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Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. Whereas primarily oriented to Pharmacy students and graduates, it can also be useful for scientist from different fields elated to pharmaceutics and pharmacology. (e.g., material scientists, material engineers, medicinal chemists, physicians) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and related biological background.Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies are included as teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), in vitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, in silico and in vitro prediction of ADME properties, or chronopharmacokinetic. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and is written with experts on the correspondent topic, including industrial scientists and academics from USA and UK.Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations. ADME Processes and Pharmaceutical Sciences is written as a core textbook for courses on pharmaceutical sciences: pharmacology, pharmacokinetics,drug delivery, biopharmaceutics, drug design and medicinal chemistry courses.

Dosage Forms, Formulation Developments and Regulations, Volume One in the Recent and Future Trends in Pharmaceutics series, explores aspects of pharmaceutics, with an original approach focused on technology, novelties and future trends in the field. The book discusses the most recent developments in pharmaceutical preformulation and formulation studies, biopharmaceutics and novel pharmaceutical formulations, regulatory affairs, and good manufacturing practices. Exciting areas such as formulation strategies, optimization techniques, the biopharmaceutical classification system, and pharmaceutical aerosols are included. The field of pharmaceutics is highly dynamic and rapidly expanding day-by-day, so it demands a variety of amplified efforts for designing and developing pharmaceutical processes and formulation strategies. This is an essential reference for researchers in academia and industry as well as advanced graduate students in pharmaceutics. - Examines trends and recent technologies in dosage, formulation and regulation - Contains contributions from leading experts in academia, research, industry and regulatory agencies - Includes high-quality illustrations, flow charts and tables for easy understanding of concepts - Discusses practical examples and research case studies

Smart drug delivery at both the micro- and nanoscale is an evolving field with numerous potential applications. It has the potential to revolutionize drug therapy by making treatments more effective, reducing side effects, and improving patient outcomes.This book presents a comprehensive review of the most recent studies on smart micro- and nanomaterials with a focus on their “smart” activity for formation of targeted and responsive drug-delivery carriers. This volume: Introduces readers to the fundamentals of these the micro- and nanoscale materials as well as approaches to smart drug delivery and drug delivery systems. Covers polymers, metals, and composite materials as well as quantum dots and carbon nanotubes. Describes of all possible stimulated systems for drug delivery such as enzyme-responsive, small molecules-responsive, thermo-responsive, pH-responsive, electric field-responsive, magnetic field-responsive, light-responsive, ultrasound-responsive, and reductive environment responsive. Offers a critical perspective on the future scope of smart drug delivery systems. This reference work is written to support researchers in the fields of materials engineering and biotechnology with the goal of improving the diagnosis and treatment of disease and patient quality of life.

The latest edition of Compounding Sterile Preparations by Ryan A. Forrey, Lindsey B. Amerine, and Angela W. Yaniv reflects the latest advancements in the field, providing you with an indispensable resource to navigate the complex landscape of sterile compounding. New in this Edition: Updated Standards: All chapters have undergone extensive revisions to align with the most recent literature and the revised USP standards. USP Chapter : Now includes information on radiopharmaceutical compounding in USP Chapter. Expanded Knowledge Base: Two brand-new chapters covering Allergenic Extracts and Corrective and Preventative Action (CAPA) Plans.

Drug Compounding for Veterinary Professionals Safely, effectively, and legally tailor drug treatments to the needs of your specific veterinary patients with this accessible guide Drug Compounding for Veterinary Professionals provides an accessible, easy-to-use guide to all aspects of prescribing individualized mixtures of medications in veterinary practice. Its emphasis on practical knowledge and its discussion of both in-house and external options make it a comprehensive introduction to using compounded medications in animals. It guides practitioners through every step of the process, from formulating a compound to working with outside pharmacists. The book presents guidance on how to get more information on current regulations, consider the risks and benefits, develop formulations, and more. Drug Compounding for Veterinary Professionals readers will also find: Figures and line drawings illustrating effective compounding techniques and concepts An emphasis on practical knowledge for clinical use Answers to frequently asked questions about drug compounding Drug Compounding for Veterinary Professionals is essential for any veterinary practitioner, veterinary pharmacologist, or student looking to understand this crucial component of patient care.

Save time and money with two books in one + online Q&A! Half pharmacology, half dosage calculations —plus an intensive, yet clear & simple review of basic math and online quizzing! Here's the must-have knowledge and guidance you need to gain a solid understanding of pharmacology and the safe administration of medications in one text. A body systems approach to pharmacology with a basic math review and a focus on drug classifications prepare you to administer specific drugs in the clinical setting. Now with online Q&A practice in Davis Edge! Purchase a new, print copy of the text and receive a FREE, 3-year subscription to Davis Edge, the online Q&A program with 1,600 questions in all, 800 for Medical Assisting and 800 for Nursing. Davis Edge helps you to create quizzes in the content areas you choose to focus on, build simulated practice exams, and track your progress every step of the way. The Text New! Pronunciations for key terms at the beginning of each chapter New! Word-building and gerontological issues features New! New appendix on intravenous therapy Basic math review helps students learn to perform the calculations necessary to administer medications correctly. Medication administration presented through pharmacology basics, techniques and procedures, supplies, safety and regulations, and prescriptions and label “Master the Essentials” tables cover side effects, precautions, contraindications, and interactions for each classification. Drug classification review tables reinforce need-to-know information in each class. “Fast Tip” boxes offer quick facts and mnemonics. “A Closer Look” boxes examine important information in detail. “Check-up Questions” throughout each chapter promote understanding and help students retain and apply the information. Coverage of specific drugs provides context for learning drug classifications. Critical-thinking exercises encourage students to think beyond the chapter and apply their new knowledge to real-life scenarios. Review questions at the end of each chapter reinforce learning. Davis Edge Online Q&A FREE, 3-year access with purchase of new, print text 800 questions for Medical Assisting a

Organ Specific Drug Delivery and Targeting to the Lungs provides up to date information on the multidisciplinary field of particle engineering and drug delivery to the lungs, including advancements of nanotechnology. The text presents a unique, pragmatic focus with case studies, that help translate scientific understanding to practical implementation. In addition to highlighting the successful case studies, it also offers practical advice on watchouts, limitations, and ‘bookend'boundaries involved in the stages of testing and development.Additional Features Include: Provides an account of particle engineering, discovery, biology, development, and delivery in relation with the advancements of nanotechnology, unlike any previous book. Brings together the leading experts and researchers in the field to critically assess and discuss various topics influencing drug delivery. Highlights the interplay of different scientific disciplines and the balance of requirements that are critical to molecule and product design. With the strategic focus on what matters during new product development, this book provides a guide to understanding and navigating new drug discovery and development for lung targets.

This work is an examination of all aspects of the science in developing effective dosage form for drug delivery Pharmaceutics refers to the subfield of pharmaceutical sciences that develops drug delivery products or devices to optimize the drug's performance once administered. This multidisciplinary field draws on physical chemistry, organic chemistry, and biophysics to generate and refine these crucial elements of medical care. Moreover, incorporating such disparate dimensions of drug product design as material properties and legal regulation bridges the gap between effective chemicals and viable medical treatments. Integrated Pharmaceutics provides a comprehensive introduction to the creation and manufacture of effective dosage forms for drug delivery. It presents its subject following the principles of physical pharmacy, product design, and drug regulations. This tripartite structure allows readers to move from theory to practice, beginning from a firm foundation of physical pharmacy principles, including drug solubility and stability estimation, rheology, and interfacial properties. From there, it proceeds to discussions of drug product design and of harmonizing pharmaceutical design with the regulatory regimens and technological standards of the United States, European Union, and Japan. Readers of the second edition of Integrated Pharmaceutics will also find: A glossary defining key terms, extensive informative appendices, and a list of references leading to the primary literature in the field for each chapter Earlier chapters are expanded, with additional new chapters including one entitled “Biotechnology Products” Supplementary instructor guide with questions and solutions available online for registered professors Updated regulatory guidelines including quality by design, design space analysis, process analytical technology, polymorphism characterization, blend sample uniformity, and stability protocolsIntegrated Pharmaceutics is a useful textbook for graduate students in pharmaceutical sciences, drug formulation and design, and biomedical engineering. In addition, professionals in the pharmaceutical industry, including regulatory bodies, will find it a helpful reference guide.

Comprehensive Resource for Pharmacy Technician Learners of All Types Pharmacy technicians serve critical roles on the healthcare team and dependency on accurate calculations is paramount to ensure medication safety and effectiveness and optimal patient outcomes. The second edition has been restructured to focus on the most important pharmacy calculation concepts—covering the fundamentals related to accuracy and basic math operations, units of measurement and conversions, critical thinking in problem solving, dosing calculations, percentages, concentration calculations, compounding formulas, intravenous infusion calculations, and business math. Offering a complete review of the basic mathematics concepts and skills, Pharmacy Calculations: An Introduction for Pharmacy Technicians 2nd Edition provides students with the pharmacy basics necessary for correctly interpreting prescriptions and drug orders, and for performing dosing calculations that technicians face every day. Who Should Read This? Pharmacy technician students enrolled in a training program, technicians preparing for the certification exam, and for those participating in on-site training. Inside the New Edition The chapters are broken down into four units and organized to complement most pharmacy technician training curricula and to support the ASHP—ACPE model curriculum: Review of Mathematics Systems of Measurement Preparing for Problem Solving in Pharmacy Dosing Calculations and Other Pharmacy Problems

The essential pharmaceutics textbook One of the world's best-known texts on pharmaceutics, Aulton's Pharmaceutics offers a complete course in one book for students in all years of undergraduate pharmacy and pharmaceutical sciences degrees. Thoroughly revised, updated and extended by experts in their fields and edited by Professors Kevin Taylor and Michael Aulton, this new edition includes the science of formulation, pharmaceutical manufacturing and drug delivery. All aspects of pharmaceutics are covered in a clear and readily accessible way and extensively illustrated throughout, providing an essential companion to the entire pharmaceutics curriculum from day one until the end of the course. - Fully updated throughout, with the addition of new chapters, to reflect advances in formulation and drug delivery science, pharmaceutical manufacturing and medicines regulation - Designed and written for newcomers to the design and manufacture of dosage forms - Relevant pharmaceutical science covered throughout - Includes the science of formulation and drug delivery - Reflects current practices and future applications of formulation and drug delivery science to small drug molecules, biotechnology products and nanomedicines - Key points boxes throughout - Over 400 online multiple choice questions

The Handbook of Pharmaceutical Manufacturing Formulations, Third Edition: Volume Six, Sterile Products is an authoritative and practical guide to the art and science of formulating drugs for commercial manufacturing. With thoroughly revised and expanded content, this sixth volume of a six-volume set, compiles data from FDA and EMA new drug applications, patents and patent applications, and other sources of generic and proprietary formulations including author's own experience, to cover the broad spectrum of cGMP formulations and issues in using these formulations in a commercial setting. A must-have collection for pharmaceutical manufacturers, educational institutions, and regulatory authorities, this is an excellent platform for drug companies to benchmark their products and for generic companies to formulate drugs coming off patent.Features: Largest source of authoritative and practical formulations, cGMP compliance guidance and self-audit suggestions Differs from other publications on formulation science in that it focuses on readily scalable commercial formulations that can be adopted for cGMP manufacturing Tackles common difficulties in formulating drugs and presents details on stability testing, bioequivalence testing, and full compliance with drug product safety elements Written by a well-recognized authority on drug and dosage form development including biological drugs and alternative medicines

The sixth edition of PharmacyPractice brings the contents completely up to date, reflecting emerging new roles for pharmacists both within the traditional employment areas of hospital and community pharmacy, as well as other developing roles supporting the public health agenda, governance, risk management, prescribing and pharmaco-economics. Each chapter begins with Study Points and ends with Key Points to reinforce learning. Appendices include medical abbreviations, Latin terms and abbreviations, systems of weights and measurements and presentation skills. Some chapters also carry self-assessment questions for more complex areas of pharmaceutical practice. New editor on the team, Louise Cogan. Many new contributors, comprising practising pharmacists, teachers of pharmacy, and pharmacists with joint appointments between hospital/community pharmacy and universities. Now with companion e-book included on StudentConsult New chapters on Consent History Taking/ Gathering Information Advice giving and the pharmacist as a Health Trainer Using calculations in pharmacy practice Continuing professional development and revalidation Intra and inter professional working, The role of the pharmacist in medicines optimization

The book provides a single volume covering detailed descriptions about various delivery systems, their principles and how these are put in use for the treatment of multiple diseases. It is divided into four sections where the first section deals with the introduction and importance of novel drug delivery system. The second section deals with the most advanced drug delivery systems like microbubbles, dendrimers, lipid-based nanoparticles, nanofibers, microemulsions etc., describing the major principles and techniques of the preparations of the drug delivery systems. The third section elaborates on the treatments of diverse diseases like cancer, topical diseases, tuberculosis etc. The fourth and final section provides a brief informative description about the regulatory aspects of novel drug delivery system that is followed in various countries.

Published in 1983: Volume 2 deals with critical analyses of various test methodologies of polymeric implants, including their acute and chronic toxicological evaluation.

Published in 1983: Volume 1 deals with basic pharmacological aspects of controlled drug delivery, transport of small molecules through polymers, biodegradation of polymers with or without enzymatic involvement, and drug carriers.

Pharmaceutical Calculations: A Conceptual Approach, is a book that combines conceptual and procedural understanding for students and will guide you to master prerequisite skills to carry out accurate compounding and dosage regimen calculations. It is a book that makes the connection between basic sciences and pharmacy. It describes the most important concepts in pharmaceutical sciences thoroughly, accurately and consistently through various commentaries and activities to make you a scientific thinker, and to help you succeed in college and licensure exams. Calculation of the error associated with a dose measurement can only be carried out after understanding the concept of accuracy versus precision in a measurement. Similarly, full appreciation of drug absorption and distribution to tissues can only come about after understanding the process of transmembrane passive diffusion. Early understanding of these concepts will allow reinforcement and deeper comprehension of other related concepts taught in other courses.More weight is placed on the qualitative understanding of fundamental concepts, like tonicity vs osmotic pressure, diffusion vs osmosis, crystalloids vs colloids, osmotic diuretics vs plasma expanders, rate of change vs rate constants, drug accumulation vs drug fluctuation, loading dose vs maintenance dose, body surface area (BSA) vs body weight (BW) as methods to adjust dosages, and much more, before considering other quantitative problems. In one more significant innovation, the origin and physical significance of all final forms of critical equations is always described in detail, thus, allowing recognition of the real application and limitations of an equation. Specific strategies are explained step-by-step in more than 100 practice examples taken from the fields of compounding pharmacy, pharmaceutics, pharmacokinetics, pharmacology and medicine.

It is important that medicines are administered correctly, in order to provide correct drug doses, yet not all healthcare professionals are expert in the area. This accessible book provides a definitive guide to best practice in administering medicinal formulations.Acting as a quick reference handbook for administration techniques in both the simulated and real practice environment, the book enables readers to advise patients on the correct use of their formulation. It covers the following formulation types: oral topical ocular aural nasal inhaled transdermal patches vaginal rectal. A Practical Guide to Medicines Administration is a key resource for both student and practising pharmacists who counsel and advise patients on the use of their medicines. It will also be a useful reference for nurses, nursing associates, assistant practitioners and healthcare assistants.

Formulation is a key step in the drug design process, where the active drug is combined with other substances that maximise the therapeutic potential, safety and stability of the final medicinal product. Modern formulation science deals with biologics as well as small molecules. Regulatory and quality demands, in addition to advances in processing technologies, result in growing challenges as well as possibilities for the field. Pharmaceutical Formulation provides an up to date source of information for all who wish to understand the principles and practice of formulation in the drug industry. The book provides an understanding of the links between formulation theory and the practicalities of processing in a commercial environment, giving researchers the knowledge to produce effective pharmaceutical products that can be approved and manufactured. The first chapters introduce readers to different dosage forms, including oral liquid products, topical products and solid dosage forms such as tablets and capsules. Subsequent chapters cover pharmaceutical coatings, controlled release drug delivery and dosage forms designed specifically for paediatric and geriatric patients. The final chapter provides an introduction to the vital role intellectual property plays in drug development. Covering modern processing methods and recent changes in the regulatory and quality demands of the industry, Pharmaceutical Formulation is an essential, up to date resource for students and researchers working in academia and in the pharmaceutical industry.

This book explains theoretical and technological aspects of amorphous drug formulations. It is intended for all those wishing to increase their knowledge in the field of amorphous pharmaceuticals. Conversion of crystalline material into the amorphous state, as described in this book, is a way to overcome limited water solubility of drug formulations, in this way enhancing the chemical activity and bioavailability inside the body. Written by experts from various fields and backgrounds, the book introduces to fundamental physical aspects (explaining differences between the ordered and the disordered solid states, the enhancement of solubility resulting from drugs amorphization, physical instability and how it can be overcome) as well as preparation and formulation procedures to produce and stabilize amorphous pharmaceuticals. Readers will thus gain a well-funded understanding and find a multi-faceted discussion of the properties and advantages of amorphous drugs and of the challenges in producing and stabilizing them. The book is an ideal source of information for researchers and students as well as professionals engaged in research and development of amorphous pharmaceutical products.

From a review of the previous edition: ‘For all the pharmacy students out there part of your pharmacy degree will be to study formulation design and pharmaceutics. This is the holy grail of pharmaceutical technology books. The text reads well and introduces difficult concepts in a more easy-to-understand way, it is definitely worth the money to help you get through the module, if you're doing a research project in pharmaceutical design then this would also be an excellent buy…This is essential for passing exams and developing professional competence.'This is the best known text on pharmaceutics. Its strength lies mainly in being a complete course in one book. Reviewers consistently praise its comprehensiveness and its extremely high quality-quality content. Pharmaceutics is one of the most diverse subject areas in pharmaceutical science and an understanding of it is vital for all pharmacists and scientists involved in converting drugs to medicines that can be safely delivered to a patient. The editorial and author team deliver a tour de force of accessibility, coverage and currency in this new edition of a world-class textbook. Relevant chemistry covered throughout Reflects current and future use of biotechnology products throughout Covers ongoing changes in our understanding of biopharmaceutics, certain areas of drug delivery and the significance of the solid state Includes the science of formulation and drug delivery Designed and written for newcomers to the design of dosage forms Key points boxes throughout Summaries at the end of each chapter Fully updated throughout, with particular focus on delivery of biopharmaceuticals, nanotechnology and nanomedicines, parenteral and ocular drug delivery mechanisms. Now comes with online access on StudentConsult.

Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. As an introduction oriented to pharmacy students, it is also written for scientist from different fields outside of pharmaceutics. (e.g. material scientist, material engineers, medicinal chemists) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and some biological background. Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies add valuable teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), invitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, and in silico and in vitro prediction of ADME properties. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and was written with leading experts on the correspondent topic, including scientists and academics from USA and UK (Duquesne University School of Pharmacy, Indiana University School of Medicine, University of Utah College of Pharmacy, University of Maryland, University of Bath).Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations (e.g. importance of active absorption of levodopa, implications in levodopa administration, drug drug interactions and food drug interactions emerging from the active uptake; intoxication with paracetamol as a result of glutathione depletion, CYP induction and its relationship with acute liver failure caused by paracetamol, etc).ADME Processes and Pharmaceutical Sciences is written as a core textbook for ADME processes, pharmacy, pharmacokinetics, drug delivery, biopharmaceutics, drug disposition, drug design and medicinal chemistry courses.

Dosage Form Design Parameters, Volume II, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues, the scale up of formulations, regulatory issues, intellectual property, solid state properties and polymorphism. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of dosage form design parameters. Chapters delve into a particular aspect of this fundamental field, covering principles, methodologies and the technologies employed by pharmaceutical scientists. In addition, the book contains a comprehensive examination suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnology and related industries. - Examines the history and recent developments in drug dosage forms for pharmaceutical sciences - Focuses on physicochemical aspects, prefomulation solid state properties and polymorphism - Contains extensive references for further discovery and learning that are appropriate for advanced undergraduates, graduate students and those interested in drug dosage design

Dosage Form Design Parameters, Volume I, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues, the scale up of formulations, regulatory issues, intellectual property, solid state properties and polymorphism. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of dosage form design parameters. Chapters delve into a particular aspect of this fundamental field, covering principles, methodologies and the technologies employed by pharmaceutical scientists. In addition, the book contains a comprehensive examination suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnology and related industries. - Examines the history and recent developments in drug dosage forms for pharmaceutical sciences - Focuses on physicochemical aspects, prefomulation solid state properties and polymorphism - Contains extensive references for further discovery and learning that are appropriate for advanced undergraduates, graduate students and those interested in drug dosage design

Presents a detailed discussion of important solid-state properties, methods, and applications of solid-state analysis Illustrates the various phases or forms that solids can assume and discussesvarious issues related to the relative stability of solid forms and tendencies to undergo transformation Covers key methods of solid state analysis including X-ray powder diffraction, thermal analysis, microscopy, spectroscopy, and solid state NMR Reviews critical physical attributes of pharmaceutical materials, mainly related to drug substances, including particle size/surface area, hygroscopicity, mechanical properties, solubility, and physical and chemical stability Showcases the application of solid state material science in rational selection of drug solid forms, analysis of various solid forms within drug substance and the drug product, and pharmaceutical product development Introduces appropriate manufacturing and control procedures using Quality by Design, and other strategies that lead to safe and effective products with a minimum of resources and time

Detailing formulation approaches by stage of discovery to early development, this book gives a “playbook” of practical and efficient strategies to formulate drug candidates with the least chance of failing in clinical development. • Comes from contributing authors with experience developing formulations on the frontlines of the pharmaceutical industry• Focuses on pre (or non-) clinical and early stage development, the phases where most compounds are used in drug research• Features case studies to illustrate practical challenges and solutions in formulation selection• Covers regulatory filing, drug metabolism and physical and chemical properties, toxicology formulation, biopharmaceutics classification system (BCS), screening approaches, early stage clinical formulation development, and outsourcing

Aqueous-based film coating has become routine in the pharmaceutical industry. This process eliminates the use of organic solvents and thus avoids economic, environmental, and toxicological issues related to residual solvents and solvent recovery. Aqueous-based coating, however, is complex and many variables may impact the final product and its performance. This fourth edition of Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms aims to provide insight into the factors and parameters that should be considered and controlled for the successful development and commercialization of a coated product. The fourth edition has been revised and expanded to reflect the most recent scientific advancements from the literature. The contributing authors explain in detail, using illustrated examples, appropriate steps to solve and ideally avoid formulation, processing, and stability problems and to achieve an optimized dosage form. Trade names and chemical names of commercially marketed coatings are used throughout the text to help familiarize the reader with the various materials available for pharmaceutical applications. This book will be a valuable resource for anyone in the pharmaceutical industry working in the area of aqueous-based film coating.

Safely and effectively administer more than 400 intravenous drugs with the expert guidance of this #1 IV drug handbook! Now in its 33rd edition, Gahart's 2017 Intravenous Medications: A Handbook for Nurses and Health Professionals continues to be a trusted resource its accuracy, quick-reference format, and comprehensive coverage of IV drugs. Each drug monograph includes the drug's generic name, trade name(s), drug category, pH, dosages and dose adjustments, dilution, incompatibilities, rate of administration, actions, indications and uses, contraindications, precautions, drug/lab interactions, side effects, and antidote. It's all of the information you will need for the safe administration of IV drugs — nothing more and nothing less.UNIQUE! Annual publication ensures that information includes the most recently approved IV drugs, as well as updated information on existing drugs.40-year history of impeccable accuracy reinforces the importance of safe IV drug administration.UNIQUE! Time-tested, easy-to-use page layout keeps all dosage information for each drug on either a single page or a two-page spread to prevent hand contamination by having to turn a page.Black Box Warnings and key content are highlighted to make locating key information fast and easy.Special circumstances highlighted in blue-screened text call attention to important circumstances that may not warrant black box warnings.Convenient, alphabetical format organizes all drug monographs by generic name, allowing you to find any drug in seconds.Dilution and dosage charts within monographs provide quick access to essential clinical information.Age-specific dosage variances are highlighted for geriatric, pediatric, infant, and neonatal patients. NEW! 15 new drug monographs provide current, clinically relevant drug information for new IV drugs recently approved by the FDA.NEW! Updated drug monographs throughout reflect the latest changes in IV drug therapy.NEW! Do Not Confuse With information is added at the top of each applicable monograph to enhance medication safety, and the Evolve companion website includes a link to the ISMP list of Do Not Confuse drug names.NEW! Reorganized drug side effects reflect the latest information on frequency, seriousness, and other important considerations.NEW! Alphabetical thumb tabs on the left-hand pages make it easier to look up drug monographs.

Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice, Second Edition illustrates how to develop high-quality, safe, and effective pharmaceutical products by discussing the latest techniques, tools, and scientific advances in preformulation investigation, formulation, process design, characterization, scale-up, and production operations. This book covers the essential principles of physical pharmacy, biopharmaceutics, and industrial pharmacy, and their application to the research and development process of oral dosage forms. Chapters have been added, combined, deleted, and completely revised as necessary to produce a comprehensive, well-organized, valuable reference for industry professionals and academics engaged in all aspects of the development process. New and important topics include spray drying, amorphous solid dispersion using hot-melt extrusion, modeling and simulation, bioequivalence of complex modified-released dosage forms, biowaivers, and much more. - Written and edited by an international team of leading experts with experience and knowledge across industry, academia, and regulatory settings - Includes new chapters covering the pharmaceutical applications of surface phenomenon, predictive biopharmaceutics and pharmacokinetics, the development of formulations for drug discovery support, and much more - Presents new case studies throughout, and a section completely devoted to regulatory aspects, including global product regulation and international perspectives

Guides readers on the proper use of in vitro drug release methodologies in order to evaluate the performance of special dosage forms In the last decade, the application of drug release testing has widened to a variety of novel/special dosage forms. In order to predict the in vivo behavior of such dosage forms, the design and development of the in vitro test methods need to take into account various aspects, including the dosage form design and the conditions at the site of application and the site of drug release. This unique book is the first to cover the field of in vitro release testing of special dosage forms in one volume. Featuring contributions from an international team of experts, it presents the state of the art of the use of in vitro drug release methodologies for assessing special dosage forms'performances and describes the different techniques required for each one. In Vitro Drug Release Testing of Special Dosage Forms covers the in vitro release testing of: lipid based oral formulations; chewable oral drug products; injectables; drug eluting stents; inhalation products; transdermal formulations; topical formulations; vaginal and rectal delivery systems and ophthalmics. The book concludes with a look at regulatory aspects. Covers both oral and non-oral dosage forms Describes current regulatory conditions for in vitro drug release testing Features contributions from well respected global experts in dissolution testing In Vitro Drug Release Testing of Special Dosage Forms will find a place on the bookshelves of anyone working with special dosage forms, dissolution testing, drug formulation and delivery, pharmaceutics, and regulatory affairs.

How to Develop Robust Solid Oral Dosage Forms from Conception to Post-Approval uses a practical and hands-on approach to cover the development process of solid oral dosage forms in one single source. The book details all of the necessary steps from formulation through the post-approval phase and contains industry case studies, real world advice, and troubleshooting tips. By merging the latest scientific information with practical instructions, this book provides pharmaceutical scientists in formulation research and development with a concrete look at the key aspects in the development of solid oral dosage forms. - Focuses on important topics, such as robustness, bioavailability, formulation design, continuous processing, stability tests, modified release dosage forms, international guidelines, process scale-up, and much more - Part of the Expertise in Pharmaceutical Process Technology series edited by Michael Levin - Discusses common, real-world problems and offers both theoretical and practical solutions to these everyday issues

This book provides an overview of excipients, their functionalities in pharmaceutical dosage forms, regulation, and selection for pharmaceutical products formulation. It includes development, characterization methodology, applications, and up-to-date advances through the perspectives of excipients developers, users, and regulatory experts. Covers the sources, characterization, and harmonization of excipients: essential information for optimal excipients selection in pharmaceutical development Describes the physico-chemical properties and biological effects of excipients Discusses chemical classes, safety and toxicity, and formulation Addresses recent efforts in the standardization and harmonization of excipients

The Art, Science, and Technology of Pharmaceutical Compounding presents in a logical and progressive format all the information that pharmacists and student pharmacists need to understand the purpose and processes of compounding. Author Loyd V. Allen Jr., the preeminent expert, covers basic guidelines, economic and technical factors that compounding pharmacists must consider, and all aspects of good manufacturing practices for compounded medications. In this fifth edition, all chapters have been updated and several significantly revised—particularly “Compounding with Hazardous Drugs”—and three new chapters have been added: “Pharmaceutical Compounding Errors,” “Foams,” and “Compounding with Special Ingredients.” Information on the new law affecting compounding, the Drug Quality and Security Act, is incorporated throughout the book. Chapter 14 now includes information on compounding'films.'KEY FEATURES: • The initial chapters describe the requisite facilities and equipment, record keeping, calculations, and quality control. • Three new chapters: “Pharmaceutical Compounding Errors,” “Foams,” and “Compounding with Special Ingredients.” • Fifteen chapters are devoted to the compounding of each dosage form in turn, from powders and granules to injectables. • Additional chapters cover veterinary compounding, compounding for special populations, compounding for specific procedures, compounding for clinical studies, compounding cosmetics, compounding with hazardous drugs, and compounding in the event of a natural disaster or terrorist attack. • Nine appendices provide essential information on the compounding process and examples of standard operating procedures. • The necessary ingredients and steps are listed for compounding more than 200 sample formulations, including bases, vehicles, and ingredient-specific preparations. • Updated throughout, including information on the new Drug Quality and Security Act.

Use the #1 IV drug handbook to safely administer more than 400 intravenous drugs! Gahart's Intravenous Medications: A Handbook for Nurses and Health Professionals has been trusted for more than 40 years for its accuracy, quick-reference format, and comprehensive coverage. Whether you prefer the portable print book or the eBook, each drug monograph includes the drug's generic name, trade name(s), drug category, pH, dosages and dose adjustments, dilution, incompatibilities, rate of administration, actions, indications and uses, contraindications, precautions, drug/lab interactions, side effects, and antidote. Compiled by nurse consultant Betty Gahart and pharmacist Adrienne Nazareno, this resource contains all of the information you need for the safe administration of IV drugs — nothing more than is needed, and nothing less.UNIQUE! Published annually to ensure that you have essential information on the most recently approved IV drugs, as well as updated information on existing drugs.UNIQUE! Over 400 IV drug monographs provide coverage of more drugs than any comparable handbook.UNIQUE! Time-tested, easy-to-use page layout keeps all dosage information for each drug on either a single page or a two-page spread to prevent hand contamination by having to turn a page.UPDATED! Drug side effects are reorganized according to frequency, seriousness, and other important considerations.Black Box Warnings and highlighting of key content make locating key information fast and easy.Dilution and dosage charts within monographs provide quick access to essential clinical information.Age-specific dosage variances are highlighted for geriatric, pediatric, infant, and neonatal patients. Spiral binding makes the book convenient to use in the clinical setting.Alphabetical format organizes all drug monographs by generic name, allowing you to find any drug in seconds.More than 100 lesser-used IV drugs may be accessed on the Evolve website. NEW! 9-11 new drug monographs provide you with current, clinically relevant drug information for new IV drugs recently approved by the FDA.NEW! Updated drug monographs reflect the latest changes in IV drug therapy.NEW! Do Not Confuse With information is added at the top of each applicable monograph to enhance medication safety, and the Evolve companion website includes a link to the ISMP list of Do Not Confuse drug names.NEW! Thumb tabs on left-hand pages are added to the standard right-hand thumb tabs, making it easy to look up drug monographs from either side.

Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications• Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics• Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics• Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery

The essential sterile compounding reference every pharmacist needs – now with important updates.Compounding Sterile Preparations, Fourth Edition, by E. Clyde Buchanan, Philip J. Schneider, and Ryan A. Forrey, is the most comprehensive and authoritative reference available on sterile compounding. It's a trusted resource that every pharmacist needs. The newest edition of this publication now includes: Coverage of new USP Chapter on the compounding of hazardous drugs and the existing USP Chapter Updates on regulations related to the Drug Quality and Security Act (DQSA) Seven new chapters and 16 new contributors Appendices offering more extensive reference to online resources Since the last edition published in 2009, much has changed in the world of compounding. Don't miss out on the latest updated information in this important field.

Sichere und kontaminationsfreie Arzneimittel dank intelligenter Hygienekonzepte und Produktionsabläufe: Dieser neue Praxisleitfaden zu Grundlagen und Verfahren der hygienischen Pharmaproduktion deckt alle gängigen Arzneiformen ab. Von der Personalhygiene über die Herstellungsverfahren der verschiedenen Arzneiformen (fest und flüssig, steril und nicht-steril), von den verwendeten Medien und Hilfsstoffen bis hin zur Verpackung und zur Reinigung der Anlagen werden alle potenziellen Quellen von Kontaminationen unter Berücksichtigung der aktuellen Standards und Prüfverfahren beschrieben und erklärt. Fertigungsleiter und Qualitätsprüfer in der betrieblichen Praxis sowie Sachverständige in Prüf- und Regulierungsbehörden finden hier zahlreiche in der Praxis bewährte Annleitungen zur Optimierung und Gewährleistung einer hygienisch einwandfreien Produktion der unterschiedlichsten Arzneiformen.

A needed resource for pharmaceutical scientists and cosmetic chemists, Essential Chemistry for Formulators of Semisolid and Liquid Dosages provides insight into the basic chemistry of mixing different phases and test methods for the stability study of nonsolid formulations. The book covers foundational surface/colloid chemistry, which forms the necessary background for making emulsions, suspensions, solutions, and nano drug delivery systems, and the chemistry of mixing, which is critical for further formulation of drug delivery systems into semisolid (gels, creams, lotions, and ointments) or liquid final dosages. Expanding on these foundational principles, this useful guide explores stability testing methods, such as particle size, rheological/viscosity, microscopy, and chemical, and closes with a valuable discussion of regulatory issues. Essential Chemistry for Formulators of Semisolid and Liquid Dosages offers scientists and students the foundation and practical guidance to make and analyze semisolid and liquid formulations. - Unique coverage of the underlying chemistry that makes possible stable dosages - Quality content written by experienced experts from the drug development industry - Valuable information for academic and industrial scientists developing topical and liquid dosage formulations for pharmaceutical as well as skin care and cosmetic products

Pharmaceutical Calculations is the perfect text for students or professionals aiming to understand or develop the calculations skills that play a significant role in building a competent pharmacist. This text focuses on basic math fundamentals essential for pharmaceutical calculations, followed by calculations that are more specific to compounding and formulation of individual dosage. This helpful approach incorporates solved examples for each individual section followed by practice sets, with an answer key to each problem. At the end of each chapter case studies demonstrate the application of mathematical calculations in compounding actual prescriptions. FEATURES • Practice sets • Solved problems • Case studies in the form of prescriptions

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The #1 IV drug handbook for more than 40 years, Intravenous Medications: A Handbook for Nurses and Health Professionals is trusted for its accuracy and comprehensive coverage. Whether you prefer the portable print version or one of the convenient electronic formats, each drug monograph - including those for new IV drugs recently approved by the FDA - includes the drug's generic name, common trade name(s), drug category, pH, dosages and dose adjustments, dilution, incompatibilities, rate of administration, actions, indications and uses, contraindications, precautions, drug/lab interactions, side effects, and antidote - all alphabetically organized to help you find drug information quickly and easily. UNIQUE! Published annually to ensure that you have essential information on the most recently approved IV drugs, as well as updated information on existing drugs.UNIQUE! Thorough coverage of more than 350 IV drugs provides far more information than any other comparable handbook.Updated IV drug dilution and dosage charts within monographs provide quick access to essential information.Black Box Warnings, screening, and highlighting make locating key information fast and easy.Age-specific dosage variances are highlighted for geriatric, pediatric, infant, and neonatal patients. IV drugs are listed alphabetically by generic name for quick clinical reference.Redesigned printed thumb tabs help you find information faster.UNIQUE! Time-tested page layout keep all dosage information for each drug on either a single page or a two-page spread to prevent hand contamination by having to turn a page.Consistent, easy-to-use format provides all the essential clinical information you need on IV drug administration.NEW! Eleven new drug monographs provide you with current, clinically relevant drug information for new IV drugs recently approved by the FDA.NEW! Updated drug monographs reflect the latest changes in IV drug therapy.

Design and Manufacture of Pharmaceutical Tablets offers real world solutions and outcomes of formulation and processing challenges of pharmaceutical tablets. This book includes numerous practical examples related to actual formulations that have been validated and marketed and covers important data in the areas of stability, dissolution, bioavailibity and processing. It provides important background and theoretical information on design and manufacturing and includes a full section dedicated to design experimental methodology and statistics. In addition, this book offers a a general discussion of excipients used in proper tablet design along with practical examples related to excipients. Drug development scientists in industry and academia, as well as students in the pharmaceutical sciences will greatly benefit from the practical knowledge and case examples provided throughout this book. - Incorporates important mathematical models and computational applications - Includes unique content on central composite design and augmented simplex lattice - Provides background on important design principles with emphasis on quality-based design (QBD) of pharmaceutical dosage forms

The fifth edition of Pharmaceutical Practice has been totally overhauled and restructured to bring the contents completely up to date and to reflect emerging new roles for pharmacists both within the traditional employment areas of hospital and community pharmacy, as well as other developing roles supporting the public health agenda, governance, risk management, prescribing and pharmacoeconomics. It covers a wide range of subjects relevant to pharmacy practice, including communication skills, managing a business, quality assurance, dispensing, calculations, packaging, storage and labeling of medicines, sterilization, prescriptions, hospital-based services, techniques and treatments, adverse drug reactions, cost-benefit, and medicines management. Each chapter begins with Study Point and ends with Key Points to reinforce learning. Appendices include medical abbreviations, Latin terms and abbreviations, systems of weights and measurements, presentation skills and key references. Self-assessment questions for more complex areas of pharmaceutical practice. New chapters on control of medicines; control of health professionals and their staff; ethics in practice; Standard Operating Procedures; structure and organisation of pharmacy; veterinary pharmacy; appliances; public health, and pharmacy interventions. New editor on the team, Jennie Watson. Many new contributors, comprising practising pharmacists, teachers of pharmacy, and pharmacists with joint appointments between hospital/community pharmacy and universities.

Hydrogels are attractive materials for uses in regenerative medicine due to their biocompatibility and high water absorbance and retention properties. Applications are emerging in stem cell niches, biopolymers and synthetic polymers for tissue scaffolding, wound healing and hydrogels for cellular diagnostics and delivery. Hydrogels in Cell-Based Therapies looks at the use of different polymers and other bionanomaterials to fabricate different hydrogel systems and their biomedical applications including enzyme responsive hydrogels and biomaterials, thermally responsive hydrogels, collagen gels and alginates. With complementary expertise in cell biology and soft materials, the Editors provide a comprehensive overview of recent updates in this highly topical field. This highly interdisciplinary subject will appeal to researchers in cell biology, biochemistry, biomaterials and polymer science and those interested in hydrogel applications.

Remington Education: Pharmaceutics covers the basic principles of pharmaceutics, from dosage forms to drug delivery and targeting. It addresses all the principles covered in an introductory pharmacy course. As well as offering a summary of key information in pharmaceutics, it offers numerous case studies and MCQs for self assessment.

Prescribing at a Glance The market-leading at a Glance series is used world-wide by medical students, residents, junior doctors and health professionals for its concise and clear approach and superb illustrations. Each topic is presented in a double-page spread with clear, easy-to-follow diagrams, supported by succinct explanatory text. Covering the whole medical curriculum, these introductory texts are ideal for teaching, learning and exam preparation, and are useful throughout medical school and beyond. Everything you need to know about Prescribing...at a Glance! The principles of drug therapies are fundamental to medical practitioners in all branches; but are often difficult to get to grips with. Prescribing at a Glance addresses the most common uses of prescription drugs, and follows progress from dose calculation and administration to monitoring the effects in the treatments of major presenting problems. With a focus on prescribing, this user-friendly guide helps practitioners to develop crucial knowledge and skills, including establishing accurate drug histories, planning appropriate therapies, writing safe and legal prescriptions, critically appraising the prescribing of others, patient support, accessing reliable information about medicines, and detecting adverse drug reactions. Prescribing at a Glance: Features detailed and high-quality colour illustrations throughout Includes examples of common prescribing errors, practice prescriptions and calculations Follows the structure of the WHO Good Prescribing Guide, and corresponds to the core curriculum of the British Pharmacological Society Is the perfect guide to help you prepare for the Prescribing Skills Assessment (PSA) From the series that brought you Medical Pharmacology at a Glance, and designed to help those in the later stages of their medical training become adept at the skills required for a vital yet often confusing subject, Prescribing at a Glance will help you fill in any knowledge gaps with simple step-by-step instructions, and clear, easy- to-remember guidelines. All content reviewed by students for students Wiley-Blackwell Medical Education books are designed exactly for their intended audience. All our books are developed in collaboration with students, which means our books are always published with you, the student, in mind.