1. Are histamine H1 receptors involved in ischaemia/reperfusion injury in rat heart?
- Author
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Dzierzkowska J, Witanowska A, Wojtecka-Lukasik E, Droń T, Moutiris JA, Gujski M, Poppe P, Prejbisz HH, Gajewska J, and Gajewski M
- Subjects
- Animals, Antioxidants metabolism, Heart Conduction System drug effects, Lipid Peroxidation physiology, Male, Malondialdehyde metabolism, Myocardial Ischemia enzymology, Myocardial Ischemia metabolism, Myocardial Reperfusion Injury enzymology, Myocardial Reperfusion Injury metabolism, Rats, Rats, Wistar, Myocardial Ischemia pathology, Myocardial Reperfusion Injury pathology, Receptors, Histamine H1 physiology
- Abstract
During ischaemia, there was no apparent change in malondialdehyde (MDA) content in rat myocardium. However, reoxygenation resulted in a significant increase in MDA content. The changes evoked by ischaemia and reoxygenation were significantly attenuated by addition of fenistil (histamine H1 receptor antagonist). Enzymatic antioxidant systems were not significantly modified in the different periods of ischaemia and after 30 min of reoxygenation. It is suggested, that maintenance of an adequate endogenous antioxidant reserve during ischaemia may be important in recovery upon reoxygenation.
- Published
- 1994