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83 results on '"Drug-discovery"'

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3. Methodical selected coptisine attenuates the malignancy of cholangiocarcinoma through the blockade of EGFR signalling

4. Structural and dynamic determinants for highly selective RET kinase inhibition reveal cryptic druggability

5. Collaboration Between the Patent System and Pharmaceutical Regulations for Drug-Discovery Innovation in Japan

6. Structural and dynamic determinants for highly selective RET kinase inhibition reveal cryptic druggability.

8. TriTOX: A novel Trichomonas vaginalis assay platform for high-throughput screening of compound libraries

9. Synthesis, Characterization and Complex Evaluation of Antibacterial Activity and Cytotoxicity of New Arylmethylidene Ketones and Pyrimidines with Camphane Skeletons.

10. From cells to atoms: Cryo‐EM as an essential tool to investigate pathogen biology, host–pathogen interaction, and drug discovery.

11. Synthesis and activity of benzimidazole N-Acylhydrazones against Trypanosoma cruzi, Leishmania amazonensis and Leishmania infantum.

12. Implications of Fragment-Based Drug Discovery in Tuberculosis and HIV

13. TriTOX: A novel Trichomonas vaginalis assay platform for high-throughput screening of compound libraries.

15. Fragment-Based Drug Discovery Targeting the T-Box Riboswitch

16. Methodical selected coptisine attenuates the malignancy of cholangiocarcinoma through the blockade of EGFR signalling.

17. Actinomycetes - The Repertoire of Diverse Bioactive Chemical Molecules: From Structures to Antibiotics.

18. Vascular smooth muscle cell proliferation as a therapeutic target. Part 2: Natural products inhibiting proliferation.

19. Early diagnosis and effective treatment regimens are the keys to tackle antimicrobial resistance in tuberculosis (TB): A report from Euroscicon's international TB Summit 2016.

20. Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications.

21. Small-molecule activators of a bacterial signaling pathway inhibit virulence.

22. Structural and dynamic determinants for highly selective RET kinase inhibition reveal cryptic druggability

23. Hunting for Novel Routes in Anticancer Drug Discovery: Peptides against Sam-Sam Interactions.

24. Utilizing Ayurvedic literature for the identification of novel phytochemical inhibitors of botulinum neurotoxin A.

25. Synthesis of two chiral octahydroindole scaffolds for drug discovery.

26. 2D and 3D similarity landscape analysis identifies PARP as a novel off-target for the drug Vatalanib.

27. Repurposing FDA approved drugs against the human fungal pathogen, Candida albicans.

28. Looking for SARS-CoV-2 Therapeutics Through Computational Approaches.

29. Reversing radiation-induced immunosuppression using a new therapeutic modality.

32. Metabolomics-Driven Exploration of the Chemical Drug Space to Predict Combination Antimicrobial Therapies

33. Diabetic Complications: An Update on Pathobiology and Therapeutic Strategies.

34. Cellular experiments to study the inhibition of c-Myc/MAX heterodimerization.

35. G-Protein-Coupled Receptor (GPCR) Signaling in the Carotid Body: Roles in Hypoxia and Cardiovascular and Respiratory Disease.

36. Exploring the newer oxadiazoles as real inhibitors of human SIRT2 in hepatocellular cancer cells.

37. Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A

38. Plate-based diversity subset screening generation 2: an improved paradigm for high-throughput screening of large compound files

39. Novel Strategies for Drug Discovery Based on Intrinsically Disordered Proteins (IDPs)

40. Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications

41. Metabolomics-Driven Exploration of the Chemical Drug Space to Predict Combination Antimicrobial Therapies.

42. Repurposing FDA approved drugs against the human fungal pathogen, Candida albicans

43. 2D and 3D similarity landscape analysis identifies PARP as a novel off-target for the drug Vatalanib

44. Text mining for drug discovery

45. Synthesis of small molecule inhibitors for the treatment of disease

46. WISDOM

47. The In Silico Drug Discovery Toolbox: Applications in Lead Discovery and Optimization.

48. Effect of combining in vitro estrogenicity data with kinetic characteristics of estrogenic compounds on the in vivo predictive value

49. EXPLORATION OF THE SRX-PRX AXIS AS A SMALL-MOLECULE TARGET

50. Gymnema sylvestre for Diabetes: From Traditional Herb to Future's Therapeutic.

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