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26 results on '"Drozda, Katarzyna"'

4. List of Contributors

Author

Arya, Rector, primary, Botton, Mariana R., additional, Campos, Karla Claudio, additional, Caudle, Kelly E., additional, Cavallari, Larisa H., additional, Drozda, Katarzyna, additional, Duconge, Jorge, additional, Duggirala, Ravindranath, additional, Dunnenberger, Henry M., additional, Gammal, Roseann S., additional, Jenkinson, Christopher P., additional, Lam, Y. W. Francis, additional, Lee, Edmund Jon Deoon, additional, Limenta, Michael, additional, Mallayasamy, Surulivelrajan, additional, Mohamed, Elsa Haniffah Mejia, additional, Momary, Kathryn M., additional, Owusu Obeng, Aniwaa, additional, Penzak, Scott R., additional, Samwald, Matthias, additional, Scott, Erick R., additional, Scott, Stuart A., additional, Someya, Toshiyuki, additional, Swen, Jesse J., additional, Tan-Koi, Wei Chuen, additional, Vandell, Alexander, additional, Wallsten, Richard L., additional, and Yin, Ophelia, additional

Published
2019
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16. Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals

Author

Danese, Elisa, Raimondi, Sara, Montagnana, Martina, Tagetti, Angela, Langaee, Taimour, Borgiani, Paola, Ciccacci, Cinzia, Carcas, Antonio J, Borobia, Alberto M, Tong, Hoi Y, Dávila-Fajardo, Cristina, Botton, Mariana Rodrigues, Bourgeois, Stephane, Deloukas, Panos, Caldwell, Michael D, Burmester, Jim K, Berg, Richard L, Cavallari, Larisa H, Drozda, Katarzyna, Huang, Min, Zhao, Li-Zi, Cen, Han-Jing, Gonzalez-Conejero, Rocio, Roldan, Vanessa, Nakamura, Yusuke, Mushiroda, Taisei, Gong, Inna Y, Kim, Richard B, Hirai, Keita, Itoh, Kunihiko, Isaza, Carlos, Beltrán, Leonardo, Jiménez-Varo, Enrique, Cañadas-Garre, Marisa, Giontella, Alice, Kringen, Marianne Kristiansen, Bente Foss Haug, Kari, Gwak, Hye Sun, Lee, Kyung Eun, Minuz, Pietro, Lee, Ming Ta Michael, Lubitz, Steven A, Scott, Stuart, Mazzaccara, Cristina, Sacchetti, Lucia, Ramirez, Andrea H, Zhang, Yumao, Maitland-van der Zee, Anke H, Verhoef, Talitha I, de Boer, Anthonius, Danese, Elisa, Raimondi, Sara, Montagnana, Martina, Tagetti, Angela, Langaee, Taimour, Borgiani, Paola, Ciccacci, Cinzia, Carcas, Antonio J, Borobia, Alberto M, Tong, Hoi Y, Dávila-Fajardo, Cristina, Botton, Mariana Rodrigues, Bourgeois, Stephane, Deloukas, Panos, Caldwell, Michael D, Burmester, Jim K, Berg, Richard L, Cavallari, Larisa H, Drozda, Katarzyna, Huang, Min, Zhao, Li-Zi, Cen, Han-Jing, Gonzalez-Conejero, Rocio, Roldan, Vanessa, Nakamura, Yusuke, Mushiroda, Taisei, Gong, Inna Y, Kim, Richard B, Hirai, Keita, Itoh, Kunihiko, Isaza, Carlos, Beltrán, Leonardo, Jiménez-Varo, Enrique, Cañadas-Garre, Marisa, Giontella, Alice, Kringen, Marianne Kristiansen, Bente Foss Haug, Kari, Gwak, Hye Sun, Lee, Kyung Eun, Minuz, Pietro, Lee, Ming Ta Michael, Lubitz, Steven A, Scott, Stuart, Mazzaccara, Cristina, Sacchetti, Lucia, Ramirez, Andrea H, Zhang, Yumao, Maitland-van der Zee, Anke H, Verhoef, Talitha I, and de Boer, Anthonius

Abstract

The CYP4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at individual patients' level to capture the possible effect of ethnicity, gene-gene interaction or other drugs on the association and to verify if inclusion of CYP4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta-analysis (30 articles) and of 38 new articles retrieved by a systematic review to send us individual patients' data. The final collection consists 15,754 patients split into a derivation and validation cohort. The CYP4F2*3 polymorphism was consistently associated with an increase in mean coumarin dose (+9% (95%CI 7-10%), with a higher effect in females, in patients taking acenocoumarol and in Whites. The inclusion of the CYP4F2*3 in dosing algorithms slightly improved the prediction of stable coumarin dose. New pharmacogenetic equations potentially useful for clinical practice were derived. This article is protected by copyright. All rights reserved.

Published
2019

17. Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals

Author

Pharmacoepidemiology and Clinical Pharmacology, Energy System Analysis, Afd Pharmacoepi & Clinical Pharmacology, Danese, Elisa, Raimondi, Sara, Montagnana, Martina, Tagetti, Angela, Langaee, Taimour, Borgiani, Paola, Ciccacci, Cinzia, Carcas, Antonio J, Borobia, Alberto M, Tong, Hoi Y, Dávila-Fajardo, Cristina, Botton, Mariana Rodrigues, Bourgeois, Stephane, Deloukas, Panos, Caldwell, Michael D, Burmester, Jim K, Berg, Richard L, Cavallari, Larisa H, Drozda, Katarzyna, Huang, Min, Zhao, Li-Zi, Cen, Han-Jing, Gonzalez-Conejero, Rocio, Roldan, Vanessa, Nakamura, Yusuke, Mushiroda, Taisei, Gong, Inna Y, Kim, Richard B, Hirai, Keita, Itoh, Kunihiko, Isaza, Carlos, Beltrán, Leonardo, Jiménez-Varo, Enrique, Cañadas-Garre, Marisa, Giontella, Alice, Kringen, Marianne Kristiansen, Bente Foss Haug, Kari, Gwak, Hye Sun, Lee, Kyung Eun, Minuz, Pietro, Lee, Ming Ta Michael, Lubitz, Steven A, Scott, Stuart, Mazzaccara, Cristina, Sacchetti, Lucia, Ramirez, Andrea H, Zhang, Yumao, Maitland-van der Zee, Anke H, Verhoef, Talitha I, de Boer, Anthonius, Pharmacoepidemiology and Clinical Pharmacology, Energy System Analysis, Afd Pharmacoepi & Clinical Pharmacology, Danese, Elisa, Raimondi, Sara, Montagnana, Martina, Tagetti, Angela, Langaee, Taimour, Borgiani, Paola, Ciccacci, Cinzia, Carcas, Antonio J, Borobia, Alberto M, Tong, Hoi Y, Dávila-Fajardo, Cristina, Botton, Mariana Rodrigues, Bourgeois, Stephane, Deloukas, Panos, Caldwell, Michael D, Burmester, Jim K, Berg, Richard L, Cavallari, Larisa H, Drozda, Katarzyna, Huang, Min, Zhao, Li-Zi, Cen, Han-Jing, Gonzalez-Conejero, Rocio, Roldan, Vanessa, Nakamura, Yusuke, Mushiroda, Taisei, Gong, Inna Y, Kim, Richard B, Hirai, Keita, Itoh, Kunihiko, Isaza, Carlos, Beltrán, Leonardo, Jiménez-Varo, Enrique, Cañadas-Garre, Marisa, Giontella, Alice, Kringen, Marianne Kristiansen, Bente Foss Haug, Kari, Gwak, Hye Sun, Lee, Kyung Eun, Minuz, Pietro, Lee, Ming Ta Michael, Lubitz, Steven A, Scott, Stuart, Mazzaccara, Cristina, Sacchetti, Lucia, Ramirez, Andrea H, Zhang, Yumao, Maitland-van der Zee, Anke H, Verhoef, Talitha I, and de Boer, Anthonius

Published
2019

18. Effect of CYP4F2,VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single‐Patient Data Meta‐Analysis in More Than 15,000 Individuals

Author

Danese, Elisa, primary, Raimondi, Sara, additional, Montagnana, Martina, additional, Tagetti, Angela, additional, Langaee, Taimour, additional, Borgiani, Paola, additional, Ciccacci, Cinzia, additional, Carcas, Antonio J., additional, Borobia, Alberto M., additional, Tong, Hoi Y., additional, Dávila‐Fajardo, Cristina, additional, Rodrigues Botton, Mariana, additional, Bourgeois, Stephane, additional, Deloukas, Panos, additional, Caldwell, Michael D., additional, Burmester, Jim K., additional, Berg, Richard L., additional, Cavallari, Larisa H., additional, Drozda, Katarzyna, additional, Huang, Min, additional, Zhao, Li‐Zi, additional, Cen, Han‐Jing, additional, Gonzalez‐Conejero, Rocio, additional, Roldan, Vanessa, additional, Nakamura, Yusuke, additional, Mushiroda, Taisei, additional, Gong, Inna Y., additional, Kim, Richard B., additional, Hirai, Keita, additional, Itoh, Kunihiko, additional, Isaza, Carlos, additional, Beltrán, Leonardo, additional, Jiménez‐Varo, Enrique, additional, Cañadas‐Garre, Marisa, additional, Giontella, Alice, additional, Kringen, Marianne K., additional, Haug, Kari Bente Foss, additional, Gwak, Hye Sun, additional, Lee, Kyung Eun, additional, Minuz, Pietro, additional, Lee, Ming Ta Michael, additional, Lubitz, Steven A., additional, Scott, Stuart, additional, Mazzaccara, Cristina, additional, Sacchetti, Lucia, additional, Genç, Ece, additional, Özer, Mahmut, additional, Pathare, Anil, additional, Krishnamoorthy, Rajagopal, additional, Paldi, Andras, additional, Siguret, Virginie, additional, Loriot, Marie‐Anne, additional, Kutala, Vijay Kumar, additional, Suarez‐Kurtz, Guilherme, additional, Perini, Jamila, additional, Denny, Josh C., additional, Ramirez, Andrea H., additional, Mittal, Balraj, additional, Rathore, Saurabh Singh, additional, Sagreiya, Hersh, additional, Altman, Russ, additional, Shahin, Mohamed Hossam A., additional, Khalifa, Sherief I., additional, Limdi, Nita A., additional, Rivers, Charles, additional, Shendre, Aditi, additional, Dillon, Chrisly, additional, Suriapranata, Ivet M., additional, Zhou, Hong‐Hao, additional, Tan, Sheng‐Lan, additional, Tatarunas, Vacis, additional, Lesauskaite, Vaiva, additional, Zhang, Yumao, additional, Maitland‐van der Zee, Anke H., additional, Verhoef, Talitha I., additional, de Boer, Anthonius, additional, Taljaard, Monica, additional, Zambon, Carlo Federico, additional, Pengo, Vittorio, additional, Zhang, Jieying Eunice, additional, Pirmohamed, Munir, additional, Johnson, Julie A., additional, and Fava, Cristiano, additional

Published
2019
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19. Population‐specific single‐nucleotide polymorphism confers increased risk of venous thromboembolism in African Americans

Author

Daneshjou, Roxana, primary, Cavallari, Larisa H., additional, Weeke, Peter E., additional, Karczewski, Konrad J., additional, Drozda, Katarzyna, additional, Perera, Minoli A., additional, Johnson, Julie A., additional, Klein, Teri E., additional, Bustamante, Carlos D., additional, Roden, Dan M., additional, Shaffer, Christian, additional, Denny, Joshua C., additional, Zehnder, James L., additional, and Altman, Russ B., additional

Published
2016
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20. Factors influencing pharmacokinetics of warfarin in African–Americans: implications for pharmacogenetic dosing algorithms

Author

Nagai, Rui, primary, Ohara, Minami, additional, Cavallari, Larisa H, additional, Drozda, Katarzyna, additional, Patel, Shitalben R, additional, Nutescu, Edith A, additional, Perera, Minoli A, additional, Hernandez, Wenndy, additional, Kaneko, Naoko, additional, Hibiya, Manabu, additional, and Takahashi, Harumi, additional

Published
2015
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24. Pathway analysis of genome-wide data improves warfarin dose prediction

Author

Daneshjou, Roxana, primary, Tatonetti, Nicholas P, additional, Karczewski, Konrad J, additional, Sagreiya, Hersh, additional, Bourgeois, Stephane, additional, Drozda, Katarzyna, additional, Burmester, James K, additional, Tsunoda, Tatsuhiko, additional, Nakamura, Yusuke, additional, Kubo, Michiaki, additional, Tector, Matthew, additional, Limdi, Nita A, additional, Cavallari, Larisa H, additional, Perera, Minoli, additional, Johnson, Julie A, additional, Klein, Teri E, additional, and Altman, Russ B, additional

Published
2013
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25. Pathway analysis of genome-wide data improves arfarin dose prediction.

Author

Daneshjou, Roxana, Tatonetti, Nicholas P., Karczewski, Konrad J., Sagreiya, Hersh, Bourgeois, Stephane, Drozda, Katarzyna, Burmester, James K., Tsunoda, Tatsuhiko, Nakamura, Yusuke, Kubo, Michiaki, Tector, Matthew, Limdi, Nita A., Cavallari, Larisa H., Perera, Minoli, Johnson, Julie A., Klein, Teri E., and Altman, Russ B.

Subjects
DRUG therapy, WARFARIN, PHENOTYPES, SINGLE nucleotide polymorphisms, LINKAGE disequilibrium, GENETIC correlations, PHARMACOGENOMICS
Abstract

Background: Many genome-wide association studies focus on associating single loci with target phenotypes. However, in the setting of rare variation, accumulating sufficient samples to assess these associations can be difficult. Moreover, multiple variations in a gene or a set of genes within a pathway may all contribute to the phenotype, suggesting that the aggregation of variations found over the gene or pathway may be useful for improving the power to detect associations. Results: Here, we present a method for aggregating single nucleotide polymorphisms (SNPs) along biologically relevant pathways in order to seek genetic associations with phenotypes. Our method uses all available genetic variants and does not remove those in linkage disequilibrium (LD). Instead, it uses a novel SNP weighting scheme to down-weight the contributions of correlated SNPs. We apply our method to three cohorts of patients taking warfarin: two European descent cohorts and an African American cohort. Although the clinical covariates and key pharmacogenetic loci for warfarin have been characterized, our association metric identifies a significant association with mutations distributed throughout the pathway of warfarin metabolism. We improve dose prediction after using all known clinical covariates and pharmacogenetic variants in VKORC1 and CYP2C9. In particular, we find that at least 1% of the missing heritability in warfarin dose may be due to the aggregated effects of variations in the warfarin metabolic pathway, even though the SNPs do not individually show a significant association. Conclusions: Our method allows researchers to study aggregative SNP effects in an unbiased manner by not preselecting SNPs. It retains all the available information by accounting for LD-structure through weighting, which eliminates the need for LD pruning. [ABSTRACT FROM AUTHOR]

Published
2013
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26. Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals

Author

Rajagopal Krishnamoorthy, Yusuke Nakamura, Alice Giontella, Elisa Danese, Munir Pirmohamed, Hoi Y. Tong, Angela Tagetti, Marie-Anne Loriot, Pietro Minuz, Anke H. Maitland-van der Zee, Sheng-Lan Tan, Jim K Burmester, Richard B. Kim, Jamila Alessandra Perini, Ming Ta Michael Lee, Nita A. Limdi, Min Huang, Mohamed H. Shahin, Guilherme Suarez-Kurtz, Vanessa Roldán, Carlos Isaza, Hersh Sagreiya, Hye Sun Gwak, Vijay Kumar Kutala, Han-Jing Cen, Russ B. Altman, Antonio J. Carcas, Kunihiko Itoh, Vaiva Lesauskaite, Richard L. Berg, Cristina Mazzaccara, Kyung Eun Lee, Mariana R. Botton, Jieying Eunice Zhang, Anthonius de Boer, Yumao Zhang, Inna Y. Gong, Marianne K. Kringen, Paola Borgiani, Taimour Y. Langaee, Monica Taljaard, Vacis Tatarunas, Panos Deloukas, Chrisly Dillon, Alberto M. Borobia, Michael D. Caldwell, Katarzyna Drozda, Larisa H. Cavallari, Julie A. Johnson, Stephane Bourgeois, Lucia Sacchetti, Saurabh Singh Rathore, Stuart A. Scott, Martina Montagnana, Li-Zi Zhao, Charles A. Rivers, Mahmut Ozer, Taisei Mushiroda, Cristina Lucía Dávila-Fajardo, Andras Paldi, Marisa Cañadas-Garre, Rocío González-Conejero, Talitha I. Verhoef, Sherief Khalifa, Ivet Suriapranata, Carlo Federico Zambon, Balraj Mittal, Sara Raimondi, Ece Genc, Virginie Siguret, Andrea H. Ramirez, Cinzia Ciccacci, Keita Hirai, Enrique Jiménez-Varo, Hong-Hao Zhou, Anil Pathare, Steven A. Lubitz, Josh C. Denny, Aditi Shendre, Leonardo Beltrán, Kari Bente Foss Haug, Cristiano Fava, Vittorio Pengo, Department of Biochemistry, Università degli Studi di Pavia = University of Pavia (UNIPV), Department of Morphological and Biomedical Sciences, Università degli studi di Verona = University of Verona (UNIVR), Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Queen Mary University of London (QMUL), Merck and Co., Merck & Co. Inc, Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Service d’Hématologie Biologique [CHU Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Paediatric Pulmonology, Pulmonology, APH - Personalized Medicine, Danese, Elisa, Raimondi, Sara, Montagnana, Martina, Tagetti, Angela, Langaee, Taimour, Borgiani, Paola, Ciccacci, Cinzia, Carcas, Antonio J, Borobia, Alberto M, Tong, Hoi Y, Dávila-Fajardo, Cristina, Rodrigues Botton, Mariana, Bourgeois, Stephane, Deloukas, Pano, Caldwell, Michael D, Burmester, Jim K, Berg, Richard L, Cavallari, Larisa H, Drozda, Katarzyna, Huang, Min, Zhao, Li-Zi, Cen, Han-Jing, Gonzalez-Conejero, Rocio, Roldan, Vanessa, Nakamura, Yusuke, Mushiroda, Taisei, Gong, Inna Y, Kim, Richard B, Hirai, Keita, Itoh, Kunihiko, Isaza, Carlo, Beltrán, Leonardo, Jiménez-Varo, Enrique, Cañadas-Garre, Marisa, Giontella, Alice, Kringen, Marianne K, Haug, Kari Bente Fo, Gwak, Hye Sun, Lee, Kyung Eun, Minuz, Pietro, Lee, Ming Ta Michael, Lubitz, Steven A, Scott, Stuart, Mazzaccara, Cristina, Sacchetti, Lucia, Genç, Ece, Özer, Mahmut, Pathare, Anil, Krishnamoorthy, Rajagopal, Paldi, Andra, Siguret, Virginie, Loriot, Marie-Anne, Kutala, Vijay Kumar, Suarez-Kurtz, Guilherme, Perini, Jamila, Denny, Josh C, Ramirez, Andrea H, Mittal, Balraj, Rathore, Saurabh Singh, Sagreiya, Hersh, Altman, Ru, Shahin, Mohamed Hossam A, Khalifa, Sherief I, Limdi, Nita A, Rivers, Charle, Shendre, Aditi, Dillon, Chrisly, Suriapranata, Ivet M, Zhou, Hong-Hao, Tan, Sheng-Lan, Tatarunas, Vaci, Lesauskaite, Vaiva, Zhang, Yumao, Maitland-van der Zee, Anke H, Verhoef, Talitha I, de Boer, Anthoniu, Taljaard, Monica, Zambon, Carlo Federico, Pengo, Vittorio, Zhang, Jieying Eunice, Pirmohamed, Munir, Johnson, Julie A, and Fava, Cristiano

Subjects
CYP2C9, CYP4F2, VKORC1, coumarin drugs, meta-analysis, pharmacogenetics, predictive models, Male, medicine.medical_specialty, [SDV]Life Sciences [q-bio], 030226 pharmacology & pharmacy, Polymorphism, Single Nucleotide, Article, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Coumarins, Internal medicine, Vitamin K Epoxide Reductases, Taverne, medicine, Humans, Pharmacology (medical), heterocyclic compounds, Dosing, Cytochrome P450 Family 4, Aged, Cytochrome P-450 CYP2C9, Pharmacology, Aged, 80 and over, Acenocoumarol, Dose-Response Relationship, Drug, business.industry, Middle Aged, Confidence interval, Settore MED/03 - Genetica Medica, 030220 oncology & carcinogenesis, Meta-analysis, Female, business, Pharmacogenetics, medicine.drug
Abstract

The CYP4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at individual patients' level to capture the possible effect of ethnicity, gene-gene interaction or other drugs on the association and to verify if inclusion of CYP4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta-analysis (30 articles) and of 38 new articles retrieved by a systematic review to send us individual patients' data. The final collection consists 15,754 patients split into a derivation and validation cohort. The CYP4F2*3 polymorphism was consistently associated with an increase in mean coumarin dose (+9% (95%CI 7-10%), with a higher effect in females, in patients taking acenocoumarol and in Whites. The inclusion of the CYP4F2*3 in dosing algorithms slightly improved the prediction of stable coumarin dose. New pharmacogenetic equations potentially useful for clinical practice were derived. This article is protected by copyright. All rights reserved.

Published
2019
Full Text
View/download PDF

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