Search

Your search keyword '"Dromer, C"' showing total 319 results
Start Over Author "Dromer, C"
319 results on '"Dromer, C"'

2. Quantitative CT assessment of bronchial and vascular alterations in severe precapillary pulmonary hypertension

Author

Coste F, Benlala I, Dournes G, Dromer C, Blanchard E, Girodet PO, Montaudon M, Baldacci F, Picard F, Marthan R, Laurent F, and Berger P

Subjects
computed tomography, pulmonary hypertension, COPD, prediction, Diseases of the respiratory system, RC705-779
Abstract

Florence Coste,1,2,* Ilyes Benlala,1,2,* Gaël Dournes,1–3 Claire Dromer,3 Elodie Blanchard,3 Pierre-Olivier Girodet,1–3 Michel Montaudon,1–3 Fabien Baldacci,4 François Picard,3 Roger Marthan,1–3 François Laurent,1–3,* Patrick Berger1–3,* 1Université de Bordeaux, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, F-33000 Bordeaux, France; 2Centre de Recherche Cardio-Thoracique de Bordeaux, INSERM, U1045, Université de Bordeaux, CIC1401, F-33000 Bordeaux, France; 3CHU de Bordeaux, Service d’Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires, Service de Cardiologie, CIC1401, Service d’Explorations Fonctionnelles Respiratoires, F-33600 Pessac, France; 4Université de Bordeaux, LaBRI, F-33405 Talence Cedex, France *These authors contributed equally to this work Background: Little is known about in vivo alterations at bronchial and vascular levels in severe pulmonary hypertension (PH) of different etiologies. We aimed to compare quantitative computed tomography (CT) data from the following three groups of severe precapillary PH patients: COPD, idiopathic pulmonary arterial hypertension (iPAH), and chronic thromboembolic PH (CTEPH). Patients and methods: This study was approved by the institutional review board. Severe PH patients (mean pulmonary arterial pressure [mPAP] ≥35 mmHg) with COPD, iPAH, or CTEPH (n=24, 16, or 16, respectively) were included retrospectively between January 2008 and January 2017. Univariate analysis of mPAP was performed in each severe PH group. Bronchial wall thickness (WT) and percentage of cross sectional area of pulmonary vessels less than 5 mm2 normalized by lung area (%CSA

Published
2019

3. Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung

Author

Jougon, J., Velly, J.-F., Rozé, H., Blanchard, E., Dromer, C., Antoine, M., Cappello, M., Ruiz, M., Sokolow, Y., Vanden Eynden, F., Van Nooten, G., Barvais, L., Berré, J., Brimioulle, S., De Backer, D., Créteur, J., Engelman, E., Huybrechts, I., Ickx, B., Preiser, T.J.C., Tuna, T., Van Obberghe, L., Vancutsem, N., Vincent, J.-L., De Vuyst, P., Etienne, I., Féry, F., Jacobs, F., Knoop, C., Vachiéry, J.L., Van den Borne, P., Wellemans, I., Amand, G., Collignon, L., Giroux, M., Angelescu, D., Chavanon, O., Hacini, R., Pirvu, A., Porcu, P., Albaladejo, P., Allègre, C., Bataillard, A., Bedague, D., Briot, E., Casez-Brasseur, M., Colas, D., Dessertaine, G., Durand, M., Francony, G., Hebrard, A., Marino, M.R., Oummahan, B., Protar, D., Rehm, D., Robin, S., Rossi-Blancher, M., Augier, C., Bedouch, P., Boignard, A., Bouvaist, H., Briault, A., Camara, B., Claustre, J., Chanoine, S., Dubuc, M., Quétant, S., Maurizi, J., Pavèse, P., Pison, C., Saint-Raymond, C., Wion, N., Chérion, C., Grima, R., Jegaden, O., Maury, J.-M., Tronc, F., Flamens, C., Paulus, S., Mornex, J.-F., Philit, F., Senechal, A., Glérant, J.-C., Turquier, S., Gamondes, D., Chalabresse, L., Thivolet-Bejui, F., Barnel, C., Dubois, C., Tiberghien, A., Le Pimpec-Barthes, F., Bel, A., Mordant, P., Achouh, P., Boussaud, V., Guillemain, R., Méléard, D., Bricourt, M.O., Cholley, B., Pezella, V., Brioude, G., D'Journo, X.B., Doddoli, C., Thomas, P., Trousse, D., Dizier, S., Leone, M., Papazian, L., Bregeon, F., Basire, A., Coltey, B., Dufeu, N., Dutau, H., Garcia, S., Gaubert, J.Y., Gomez, C., Laroumagne, S., Nieves, A., Picard, L.C., Reynaud-Gaubert, M., Secq, V., Mouton, G., Baron, O., Lacoste, P., Perigaud, C., Roussel, J.C., Danner, I., Haloun, A., Magnan, A., Tissot, A., Lepoivre, T., Treilhaud, M., Botturi-Cavaillès, K., Brouard, S., Danger, R., Loy, J., Morisset, M., Pain, M., Pares, S., Reboulleau, D., Royer, P.-J., Fabre, D., Fadel, E., Mercier, O., Mussot, S., Stephan, F., Viard, P., Cerrina, J., Dorfmuller, P., Ghigna, S.M., Hervén, Ph., Le Roy Ladurie, F., Le Pavec, J., Thomas de Montpreville, V., Lamrani, L., Castier, Y., Cerceau, P., Augustin, P., Jean-Baptiste, S., Boudinet, S., Montravers, P., Brugière, O., Dauriat, G., Jébrak, G., Mal, H., Marceau, A., Métivier, A.-C., Thabut, G., Lhuillier, E., Dupin, C., Bunel, V., Falcoz, P., Massard, G., Santelmo, N., Ajob, G., Collange, O., Helms, O., Hentz, J., Roche, A., Bakouboula, B., Degot, T., Dory, A., Hirschi, S., Ohlmann-Caillard, S., Kessler, L., Kessler, R., Schuller, A., Bennedif, K., Vargas, S., Stauder, J., Ali-Azouaou, S., Bonnette, P., Chapelier, A., Puyo, P., Sage, E., Bresson, J., Caille, V., Cerf, C., Devaquet, J., Dumans-Nizard, V., Felten, M.-L., Fischler, M., Si Larbi, A.-G., Leguen, M., Ley, L., Liu, N., Trebbia, G., De Miranda, S., Douvry, B., Gonin, F., Grenet, D., Hamid, A.M., Neveu, H., Parquin, F., Picard, C., Roux, A., Stern, M., Bouillioud, F., Cahen, P., Colombat, M., Dautricourt, C., Delahousse, M., D'Urso, B., Gravisse, J., Guth, A., Hillaire, S., Honderlick, P., Lequintrec, M., Longchampt, E., Mellot, F., Scherrer, A., Temagoult, L., Tricot, L., Vasse, M., Veyrie, C., Zemoura, L., Berjaud, J., Brouchet, L., Dahan, M., Mathe, F.O., Benahoua, H., DaCosta, M., Serres, I., Merlet-Dupuy, V., Grigoli, M., Didier, A., Murris, M., Crognier, L., Fourcade, O., Krueger, T., Ris, H.B., Gonzalez, M., Jolliet, Ph., Marcucci, C., Chollet, M., Gronchi, F., Courbon, C., Berutto, C., Manuel, O., Koutsokera, A., Aubert, J.-D., Nicod, L.P., Mouraux, S., Bernasconi, E., Pattaroni, C., Marsland, B.J., Soccal, P.M., Rochat, T., Lücker, L.M., Hillinger, S., Inci, I., Weder, W., Schuepbach, R., Zalunardo, M., Benden, C., Schuurmans, M.M., Gaspert, A., Holzmann, D., Müller, N., Schmid, C., Vrugt, B., Fritz, A., Maier, D., Deplanche, K., Koubi, D., Ernst, F., Paprotka, T., Schmitt, M., Wahl, B., Boissel, J.-P., Olivera-Botello, G., Trocmé, C., Toussaint, B., Bourgoin-Voillard, S., Sève, M., Benmerad, M., Siroux, V., Slama, R., Auffray, C., Charron, D., Lefaudeux, D., Pellet, J., Mouraux, Stéphane, Bernasconi, Eric, Pattaroni, Céline, Koutsokera, Angela, Aubert, John-David, Claustre, Johanna, Pison, Christophe, Royer, Pierre-Joseph, Magnan, Antoine, Kessler, Romain, Benden, Christian, Soccal, Paola M., Marsland, Benjamin J., and Nicod, Laurent P.

Published
2018
Full Text
View/download PDF

4. French practical guidelines for the diagnosis and management of idiopathic pulmonary fibrosis – 2017 update. Full-length version

Author

Cottin, V., Crestani, B., Cadranel, J., Cordier, J.-F., Marchand-Adam, S., Prévot, G., Wallaert, B., Bergot, E., Camus, P., Dalphin, J.-C., Dromer, C., Gomez, E., Israel-Biet, D., Jouneau, S., Kessler, R., Marquette, C.-H., Reynaud-Gaubert, M., Aguilaniu, B., Bonnet, D., Carré, P., Danel, C., Faivre, J.-B., Ferretti, G., Just, N., Lebargy, F., Philippe, B., Terrioux, P., Thivolet-Béjui, F., Trumbic, B., and Valeyre, D.

Published
2017
Full Text
View/download PDF

5. French practical guidelines for the diagnosis and management of idiopathic pulmonary fibrosis – 2017 update. Short-length version

Author

Cottin, V., Crestani, B., Cadranel, J., Cordier, J.-F., Marchand-Adam, S., Prévot, G., Wallaert, B., Bergot, E., Camus, P., Dalphin, J.-C., Dromer, C., Gomez, E., Israel-Biet, D., Jouneau, S., Kessler, R., Marquette, C.-H., Reynaud-Gaubert, M., Aguilaniu, B., Bonnet, D., Carré, P., Danel, C., Faivre, J.-B., Ferretti, G., Just, N., Lebargy, F., Philippe, B., Terrioux, P., Thivolet-Béjui, F., Trumbic, B., and Valeyre, D.

Published
2017
Full Text
View/download PDF

6. T Cells Promote Bronchial Epithelial Cell Secretion of Matrix Metalloproteinase-9 via a C-C Chemokine Receptor Type 2 Pathway: Implications for Chronic Lung Allograft Dysfunction

Author

Pain, M., Royer, P.-J., Loy, J., Girardeau, A., Tissot, A., Lacoste, P., Roux, A., Reynaud-Gaubert, M., Kessler, R., Mussot, S., Dromer, C., Brugière, O., Mornex, J.-F., Guillemain, R., Dahan, M., Knoop, C., Botturi, K., Pison, C., Danger, R., Brouard, S., and Magnan, A.

Published
2017
Full Text
View/download PDF

13. O.20A - Fond génétique partagé entre la pneumopathie interstitielle diffuse associée à la polyarthrite rhumatoïde et la fibrose pulmonaire idiopathique

Author

Juge, P.A., Borie, R., Kannengiesser, C., Gazal, S., Revy, P., Wemeau-Stervinou, L., Debray, M.P., Ottaviani, S., Marchand-Adam, S., Nathan, N., Thabut, G., Richez, C., Nunes, H., Callebaut, I., Justet, A., Leulliot, N., Bonnefond, A., Salgado, D., Richette, P., Desvignes, J.P., Lioté, H., Froguel, P., Allanore, Y., Sand, O., Dromer, C., Flipo, R.M., Clément, A., Béroud, C., Sibilia, J., Coustet, B., Cottin, V., Boissier, M.C., Wallaert, B., Schaeverbeke, T., Le Moal, F. Dastot, Frazier-Mironer, A., Ménard, C., Soubrier, M., Saindenberg, N., Valeyre, D., Amselem, S., Boileau, C., Crestani, B., and Dieudé, P.

Published
2016
Full Text
View/download PDF

14. Operational considerations for the management of non-communicable diseases in humanitarian emergencies

Author

Jacquerioz, Frédérique Aline, Beran, David Henri, Hering, H., Boulle, P., Chappuis, François, Dromer, C., Saaristo, P., and Aebischer Perone, Sigiriya

Subjects
Ethics, Humanitarian emergencies, Humanitarian agencies, Crises, Conflicts, Continuum of care, Non-communicable diseases, Guidelines, Health services, ddc:613
Abstract

Non-communicable diseases (NCD) represent an increasing global challenge with the majority of mortality occurring in low- and middle-income countries (LMICs). Concurrently, many humanitarian crises occur in these countries and the number of displaced persons, either refugees or internally displaced, has reached the highest level in history. Until recently NCDs in humanitarian contexts were a neglected issue, but this is changing. Humanitarian actors are now increasingly integrating NCD care in their activities and recognizing the need to harmonize and enhance NCD management in humanitarian crises. However, there is a lack of a standardized response during operations as well as a lack of evidence-based NCD management guidelines in humanitarian settings. An informal working group on NCDs in humanitarian settings, formed by members of the World Health Organization, Médecins Sans Frontières, the International Committee of the Red Cross, the International Federation of the Red Cross and others, and led by the United Nations High Commissioner for Refugees, teamed up with the University of Geneva and Geneva University Hospitals to develop operational considerations for NCDs in humanitarian settings. This paper presents these considerations, aiming at ensuring appropriate planning, management and care for NCD-affected persons during the different stages of humanitarian emergencies. Key components include access to treatment, continuity of care including referral pathways, therapeutic patient education/patient self-management, community engagement and health promotion. In order to implement these components, a standardized approach will support a consistent response, and should be based on an ethical foundation to ensure that the “do no harm” principle is upheld. Advocacy supported by evidence is important to generate visibility and resource allocation for NCDs. Only a collaborative approach of all actors involved in NCD management will allow the spectrum of needs and continuum of care for persons affected by NCDs to be properly addressed in humanitarian programmes.

Published
2021

18. OP0036 METHOTREXATE AND RHEUMATOID ARTHRITIS ASSOCIATED INTERSTITIAL LUNG DISEASE

Author

Juge, P. A., primary, Lee, J. S., additional, Lau, J., additional, Kawano, L., additional, Rojas-Serrano, J., additional, Sebastiani, M., additional, Koduri, G., additional, Matteson, E., additional, Bonfiglioli, K., additional, Sawamura, M., additional, Kairalla, R., additional, Cavagna, L., additional, Bozzalla Cassione, E., additional, Manfredi, A., additional, Mejia, M., additional, Rodríguez Henríquez, P., additional, Gonzalez-Perez, M. I., additional, Falfan-Valencia, R., additional, Buendia-Roldan, I., additional, Perez-Rubio, G., additional, Ebstein, E., additional, Gazal, S., additional, Borie, R., additional, Ottaviani, S., additional, Kannengiesser, C., additional, Wallaert, B., additional, Uzunhan, Y., additional, Nunes, H., additional, Valeyre, D., additional, Saidenberg Kermanac’h, N., additional, Boissier, M. C., additional, Wemeau Stervinou, L., additional, Flipo, R. M., additional, Marchand-Adam, S., additional, Richette, P., additional, Allanore, Y., additional, Dromer, C., additional, Truchetet, M. E., additional, Richez, C., additional, Schaeverbeke, T., additional, Lioté, H., additional, Thabut, G., additional, Deane, K., additional, Solomon, J., additional, Doyle, T., additional, Ryu, J. H., additional, Rosas, I. O., additional, Holers, V. M., additional, Boileau, C., additional, Debray, M. P., additional, Porcher, R., additional, Schwartz, D. A., additional, Vassallo, R., additional, Crestani, B., additional, and Dieudé, P., additional

Published
2020
Full Text
View/download PDF

19. Drug-resistant cytomegalovirus in transplant recipients: a French cohort study

Author

Hantz, Sébastien, Garnier-Geoffroy, Françoise, Mazeron, Marie-Christine, Garrigue, Isabelle, Merville, Pierre, Mengelle, Catherine, Rostaing, Lionel, Saint Marcoux, Franck, Essig, Marie, Rerolle, Jean-Philippe, Cotin, Sébastien, Germi, Raphaëlle, Pillet, Sylvie, Lebranchu, Yvon, Turlure, Pascal, Alain, Sophie, Herbein, Georges, Coaquette, Alain, Lafon, Marie Edith, Garrigue, Isabelle, Archimbaud, Christine, Henquell, Cécile, Peigue-Lafeuille, Hélène, Pothier, Pierre, Bour, Jean Baptiste, Cesaire, Raymond, Majioullah, Fatimah, Morand, Patrice, Germi, Raphaëlle, Morel-Baccard, Christine, Signori-Schmuck, Anne, Alain, Sophie, Hantz, Sébastien, Grosjean, Jérôme, Morfin-Sherpa, Florence, Billaud, Geneviève, Domenach, Vinca, Andre, Patrice, Milon, Marie Paule, Segondy, Michel, Foulongne, Vincent, Agius, Gérard, Beby-Defaux, Agnès, Pozzetto, Bruno, Pillet, Sylvie, Mansuy, Jean Michel, Mengelle, Catherine, Gaudio-Castelain, Sandrine, Ducancelle, Alexandra, Lunel, Françoise, Payan, Christopher, Gouarin, Stéphanie, Dewilde, Anny, Bressolette, Céline, Coste-Burel, Marianne, Imbert-Marcille, Berthe-Marie, Andreoletti, Laurent, Leveque, Nicolas, Venard, Véronique, Jeulin, Hélène, Minjolle, Sophie, Gueudin, Marie, Colimon, Ronald, Stoll-Keller, Françoise, Fafi-Kremer, Samira, Dubois, F., Gaudy, Catherine, Deny, Paul, Vezinet, Françoise Brun, Houhou, Nadira, Honderlick, Patrick, Mazeron, Marie Christine, Leruez-Ville, Marianne, Vaghefi, Parissa, Dussaix, Elisabeth, Agut, Henri, Boutolleau, David, Deback, Claire, Scieux, Catherine, Le Goff, Jérôme, Ducloux, Didier, Vanlemmens, Claire, Larosa, Fabrice, Neau-Cransac, M., Dromer, C., Rosier, Emmanuelle, Merville, Pierre, Douillet, Marine, Morel, Delphine, Moreau, Karine, Martin, Séverine, Billes, Marc-Alain, Milpied, Noel, Tabrizi, Reza, Vigouroux, Stéphane, Melot, Cyril, Deteix, Patrice, Heng, Anne-Elisabeth, Mackaya, Léandre, Casanova, Sandrine, Bay, Jacques-Olivier, Demeocq, François, Duee, Frédéric, Mousson, Christiane, Hillon, Patrick, Minello, Anne, Charve, Philippe, Tanter, Yves, Bayle, François, Janbon, Bénédicte, Borrel, Elisabeth, Boignard, Aude, Neron, Linda, Pison, Christophe, Saint-Raymond, Christel, Brion, Jean Paul, Cahn, Jean Yves, Bordessoule, Dominique, Turlure, Pascal, Bompart, Frédérica, Philippon, Céline, Essig, Marie, Aldigier, Jean-Claude, Rerolle, Jean Philippe, Dickson, Zarah, Leprivey, Valérie, Roger-Rolle, Florence, Piguet, Christophe, Marquet, Pierre, Francois, Bruno, Pouteil-Noble, Claire, Mialou, Valérie, Mourad, Georges, Mariat, Christophe, Cornillon, Jérôme, Tavernie-Tardy, Emmanuelle, Attal, M., Huynh, Anne, Rostaing, Lionel, Kamar, Nassim, Mencia, Danièle, Crognier, Laure, de Ligny, Bruno Hurault, Hazzan, Marc, Bordigoni, Pierre, Pall-Kondolff, Sandrine, Salmon, Alexandra, Clement, Laurence, Chevallier, Patrice, Le Gouill, Steven, Gastinne, Thomas, Delaunay, Jacques, Ayari, Sameh, Guillaume, Thierry, Mohty, Mohammed, Moreau, Philippe, Robin, Marie-Aude, Le Houerou, Claire, Giral, Magali, Papuchon, Emmanuelle, Pattier, Sabine, Treilhaud, Michèle, Camus, Christophe, Etienne, Isabelle, Moulin, Bruno, Caillard-Ohlmann, Sophie, Lioure, Bruno, Cojean, Nadine, Lutz, Patrick, Uettwiller, Françoise, Entz-Werle, Natacha, Laplace, Annegret, Buchler, Matthias, Lebranchu, Yvon, Barbet, Christelle, Fourchy, Dominique, Stern, Marc, Grenet, Dominique, Delahousse, Michel, Karras, Alexandre, Saliba, Faouzi, Ichai, Philippe, Dhedin, Nathalie, Vernant, Jean-Paul, Uzunov, Madalina, Barrou, Benoît, Glotz, Denis, Peraldi, Marie-Noëlle, Langner, Nathalie, and Ribaud, Patricia

Published
2010
Full Text
View/download PDF

26. MUC5B promoter variant and rheumatoid arthritis with interstitial lung disease

Author

Juge, P.-A. Lee, J.S. Ebstein, E. Furukawa, H. Dobrinskikh, E. Gazal, S. Kannengiesser, C. Ottaviani, S. Oka, S. Tohma, S. Tsuchiya, N. Rojas-Serrano, J. González-Pérez, M.I. Mejía, M. Buendía-Roldán, I. Falfán-Valencia, R. Ambrocio-Ortiz, E. Manali, E. Papiris, S.A. Karageorgas, T. Boumpas, D. Antoniou, K. Van Moorsel, C.H.M. Van Der Vis, J. De Man, Y.A. Grutters, J.C. Wang, Y. Borie, R. Wemeau-Stervinou, L. Wallaert, B. Flipo, R.-M. Nunes, H. Valeyre, D. Saidenberg-Kermanac'H, N. Boissier, M.-C. Marchand-Adam, S. Frazier, A. Richette, P. Allanore, Y. Sibilia, J. Dromer, C. Richez, C. Schaeverbeke, T. Lioté, H. Thabut, G. Nathan, N. Amselem, S. Soubrier, M. Cottin, V. Clément, A. Deane, K. Walts, A.D. Fingerlin, T. Fischer, A. Ryu, J.H. Matteson, E.L. Niewold, T.B. Assayag, D. Gross, A. Wolters, P. Schwarz, M.I. Holers, M. Solomon, J.J. Doyle, T. Rosas, I.O. Blauwendraat, C. Nalls, M.A. Debray, M.-P. Boileau, C. Crestani, B. Schwartz, D.A. Dieudé, P.

Abstract

BACKGROUND: Given the phenotypic similarities between rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we hypothesized that the strongest risk factor for the development of idiopathic pulmonary fibrosis, the gain-of-function MUC5B promoter variant rs35705950, would also contribute to the risk of ILD among patients with RA. METHODS: Using a discovery population and multiple validation populations, we tested the association of the MUC5B promoter variant rs35705950 in 620 patients with RA-ILD, 614 patients with RA without ILD, and 5448 unaffected controls. RESULTS: Analysis of the discovery population revealed an association of the minor allele of the MUC5B promoter variant with RA-ILD when patients with RA-ILD were compared with unaffected controls (adjusted odds ratio, 3.8; 95% confidence interval [CI], 2.8 to 5.2; P = 9.7×10-17). The MUC5B promoter variant was also significantly overrepresented among patients with RA-ILD, as compared with unaffected controls, in an analysis of the multiethnic case series (adjusted odds ratio, 5.5; 95% CI, 4.2 to 7.3; P = 4.7×10-35) and in a combined analysis of the discovery population and the multiethnic case series (adjusted odds ratio, 4.7; 95% CI, 3.9 to 5.8; P = 1.3×10-49). In addition, the MUC5B promoter variant was associated with an increased risk of ILD among patients with RA (adjusted odds ratio in combined analysis, 3.1; 95% CI, 1.8 to 5.4; P = 7.4×10-5), particularly among those with evidence of usual interstitial pneumonia on high-resolution computed tomography (adjusted odds ratio in combined analysis, 6.1; 95% CI, 2.9 to 13.1; P = 2.5×10-6). However, no significant association with the MUC5B promoter variant was observed for the diagnosis of RA alone. CONCLUSIONS: We found that the MUC5B promoter variant was associated with RA-ILD and more specifically associated with evidence of usual interstitial pneumonia on imaging. Copyright © 2018 Massachusetts Medical Society.

Published
2018

27. Donor Club Cell Secretory Protein G38A Polymorphism Is Associated With a Decreased Risk of Primary Graft Dysfunction in the French Cohort in Lung Transplantation

Author

Hin, A., Kannengiesser, C., Roussel, A., Renaud-Picard, B., Roux, A., Reynaud-Gaubert, M., Claustre, J., Tissot, A., Guillemain, R., Mornex, Jean-François, Mussot, S., Dromer, C., Dahan, M., Brugiere, O., Mercier, O., Borie, R., Pretolani, M., Castier, Y., Mordant, P., Consortium, COLT, Infections Virales et Pathologie Comparée - UMR 754 (IVPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), and Vaincre la Mucoviscidose

Subjects
Male, Adult, medicine.medical_specialty, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Primary Graft Dysfunction, 030230 surgery, Gastroenterology, Polymorphism, Single Nucleotide, Tissue Donors, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Risk Factors, Internal medicine, Medicine, Lung transplantation, Uteroglobin, Humans, Prospective Studies, Prospective cohort study, Retrospective Studies, Primary Graft Dysfunction/*genetics, Transplantation, Lung, Uteroglobin/*genetics, business.industry, Retrospective cohort study, Odds ratio, Single Nucleotide, respiratory system, Middle Aged, medicine.anatomical_structure, Treatment Outcome, 030228 respiratory system, Reperfusion Injury, Cohort, Multivariate Analysis, Female, Gene-Environment Interaction, France, business, Polymorphism, Lung Transplantation, Lung Transplantation/*methods
Abstract

BACKGROUND: Club Cell Secretory Protein (CCSP) G38A polymorphism has recently been involved in lung epithelial susceptibility to external injuries. Lung transplantation (LT) is currently limited by ischemia-reperfusion injury leading to primary graft dysfunction (PGD). We thus hypothesized that donor CCSP G38A polymorphism might impact the risk of PGD after LT. METHODS: We focused on LT included in the French multicentric Cohort in Lung Transplantation (COLT), performed between January 2009 and December 2014, and associated with preoperative blood samples from the donor and the recipient. Characteristics of the donors, recipients, procedures, early and late outcomes were prospectively recorded in COLT. The CCSP serum concentration and CCSP gene G38A polymorphism were retrospectively determined in a blind manner. Their association with grade 3 PGD was studied in univariate and multivariate analysis. RESULTS: The study group included 104 LT donors and recipients, 84 with grade 0 to 2 PGD and 20 with grade 3 PGD. Preoperative CCSP serum concentration was significantly higher in the donors (median, 22.54 ng/mL; interquartile range, 9.6-43.9) than in the recipients (median, 7.03 ng/mL; interquartile range, 0.89-19.2; P \\textless 0.001) but none impacted the risk of grade 3 PGD (P = 0.93 and P = 0.69, respectively). Donor CCSP G38A polymorphism was associated with a decreased risk of grade 3 PGD in univariate (AG + AA 3/21 = 14.2% vs GG 10/26 = 38.4%, P = 0.044) and multivariate analysis (odds ratio associated with AG + AA, 0.22; 95% confidence interval, 0.041-0.88; P = 0.045), but recipient CCSP G38A polymorphism was not. CONCLUSIONS: Donor CCSP G38A polymorphism is associated with a decreased risk of severe PGD after LT in the COLT study. These findings should be confirmed in the frame of a prospective study.

Published
2018
Full Text
View/download PDF

28. COLT: Ten years of research in lung transplantation, results and perspectives

Author

Tissot, A., Foureau, A., Brosseau, C., Danger, R., Roux, A., Bernasconi, E., Gomez, C., Durand, M., Picard, B. R., Le Pavec, J., Claustre, J., Lacoste, P., Benmerad, M., Pain, M., Siroux, V., Royer, P. -J., Mordant, P., Reynaud-Gaubert, M., Kessler, R., Brugiere, O., Mornex, J. -F, Dromer, C., Dahan, M., Knoop, C., Boussaud, V., Koutsokera, A., Botturi-Cavailles, K., Durand, E., Loy, J., Nicod, L., Pison, C., Brouard, S., Blanc, F. -X., Magnan, A., Colt, Consortium, Immunoregulation And Immunointervention in Transplantation and Autoimmunity (Team 4 - U1064 Inserm - CRTI), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Laboratoire d'étude des marériaux, Université de Brest (UBO), Service de pneumologie [Hôpital Foch], Hôpital Foch [Suresnes], CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pneumologie et Réanimation, Centre de reference de l'hypertension artérielle pulmonaire, Hôpital Antoine Béclère, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Sud (Paris 11), Dr SPOC, Paris, Center for Public Health Research (CSISP), University of Valencia, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service de Pneumologie, Nouvel Hôpital Civil Strasbourg, CHU Bordeaux [Bordeaux], Ecole Nationale Supérieure de Chimie de Rennes (ENSCR), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Intervention, innovation, imagerie, ingénierie en santé - UFC (I4S), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), ANR-17-CE17-0008,Biket,Cellules B GZMB+, un facteur clé de l'immunité chez l'homme?(2017), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de transplantation pulmonaire [Hôpital Foch, Suresnes] (Pneumologie), Hôpital Foch [Suresnes]-Centre de fibrose kystique adulte [Hôpital Foch, Suresnes], Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème (UMR LISAH), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut de Recherche pour le Développement (IRD [ Madagascar])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Ecole Nationale Supérieure de Chimie de Rennes, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux - Clermont Auvergne (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne (UCA), Université Clermont Auvergne (UCA), Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA)

Subjects
Cohort Studies, Biomedical Research, Postoperative Complications, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Chronic Disease, Graft Survival, Humans, History, 20th Century, Primary Graft Dysfunction, History, 21st Century, ComputingMilieux_MISCELLANEOUS, Lung Transplantation
Abstract

National audience

Published
2018
Full Text
View/download PDF

29. Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire idiopathique – Actualisation 2017. Version longue

Author

Cottin, Vincent, Crestani, B., Cadranel, J., Cordier, J.F., Marchand Adam, S., Prevot, Ghislaine, Wallaert, B., Bergot, E., Camus, P., Dalphin, J-C, Dromer, C., Gomez, E., Israel-Biet, D., Jouneau, Stéphane, Kessler, R., Marquette, C.-H., Reynaud-Gaubert, M., Aguilaniu, B., Bonnett, D., Carré, P., Danel, C., Faivre, J.-B., Ferretti, G., Just, N., Lebargy, F., Philippe, B., Terrioux, P., Thivolet-Bejui, F., Trumbic, B., Valeyre, D., Service de Pneumologie, Centre de Référence National des Maladies Pulmonaires Rares, Hospices Civils de Lyon (HCL), Centre de compétences pour les maladies pulmonaires rares, Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Abstract

National audience; La fibrose pulmonaire idiopathique (FPI) est la forme la plus fréquente de pneumopathie interstitielle diffuse (PID) idiopathique chronique chez l’adulte. Il s’agit d’une maladie fibroproliférative, irréversible, de cause inconnue, dont l’évolution est habituellement progressive, survenant principalement à partir de 60 ans et limitée aux poumons. Qualifiée de maladie orpheline notamment en raison de l’absence de traitement ayant fait la preuve formelle de son efficacité jusqu’à une période très récente, la FPI est une maladie rare dont la prévalence a été évaluée aux États-Unis entre 14 et 28/100 000 personnes [1], ce qui correspondrait à un minimum de 9000 patients en France et une incidence entre 6,8 et 9/100 000 par an [1,2], soit un minimum de 4400 nouveaux patients par an en France.

Published
2017
Full Text
View/download PDF

30. Blood gene expression predicts bronchiolitis obliterans syndrome appearance after lung transplantation

Author

Danger, Richard, Royer, Pierre J., Reboulleau, D., Loy, J., Tissot, A., Lacoste, P., Roux, A., Reynaud-Gaubert, M., Kessler, R., Mussot, S., Dromer, C., Brugiere, O., Mornex, J., Guillemain, R., Dahan, M., Knoop, C., Botturi, K., Pison, C., Nicod, L., Brouard, S., Magnan, Antoine, SysCLAD, ., Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Nantes (CHU Nantes), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Aix Marseille Université (AMU), Centre Hospitalier Universitaire de Strasbourg (CHU de Strasbourg ), Service de Chirurgie Thoracique, Vasculaire et Transplantation Cardiopulmonaire, Hôpital Marie Lannelongue, CHU Bordeaux [Bordeaux], Service Pneumologie et Transplantation Pulmonaire, Hôpital Foch [Suresnes], Infections Virales et Pathologie Comparée - UMR 754 (IVPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), CHU Toulouse [Toulouse], Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Clinique Universitaire de Pneumologie, Pôle Thorax et Vaisseaux, Centre Hospitalier Universitaire de Grenoble, Centre Hospitalier Universitaire Vaudois (CHUV), Systems prediction of Chronic Lung Allograft Dysfunction, Partenaires INRAE, Unité de recherche de l'institut du thorax (ITX-lab), Hôpital Marie-Lannelongue, Institut National de la Recherche Agronomique (INRA)-École Pratique des Hautes Études (EPHE), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Centre Hospitalier Universitaire [Grenoble] (CHU)

Subjects
gene expression, graft survival, lung transplantation, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, ComputingMilieux_MISCELLANEOUS
Abstract

Volume: 17 Supplement: 3 Special Issue: SI; International audience

Published
2017

31. Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome Appearance After Lung Transplantation

Author

Danger, R., Royer, Pierre-Joseph, Reboulleau, D., Loy, J., Tissot, A., Lacoste, P., Roux, A., Reynaud-Gaubert, M., Kessler, R., Mussot, S., Dromer, C., BrugiSre, O., Mornex, J., Guillemain, R., Dahan, M., Knoop, C., Botturi, K., Pison, C., Nicod, L., Brouard, S., Magnan, A., Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Service de Pneumologie, Nouvel Hôpital Civil Strasbourg, Clinique de pneumologie, CHU Grenoble, Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Intervention, innovation, imagerie, ingénierie en santé - UFC (I4S), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE)

Subjects
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Abstract

American Transplant Congress, Chicago, IL, APR 29-MAY 03, 2017; International audience; no abstract

Published
2017

32. COLT : 10 ans de recherche en transplantation pulmonaire, résultats et perspectives

Author

Tissot, A., primary, Foureau, A., additional, Brosseau, C., additional, Danger, R., additional, Roux, A., additional, Bernasconi, E., additional, Gomez, C., additional, Durand, M., additional, Picard, B.R., additional, Le Pavec, J., additional, Claustre, J., additional, Lacoste, P., additional, Benmerad, M., additional, Pain, M., additional, Siroux, V., additional, Royer, P.-J., additional, Mordant, P., additional, Reynaud-Gaubert, M., additional, Kessler, R., additional, Brugière, O., additional, Mornex, J.-F., additional, Dromer, C., additional, Dahan, M., additional, Knoop, C., additional, Boussaud, V., additional, Koutsokera, A., additional, Botturi-Cavaillès, K., additional, Durand, E., additional, Loy, J., additional, Nicod, L., additional, Pison, C., additional, Brouard, S., additional, Blanc, F.-X., additional, and Magnan, A., additional

Published
2018
Full Text
View/download PDF

33. Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung

Author

Mouraux, Stéphane, primary, Bernasconi, Eric, additional, Pattaroni, Céline, additional, Koutsokera, Angela, additional, Aubert, John-David, additional, Claustre, Johanna, additional, Pison, Christophe, additional, Royer, Pierre-Joseph, additional, Magnan, Antoine, additional, Kessler, Romain, additional, Benden, Christian, additional, Soccal, Paola M., additional, Marsland, Benjamin J., additional, Nicod, Laurent P., additional, Jougon, J., additional, Velly, J.-F., additional, Rozé, H., additional, Blanchard, E., additional, Dromer, C., additional, Antoine, M., additional, Cappello, M., additional, Ruiz, M., additional, Sokolow, Y., additional, Vanden Eynden, F., additional, Van Nooten, G., additional, Barvais, L., additional, Berré, J., additional, Brimioulle, S., additional, De Backer, D., additional, Créteur, J., additional, Engelman, E., additional, Huybrechts, I., additional, Ickx, B., additional, Preiser, T.J.C., additional, Tuna, T., additional, Van Obberghe, L., additional, Vancutsem, N., additional, Vincent, J.-L., additional, De Vuyst, P., additional, Etienne, I., additional, Féry, F., additional, Jacobs, F., additional, Knoop, C., additional, Vachiéry, J.L., additional, Van den Borne, P., additional, Wellemans, I., additional, Amand, G., additional, Collignon, L., additional, Giroux, M., additional, Angelescu, D., additional, Chavanon, O., additional, Hacini, R., additional, Pirvu, A., additional, Porcu, P., additional, Albaladejo, P., additional, Allègre, C., additional, Bataillard, A., additional, Bedague, D., additional, Briot, E., additional, Casez-Brasseur, M., additional, Colas, D., additional, Dessertaine, G., additional, Durand, M., additional, Francony, G., additional, Hebrard, A., additional, Marino, M.R., additional, Oummahan, B., additional, Protar, D., additional, Rehm, D., additional, Robin, S., additional, Rossi-Blancher, M., additional, Augier, C., additional, Bedouch, P., additional, Boignard, A., additional, Bouvaist, H., additional, Briault, A., additional, Camara, B., additional, Claustre, J., additional, Chanoine, S., additional, Dubuc, M., additional, Quétant, S., additional, Maurizi, J., additional, Pavèse, P., additional, Pison, C., additional, Saint-Raymond, C., additional, Wion, N., additional, Chérion, C., additional, Grima, R., additional, Jegaden, O., additional, Maury, J.-M., additional, Tronc, F., additional, Flamens, C., additional, Paulus, S., additional, Mornex, J.-F., additional, Philit, F., additional, Senechal, A., additional, Glérant, J.-C., additional, Turquier, S., additional, Gamondes, D., additional, Chalabresse, L., additional, Thivolet-Bejui, F., additional, Barnel, C., additional, Dubois, C., additional, Tiberghien, A., additional, Le Pimpec-Barthes, F., additional, Bel, A., additional, Mordant, P., additional, Achouh, P., additional, Boussaud, V., additional, Guillemain, R., additional, Méléard, D., additional, Bricourt, M.O., additional, Cholley, B., additional, Pezella, V., additional, Brioude, G., additional, D'Journo, X.B., additional, Doddoli, C., additional, Thomas, P., additional, Trousse, D., additional, Dizier, S., additional, Leone, M., additional, Papazian, L., additional, Bregeon, F., additional, Basire, A., additional, Coltey, B., additional, Dufeu, N., additional, Dutau, H., additional, Garcia, S., additional, Gaubert, J.Y., additional, Gomez, C., additional, Laroumagne, S., additional, Nieves, A., additional, Picard, L.C., additional, Reynaud-Gaubert, M., additional, Secq, V., additional, Mouton, G., additional, Baron, O., additional, Lacoste, P., additional, Perigaud, C., additional, Roussel, J.C., additional, Danner, I., additional, Haloun, A., additional, Magnan, A., additional, Tissot, A., additional, Lepoivre, T., additional, Treilhaud, M., additional, Botturi-Cavaillès, K., additional, Brouard, S., additional, Danger, R., additional, Loy, J., additional, Morisset, M., additional, Pain, M., additional, Pares, S., additional, Reboulleau, D., additional, Royer, P.-J., additional, Fabre, D., additional, Fadel, E., additional, Mercier, O., additional, Mussot, S., additional, Stephan, F., additional, Viard, P., additional, Cerrina, J., additional, Dorfmuller, P., additional, Ghigna, S.M., additional, Hervén, Ph., additional, Le Roy Ladurie, F., additional, Le Pavec, J., additional, Thomas de Montpreville, V., additional, Lamrani, L., additional, Castier, Y., additional, Cerceau, P., additional, Augustin, P., additional, Jean-Baptiste, S., additional, Boudinet, S., additional, Montravers, P., additional, Brugière, O., additional, Dauriat, G., additional, Jébrak, G., additional, Mal, H., additional, Marceau, A., additional, Métivier, A.-C., additional, Thabut, G., additional, Lhuillier, E., additional, Dupin, C., additional, Bunel, V., additional, Falcoz, P., additional, Massard, G., additional, Santelmo, N., additional, Ajob, G., additional, Collange, O., additional, Helms, O., additional, Hentz, J., additional, Roche, A., additional, Bakouboula, B., additional, Degot, T., additional, Dory, A., additional, Hirschi, S., additional, Ohlmann-Caillard, S., additional, Kessler, L., additional, Kessler, R., additional, Schuller, A., additional, Bennedif, K., additional, Vargas, S., additional, Stauder, J., additional, Ali-Azouaou, S., additional, Bonnette, P., additional, Chapelier, A., additional, Puyo, P., additional, Sage, E., additional, Bresson, J., additional, Caille, V., additional, Cerf, C., additional, Devaquet, J., additional, Dumans-Nizard, V., additional, Felten, M.-L., additional, Fischler, M., additional, Si Larbi, A.-G., additional, Leguen, M., additional, Ley, L., additional, Liu, N., additional, Trebbia, G., additional, De Miranda, S., additional, Douvry, B., additional, Gonin, F., additional, Grenet, D., additional, Hamid, A.M., additional, Neveu, H., additional, Parquin, F., additional, Picard, C., additional, Roux, A., additional, Stern, M., additional, Bouillioud, F., additional, Cahen, P., additional, Colombat, M., additional, Dautricourt, C., additional, Delahousse, M., additional, D'Urso, B., additional, Gravisse, J., additional, Guth, A., additional, Hillaire, S., additional, Honderlick, P., additional, Lequintrec, M., additional, Longchampt, E., additional, Mellot, F., additional, Scherrer, A., additional, Temagoult, L., additional, Tricot, L., additional, Vasse, M., additional, Veyrie, C., additional, Zemoura, L., additional, Berjaud, J., additional, Brouchet, L., additional, Dahan, M., additional, Mathe, F.O., additional, Benahoua, H., additional, DaCosta, M., additional, Serres, I., additional, Merlet-Dupuy, V., additional, Grigoli, M., additional, Didier, A., additional, Murris, M., additional, Crognier, L., additional, Fourcade, O., additional, Krueger, T., additional, Ris, H.B., additional, Gonzalez, M., additional, Jolliet, Ph., additional, Marcucci, C., additional, Chollet, M., additional, Gronchi, F., additional, Courbon, C., additional, Berutto, C., additional, Manuel, O., additional, Koutsokera, A., additional, Aubert, J.-D., additional, Nicod, L.P., additional, Mouraux, S., additional, Bernasconi, E., additional, Pattaroni, C., additional, Marsland, B.J., additional, Soccal, P.M., additional, Rochat, T., additional, Lücker, L.M., additional, Hillinger, S., additional, Inci, I., additional, Weder, W., additional, Schuepbach, R., additional, Zalunardo, M., additional, Benden, C., additional, Schuurmans, M.M., additional, Gaspert, A., additional, Holzmann, D., additional, Müller, N., additional, Schmid, C., additional, Vrugt, B., additional, Fritz, A., additional, Maier, D., additional, Deplanche, K., additional, Koubi, D., additional, Ernst, F., additional, Paprotka, T., additional, Schmitt, M., additional, Wahl, B., additional, Boissel, J.-P., additional, Olivera-Botello, G., additional, Trocmé, C., additional, Toussaint, B., additional, Bourgoin-Voillard, S., additional, Sève, M., additional, Benmerad, M., additional, Siroux, V., additional, Slama, R., additional, Auffray, C., additional, Charron, D., additional, Lefaudeux, D., additional, and Pellet, J., additional

Published
2018
Full Text
View/download PDF

35. Les Auteurs

Author

Abroug, F., Abtan, J., Aguilar, C., Aissaoui, N., Ait Hssain, A., Ait-Oufella, H., Ajzenberg, N., Aloy, B., Ammirati, C., Amoura, Z., Amstutz, P., Anglicheau, D., Annane, D., Anxionnat, R., Arab, K., Argaud, L., Arnaout, M., Arrivé, L., Assouad, J., Aubron, C., Augis, V., Ayari, H., Azabou, E., Azoulay, E., Bakhos, D., Bailly, E., Bailly, P., Baldolli, A., Barbaud, A., Barbier, F., Barbut, F., Bardon, J., Barraud, D., Barreda, T., Barrot, L., Barry, B., Bartier, J.-C., Bastien, O., Baud, F.J., Baudel, J.-L., Beaussier, M., Bedos, J.-P., Bédry, R., Béduneau, G., Beloncle, F., Beltrami, A., Benghanem, S., Ben Ammar, M., Ben Hadj Salem, O., Benchetrit, D., Benyamina, M., Benzidi, Y., Bernardin, G., Bertholdt, C., Bertocchio, J.-P., Bertoletti, L., Bertrand, C., Besnier, E., Beuret, P., Beydon, L., Bialais, É., Bienaimé, F., Bigé, N., Bihan, K., Bilbault, P., Binoche, A., Biour, M., Birgand, G., Bitker, L., Blanc, J.-V., Blatteau, J.-E., Blivet, S., Blot, F., Bodenes, L., Boels, D., Bohé, J., Boissier, F., Boiteau, R., Boles, J.-M., Bollaert, P.-E., Bondeelle, L., Bonnet, N., Boudon, M., Bouglé, A., Boulain, T., Boulanger, D., Bounab, R., Bourcier, S., Bourigault, C., Bourenne, J., Bouteau, I., Boutonnet, M., Bouzgarrou, R., Boyer, A., Boyer, D., Boyer-Suavet, S., Bracard, S., Brault, C., Bretonnière, C., Bréchot, N., Bridoux, F., Brivet, F.-G., Brochard, L., Bruder, N., Bruneel, F., Brunet, J., Burgel, P.-R., Buscot, M., Cabrio, D., Cadranel, J., Calvet, L., Camus, C., Canaud, B., Canellas, A., Canet, E., Capaldo, L., Capellier, G., Carbonell, N., Cariou, A., Carli, P., Carpentier, D., Carrat, F., Carteaux, G., Casolla, B., Castanares-Zapatero, D., Castelain, V., Cavaillon, J.-M., Cecchini, J., Cha, O., Chamaraux-Tran, T.-N., Champigneulle, B., Chanard, J., Charles, P.-E., Charpentier, J., Chastre, J., Chaussard, M., Chemla, D., Cherifa, M., Chiche, J.-D., Cholley, B., Chopin, C., Chosidow, O., Choukroun, M.-L., Clair, B., Claude, F., Clavier, T., Clément, E., Clere-Jehl, R., Clouzeau, B., Cochereau, I., Cohen, Y., Collins, M., Combes, A., Commandeur, D., Contou, D., Coppo, P., Cordonnier, C., Coriat, P., Cornelis, F., Costedoat-Chalumeau, N., Cottin, V., Cour, M., Coutrot, M., Couturier, J., Couzigou, C., Cravoisy-Popovic, A., Crozier, S., Danel, V., Danin, P.-E., Dargaud, Y., Darmaun, D., Darmon, M., Daubin, C., David, S., De Backer, D., De Cagny, B., Decavèle, M., Decousus, H., Degos, V., De Groote, E., De Jong, A., Dekeyser, T., Delabranche, X., Delahaye, A., Delarue, J., Delclaux, C., Delemazure, J., Delile, E., Delisle, S., Dellamonica, J., Delluc, A., Delplancq, H., Deltour, S., De Martin, E., Demeret, S., Demiselle, J., De Montalembert, M., Demoule, A., Dépret, F., de Prost, N., Dequatre-Ponchelle, N., Dequin, P.-F., Deray, G., Derelle, A.-L., Deriaz, H., De Schryver, N., Deshayes, S., Desmettre, T., Desrousseaux, J., Dessevre, A., Dewitte, A., Deye, N., Dhainaut, J.-F., Didier, S., Diehl, J.-L., Di Martino, V., Djibré, M., Dolz, M., Dorandeu, F., Dorent, R., Do Vale, J., Dres, M., Dreyfuss, D., Dromer, C., Dubée, V., Duburcq, T., Duceau, B., Du Cheyron, D., Ducloy-Bouthors, A.-S., Dugernier, J., Durand, A., Durand, F., Duranteau, J., Durocher, A., Dussaule, J.-C., Eckert, C., Écotière, L., Ehrmann, S., El Gharbi, F., Elbaz, M., Embriaco, N., Étienne, H., Essig, M., Fagon, J.-Y., Fagot-Gandet, F., Fartoukh, M., Faugeras, F., Favory, R., Faisy, C., Ferrière, N., Ferry, T., Flamant, M., Folscheid, D., Fontaine, E., Forel, J.-M., Fourrier, F, Fraipont, V., Franchineau, G., Francoz, C., Frat, J.-P., Fresco, R., Friedlander, G., Friedman, D., Fromentin, M., Gainnier, M., Galanaud, D., Garcia, H., Garret, C., Garrouste-Orgeas, M., Gateau, C., Geeraerts, T., Gehanno, P., Gempp, E., Geri, G., Germain, A., Giacardi, C., Gibelin, A., Gibot, S., Girardot, T., Girault, C., Giura, G., Gkalea, V., Godard, A., Godeau, B., Goffinet, F., Gonzalez-Bermejo, J., Gory, B., Gouëllo, J.-P., Goulenok, C., Goursaud, S., Goury, A., Goutagny, S., Graftieaux, J.-P., Grangé, S., Grimaldi, D., Gros, A., Gruson, D., Gruson-Vescovali, D., Guérin, C., Guérot, E., Guettrot-Imbert, G., Guervilly, C., Guidet, B., Guillon, A., Guillot, M., Guitton, C., Gutton, Ch., Haidar, M., Halimi, C., Hamada, S., Hammoud, K., Hansmann, Y., Hariri, G., Harlay, M.-L., Harrois, A., Harry, P., Hauw-Berlemont, C., Hébuterne, X., Hejblum, G., Helms, J., Hékimian, G., Heming, N., Herbrecht, J.-E., Hertig, A., Heshmati, F., Hickmann, C., Hites, M., Hong Tuan Ha, V., Houfflin-Debarge, V., Houhou, N., Houillier, P., Hua, C., Hullin, T., Humbert, M., Hugon-Vallet, É., Hurel, D., Ichaï, P., Ioos, V., Isnard-Bagnis, C., Jaber, S., Jacobs, F., Jacquens, A., Jaffal, K., Jaïs, X., Janus, N., Jardel, B., Jars-Guincestre, M.-C., Jaubert, P., Jehl, F., Jirka, A., Joannès-Boyau, O., Joffre, J., Jolliet, P., Joly, F., Joly, L.-M., Joly-Guillou, M.-L., Jouffroy, R., Jonard, M., Jougon, J., Jourdain, M., Jozwiak, M., Jully, M., Jung, B., Juniat, A.-A., Kandji, M., Kanfer, A., Karoubi, P., Kentish-Barnes, N., Kerlan, V., Khalil, A., Kim, S., Kimmoun, A., Klouche, K., Koffel, J.-C., Kopferschmitt, J., Laaban, J.P., Labadie, M., Labbé, V., Lachâtre, M., Labrousse, J., Lacroix, D., Lancel, S., Lanceleur, A., Landais, M., Landelle, C., Landman, C., Lanternier, F., Larcher, R., Launay-Vacher, V., Langeron, O., Lapostolle, F., Larmignat, P., Laterre, P.-F., Laudenbach, V., Laurent, V., Lautrette, A., Lavillegrand, J.-R., Lavolé, A., Law-ye, B., Lebas, B., Lebranchu, Y., Lebreton, G., Lebrun-Vignes, B., Leclercq, D., Le Conte, P., Le Corre, B., Lefaucheur, J.-P., Lefevre, J., Leflon-Guibout, V., Léger, D., Legrand, M., Le Gouez, A., Leguay, T., Lejay, M., Lellouche, F., Lemaire, F., Lemaitre, C., Lemarié, J., Lemiale, V., Lemonnier, M.-P., Lepape, A., Leprince, P., Leray-Moraguès, H., Léon, A., Leone, M., Lerolle, N., Le Roux, M., Leroy, O., Leteurtre, S., Lescot, T., Le Tulzo, Y., Leverve, X., Levy, B., Lévy, P., L'Her, E., Liao, L., Lienhart, A., Llitjos, J.-F., Lofaso, F., Lothe, M.-N., Loubières, Y., Louge, P., Lucet, J.-C., Luyt, C.E., Lyazidi, A., Maamar, A., Mahieu, R., Maillet, J.-M., Mainardi, J.-L., Maître, B., Maizel, J., Mallaret, M.-R., Mancebo, J., Manzo-Silberman, S., Marchalot, A., Marit, G., Markowicz, P., Marqué, S., Martin, O., Martin-Lefèvre, L., Marx, T., Massanet, P.L., Mathian, A., Mathieu, C., Mathieu, D., Maury, E., Maxime, V., Mazeraud, A., Meffert, A., Mégarbane, B., Mehl, J., Mekontso Dessap, A., Melchior, C., Meng, P., Mentec, H., Mercier, F.-J., Mercat, A., Merdji, H., Méresse, Z., Mertes, P.-M., Mesland, J.-B., Meyer, G., Meynard, J.-L., Meziani, F., Miatello, J., Michard, B., Mira, J.-P., Mismetti, P., Misset, B., Miyara, M., Moga, L., Mohty, M., Monchi, M., Monéger, G., Monneret, G., Monnet, X., Monnier-Cholley, L., Montani, D., Mora, P., Morau, E., Moreau, AS., Morel, G., Morawiec, E., Mortaza, S., Mottier, D., Murgier, M., Naccache, L., Nace, L., Naeije, R., Naïm, G., Nave, S., Nitenberg, A., Nouette-Gaulain, K., Nouri-Neuville, M., Nousbaum, J.B., Novy, E., Nuss, P., Obadia, É., Offenstadt, G., Oger, E., Onimus, T., Orlikowski, D., Oro, S., Osman, O., Ouanes, I., Ouanes-Besbes, L., Ouedraogo, R., Outin, H., Oziel, J., Ozier, Y., Pajot, O., Papazian, L., Parmentier, E., Parquin, F., Parrilla, F.J., Parrot, A., Pasquet, A., Pateron, D., Paugam-Burtz, C., Peigné, M., Peineau, S., Pelaccia, T., Pène, F., Perrotin, D., Pessey, F., Pham, T., Philit, F., Pichené, C., Picod, A., Piette, J.-C., Pillet, O., Pilmis, B., Pineau, J., Pineton de Chambrun, M., Piquilloud, L., Pirracchio, R., Piton, G., Plantefève, G., Podglajen, I., Poidevin, A., Poissy, J., Pottecher, J., Poujol, A.-L., Poussardin, C., Prat, F., Préau, S., Preiser, J.-C., Prevel, R., Prot-Bertoye, C., Pruvo, J.-P., Pujol, S., Puntous, M., Quenot, J.-P., Quevrain, E., Quillerou, B., Rabaud, C., Raynard, B., Raynaud, L., Regard, L., Reignier, J., Reizine, F., Réminiac, F., Renault, A., Revest, M., Ricard, J.-D., Richalet, J-P., Richard, C., Richard, J-C.M., Ricôme, J.-L., Ridel, C., Rigollot, M., Rigaud, J.-P., Rigolet, A., Rimmelé, T., Rineau, E., Robert, R., Robert, T., Robineau, O., Roch, A., Roesler, J., Roger, I., Rohaut, B., Roullet, S., Rousset, D., Roux, D., Rozé, H., Rudler, M., Rugeri, L., Ruppé, E., Sab, J.-M., Sacleux, S.-C., Saliba, F., Samuel, D., Sauder, P., Saulnier, F., Sauvanet, A., Savale, L., Savoye, G., Schlemmer, B., Schlemmer, F., Schmidt, E., Schmidt, M., Schneider, F., Schneider, S.M., Schortgen, F., Schuby, M., Schwan, R., Schwebel, C., Seguin, A., Seksik, P., Senneville, É., Seronde, M.-F., Sharshar, T., Sigaut, S., Silva, S., Si-Tahar, M., Sitbon, O., Sivanandamoorthy, S., Slama, M., Sollet, J.-P., Somme, D., Sonneville, R., Souday, V., Soufir, L., Soussi, S., Souweine, B., Spaulding, C., Squara, P., Steg, P.-G., Sterlin, D., Stiel, L., Sublon, M., Sudre, E., Surgers, L., Szychowiak, P., Tacquard, C., Tadié, J.-M., Talvard, O., Tamburini, J., Tamion, F., Tarazona, V., Tardy, B., Taright, N., Tasseau, F., Tattevin, P., Tauzin-Fin, P., Tazarourte, K., Teboul, J.-L., Terzi, N., Thabut, D., Thaler, F., Thellier, D., Thervet, E., Thévenot, T., Thibault, M., Thibault, R., Thierry, A., Thille, A.W., Thomas, G., Thumerel, M., Thuong, M., Thy, M., Timsit, J.-F., Tissières, P., Tonnelet, R., Touchard, G., Tournoy, A., Tourtier, J.-P., Tourtier, Y., Tran Van Nhieu, J., Troché, G., Trouillet, J.L., Ubeaud-Séquier, G., Uhel, F., Urbina, T., Valeyrie-Allanore, L., Van de Louw, A., Van der Meersch, G., Vargas, F., Velly, L., Venet, F., Verdon, R., Veyradier, A., Vieillard-Baron, A., Vignon, Ph., Vigué, B., Villers, D., Vinsonneau, C., Voiriot, G., Weil-Verhoeven, D., Wiel, É., Wittebole, X., Woch, S., Woerther, P.-L., Woimant, F., Wolff, M., Wysocki, M., Xhaard, A., Yazdanpanah, Y., Zafrani, L., Zahar, J.-R., Zarrouk, V., Zéni, F., Zerbib, P., Zerbib, Y., Zieleskiewicz, L., Zlotnik, D., and Zuber, B.

Published
2020
Full Text
View/download PDF

36. RETRAIT: Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire idiopathique – Actualisation 2017. Version courte

Author

Cottin, V., primary, Crestani, B., additional, Cadranel, J., additional, Cordier, J.-F., additional, Marchand-Adam, S., additional, Prévot, G., additional, Wallaert, B., additional, Bergot, E., additional, Camus, P., additional, Dalphin, J.-C., additional, Dromer, C., additional, Gomez, E., additional, Israel-Biet, D., additional, Jouneau, S., additional, Kessler, R., additional, Marquette, C.-H., additional, Reynaud-Gaubert, M., additional, Aguilaniu, B., additional, Bonnet, D., additional, Carré, P., additional, Danel, C., additional, Faivre, J.-B., additional, Ferretti, G., additional, Just, N., additional, Lebargy, F., additional, Philippe, B., additional, Terrioux, P., additional, Thivolet-Béjui, F., additional, Trumbic, B., additional, and Valeyre, D., additional

Published
2017
Full Text
View/download PDF

37. RETRAIT : Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire idiopathique : actualisation 2017. Résumé

Author

Cottin, V., primary, Crestani, B., additional, Cadranel, J., additional, Cordier, J.-F., additional, Marchand-Adam, S., additional, Prévot, G., additional, Wallaert, B., additional, Bergot, E., additional, Camus, P., additional, Dalphin, J.-C., additional, Dromer, C., additional, Gomez, E., additional, Israel-Biet, D., additional, Jouneau, S., additional, Kessler, R., additional, Marquette, C.-H., additional, Reynaud-Gaubert, M., additional, Aguilaniu, B., additional, Bonnet, D., additional, Carré, P., additional, Danel, C., additional, Faivre, J.-B., additional, Ferretti, G., additional, Just, N., additional, Lebargy, F., additional, Philippe, B., additional, Terrioux, P., additional, Thivolet-Béjui, F., additional, Trumbic, B., additional, and Valeyre, D., additional

Published
2017
Full Text
View/download PDF

38. RETRAIT: Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire idiopathique–Actualisation 2017. Version longue

Author

Cottin, V., primary, Crestani, B., additional, Cadranel, J., additional, Cordier, J.-F., additional, Marchand-Adam, S., additional, Prévot, G., additional, Wallaert, B., additional, Bergot, E., additional, Camus, P., additional, Dalphin, J.-C., additional, Dromer, C., additional, Gomez, E., additional, Israel-Biet, D., additional, Jouneau, S., additional, Kessler, R., additional, Marquette, C.-H., additional, Reynaud-Gaubert, M., additional, Aguilaniu, B., additional, Bonnet, D., additional, Carré, P., additional, Danel, C., additional, Faivre, J.-B., additional, Ferretti, G., additional, Just, N., additional, Lebargy, F., additional, Philippe, B., additional, Terrioux, P., additional, Thivolet-Béjui, F., additional, Trumbic, B., additional, and Valeyre, D., additional

Published
2017
Full Text
View/download PDF

39. AB0007 Shared genetic predisposition in rheumatoid arthritis–interstitial lung disease and familial pulmonary fibrosis

Author

Juge, PA, primary, Borie, R, additional, Kannengiesser, C, additional, Gazal, S, additional, Revy, P, additional, Wemeau-Stervinou, L, additional, Debray, MP, additional, Ottaviani, S, additional, Marchand-Adam, S, additional, Nathan, N, additional, Thabut, G, additional, Richez, C, additional, Nunes, H, additional, Callebaut, I, additional, Justet, A, additional, Richette, P, additional, Lioté, H, additional, Allanore, Y, additional, Sand, O, additional, Dromer, C, additional, Flipo, RM, additional, Clément, A, additional, Sibilia, J, additional, Coustet, B, additional, Cottin, V, additional, Boissier, MC, additional, Wallaert, B, additional, Schaeverbeke, T, additional, Florence, DLM, additional, Frazier, A, additional, Ménard, C, additional, Soubrier, M, additional, Saidenberg, N, additional, Valeyre, D, additional, Amselem, S, additional, Boileau, C, additional, Crestani, B, additional, and Dieudé, P, additional

Published
2017
Full Text
View/download PDF

41. Tidal Volume during Assisted Ventilation after Double-Lung Transplantation

Author

Roze, H., Piquilloud, L., RICHARD, J. C. M., Jougon, J., Dromer, C., Mercat, A., Ouattara, A., Brochard, L., Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases, and Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Article CLINIQUE, respiratory system, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, respiratory tract diseases
Abstract

The rate of lung transplants is increasing, and these patients frequently develop respiratory complications necessitating mechanical ventilation (1). When treating these patients, the risks of mechanical ventilation constitute an important concern, and clinicians aim to simultaneously protect the lung while avoiding ventilator-induced diaphragm dysfunction by maintaining spontaneous breathing. Targeting the ideal VT for each patient is challenging. According to the underlying lung disease of the recipient and his or her previous total lung capacity (TLC), the size of the transplanted lungs may differ from the theoretical TLC based on height. Actual TLC can vary considerably from one transplanted patient to the next and is poorly correlated with height (2). Furthermore, bipulmonary transplanted patients have denervated lungs without vagal afferent fibers. As a consequence, some feedback mechanisms necessary for control of breathing may be lacking, which can result in large VT, as shown in animals (3) and during exercise in lung-transplanted patients (4). Neurally adjusted ventilatory assist (NAVA) is a mode of ventilation that delivers support in proportion to diaphragmatic electrical activity, the latter being a direct expression of neural inspiratory activity (5). Over a certain range of assist, the patient is able to fully control his or her VT, which is not the case with traditional modes of assist. We analyzed VT in patients ventilated with NAVA after bilateral lung transplantation. We compared these volumes with nontransplanted patients at a similar stage of difficult weaning, using the same approach to titrate NAVA. In addition, we examined the relationship between the patient’s VT under NAVA and their most recent TLC.

Published
2015
Full Text
View/download PDF

43. Fond génétique partagé entre la pneumopathie interstitielle diffuse associée à la polyarthrite rhumatoïde et la fibrose pulmonaire idiopathique

Author

Juge, P.A., primary, Borie, R., additional, Kannengiesser, C., additional, Gazal, S., additional, Revy, P., additional, Wemeau-Stervinou, L., additional, Debray, M.P., additional, Ottaviani, S., additional, Marchand-Adam, S., additional, Nathan, N., additional, Thabut, G., additional, Richez, C., additional, Nunes, H., additional, Callebaut, I., additional, Justet, A., additional, Leulliot, N., additional, Bonnefond, A., additional, Salgado, D., additional, Richette, P., additional, Desvignes, J.P., additional, Lioté, H., additional, Froguel, P., additional, Allanore, Y., additional, Sand, O., additional, Dromer, C., additional, Flipo, R.M., additional, Clément, A., additional, Béroud, C., additional, Sibilia, J., additional, Coustet, B., additional, Cottin, V., additional, Boissier, M.C., additional, Wallaert, B., additional, Schaeverbeke, T., additional, Moal, F. Dastot Le, additional, Frazier, A., additional, Ménard, C., additional, Soubrier, M., additional, Saidenberg, N., additional, Valeyre, D., additional, Amselem, S., additional, Boileau, C., additional, Crestani, B., additional, and Dieude, P., additional

Published
2017
Full Text
View/download PDF

44. Fond génétique partagé entre la pneumopathie interstitielle diffuse associée à la polyarthrite rhumatoïde et la fibrose pulmonaire idiopathique

Author

Juge, P.A., primary, Borie, R., additional, Kannengiesser, C., additional, Gazal, S., additional, Revy, P., additional, Wemeau-Stervinou, L., additional, Debray, M.P., additional, Ottaviani, S., additional, Marchand-Adam, S., additional, Nathan, N., additional, Thabut, G., additional, Richez, C., additional, Nunes, H., additional, Callebaut, I., additional, Justet, A., additional, Leulliot, N., additional, Bonnefond, A., additional, Salgado, D., additional, Richette, P., additional, Desvignes, J.P., additional, Lioté, H., additional, Froguel, P., additional, Allanore, Y., additional, Sand, O., additional, Dromer, C., additional, Flipo, R.M., additional, Clément, A., additional, Béroud, C., additional, Sibilia, J., additional, Coustet, B., additional, Cottin, V., additional, Boissier, M.C., additional, Wallaert, B., additional, Schaeverbeke, T., additional, Le Moal, F. Dastot, additional, Frazier-Mironer, A., additional, Ménard, C., additional, Soubrier, M., additional, Saindenberg, N., additional, Valeyre, D., additional, Amselem, S., additional, Boileau, C., additional, Crestani, B., additional, and Dieudé, P., additional

Published
2016
Full Text
View/download PDF

45. Treatment of idiopathic pulmonary fibrosis with ambrisentan: a parallel, randomized trial

Author

Raghu, G, Behr, J, Brown, K, Egan, J, Kawut, S, Flaherty, K, Martinez, F, Nathan, S, Wells, A, Collard, H, Costabel, U, Richeldi, L, de Andrade, J, Khalil, N, Morrison, L, Lederer, D, Shao, L, Li, X, Pedersen, P, Montgomery, A, Chien, J, O'Riordan, T, Amin, D, Baker, A, Baratz, D, Baughman, R, Cagino, A, Chan, A, Chapman, J, Cordova, F, Edelman, J, Enelow, R, Ettinger, N, Glassberg, M, Golden, J, Ilowite, J, Kreider, M, Kureishy, S, Lancaster, L, Limper, A, Strek, M, Padilla, M, Fisher, M, Riley, D, Mohabir, P, Safdar, Z, Sahn, S, Schaumberg, T, Scholand, M, Smith, C, Sussman, R, Yung, G, Saggar, R, Geffen, D, Zibrak, J, Alvarez, J, Chan, K, Ruzi, J, Mcconnell, J, Mehta, J, Verghese, G, Talwar, A, Haddad, T, Sood, N, Goldberg, H, Sundar, K, Ziedalski, T, Gibson, K, Chan, C, Lien, D, Fell, C, Fox, G, Poirier, C, Provencher, S, Wilcox, P, Vilayi Weiler, Z, Kramer, M, Yigla, M, Baloira, A, Parakova, Z, Kra, H, Schwarz, Y, Martinez, C, Ben Dov, I, Kahler, C, Xaubet, A, Skrickova, J, Kolek, V, Parfrey, H, Echave Sustaeta, J, Wuyts, W, Geiser, T, Muller Quernheim, J, Whyte, M, Pfeifer, M, Grohe, C, Bourdin, A, Olschewski, H, Sibille, Y, Snizek, T, Vytiska, J, Pesek, M, Crestani, B, Wallaert, B, Chanez, P, Biet, D, Pompidou, G, Dromer, C, Gläser, S, Wagner, U, Witt, C, Herth, F, Hoeffken, G, Coswig, F, Breuer, R, Kerem, E, Adir, Y, Agostini, C, Cremona, G, Vitulo, P, Poletti, V, Rottoli, P, Rybacki, C, Piotrowski, W, Morera, J, Hattotuwa, K, Warburton, C, Corris, P, Leonard, C, Booth, H, Britton, M, Marchand Adam, S, Marquette, C, Tamm, M, Lazor, R, Chalmers, G, Hirani, N, De Vuyst, P, Saltini, C, Harari, S, Maher, T, Campos, F, Ramirez, A, Wehbe, L, Altieri, H, Fuchigami, A, Salinas, C, Mattos, W, Posadas, R, Fiss, E, Diaz Castanon, J, Munoz, S, Ramirez, L, Chercoff, J, Fritscher, C, Cardoso, A, Moreira, M, Steidle, L, Arakaki, J, Florenzano, M, Leon, L, Bernardini, S, Gilberto, A, Duque, C, Awad, C, Severiche, D, Lucro, D, Grimaldos, F, Rubin, A, Barrera, C, Ore, D, Heredia, C, Mazzei, J, Matiz, C, Glanville, A, Hopkins, P, Smallwood, D, Veitch, E, Musk, M, Glaspole, I, Wood Baker, R, Veale, A, and Costabel, Ulrich (Beitragende*r)

Subjects
Adult, Male, medicine.medical_specialty, Ambrisentan, Endothelin A Receptor Antagonists, Settore MED/10 - Malattie dell'Apparato Respiratorio, Medizin, Placebo, Idiopathic pulmonary fibrosis, Aged, Aged, 80 and over, Disease Progression, Double-Blind Method, Female, Humans, Idiopathic Pulmonary Fibrosis, Lung, Middle Aged, Phenylpropionates, Prospective Studies, Pyridazines, Treatment Outcome, Internal medicine, 80 and over, Internal Medicine, medicine, Clinical endpoint, Prospective cohort study, business.industry, Hazard ratio, General Medicine, medicine.disease, Interim analysis, Pulmonary hypertension, Surgery, business, medicine.drug
Abstract

BACKGROUND Idiopathic pulmonary fibrosis (IPF) is characterized by formation and proliferation of fibroblast foci. Endothelin-1 induces lung fibroblast proliferation and contractile activity via the endothelin A (ETA) receptor. OBJECTIVE To determine whether ambrisentan, an ETA receptor-selective antagonist, reduces the rate of IPF progression. DESIGN Randomized, double-blind, placebo-controlled, event-driven trial. (ClinicalTrials.gov: NCT00768300). SETTING Academic and private hospitals. PARTICIPANTS Patients with IPF aged 40 to 80 years with minimal or no honeycombing on high-resolution computed tomography scans. INTERVENTION Ambrisentan, 10 mg/d, or placebo. MEASUREMENTS Time to disease progression, defined as death, respiratory hospitalization, or a categorical decrease in lung function. RESULTS The study was terminated after enrollment of 492 patients (75% of intended enrollment; mean duration of exposure to study medication, 34.7 weeks) because an interim analysis indicated a low likelihood of showing efficacy for the end point by the scheduled end of the study. Ambrisentan-treated patients were more likely to meet the prespecified criteria for disease progression (90 [27.4%] vs. 28 [17.2%] patients; P = 0.010; hazard ratio, 1.74 [95% CI, 1.14 to 2.66]). Lung function decline was seen in 55 (16.7%) ambrisentan-treated patients and 19 (11.7%) placebo-treated patients (P = 0.109). Respiratory hospitalizations were seen in 44 (13.4%) and 9 (5.5%) patients in the ambrisentan and placebo groups, respectively (P = 0.007). Twenty-six (7.9%) patients who received ambrisentan and 6 (3.7%) who received placebo died (P = 0.100). Thirty-two (10%) ambrisentan-treated patients and 16 (10%) placebo-treated patients had pulmonary hypertension at baseline, and analysis stratified by the presence of pulmonary hypertension revealed similar results for the primary end point. LIMITATION The study was terminated early. CONCLUSION Ambrisentan was not effective in treating IPF and may be associated with an increased risk for disease progression and respiratory hospitalizations. PRIMARY FUNDING SOURCE Gilead Sciences.

Published
2013

46. Treatment of Idiopathic Pulmonary Fibrosis With Ambrisentan

Author

Raghu, G, Behr, J, Brown, Kk, Egan, Jj, Kawut, Sm, Flaherty, Kr, Martinez, Fj, Nathan, Sd, Wells, Au, Collard, Hr, Costabel, U, Richeldi, L, de Andrade, J, Khalil, N, Morrison, Ld, Lederer, Dj, Shao, L, Li, X, Pedersen, Ps, Montgomery, Ab, Chien, Jw, O'Riordan, Tg, ARTEMIS IPF Investigators: Amin, D, Baker, A, Baratz, D, Baughman, R, Cagino, A, Chan, A, Chapman, J, Cordova, F, Edelman, J, Enelow, R, Ettinger, N, Glassberg, M, Golden, J, Ilowite, J, Kreider, M, Kureishy, S, Lancaster, L, Lederer, D, Limper, A, Morrison, L, Nathan, S, Strek, M, Padilla, M, Fisher, M, Riley, D, Mohabir, P, Safdar, Z, Sahn, S, Schaumberg, T, Scholand, Mb, Smith, C, Sussman, R, Yung, G, Saggar, R, Geffen, D, Zibrak, J, Alvarez, J, Chan, K, Ruzi, J, Mcconnell, J, Mehta, J, Verghese, G, Talwar, A, Haddad, T, Sood, N, Goldberg, H, Sundar, K, Ziedalski, T, Gibson, K, Chan, C, Lien, D, Fell, C, Fox, G, Poirier, C, Provencher, S, Wilcox, P, Vilayi Weiler, Z, Kramer, M, Yigla, M, Baloira, A, Parakova, Z, Kra, H, Schwarz, Y, Martinez, C, Ben Dov, I, Kahler, C, Xaubet, A, Skrickova, J, Kolek, V, Parfrey, H, Echave Sustaeta, J, Wuyts, W, Geiser, T, Muller Quernheim, J, Whyte, M, Pfeifer, M, Grohe, C, Bourdin, A, Olschewski, H, Sibille, Y, Snizek, T, Vytiska, J, Pesek, M, Crestani, B, Wallaert, B, Chanez, P, Biet, Di, Pompidou, G, Dromer, C, Gläser, S, Wagner, U, Witt, C, Herth, F, Hoeffken, G, Coswig, F, Egan, J, Breuer, R, Kerem, E, Adir, Y, Agostini, Carlo, Cremona, G, Vitulo, P, Poletti, V, Rottoli, P, Rybacki, C, Piotrowski, W, Morera, J, Hattotuwa, K, Warburton, C, Corris, P, Leonard, C, Booth, H, Britton, M, Marchand Adam, S, Marquette, Ch, Tamm, M, Lazor, R, Chalmers, Gw, Hirani, N, De Vuyst, P, Saltini, C, Harari, Sa, Maher, T, Campos, F, Ramirez, A, Wehbe, L, Altieri, H, Fuchigami, Am, Salinas, Cc, Mattos, W, Posadas, R, Fiss, E, Diaz Castanon, J, Munoz, S, Ramirez, Ln, Chercoff, J, Fritscher, Cc, Cardoso, A, Moreira, Ma, Steidle, L, Arakaki, J, Florenzano, M, Leon, Lp, Bernardini, Su, Gilberto, A, Duque, Ca, Awad, C, Severiche, D, Lucro, De, Grimaldos, Fb, Rubin, A, Barrera, Ci, Ore, Dj, Heredia, C, Mazzei, J, Matiz, C, Glanville, A, Hopkins, P, Smallwood, D, Veitch, E, Musk, M, Glaspole, I, Wood Baker, R, and Veale, A.

Published
2013

47. Riociguat for the treatment of pulmonary arterial hypertension

Author

Ghofrani, Ha, Galiè, N, Grimminger, F, Grünig, E, Humbert, M, Jing, Zc, Keogh, Am, Langleben, D, Kilama, Mo, Fritsch, A, Neuser, D, Rubin, Lj, 1 Study Group including Bortman G, Patent, Keogh, A, Kermeen, F, Feenstra, J, Williams, T, Reeves, G, Kilpatrick, D, Lang, I, Kahler, C, Mascherbauer Steringer, R, Vachiery, Jl, Delcroix, M, Meyer, G, Arakaki, J, Santana, M, Waetge, D, Granton, J, Helmersen, D, He, J, Jing, Z, Zhou, D, Huang, Y, Wang, C, Jansa, P, Neilsen Kudsk JE, Hachulla, E, De Groote, P, Frachon, I, Bourdin, A, Pison, C, Bauer, F, Dromer, C, Marquette, Ch, Degano, B, Neurohr, C, Wilkens, H, Hoffken, G, Hoeper, M, Ghofrani, A, Wirtz, H, Rosenkranz, S, Ewert, R, Orfanos, S, Kramer, M, Ben Gal, T, Scelsi, L, Vizza, C, Harari, S, Confalonieri, M, Albera, Carlo, Fukumoto, Y, Sano, M, Hatano, M, Saji, T, Tanaka, S, Takeda, Y, Takehara, K, Matsubara, H, Kihara, Y, Shiohira, Y, Kawai, H, Homma, S, Satoh, T, Tokunaga, T, Ishizaki, T, Diaz, C, Zamudio, T, De Los Rios, M, Estupian, S, Cacho, Jr, Gamba, M, Beckert, L, Torbicki, A, Castro, G, Reis, A, Agapito, A, Martins, S, Kim, H, Lee, S, Chang, H, Song, Y, Chazova, I, Moiseeva, O, Lim, S, Yip, J, Barbera, J, Roman, A, Palma Jdel, C, Reitan, O, Soderberg, S, Jansson, K, Speich, R, Hsu, Hh, Lin, Hy, Cheng, Cc, Phrommintikul, A, Jaimchariyatam, N, Sayin, T, Kultursay, H, Ongen, G, Pepke Zaba, J, Coghlan, G, Peacock, A, Gibbs, J, Wagoner, L, Badesch, D, Frost, A, Hill, N, Allen, R, Waxman, A, Sood, N, Torres, F, Minai, O, Shapiro, S, Klinger, J, Engel, P, Garcia, H, Schuller, D, Poch, D, Rosenzweig, E, Mcconnell, J, Rischard, F, Olschewski, H, Haverkamp, W, Lehmacher, W, Hoischen, S, Collamati, S, Dehay, J, Hallmann, M, Menezes, F., Ghofrani HA, Galiè N, Grimminger F, Grünig E, Humbert M, Jing ZC, Keogh AM, Langleben D, Kilama MO, Fritsch A, Neuser D, Rubin LJ, and PATENT-1 Study Group

Subjects
medicine.medical_specialty, business.industry, General Medicine, Placebo, medicine.disease, Pulmonary hypertension, Riociguat, law.invention, Surgery, Clinical trial, chemistry.chemical_compound, medicine.anatomical_structure, Randomized controlled trial, chemistry, DRUG THERAPY, law, Anesthesia, riociguat, pulmonary arterial hypertension, Clinical endpoint, Vascular resistance, Medicine, business, Macitentan, medicine.drug
Abstract

Riociguat, a soluble guanylate cyclase stimulator, has been shown in a phase 2 trial to be beneficial in the treatment of pulmonary arterial hypertension. METHODS: In this phase 3, double-blind study, we randomly assigned 443 patients with symptomatic pulmonary arterial hypertension to receive placebo, riociguat in individually adjusted doses of up to 2.5 mg three times daily (2.5 mg-maximum group), or riociguat in individually adjusted doses that were capped at 1.5 mg three times daily (1.5 mg-maximum group). The 1.5 mg-maximum group was included for exploratory purposes, and the data from that group were analyzed descriptively. Patients who were receiving no other treatment for pulmonary arterial hypertension and patients who were receiving endothelin-receptor antagonists or (nonintravenous) prostanoids were eligible. The primary end point was the change from baseline to the end of week 12 in the distance walked in 6 minutes. Secondary end points included the change in pulmonary vascular resistance, N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, World Health Organization (WHO) functional class, time to clinical worsening, score on the Borg dyspnea scale, quality-of-life variables, and safety. RESULTS: By week 12, the 6-minute walk distance had increased by a mean of 30 m in the 2.5 mg-maximum group and had decreased by a mean of 6 m in the placebo group (least-squares mean difference, 36 m; 95% confidence interval, 20 to 52; P

Published
2013

48. RETRAIT : Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire idiopathique : actualisation 2017. Résumé

Author

Cottin, V., Crestani, B., Cadranel, J., Cordier, J.-F., Marchand-Adam, S., Prévot, G., Wallaert, B., Bergot, E., Camus, P., Dalphin, J.-C., Dromer, C., Gomez, E., Israel-Biet, D., Jouneau, S., Kessler, R., Marquette, C.-H., Reynaud-Gaubert, M., Aguilaniu, B., Bonnet, D., Carré, P., Danel, C., Faivre, J.-B., Ferretti, G., Just, N., Lebargy, F., Philippe, B., Terrioux, P., Thivolet-Béjui, F., Trumbic, B., and Valeyre, D.

Abstract

L’éditeur a le regret de vous informer que cet article ayant déjà été publié dans Rev Mal Respir2017;34:834–851. Doi : 10.1016/j.rmr.2017.07.022. Cette seconde publication faite par erreur a été retirée.

Published
2024
Full Text
View/download PDF

49. RETRAIT: Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire idiopathique – Actualisation 2017. Version courte

Author

Cottin, V., Crestani, B., Cadranel, J., Cordier, J.-F., Marchand-Adam, S., Prévot, G., Wallaert, B., Bergot, E., Camus, P., Dalphin, J.-C., Dromer, C., Gomez, E., Israel-Biet, D., Jouneau, S., Kessler, R., Marquette, C.-H., Reynaud-Gaubert, M., Aguilaniu, B., Bonnet, D., Carré, P., Danel, C., Faivre, J.-B., Ferretti, G., Just, N., Lebargy, F., Philippe, B., Terrioux, P., Thivolet-Béjui, F., Trumbic, B., and Valeyre, D.

Abstract

L’éditeur a le regret de vous informer que cet article ayant déjà été publié dans Rev Mal Respir2017;34:852–899. Doi: 10.1016/j.rmr.2017.07.019. Cette seconde publication faite par erreur a été retirée.

Published
2024
Full Text
View/download PDF

50. RETRAIT: Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire idiopathique–Actualisation 2017. Version longue

Author

Cottin, V., Crestani, B., Cadranel, J., Cordier, J.-F., Marchand-Adam, S., Prévot, G., Wallaert, B., Bergot, E., Camus, P., Dalphin, J.-C., Dromer, C., Gomez, E., Israel-Biet, D., Jouneau, S., Kessler, R., Marquette, C.-H., Reynaud-Gaubert, M., Aguilaniu, B., Bonnet, D., Carré, P., Danel, C., Faivre, J.-B., Ferretti, G., Just, N., Lebargy, F., Philippe, B., Terrioux, P., Thivolet-Béjui, F., Trumbic, B., and Valeyre, D.

Abstract

L’éditeur a le regret de vous informer que cet article ayant déjà été publié dans Rev Mal Respir2017;34:900–68. Doi: 10.1016/j.rmr.2017.07.017. Cette seconde publication faite par erreur a été retirée.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results