, Michael D., Khanna, Dinesh, Guyatt, Gordon, Mirza, Reza D., Aggarwal, Rohit, Allen, Aberdeen, Assassi, Shervin, Buckley, Lenore, Chami, Hassan A., Corwin, Douglas S., Dellaripa, Paul F., Domsic, Robyn T., Doyle, Tracy J., Falardeau, Catherine Marie, and Frech, Tracy M.

Subjects
RHEUMATISM, AUTOIMMUNE diseases, EVALUATION methodology, PHYSICIANS, MEDICAL personnel
Abstract

Objective: We provide evidence‐based recommendations regarding the treatment of interstitial lung disease (ILD) in adults with systemic autoimmune rheumatic diseases (SARDs). Methods: We developed clinically relevant population, intervention, comparator, and outcomes questions. A systematic literature review was then performed, and the available evidence was rated using the Grading of Recommendations, Assessment, Development, and Evaluation methodology. A panel of clinicians and patients reached consensus on the direction and strength of the recommendations. Results: Thirty‐five recommendations were generated (including two strong recommendations) for first‐line SARD‐ILD treatment, treatment of SARD‐ILD progression despite first‐line ILD therapy, and treatment of rapidly progressive ILD. The strong recommendations were against using glucocorticoids in systemic sclerosis–ILD as a first‐line ILD therapy and after ILD progression. Otherwise, glucocorticoids are conditionally recommended for first‐line ILD treatment in all other SARDs. Conclusion: This clinical practice guideline presents the first recommendations endorsed by the American College of Rheumatology and American College of Chest Physicians for the treatment of ILD in people with SARDs. [ABSTRACT FROM AUTHOR]

Published
2024
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35. 2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Screening and Monitoring of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases.

Author

Johnson, Sindhu R., Bernstein, Elana J., Bolster, Marcy B., Chung, Jonathan H., Danoff, Sonye K., George, Michael D., Khanna, Dinesh, Guyatt, Gordon, Mirza, Reza D., Aggarwal, Rohit, Allen, Aberdeen, Assassi, Shervin, Buckley, Lenore, Chami, Hassan A., Corwin, Douglas S., Dellaripa, Paul F., Domsic, Robyn T., Doyle, Tracy J., Falardeau, Catherine Marie, and Frech, Tracy M.

Subjects
CONNECTIVE tissue diseases, PULMONARY function tests, RHEUMATISM, MEDICAL screening, SYSTEMIC scleroderma, INTERSTITIAL lung diseases
Abstract

Objective: We provide evidence‐based recommendations regarding screening for interstitial lung disease (ILD) and the monitoring for ILD progression in people with systemic autoimmune rheumatic diseases (SARDs), specifically rheumatoid arthritis, systemic sclerosis, idiopathic inflammatory myopathies, mixed connective tissue disease, and Sjögren disease. Methods: We developed clinically relevant population, intervention, comparator, and outcomes questions related to screening and monitoring for ILD in patients with SARDs. A systematic literature review was performed, and the available evidence was rated using the Grading of Recommendations, Assessment, Development, and Evaluation methodology. A Voting Panel of interdisciplinary clinician experts and patients achieved consensus on the direction and strength of each recommendation. Results: Fifteen recommendations were developed. For screening people with these SARDs at risk for ILD, we conditionally recommend pulmonary function tests (PFTs) and high‐resolution computed tomography of the chest (HRCT chest); conditionally recommend against screening with 6‐minute walk test distance (6MWD), chest radiography, ambulatory desaturation testing, or bronchoscopy; and strongly recommend against screening with surgical lung biopsy. We conditionally recommend monitoring ILD with PFTs, HRCT chest, and ambulatory desaturation testing and conditionally recommend against monitoring with 6MWD, chest radiography, or bronchoscopy. We provide guidance on ILD risk factors and suggestions on frequency of testing to evaluate for the development of ILD in people with SARDs. Conclusion: This clinical practice guideline presents the first recommendations endorsed by the American College of Rheumatology and American College of Chest Physicians for the screening and monitoring of ILD in people with SARDs. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Contributors

Author

Ahearn, Joseph M., primary, Alarcón-Riquelme, Marta E., additional, Almaani, Salem J., additional, Anolik, Jennifer H., additional, Aranow, Cynthia, additional, Bacalao, Maria A., additional, Barilla-LaBarca, Maria-Louise, additional, Barnas, Jennifer L., additional, Barturen, Guillermo, additional, Bermas, Bonnie L., additional, Bernatsky, Sasha, additional, Bruce, I.N., additional, Bucala, Richard, additional, Buyon, Jill P., additional, Carnero-Montoro, Elena, additional, Clarke, Ann E., additional, Clowse, Megan E.B., additional, Concha, Josef Symon S., additional, Dellaripa, Paul, additional, Diamond, Betty, additional, Doyle, Tracy J., additional, Fernando, Michelle M.A., additional, Fisk, John D., additional, Furie, Richard, additional, Gordon, Caroline, additional, Greiling, Teri M., additional, Han, Shuhong, additional, Hanly, John G., additional, Hile, Grace A., additional, Horowitz, Diane, additional, Isenberg, David, additional, Izmirly, Peter, additional, Jacobs, Barbara, additional, James, Judith A., additional, Kahlenberg, J. Michelle, additional, Kalunian, Kenneth C., additional, Kang, Insoo, additional, Kaplan, Mariana J., additional, Khamashta, Munther A., additional, Kim, Mimi, additional, Knight, Jason S., additional, Koumpouras, Fotios, additional, Kriegel, Martin A., additional, La Cava, Antonio, additional, Ladouceur, Alexandra, additional, Lahita, Robert G., additional, Lee, Iris Jung-Won, additional, Lessard, Christopher J., additional, Lewandowski, Laura B., additional, Liang, Yun, additional, Liu, Chau-Ching, additional, Mackay, Meggan, additional, Madaio, Michael P., additional, Marder, Galina, additional, Matteson, Eric L., additional, McCoy, Sara, additional, McMahon, Maureen, additional, Meffre, Eric, additional, Mejia-Vilet, Juan, additional, Merrill, Joan, additional, Morand, Eric F., additional, Moreira Pinto, Sara, additional, Nakabo, Shuichiro, additional, Northcott, Melissa, additional, Omisade, Antonina, additional, Ortel, Thomas L., additional, Perl, Andras, additional, Ramsey-Goldman, Rosalind, additional, Reeves, Westley H., additional, Reyes-Thomas, Joyce, additional, Reynolds, J.A., additional, Richardson, Bruce, additional, Rodriguez, Juan Vicente, additional, Rovin, Brad H., additional, Rudinskaya, Alla, additional, Ruiz-Irastorza, Guillermo, additional, Saxena, Amit, additional, Schanberg, Laura E., additional, Sharma, Tarun S., additional, Skaggs, Brian, additional, Somers, Emily C., additional, Stohl, William, additional, Talabi, Mehret Birru, additional, Tessneer, Kandice L., additional, Tsao, Betty P., additional, Ugarte, Amaia, additional, Volpe, Bruce T., additional, Vyse, Timothy J., additional, Wainwright, Benjamin J., additional, Ward, Michael M., additional, Wasko, Mary Chester M., additional, Werth, Victoria P., additional, Wise, Leanna, additional, Zhuang, Haoyang, additional, and Zuo, Yu, additional

Published
2021
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40. Short peripheral blood leukocyte telomere length in rheumatoid arthritis-interstitial lung disease

Author

Doyle, Tracy J, primary, Juge, Pierre-Antoine, additional, Peljto, Anna L, additional, Lee, Seoyeon, additional, Walts, Avram D, additional, Esposito, Anthony Joseph, additional, Poli, Sergio, additional, Gill, Ritu, additional, Hatabu, Hiroto, additional, Nishino, Mizuki, additional, Dellaripa, Paul F, additional, Weinblatt, Michael E, additional, Shadick, Nancy A, additional, Demoruelle, M Kristen, additional, Sparks, Jeffrey A, additional, Rosas, Ivan O, additional, Granger, Benjamin, additional, Deane, Kevin D, additional, Crestani, Bruno, additional, Wolters, Paul J, additional, Dieudé, Philippe, additional, and Lee, Joyce S, additional

Published
2023
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41. Rheumatoid arthritis, quantitative parenchymal lung features and mortality among smokers

Author

McDermott, Gregory C, primary, Hayashi, Keigo, additional, Yoshida, Kazuki, additional, Juge, Pierre-Antoine, additional, Moll, Matthew, additional, Cho, Michael H, additional, Doyle, Tracy J, additional, Kinney, Gregory L, additional, Dellaripa, Paul F, additional, Wallace, Zachary S, additional, Regan, Elizabeth A, additional, Hunninghake, Gary M, additional, Silverman, Edwin K, additional, Ash, Samuel Y, additional, Estepar, Raul San Jose, additional, Washko, George R, additional, and Sparks, Jeffrey A, additional

Published
2023
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42. Activation of CD8+ T Cells in Chronic Obstructive Pulmonary Disease Lung

Author

Villaseñor-Altamirano, Ana B., primary, Jain, Dhawal, additional, Jeong, Yunju, additional, Menon, Jaivardhan A., additional, Kamiya, Mari, additional, Haider, Hibah, additional, Manandhar, Reshmi, additional, Sheikh, Muhammad Dawood Amir, additional, Athar, Humra, additional, Merriam, Louis T., additional, Ryu, Min Hyung, additional, Sasaki, Takanori, additional, Castaldi, Peter J., additional, Rao, Deepak A., additional, Sholl, Lynette M., additional, Vivero, Marina, additional, Hersh, Craig P., additional, Zhou, Xiaobo, additional, Veerkamp, Justus, additional, Yun, Jeong H., additional, Kim, Edy Y., additional, Koch, Markus, additional, Arduini, Alessandro, additional, Cernecka, Hana, additional, Schmidt, Nicole, additional, Laux-Biehlmann, Alexis, additional, Brockschnieder, Damian, additional, Cong, Xiaofei, additional, Engler, Anna, additional, Ibrahim, Mahmoud, additional, Kryukov, Ivan, additional, Kumawat, Kuldeep, additional, Lang, T., additional, Leathurby, Yelena, additional, Lin, Xin, additional, Meding, Joerg, additional, Neideck, Carlos, additional, Obraztsova, Kseniya, additional, Pavuluri, C., additional, Platzk, Magdalena, additional, Smith, Patrick, additional, Sohler, Florian, additional, Srivastava, Salil, additional, Srinivasa, P., additional, Strunz, Tobias, additional, Sylvia, Jody, additional, Vaas, Lea, additional, Zink, Alex, additional, Zhang, Lingyao, additional, Zeng, L., additional, Silverman, Edwin, additional, Carey, Vincent, additional, Castaldi, Peter, additional, Cho, Michael, additional, DeMeo, Dawn, additional, Hersh, Craig, additional, Hobbs, Brian, additional, Moll, Matthew, additional, Rijhwani, Heena, additional, Yun, Jeong, additional, Levy, Bruce D., additional, Tesfaigzi, Yohannes, additional, Bai, Yan, additional, Baron, Rebecca, additional, Doyle, Tracy, additional, El-Chemaly, Souheil, additional, Fredenburgh, Laura, additional, Hunninghake, G. Matt, additional, Krishnamoorthy, Nandini, additional, Mebratu, Yohannes, additional, Perrella, Mark, additional, Quintero, Joselyn Rojas, additional, Negasi, Zerihun, additional, Rahman, Mizanur, additional, Tassew, Dereje, additional, Sharma, Nirmal, additional, Tamura, Tomoyoshi, additional, Villaseñor-Altamirano, Ana B., additional, Medoff, Benjamin, additional, Abe, Elizabeth, additional, Black, Katherine, additional, Hardin, Corey, additional, Knipe, Rachel, additional, Shea, Barry, additional, Spiney, Jill, additional, Albsuharif, Mahaa, additional, Giacona, Francesca, additional, Jayaswai, Armin, additional, Keras, Greg, additional, Lee, Sool, additional, Liu, Jianyuan, additional, Pavuluri, Chandan, additional, Pham, Betty, additional, Saliba, Samuel, additional, Srivastava, Pooja, additional, Wang, Yichao, additional, and Xu, Shuang, additional

Published
2023
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43. Risk Factors and Biomarkers of RA-ILD

Author

Doyle, Tracy J., Dellaripa, Paul F., Rosas, Ivan O., Rounds, Sharon I.S., Series editor, Dixon, Anne, Series editor, Schnapp, Lynn M., Series editor, Fischer, Aryeh, editor, and Lee, Joyce S., editor

Published
2018
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45. Effectiveness and Tolerability of Antifibrotics in Rheumatoid Arthritis-associated Interstitial Lung Disease

Author

Juge, Pierre-Antoine, primary, Hayashi, Keigo, additional, McDermott, Gregory C, additional, Vanni, Kathleen MM, additional, Kowalski, Emily, additional, Qian, Grace, additional, Bade, Katarina, additional, Saavedra, Alene, additional, Dieudé, Philippe, additional, Dellaripa, Paul F, additional, Doyle, Tracy J, additional, and Sparks, Jeffrey A, additional

Published
2023
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48. Rheumatoid arthritis and changes on spirometry by smoking status in two prospective longitudinal cohorts.

Author

Keigo Hayashi, McDermott, Gregory C., Juge, Pierre-Antoine, Moll, Matthew, Cho, Michael H., Xiaosong Wang, Paudel, Misti L., Doyle, Tracy J., Kinney, Gregory L., Sansone-Poe, Danielle, Young, Kendra, Dellaripa, Paul F., Wallace, Zachary S., Regan, Elizabeth A., Hunninghake, Gary M., Silverman, Edwin K., Ash, Samuel Y., Estepar, Raul San Jose, Washko, George R., and Sparks, Jeffrey A.

Published
2024
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50. Better coordination and upfront planning can help avoid major project disputes

Author

Simms, Carl, Zheng, Baoqiang, Doyle, Tracy, and Scott, Sid

Subjects
Railroads -- Innovations -- Reports, Business, Transportation industry
Abstract

An unfortunate consequence of adopting new technology for railway projects and products is that it can lead to disputes and claims between the parties involved. Carl Simms, director--HKA Europe, Baoqiang [...]

Published
2021

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