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6. Reply to Corticosteroid‐Induced Osteonecrosis in COVID‐19: A Call for Caution

Author

Yu, Elaine W, Tsourdi, Elena, Clarke, Bart L, Bauer, Douglas C, and Drake, Matthew T

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Adrenal Cortex Hormones, COVID-19, Humans, Osteonecrosis, Pandemics, SARS-CoV-2, Engineering, Medical and Health Sciences, Anatomy & Morphology, Biological sciences, Biomedical and clinical sciences
Published
2020

7. Osteoporosis Management in the Era of COVID‐19

Author

Yu, Elaine W, Tsourdi, Elena, Clarke, Bart L, Bauer, Douglas C, and Drake, Matthew T

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Osteoporosis, Aging, Musculoskeletal, Good Health and Well Being, Absorptiometry, Photon, Biomarkers, Bone Density, Bone Density Conservation Agents, COVID-19, Continuity of Patient Care, Coronavirus Infections, Denosumab, Disease Management, Drug Administration Schedule, Estrogen Replacement Therapy, Fractures, Spontaneous, Home Care Services, Humans, Immunosuppression Therapy, Pandemics, Pneumonia, Viral, Raloxifene Hydrochloride, Recurrence, Telemedicine, Thrombophilia, Unnecessary Procedures, ABALOPARATIDE, BISPHOSPHONAT, DENOSUMAB, FRACTURES, OSTEOPOROSIS, ROMOSOZUMAB, TERIPARATIDE, Biological Sciences, Engineering, Medical and Health Sciences, Anatomy & Morphology, Biological sciences, Biomedical and clinical sciences
Abstract

Osteoporosis is a chronic condition that reflects reduced bone strength and an associated increased risk for fracture. As a chronic condition, osteoporosis generally requires sustained medical intervention(s) to limit the risks for additional bone loss, compromise of skeletal integrity, and fracture occurrence. Further complicating this issue is the fact that the abrupt cessation of some therapies can be associated with an increased risk for harm. It is in this context that the COVID-19 pandemic has brought unprecedented disruption to the provision of health care globally, including near universal requirements for social distancing. In this Perspective, we provide evidence, where available, regarding the general care of patients with osteoporosis in the COVID-19 era and provide clinical recommendations based primarily on expert opinion when data are absent. Particular emphasis is placed on the transition from parenteral osteoporosis therapies. It is hoped that these recommendations can be used to safely guide care for patients with osteoporosis until a return to routine clinical care standards is available. © 2020 American Society for Bone and Mineral Research.

Published
2020

8. American Society for Bone and Mineral Research‐Orthopaedic Research Society Joint Task Force Report on Cell‐Based Therapies – Secondary Publication

Author

O'Keefe, Regis J, Tuan, Rocky S, Lane, Nancy E, Awad, Hani A, Barry, Frank, Bunnell, Bruce A, Colnot, Céline, Drake, Matthew T, Drissi, Hicham, Dyment, Nathaniel A, Fortier, Lisa A, Guldberg, Robert E, Kandel, Rita, Little, David G, Marshall, Mary F, Mao, Jeremy J, Nakamura, Norimasa, Proffen, Benedikt L, Rodeo, Scott A, Rosen, Vicki, Thomopoulos, Stavros, Schwarz, Edward M, and Serra, Rosa

Subjects
Engineering, Biomedical Engineering, Regenerative Medicine, Musculoskeletal, animal models, cell, tissue signaling, transcription factors, cells of bone, clinical trials, genetic research, cell/tissue signaling, Clinical Sciences, Human Movement and Sports Sciences, Orthopedics, Biomedical engineering, Sports science and exercise
Abstract

Cell-based therapies, defined here as the delivery of cells in vivo to treat disease, have recently gained increasing public attention as a potentially promising approach to restore structure and function to musculoskeletal tissues. Although cell-based therapy has the potential to improve the treatment of disorders of the musculoskeletal system, there is also the possibility of misuse and misrepresentation of the efficacy of such treatments. The medical literature contains anecdotal reports and research studies, along with web-based marketing and patient testimonials supporting cell-based therapy. Both the American Society for Bone and Mineral Research (ASBMR) and the Orthopaedic Research Society (ORS) are committed to ensuring that the potential of cell-based therapies is realized through rigorous, reproducible, and clinically meaningful scientific discovery. The two organizations convened a multidisciplinary and international Task Force composed of physicians, surgeons, and scientists who are recognized experts in the development and use of cell-based therapies. The Task Force was charged with defining the state-of-the art in cell-based therapies and identifying the gaps in knowledge and methodologies that should guide the research agenda. The efforts of this Task Force are designed to provide researchers and clinicians with a better understanding of the current state of the science and research needed to advance the study and use of cell-based therapies for skeletal tissues. The design and implementation of rigorous, thorough protocols will be critical to leveraging these innovative treatments and optimizing clinical and functional patient outcomes. In addition to providing specific recommendations and ethical considerations for preclinical and clinical investigations, this report concludes with an outline to address knowledge gaps in how to determine the cell autonomous and nonautonomous effects of a donor population used for bone regeneration. © 2020 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:485-502, 2020.

Published
2020

11. American Society for Bone and Mineral Research‐Orthopaedic Research Society Joint Task Force Report on Cell‐Based Therapies

Author

O'Keefe, Regis J, Tuan, Rocky S, Lane, Nancy E, Awad, Hani A, Barry, Frank, Bunnell, Bruce A, Colnot, Céline, Drake, Matthew T, Drissi, Hicham, Dyment, Nathaniel A, Fortier, Lisa A, Guldberg, Robert E, Kandel, Rita, Little, David G, Marshall, Mary F, Mao, Jeremy J, Nakamura, Norimasa, Proffen, Benedikt L, Rodeo, Scott A, Rosen, Vicki, Thomopoulos, Stavros, Schwarz, Edward M, and Serra, Rosa

Subjects
Biomedical and Clinical Sciences, Regenerative Medicine, 5.2 Cellular and gene therapies, Development of treatments and therapeutic interventions, Musculoskeletal, Advisory Committees, Bone and Bones, Humans, Minerals, Orthopedics, Societies, Medical, United States, ANIMAL MODELS, CELL, TISSUE SIGNALING, TRANSCRIPTION FACTORS, CELLS OF BONE, CLINICAL TRIALS, GENETIC RESEARCH, CELL/TISSUE SIGNALING, CELL/TISSUE SIGNALING, TRANSCRIPTION FACTORS, Biological Sciences, Engineering, Medical and Health Sciences, Anatomy & Morphology, Biological sciences, Biomedical and clinical sciences
Abstract

Cell-based therapies, defined here as the delivery of cells in vivo to treat disease, have recently gained increasing public attention as a potentially promising approach to restore structure and function to musculoskeletal tissues. Although cell-based therapy has the potential to improve the treatment of disorders of the musculoskeletal system, there is also the possibility of misuse and misrepresentation of the efficacy of such treatments. The medical literature contains anecdotal reports and research studies, along with web-based marketing and patient testimonials supporting cell-based therapy. Both the American Society for Bone and Mineral Research (ASBMR) and the Orthopaedic Research Society (ORS) are committed to ensuring that the potential of cell-based therapies is realized through rigorous, reproducible, and clinically meaningful scientific discovery. The two organizations convened a multidisciplinary and international Task Force composed of physicians, surgeons, and scientists who are recognized experts in the development and use of cell-based therapies. The Task Force was charged with defining the state-of-the art in cell-based therapies and identifying the gaps in knowledge and methodologies that should guide the research agenda. The efforts of this Task Force are designed to provide researchers and clinicians with a better understanding of the current state of the science and research needed to advance the study and use of cell-based therapies for skeletal tissues. The design and implementation of rigorous, thorough protocols will be critical to leveraging these innovative treatments and optimizing clinical and functional patient outcomes. In addition to providing specific recommendations and ethical considerations for preclinical and clinical investigations, this report concludes with an outline to address knowledge gaps in how to determine the cell autonomous and nonautonomous effects of a donor population used for bone regeneration. © 2019 American Society for Bone and Mineral Research.

Published
2020

17. Treatment of multiple myeloma-related bone disease: recommendations from the Bone Working Group of the International Myeloma Working Group

Author

Terpos, Evangelos, Zamagni, Elena, Lentzsch, Suzanne, Drake, Matthew T, García-Sanz, Ramón, Abildgaard, Niels, Ntanasis-Stathopoulos, Ioannis, Schjesvold, Fredrik, de la Rubia, Javier, Kyriakou, Charalampia, Hillengass, Jens, Zweegman, Sonja, Cavo, Michele, Moreau, Philippe, San-Miguel, Jesus, Dimopoulos, Meletios A, Munshi, Nikhil, Durie, Brian G M, and Raje, Noopur

Published
2021
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22. Managing Osteoporosis in Patients on Long‐Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research

Author

Adler, Robert A, El-Hajj Fuleihan, Ghada, Bauer, Douglas C, Camacho, Pauline M, Clarke, Bart L, Clines, Gregory A, Compston, Juliet E, Drake, Matthew T, Edwards, Beatrice J, Favus, Murray J, Greenspan, Susan L, McKinney, Ross, Pignolo, Robert J, and Sellmeyer, Deborah E

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Osteoporosis, Clinical Trials and Supportive Activities, Aging, Physical Injury - Accidents and Adverse Effects, Patient Safety, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Musculoskeletal, Advisory Committees, Age Factors, Diphosphonates, Female, Femoral Fractures, Humans, Imidazoles, Male, Risk Factors, Sex Factors, Spinal Fractures, Zoledronic Acid, BISPHOSPHONATES, LONG TERM-BISPHOSPHONATE USE, RISK BENEFIT, DRUG HOLIDAY, OTHER OSTEOPOROSIS THERAPIES, Biological Sciences, Engineering, Medical and Health Sciences, Anatomy & Morphology, Biological sciences, Biomedical and clinical sciences
Abstract

Bisphosphonates (BPs) are the most commonly used medications for osteoporosis. This ASBMR report provides guidance on BP therapy duration with a risk-benefit perspective. Two trials provided evidence for long-term BP use. In the Fracture Intervention Trial Long-term Extension (FLEX), postmenopausal women receiving alendronate for 10 years had fewer clinical vertebral fractures than those switched to placebo after 5 years. In the HORIZON extension, women who received 6 annual infusions of zoledronic acid had fewer morphometric vertebral fractures compared with those switched to placebo after 3 years. Low hip T-score, between -2 and -2.5 in FLEX and below -2.5 in HORIZON extension, predicted a beneficial response to continued therapy. Hence, the Task Force suggests that after 5 years of oral BP or 3 years of intravenous BP, reassessment of risk should be considered. In women at high risk, for example, older women, those with a low hip T-score or high fracture risk score, those with previous major osteoporotic fracture, or who fracture on therapy, continuation of treatment for up to 10 years (oral) or 6 years (intravenous), with periodic evaluation, should be considered. The risk of atypical femoral fracture, but not osteonecrosis of the jaw, clearly increases with BP therapy duration, but such rare events are outweighed by vertebral fracture risk reduction in high-risk patients. For women not at high fracture risk after 3 to 5 years of BP treatment, a drug holiday of 2 to 3 years can be considered. The suggested approach for long-term BP use is based on limited evidence, only for vertebral fracture reduction, in mostly white postmenopausal women, and does not replace the need for clinical judgment. It may be applicable to men and patients with glucocorticoid-induced osteoporosis, with some adaptations. It is unlikely that future trials will provide data for formulating definitive recommendations. © 2015 American Society for Bone and Mineral Research.

Published
2016

24. List of contributors

Author

Abrahamsen, Bo, primary, Adler, Robert A., additional, Ajjour, Sara, additional, Alemi, Mohammad Mehdi, additional, Anderson, Dennis E., additional, Arnett, Timothy R., additional, Assaad, Mariam A., additional, Ballane, Ghada T., additional, Baron, Roland, additional, Bassett, J.H. Duncan, additional, Bauer, Douglas C., additional, Bauman, William A., additional, Beavers, Kristen M., additional, Berry, Sarah D., additional, Bilezikian, John P., additional, Biver, Emmanuel, additional, Bliuc, Dana, additional, Bonewald, Lynda F., additional, Boskey, Adele L., additional, Bouxsein, Mary L., additional, Bravenboer, Nathalie, additional, Brown, Todd T., additional, Bukata, Susan V., additional, Burkhart, Katelyn, additional, Canalis, Ernesto, additional, Cardozo, Christopher, additional, Castillo, Alesha B., additional, Cauley, Jane A., additional, Center, Jacqueline R., additional, Chen, Julia C., additional, Civitelli, Roberto, additional, Cohen, Adi, additional, Cosman, Felicia, additional, Crandall, Carolyn J., additional, Crawford, Brooke M., additional, Cusano, Natalie E., additional, de Paula, Francisco J.A., additional, Delbaere, Kim, additional, Dempster, David W., additional, Diab, Dima L., additional, Dick-de-Paula, Ingrid, additional, DiMeglio, Linda A., additional, Drake, Matthew T., additional, Dubrovsky, Alanna M.K., additional, D’Onofrio, Luca, additional, Eastell, Richard, additional, Elder, Grahame J., additional, El-Hajj Fuleihan, Ghada A., additional, Ensrud, Kristine E., additional, Ferrari, Serge, additional, Freudenthal, Bernard, additional, Genant, Harry K., additional, Gerstenfeld, Louis C., additional, Giangregorio, Lora, additional, Gielen, Evelien, additional, Gold, Deborah T., additional, Goldring, Steven R., additional, Gordon, Catherine M., additional, Gori, Francesca, additional, Greendale, Gail A., additional, Griffith, James F., additional, Hadji, Peyman, additional, Hernandez, Christopher J., additional, Hoggatt, Jonathan, additional, Houston, Denise K., additional, Hussein, Amira I., additional, Jacobs, Christopher R., additional, Jiang, Xuezhi, additional, Johnston, James D., additional, Kagan, Risa, additional, Karim, Lamya, additional, Karvonen-Gutierrez, Carrie, additional, Katzman, Wendy B., additional, Kawai, Masanobu, additional, Khosla, Sundeep, additional, Kiel, Douglas P., additional, Kontulainen, Saija A., additional, Kostenuik, Paul, additional, Krez, Alexandra, additional, Kronenberg, Henry, additional, Kumar, Rajiv, additional, Lane, Nancy E., additional, Langsetmo, Lisa, additional, Laurent, Michaël R., additional, Lawenius, L., additional, Leikin, Sergey, additional, Leslie, William D., additional, Lewiecki, E. Michael, additional, Liu, Minghao, additional, Liu, Yi, additional, Lord, Stephen R., additional, Lorenzo, Joseph, additional, Ma, Nina S., additional, Maalouf, Naim M., additional, Marcus, Robert, additional, McClung, Michael R., additional, Mendes, Marcela Moraes, additional, Miller, Paul D., additional, Misra, Madhusmita, additional, Mohseni, Mahshid, additional, Morgan, Elise F., additional, Morin, Suzanne N., additional, Mukaddam, Mona Al, additional, Mulder, Chris J.J., additional, Nair, Nandini, additional, Napoli, Nicola, additional, Nasomyont, Nat, additional, Nelson, Dorothy A., additional, Nieves, Jeri W., additional, Nissenson, Robert, additional, Ohlsson, Claes, additional, Oleson, Christina V., additional, Ortinau, Laura, additional, Orwoll, Eric, additional, Ott, Susan M., additional, Pacifici, Roberto, additional, Palermo, Andrea, additional, Parfitt, A.M., additional, Park, Dongsu, additional, Provot, Sylvain, additional, Randhawa, Sonia Bhandari, additional, Randolph, John F., additional, Rivadeneira, Fernando, additional, Robey, Pamela Gehron, additional, Robinson, Lauren, additional, Rogers-Soeder, Tara, additional, Roodman, G. David, additional, Rosen, Clifford J., additional, Saag, Kenneth G., additional, Sahni, Shivani, additional, Sakhaee, Khashayar, additional, Scadden, David T., additional, Schafer, Anne L., additional, Schipani, Ernestina, additional, Serra, Monica C., additional, Shapiro, Jay R., additional, Sherrington, Catherine, additional, Shikany, James M., additional, Silverberg, Shonni J., additional, Singer, Andrea J., additional, Sjögren, K., additional, Snyder, Peter J., additional, Stein, Emily M., additional, Swanson, Christine M., additional, Szulc, Pawel, additional, Taxel, Pamela, additional, Tebben, Peter J., additional, Twardowski, Sarah E., additional, Uitterlinden, André G., additional, Vaidya, Rachana, additional, Vallera, Cristianna, additional, van Bodegraven, Adriaan A., additional, van der Eerden, Bram C.J., additional, van der Meulen, Marjolein C.H., additional, van Wijnen, André J., additional, Vanderschueren, Dirk, additional, Wactawski-Wende, Jean, additional, Watts, Laura, additional, Watts, Nelson B., additional, Weaver, Ashley A., additional, Weinstein, Robert S., additional, Williams, Graham R., additional, Wu, Joy, additional, Wu, Karin C., additional, Yin, Michael T., additional, Yu, Elaine W., additional, and Zhou, Hua, additional

Published
2021
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30. List of Contributors

Author

Abraham, David, primary, Almeida, Maria, additional, Ambrogini, Elena, additional, Arnold, Andrew, additional, Bakos, Bence, additional, Bergwitz, Clemens, additional, Bikle, Daniel D., additional, Bilezikian, John P., additional, Binkley, Neil, additional, Bisello, Alessandro, additional, Bonewald, L.F., additional, Bou-Gharios, George, additional, Bouillon, Roger, additional, Bouxsein, Mary L., additional, Boyce, Brendan F., additional, Boyd, Steven, additional, Brandi, Maria Luisa, additional, Burr, David B., additional, Calvi, Laura M., additional, Canalis, Ernesto, additional, Cao, Xu, additional, Carmeliet, Geert, additional, Carpenter, Thomas O., additional, Chang, Wenhan, additional, Chim, Shek Man, additional, Choudhary, Shilpa, additional, Christakos, Sylvia, additional, Chun, Yong-Hee Patricia, additional, Cipriani, Cristiana, additional, Civitelli, Roberto, additional, Clemens, Thomas L., additional, Collins, Michael T., additional, Conte, Caterina, additional, Cooper, Mark S., additional, Cornish, Jillian, additional, Cremers, Serge, additional, Dawson-Hughes, Bess, additional, de Crombrugghe, Benoit, additional, DeLuca, Hector F., additional, Dempster, David W., additional, Drake, Matthew T., additional, Ducy, Patricia, additional, Ebetino, Frank H., additional, Engelke, Klaus, additional, Erben, Reinhold G., additional, Eyre, David R., additional, Farber, Charles R., additional, Feigenson, Marina, additional, Ferron, Mathieu, additional, Florenzano, Pablo, additional, Fontana, Francesca, additional, Foster, Brian L., additional, Friedman, Peter A., additional, Fukumoto, Seiji, additional, Gamer, Laura W., additional, Gardella, Thomas J., additional, Garnero, Patrick, additional, Genant, Harry K., additional, Giusti, Francesca, additional, Göbel, Andy, additional, Goltzman, David, additional, Gorski, Jeffrey P., additional, Griffith, James, additional, G Russell, R. Graham, additional, Hankenson, Kurt D., additional, Hannan, Fadil M., additional, Harris, Stephen E., additional, Hartley, Iris R., additional, Hartmann, Christine, additional, Heaney, Robert P., additional, Hendy, Geoffrey N., additional, Hilton, Matthew J., additional, Hofbauer, Lorenz C., additional, Holdsworth, Gill, additional, Hsu, Yi-Hsiang, additional, Hudson, David M., additional, Hurley, Marja, additional, Insogna, Karl L., additional, Jilka, Robert L., additional, Johnson, Mark L., additional, Johnson, Rachelle W., additional, Jones, Glenville, additional, Judex, Stefan, additional, Jüppner, Harald, additional, Kalajzic, Ivo, additional, Karsenty, Gérard, additional, Ke, Hua Zhu, additional, Khosla, Sundeep, additional, Kiel, Douglas P., additional, Klein-Nulend, J., additional, Ko, Frank C., additional, Kobayashi, Yasuhiro, additional, Konrad, Martin, additional, Kostenuik, Paul J., additional, Kovacs, Christopher S., additional, Kremer, Richard, additional, Krishnan, Venkatesh, additional, Kronenberg, Henry M., additional, Lakatos, Peter A., additional, Liberman, Uri A., additional, Lorenzo, Joseph A., additional, Lynch, Conor C., additional, Lyons, Karen M., additional, Ma, Y. Linda, additional, Maes, Christa, additional, Mannstadt, Michael, additional, Manolagas, Stavros, additional, Marcus, Robert, additional, Maridas, David E., additional, Marie, Pierre J., additional, Marini, Francesca, additional, Markovac, Jasna, additional, Martin, T. John, additional, Matthews, Brya G., additional, Maurizi, Antonio, additional, Mirfakhraee, Sasan, additional, Moe, Sharon M., additional, Monroe, David G., additional, Moreira, Carolina A., additional, Müller, Ralph, additional, Musson, David S., additional, Nakatani, Teruyo, additional, Naot, Dorit, additional, Napoli, Nicola, additional, Naveh-Many, Tally, additional, Nemeth, Edward F., additional, Nickolas, Thomas L., additional, Ominsky, Michael S., additional, Ono, Noriaki, additional, Ornitz, David M., additional, Partridge, Nicola C., additional, Patel, Vihitaben S., additional, Pike, J. Wesley, additional, Pilbeam, Carol, additional, Plum, Lori, additional, Potts, John T., additional, Puzas, J. Edward, additional, Rachner, Tilman D., additional, Rakian, Audrey, additional, Rakian, Rubie, additional, Renthal, Nora E., additional, Rhoades (Sterling), Julie A., additional, Riminucci, Mara, additional, Roberts, Scott J., additional, Robey, Pamela Gehron, additional, Rogers, Michael J., additional, Roodman, G. David, additional, Rosen, Clifford J., additional, Rosen, Vicki, additional, Rowe, David W., additional, Rubin, Janet, additional, Rubin, Clinton T., additional, Schlingmann, Karl P., additional, Seeman, Ego, additional, Seibel, Markus J., additional, Sempos, Chris, additional, Shoback, Dolores M., additional, Silve, Caroline, additional, Silver, Justin, additional, Sims, Natalie A., additional, Singer, Frederick R., additional, Stains, Joseph P., additional, Stegen, Steve, additional, Stern, Paula H., additional, Tabacco, Gaia, additional, Takacs, Istvan, additional, Takahashi, Naoyuki, additional, Tay, Donovan, additional, Teti, Anna, additional, Thakker, Rajesh V., additional, Tomlinson, Ryan E., additional, Tonelli, Francesco, additional, Towler, Dwight A., additional, Tsourdi, Elena, additional, Tu, Chia-Ling, additional, Udagawa, Nobuyuki, additional, Weaver, Connie M., additional, Wein, Marc N., additional, Weinstein, Lee S., additional, Weis, MaryAnn, additional, Whyte, Michael P., additional, Williams, Bart O., additional, Xu, Xin, additional, Yakar, Shoshana, additional, Yang, Yingzi, additional, Zanotti, Stefano, additional, and Zhou, Hong, additional

Published
2020
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36. Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Author

Weivoda, Megan M., Chew, Chee Kian, Monroe, David G., Farr, Joshua N., Atkinson, Elizabeth J., Geske, Jennifer R., Eckhardt, Brittany, Thicke, Brianne, Ruan, Ming, Tweed, Amanda J., McCready, Louise K., Rizza, Robert A., Matveyenko, Aleksey, Kassem, Moustapha, Andersen, Thomas Levin, Vella, Adrian, Drake, Matthew T., Clarke, Bart L., Oursler, Merry Jo, and Khosla, Sundeep

Published
2020
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41. Targeting cellular senescence prevents age-related bone loss in mice

Author

Farr, Joshua N, Xu, Ming, Weivoda, Megan M, Monroe, David G, Fraser, Daniel G, Onken, Jennifer L, Negley, Brittany A, Sfeir, Jad G, Ogrodnik, Mikolaj B, Hachfeld, Christine M, LeBrasseur, Nathan K, Drake, Matthew T, Pignolo, Robert J, Pirtskhalava, Tamar, Tchkonia, Tamara, Oursler, Merry Jo, Kirkland, James L, and Khosla, Sundeep

Subjects
Osteoporosis -- Genetic aspects -- Prevention -- Research, Cell aging -- Physiological aspects -- Genetic aspects -- Research, Biological sciences, Health
Abstract

Author(s): Joshua N Farr [1]; Ming Xu [1]; Megan M Weivoda [1]; David G Monroe [1]; Daniel G Fraser [1]; Jennifer L Onken [1]; Brittany A Negley [1]; Jad G [...]

Published
2017
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43. Abstract PR012: Pre-malignant plasma cells exhibit a senescence-like phenotype and accumulation of transposable elements

Author

Borges, Gabriel Alvares, primary, Guilatco, Angelo Jose, additional, Hachfeld, Christine M., additional, Ruan, Ming, additional, Royzenblat, Sonya, additional, Xu, Ming, additional, Edwards, Claire M., additional, Diaz-delCastillo, Marta, additional, Andersen, Thomas L., additional, Kourelis, Taxiarchis, additional, Tchkonia, Tamar, additional, Kirkland, James L., additional, Drake, Matthew T., additional, and Weivoda, Megan, additional

Published
2023
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44. Abstract B020: Pre-malignant plasma cells exhibit a senescence-like phenotype and accumulation of transposable elements

Author

Borges, Gabriel Alvares, primary, Guilatco, Angelo Jose, additional, Hachfeld, Christine M., additional, Ruan, Ming, additional, Royzenblat, Sonya, additional, Xu, Ming, additional, Edwards, Claire M., additional, Diaz-delCastillo, Marta, additional, Andersen, Thomas L., additional, Kourelis, Taxiarchis, additional, Tchkonia, Tamar, additional, Kirkland, James L., additional, Drake, Matthew T., additional, and Weivoda, Megan, additional

Published
2023
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47. A Systematic Review Supporting the Endocrine Society Clinical Practice Guideline on the Treatment of Hypercalcemia of Malignancy in Adults

Author

Seisa, Mohamed O, primary, Nayfeh, Tarek, additional, Hasan, Bashar, additional, Firwana, Mohammed, additional, Saadi, Samer, additional, Mushannen, Ahmed, additional, Shah, Sahrish H, additional, Rajjoub, Noora S, additional, Farah, Magdoleen H, additional, Prokop, Larry J, additional, Wang, Zhen, additional, Fuleihan, Ghada El-Hajj, additional, Drake, Matthew T, additional, and Murad, Mohammad Hassan, additional

Published
2022
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49. MGUS and SMM Plasma Cells Exhibit a Senescence-like Phenotype and Accumulation of Transposable Elements That May Contribute to Disease Progression

Author

Alvares Borges, Gabriel, primary, Guilatco, Angelo Jose, additional, Hachfeld, Christine M., additional, Ruan, Ming, additional, Royzenblat, Sonya, additional, Xu, Ming, additional, Edwards, Claire M., additional, Diaz-delCastillo, Marta, additional, Andersen, Thomas L., additional, Kourelis, Taxiarchis, additional, Tchkonia, Tamar, additional, Kirkland, James L., additional, Drake, Matthew T., additional, and Weivoda, Megan, additional

Published
2022
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