Search

Your search keyword '"Dries Noé"' showing total 3 results
Start Over Author "Dries Noé"
3 results on '"Dries Noé"'

1. Arteriovenous Fistulae in Chronic Kidney Disease and the Heart: Physiological, Histological, and Transcriptomic Characterization of a Novel Rat Model

Author

Jef Van den Eynde, Xander Jacquemyn, Nicolas Cloet, Dries Noé, Hilde Gillijns, Marleen Lox, Willy Gsell, Uwe Himmelreich, Aernout Luttun, Keir McCutcheon, Stefan Janssens, and Wouter Oosterlinck

Subjects
animal model, arteriovenous fistula, cardiorenal syndrome, chronic kidney disease, heart failure, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Arteriovenous fistulae (AVFs) are the gold standard for vascular access in those requiring hemodialysis but may put an extra hemodynamic stress on the cardiovascular system. The complex interactions between the heart, kidney, and AVFs remain incompletely understood. Methods and Results We characterized a novel rat model of five‐sixths partial nephrectomy (NX) and AVFs. NX induced increases in urea, creatinine, and hippuric acid. The addition of an AVF (AVF+NX) further increased urea and a number of uremic toxins such as trimethylamine N‐oxide and led to increases in cardiac index, left and right ventricular volumes, and right ventricular mass. Plasma levels of uremic toxins correlated well with ventricular morphology and function. Heart transcriptomes identified altered expression of 8 genes following NX and 894 genes following AVF+NX, whereas 290 and 1431 genes were altered in the kidney transcriptomes, respectively. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analysis revealed gene expression changes related to cell division and immune activation in both organs, suppression of ribosomes and transcriptional activity in the heart, and altered renin‐angiotensin signaling as well as chronodisruption in the kidney. All except the latter were worsened in AVF+NX compared with NX. Conclusions Inflammation and organ dysfunction in chronic kidney disease are exacerbated following AVF creation. Furthermore, our study provides important information for the discovery of novel biomarkers and therapeutic targets in the management of cardiorenal syndrome.

Published
2022
Full Text
View/download PDF

2. Matched comparison between external aortic root support and valve-sparing root replacement

Author

Lucas Van Hoof, Marie Lamberigts, Dries Noé, Ismail El-Hamamsy, Emmanuel Lansac, Jolanda Kluin, Laurent de Kerchove, John Pepper, Tom Treasure, Bart Meuris, Filip Rega, Peter Verbrugghe, Cardiothoracic Surgery, and ACS - Heart failure & arrhythmias

Subjects
Aortic Valve Insufficiency, Cardiology and Cardiovascular Medicine, Aortic Aneurysm, Marfan Syndrome
Abstract

ObjectivesDifferences in indication and technique make a randomised comparison between valve-sparing root replacement (VSRR) and personalised external aortic root support (PEARS) challenging. We performed a propensity score (PS)-matched comparison of PEARS and VSRR for syndromic root aneurysm.MethodsPatients in the PEARS 200 Database and Aortic Valve Insufficiency and ascending aorta Aneurysm InternATiOnal Registry (undergoing VSRR) with connective tissue disease operated electively for root aneurysm ResultsMedian follow-up was 25 and 55 months for 159 PEARS and 142 VSRR patients. Seven (4.4%) patients undergoing PEARS required an intervention for coronary injury or impingement, resulting in one death (0.6%). After VSRR, there were no early deaths, 10 (7%) reinterventions for bleeding and 1 coronary intervention. Survival for matched cohorts at 5 years was similar (PEARS 98% vs VSRR 99%, p=0.99). There was no difference in freedom from valve or ascending aortic/arch reintervention between matched groups. Freedom from AR ≥2/4 at 5 years in the matched cohorts was 97% for PEARS vs 92% for VSRR (p=0.55). There were no type A dissections.ConclusionsVSRR and PEARS offer favourable mid-term survival, freedom from reintervention and preservation of valve function. Both treatments deserve their place in the surgical repertoire, depending on a patient’s disease stage. This study is limited by its retrospective nature and different follow-ups in both cohorts.

Published
2023

3. Revascularization strategies in patients with multivessel coronary artery disease: a Bayesian network meta-analysis

Author

Jef Van den Eynde, Katrien Bomhals, Dries Noé, Xander Jacquemyn, Keir McCutcheon, Johan Bennett, John D Puskas, and Wouter Oosterlinck

Subjects
Pulmonary and Respiratory Medicine, Multivessel disease, Network Meta-Analysis, Coronary artery bypass grafting, Bayes Theorem, Coronary Artery Disease, Percutaneous coronary intervention, Stroke, Percutaneous Coronary Intervention, Treatment Outcome, Humans, Surgery, Cardiology and Cardiovascular Medicine, Network meta-analysis, Hybrid coronary revascularization
Abstract

Treatment modalities for multivessel disease have rapidly evolved, yet the preferred strategy remains controversial. This meta-analysis compared outcomes after on-pump (ONCAB), off-pump coronary artery bypass grafting (OPCAB), percutaneous coronary intervention (PCI) or hybrid coronary revascularization. A comprehensive search for observational studies and randomized controlled trials published by August 2020 was performed. A Bayesian network meta-analysis was conducted for early (12 months) outcomes. A total of 119 studies were included (n = 700 458 patients). The main analysis was confined to 31 randomized controlled trials (n = 24 932 patients). PCI was associated with lower early mortality [odds ratio (OR) 0.50, 95% confidence interval (CI) 0.31-0.79] and stroke (OR 0.22, 95% CI 0.06-0.60) rates compared with ONCAB, whereas a reduced risk of early myocardial infarction was observed with OPCAB compared with ONCAB (OR 0.53, 95% CI 0.32-0.83). Late target vessel revascularization and major adverse cardiac and cerebrovascular events were both increased with PCI compared with ONCAB, OPCAB and hybrid coronary revascularization (by 127-203% and 59-64%, respectively), and late major adverse cardiac events were increased in PCI compared with ONCAB and OPCAB (by 64% and 59%). However, PCI was associated with a significantly lower risk of late stroke compared with ONCAB (OR 0.70, 95% CI 0.52-0.89). Sensitivity analyses (i) including observational studies and (ii) limiting to studies with recent cohorts confirmed the findings of the main analysis. Surgical approaches for revascularization remain superior to PCI in patients with multivessel disease. Hybrid coronary revascularization might be viable for some patients, although more evidence from randomized controlled trials is warranted. ispartof: INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY vol:34 issue:6 pages:947-957 ispartof: location:England status: published

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results