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Your search keyword '"Drexler, Hannes CA"' showing total 8 results
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8 results on '"Drexler, Hannes CA"'

2. Codon Pair-Specific Translation Defects Trigger Ribosome-Associated Quality Control to Avoid Proteotoxic Stress

Author

Wu, Jie, primary, Eggers, Cristian, additional, Sin, Olga, additional, Koziej, Lukasz, additional, Mancilla, Hector, additional, Mollet, Fabienne, additional, Scholer, Hans R, additional, Drexler, Hannes CA, additional, Ranff, Tristan, additional, Fufezan, Christian, additional, Kraft, Claudine, additional, Glatt, Sebastian, additional, Bruder, Jan M, additional, and Leidel, Sebastian A, additional

Published
2024
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3. Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism

Author

Duethorn, Binyamin, Groll, Fabian, Rieger, Bettina, Drexler, Hannes CA, Brinkmann, Heike, Kremer, Ludmila, Stehling, Martin, Borowski, Marie-Theres, Mildner, Karina, Zeuschner, Dagmar, Zernicka-Goetz, Magdalena, Stemmler, Marc P, Busch, Karin B, Vaquerizas, Juan M, Bedzhov, Ivan, Drexler, Hannes CA [0000-0002-8285-0644], Borowski, Marie-Theres [0000-0003-3648-7757], Zeuschner, Dagmar [0000-0002-6712-0192], Zernicka-Goetz, Magdalena [0000-0002-7004-2471], Stemmler, Marc P [0000-0002-7866-3686], Vaquerizas, Juan M [0000-0002-6583-6541], Bedzhov, Ivan [0000-0002-2122-6485], and Apollo - University of Cambridge Repository

Subjects
Male, Pluripotent Stem Cells, Science, 631/136/2086, General Physics and Astronomy, 631/532/2064, Embryonic Development, 631/80/642/333/1465, 13/109, Membrane trafficking, 13, 14, 96/31, General Biochemistry, Genetics and Molecular Biology, Article, 38, Mice, 13/100, Animals, 96/2, Embryonic Stem Cells, Cell Proliferation, 42, 64, Multidisciplinary, 631/80/313, 631/136/532/2064, 82/58, General Chemistry, Energy metabolism, Cytoskeletal Proteins, Blastocyst, 14/63, Embryogenesis, 38/77, 38/39, 64/60, Female
Abstract

Lima1 is an extensively studied prognostic marker of malignancy and is also considered to be a tumour suppressor, but its role in a developmental context of non-transformed cells is poorly understood. Here, we characterise the expression pattern and examined the function of Lima1 in mouse embryos and pluripotent stem cell lines. We identify that Lima1 expression is controlled by the naïve pluripotency circuit and is required for the suppression of membrane blebbing, as well as for proper mitochondrial energetics in embryonic stem cells. Moreover, forcing Lima1 expression enables primed mouse and human pluripotent stem cells to be incorporated into murine pre-implantation embryos. Thus, Lima1 is a key effector molecule that mediates the pluripotency control of membrane dynamics and cellular metabolism., How pluripotency transcription factors regulate the cellular architecture and energetics has remained largely unknown. Here the authors identify Lima1 as a key effector that mediates the pluripotency control of membrane dynamics and cellular metabolism.

Published
2021

4. EGR4-dependent decrease of UTF1 is associated with failure to reserve spermatogonial stem cells in infertile men

Author

Di Persio, Sara, primary, Tekath, Tobias, additional, Siebert-Kuss, Lara Marie, additional, Cremers, Jann-Frederik, additional, Wistuba, Joachim, additional, Li, Xiaolin, additional, Meyer zu Hörste, Gerd, additional, Drexler, Hannes CA, additional, Wyrwoll, Margot Julia, additional, Tüttelmann, Frank, additional, Dugas, Martin, additional, Kliesch, Sabine, additional, Schlatt, Stefan, additional, Laurentino, Sandra, additional, and Neuhaus, Nina, additional

Published
2021
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6. Endothelial EphB4 maintains vascular integrity and transport function in adult heart

Author

Luxán, Guillermo, primary, Stewen, Jonas, additional, Díaz, Noelia, additional, Kato, Katsuhiro, additional, Maney, Sathish K, additional, Aravamudhan, Anusha, additional, Berkenfeld, Frank, additional, Nagelmann, Nina, additional, Drexler, Hannes CA, additional, Zeuschner, Dagmar, additional, Faber, Cornelius, additional, Schillers, Hermann, additional, Hermann, Sven, additional, Wiseman, John, additional, Vaquerizas, Juan M, additional, Pitulescu, Mara E, additional, and Adams, Ralf H, additional

Published
2019
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7. Author response: Endothelial EphB4 maintains vascular integrity and transport function in adult heart

Author

Luxán, Guillermo, primary, Stewen, Jonas, additional, Díaz, Noelia, additional, Kato, Katsuhiro, additional, Maney, Sathish K, additional, Aravamudhan, Anusha, additional, Berkenfeld, Frank, additional, Nagelmann, Nina, additional, Drexler, Hannes CA, additional, Zeuschner, Dagmar, additional, Faber, Cornelius, additional, Schillers, Hermann, additional, Hermann, Sven, additional, Wiseman, John, additional, Vaquerizas, Juan M, additional, Pitulescu, Mara E, additional, and Adams, Ralf H, additional

Published
2019
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8. Abstract 2997: Dynarrestin, a novel dynein inhibitor that does not block ciliogenesis

Author

Baumann, Matthias, primary, Höing, Susanne, additional, Yeh, Ting-Yu, additional, Martinez, Nancy, additional, Habenberger, Peter, additional, Kremer, Lea, additional, Drexler, Hannes CA., additional, Küchler, Philipp, additional, Reinhardt, Peter, additional, Choidas, Axel, additional, Zischinsky, Mia-Lisa, additional, Zischinsky, Gunther, additional, Ketcham, Stephanie A., additional, Wagner, Lydia, additional, Nussbaumer, Peter, additional, Ziegler, Slava, additional, Klebl, Bert, additional, Schroer, Trina, additional, Schöler, Hans R., additional, Waldmann, Herbert, additional, and Sterneckert, Jared L., additional

Published
2016
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