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In waterway regulation engineering, submerged reefs are quite susceptible to the repetitive oblique strike from drop hammer and impact drilling, leading to a repetitive compression–shear impacting. Understanding the dynamic responses and failure mechanism of saturated rocks subjected to repetitive compression–shear impacting is thus of great significance for the efficient removal of submerged reefs. In this study, using the split Hopkinson pressure bar (SHPB) apparatus, the repetitive compression–shear impacting tests were conducted on the saturated and dry sandstone specimen from the harbor excavation project in Guoyuan Port (Chongqing, China). Our experimental results indicate that the increasing loading rate or shear component in the dynamic loading has a negative influence on the bearing capacity of saturated sandstone subjected to repetitive impacting. The deformability of saturated rocks increases as the impacting number or the shear component in the dynamic loading. The energy absorption ability as well as the energy utilization of the saturated rocks is highly improved by implementing repetitive compression–shear impacting, and such improvement yields an ascension limit with the increasing shear component in the dynamic loading. As the shear component introduces into the repetitive impacting loading, the failure patterns of rocks change from the relative tensile mode with a large deformation band along the loading direction to the combined compression–shear mode with two parallel large deformation bands inclined to the loading direction, the water content between the mineral grains promotes the shear failure in rock dynamic testing. These results can provide a better understanding of the dynamic responses and failure properties of saturated rocks subjected to repetitive compression–shear impacting. Highlights: Illustrated influences of repetitive compression–shear impacting on the bearing capacity and deformability of saturated and dry rocks. Investigated energy dissipation of saturated and dry rocks under repetitive combined compression–shear impacting. Revealed failure patterns of saturated and dry rocks under repetitive combined compression–shear impacting. [ABSTRACT FROM AUTHOR]

Fire safety evacuation has been used in numerous different kinds of buildings. This research conducts a scientometric review of fire safety evacuation applications and advances in the buildings to clarify the research trends of fire evacuation in the future and provide guidance for relevant research. A total of 3312 journals and conference proceedings were analyzed through different dimensions. The result proves that evacuation environments concentrate mainly on residential building, commercial building, school, and railway station. The characteristics of the evacuee have been gradually refined in recent years, including children, the elderly, patients, and vulnerable groups. The main experimental approaches of fire safety evacuation are evacuation drills, site records, and VR/AR experiments. The crowd behavior models mainly consist of six types: a cellular automata model, a social force model, a lattice gas model, a game-theoretic model, an animal agent-based model, and a computer agent-based model. The analysis results in the theoretical method are becoming gradually closer to the behavioral characteristics and movement data of the crowd during the actual evacuation with improvements of practical considerations. The study of evacuation drills, disaster rescue, emergencies, and other external environmental factors will become the forefront of future research, and subway stations, airports, high-rise building, and other personnel places will be the focus of the study of crowd evacuation. [ABSTRACT FROM AUTHOR]

The drilling-hammer method is adopted for the breaking over submerged reefs in waterway regulation engineering. However, rocks with pre-drilled holes are highly susceptible to the repetitive impacts from drop hammers or drilling equipment. Exploring the dynamic responses and failure behaviors of drilled-hole rocks under repetitive impacting is important for promoting implementation of this technique. In this study, the repetitive impacting tests were conducted on the drilled rocks by the split Hopkinson pressure bar to investigate the rock bearing capacity, deformation property, failure behavior, and energy evolution. The results indicate that the presence of pre-drilled holes and the decreasing loading rates attenuate the bearing capacity of rocks subjected to repetitive impacting. In contrast, the rock deformation capacity is impacted subtly by the impact loading rate and increases with the number of impacts and borehole size. The drilled rock failure occurred with the prevalence of intergranular fractures; subsequently, the proportion of transgranular fractures increased, contributing to the loading rate-dependent bearing capacity. The inverted S-shaped damage evolution curve was assessed using the inverted logistic growth model. The specimen absorbed few incident energies for fracture generation and propagation, and the rock with a larger drill size displays higher energy utilization and larger fragments. • Illustrated the influences of repetitive impacting on the bearing capacity and deformability of pre-cracked hole rocks. • Revealed the failure behavior and fracture mechanism of pre-cracked hole rocks under repetitive impacting. • Depicted the damage evolution of pre-cracked hole rocks under repetitive impacting by the inverted logistic growth model. • Investigated the dynamic energy dissipation of pre-cracked hole rocks under repetitive impacting. [ABSTRACT FROM AUTHOR]

Rocks in the deep underground are likely subjected to both hydrostatic confining pressure and dynamic compression–shear load. Thus, accurately characterizing the dynamic properties and failure mechanism of hydrostatically confined rocks under combined compression–shear impacting is crucial for the stability assessment of deep underground rock structures. In this study, on the basis of an improved split Hopkinson pressure bar (SHPB) apparatus, the combined dynamic compression–shear tests are performed on inclined cylindrical sandstone specimens with hydrostatic confining pressures. During the test, the dynamic force balance of rock specimens can be well satisfied using the pulse shaping technique. Our results show that the hydrostatic confining pressure and dynamic loading rate help strengthen the load-carrying capacity of rocks. In contrast, the shear component in the dynamic load limits the dynamic peak stress of rocks. As hydrostatic confining pressure increases, the failure surface based on the Drucker–Prager criterion gradually expands outward. Under dynamic loading, the compressive deformation modulus of rocks decreases with increasing shear component in the dynamic load, contrary to its response to hydrostatic confining pressure. Fragmentation analysis indicates that the hydrostatic confining pressure and the shear component of dynamic loading restrict the fracture behavior of rocks. Besides, as the specimen inclination angle and the hydrostatic confining pressure increase, the failure pattern of rock specimens changes from the tensile-dominated failure with a truncated conical surface to the shear-dominated failure with a single shear plane along its short diagonal. [ABSTRACT FROM AUTHOR]

A comprehensive computational fluid dynamic (CFD) model of CEES‐developed polyethylenimine impregnated protonated titanate nanotubes (PEI‐PTNTs) was developed using the Multiphase Flow with Interphase eXchanges (MFiX) package to evaluate the performance of the PEI‐PTNTs in a 1‐MW pilot‐scale carbon capture reactor developed by the National Energy Technology Laboratory (NETL). In this CFD model, the momentum, continuity, and energy transport equations were integrated with the first‐order chemistry model for chemical kinetics of heterogeneous reactions to predict the adsorption of CO2 onto amine‐based sorbent particles and the reactor temperature. Based on the amount of the CO2 adsorption obtained in the small‐scale experiment, the coefficients for the chemical reaction equations of PEI‐PTNTs are adjusted. The adjusted PEI‐PTNTs model is applied to the simplified numerical model of 1‐MW pilot‐scale carbon capture system, which is calibrated through the comparison between our simulation results and the results provided by NETL. This calibrated CFD model is used for selecting the optimized flow rate of the gas phase. Our study shows that the optimized gas flow rate to absorb 100% CO2 without loss is 1.5 kg/s, but if higher absorption rate is preferable despite some loss of CO2 absorption in the reactor, a higher flow rate than 1.5 kg/s can be selected. [ABSTRACT FROM AUTHOR]

To implement sustainable water resource management, the industries that produce a huge amount of wastewater are aiming to recycle wastewater. Reverse osmosis (RO) is an advanced membrane process that can produce potable water from wastewater. However, the presence of diverse pollutants in the wastewater necessitates effective pretreatment to ensure successful RO implementation. This study evaluated the efficiency of microfiltration (MF) and ultrafiltration (UF) as two pretreatment methods prior to RO, i.e., MF-RO and UF-RO, for recycling poultry slaughterhouse wastewater (PSWW). The direct treatment of PSWW with RO (direct RO) was also considered for comparison. In this study, membrane technology serves as a post treatment for PSWW, which was conventionally treated at Sanderson Farm. The results demonstrated that all of the processes, including MF-RO, UF-RO, and direct RO treatment of PSWW, rejected 100% of total phosphorus (TP), over 91.2% of chemical oxygen demand (COD), and 87% of total solids (TSs). Total nitrogen (TN) levels were reduced to 5 mg/L for MF-RO, 4 mg/L for UF-RO, and 9 mg/L for direct RO. In addition, the pretreatment of PSWW with MF and UF increased RO flux from 46.8 L/m2 h to 51 L/m2 h, an increase of approximately 9%. The product water obtained after MF-RO, UF-RO, and direct RO meets the required potable water quality standards for recycling PSWW in the poultry industry. A cost analysis demonstrated that MF-RO was the most economical option among membrane processes, primarily due to MF operating at a lower pressure and having a high water recovery ratio. In contrast, the cost of using RO without MF and UF pretreatments was approximately 2.6 times higher because of cleaning and maintenance expenses related to fouling. This study concluded that MF-RO is a preferable option for recycling PSWW. This pretreatment method would significantly contribute to environmental sustainability by reusing well-treated PSWW for industrial poultry purposes while maintaining cost efficiency. [ABSTRACT FROM AUTHOR]

The cracked chevron notched semi-circular bend (CCNSCB) method has been utilized in split Hopkinson pressure bar (SHPB) tests to measure the rock dynamic mode I fracture toughness. However, the measuring principle has never been thoroughly evaluated. In this study, a three-dimensional discrete element method has been employed to numerically investigate the dynamic fracture mechanism of CCNSCB specimens in SHPB testing considering different loading rates and supporting spans. Our results show that, even if the dynamic force balance can be efficiently satisfied, the conventional quasi-static analysis can still be questionable. For specimens with smaller supporting spans, the developing crack fronts are rather curved during the loading process, and the critical crack length is highly dependent on the loading rates. While for specimens with a large supporting span, the crack profiles are less affected and the critical crack fronts are finely confined within the chevron ligament with few undesirable damages. Thus, the CCNSCB method with a larger supporting span appear to be sound in the SHPB tests for measuring dynamic mode I fracture toughness of rocks. [ABSTRACT FROM AUTHOR]

Automatic segmentation and quantification of skeletal structures has a variety of applications for biological research. Although solutions for good quality X-ray images of human skeletal structures are in existence in recent years, automatic solutions working on poor quality X-ray images of mice are rare. This paper proposes a fully automatic solution for spine segmentation and curvature quantification from X-ray images of mice. The proposed solution consists of three stages, namely preparation of the region of interest, spine segmentation, and spine curvature quantification, aiming to overcome technical difficulties in processing the X-ray images. We examined six different automatic measurements for quantifying the spine curvature through tests on a sample data set of 100 images. The experimental results show that some of the automatic measures are very close to and consistent with the best manual measurement results by annotators. The test results also demonstrate the effectiveness of the curvature quantification produced by the proposed solution in distinguishing abnormally shaped spines from the normal ones with accuracy up to 98.6%. [ABSTRACT FROM AUTHOR]

Classical molecular dynamics (MD) simulations coupled with metadynamics (MTD) simulations were used to investigate lysozyme unfolding in physiological 0.154 M NaCl salt concentration as well as in 0.5 and 1 M NaCl salt solutions. It was found that lysozyme unfolding dynamics is strongly dependent on the salt concentration. Moreover, the stable low energy denatured states are also different in different salt concentrations. Salt ion−protein interaction seems to stabilize both the native and denatured states, but their relative stability depends on salt concentration. Our simulation results and complementary experimental measurements demonstrate that salt ion−protein interactions facilitate lysozyme unfolding. [ABSTRACT FROM AUTHOR]

Combined quantum mechanical calculations and classical molecular dynamics simulations were conducted to investigate the hydration properties of carboxybetaine zwitterion brushes with varying separation distances between the quaternary ammonium cation and carboxylic anion. The brushes consist of zwitterion trimers and are investigated to mimic interacting zwitterion chains grafted on a substrate as well as polymers with interacting zwitterion side chains. Our results show that the values of both positive and negative charges, their separation distances as well as chain interactions appear to play a critical role in the hydration properties of the zwitterions. The overall hydration property of these zwitterions is dictated by the competition between the strong hydration of the charged groups and the dehydration of the hydrocarbon chains. The strongest hydration occurs when the -CH2- unit in the hydrocarbon chain reaches 6-8 for these trimers. Further increase in the hydrocarbon chain length to 10-14 leads to significant and sudden dehydration of the trimers. The water structure and the water residence time surrounding the zwitterions also demonstrate substantial alteration at this length scale. This hydrophilic-to-hydrophobic transition is induced by the hydrophobic interactions of the trimer chains. Our hydration results could explain the observed trend of the superiority of the methylated carbohydrates and poly(ethylene glycol) as antifouling materials compared to corresponding hydroxylterminated compounds. [ABSTRACT FROM AUTHOR]

Nanofiltrationmembranes were surface modified by grafting poly(acrylic acid) (PAA)nanochains using a UV initiated free radical polymerization method.These pH sensitive membranes were then used to separate monosaccharides,disaccharides, and their mixtures from filtration feed streams. Itwas found that pH dramatically affects the flux, rejection, and selectivityusing these modified pH sensitive nanofiltration membranes. Membraneperformance could be enhanced not only by the conformational changesof the grafted surface layer due to protonation and deprotonationof the acid groups on the polymer chains but also from the differentinteractions between the sugar molecules and the neutral PAA chainor its negative conjugate. Classical molecular dynamics (MD) simulationswere conducted to investigate the specific interactions between glucose/sucroseand the neutral/negatively charged PAA chains. The simulation resultsshow that both sugar size and PAA charge affect significantly thesugar-polymer interactions. [ABSTRACT FROM AUTHOR]

Abstract: We performed systematic first principles calculations based on density functional theory to probe the energetics of dissociation of water molecules on small (TiO2) n (n =3, 4, 6, 8, and 10) clusters. We found that the (TiO2) n clusters have a strong ability to adsorb water molecules and the dissociative adsorption of water molecules on the surface of (TiO2) n clusters with a three step process is irreversible, size-dependent and energetically more favorable than the same on the surfaces of titanium oxide. Charged (TiO2) n cluster also have strong ability in H2O molecule splitting similar as neutral ones. The efficiency of water molecules dissociating on (TiO2) n cluster surface varies inversely with the cluster size due to the steric effect. Our results indicate a higher efficiency of small clusters of titanium oxide in dissociating water molecules than its low index surfaces of bulk terminated. [Copyright &y& Elsevier]

To provide useful information on dissociation of water molecule on (TiO2)n clusters for experimental verification, we have calculated the infrared (IR) and Raman spectra of three possible states involved, namely molecularly adsorbed state, metastable state and dissociatively adsorbed state, using density functional theory at the B3LYP/6-311G(d) level. We find that the characteristic bands of H2O molecules below 2000 cm-1 in both IR and Raman spectra vanish upon both molecular and dissociative adsorption of H2O. In the high frequency range of 3600-4200 cm-1, the adsorption caused the single IR peak of water to split into two bands, while the dissociation removed the one at lower frequency and blue shifted slightly the higher frequency band. The two Raman peaks of the water molecule in the same high frequency range were slightly blue shifted upon adsorption but the one at lower frequency was removed upon dissociation, while the one at high frequency blue shifted slightly. The intensities of vibrational modes of water in 3600-4200 cm-1 are generally significantly enhanced upon both molecular and dissociative adsorption. Our results show clearly signatures of dissociation of water molecule into hydroxyl radical at the terminal site. [ABSTRACT FROM AUTHOR]

Abstract: Quantum mechanical calculations were carried out to determine the mechanisms for the superiority of the imidazolium acetate-based ionic liquids to the corresponding chloride-based ionic liquids. Our results indicate that the imidazolium cation can react with the acetate anion to generate a carbene, a highly reactive intermediate. The carbene produced then reacts with cellulose to facilitate its dissolution in the ionic liquid solvents in addition to the stronger hydrogen bonds formed between the acetate anion and the hydroxyl groups on cellulose. The mechanisms for the imidazolium cation and acetate anion reactions involve the initial ion pairing of the cation and anion via hydrogen bonding and electrostatic interactions. The hydrogen bond formed between the C2–H on the imidazolium cation and COO− of the anion facilitates the transfer of the H+ to the anion to form a carbene intermediate. [Copyright &y& Elsevier]

Classical molecular dynamics simulations were carried out to investigate the hydrophilic to hydrophobic transition of PNIPAM- co-PEGMA close to its lower critical solution temperature (LCST) in 1 M NaCl solution. PNIPAM- co-PEGMA is a copolymer of poly( N-isopropylacrylamide) (PNIPAM) and poly(ethylene glycol) methacrylate (PEGMA). The copolymer consists of 38 monomer units of NIPAM with two PEGMA chains attached to the PNIAPM backbone. The PNIPAM- co-PEGMA was observed to go through the hydrophilic−hydrophobic conformational change for simulations at temperature slightly above its LCST. Na+ ions were found to bind strongly and directly with amide O, even more strongly with the O atoms on PEGAMS chains, whereas Cl− ions only exhibit weak interaction with the polymer. Significantly a novel caged stable metal-organic complex involving a Na+ ion coordinated by six O atoms from the copolymer was observed after the PNIPAM- co-PEGMA copolymer went through conformational transition to form a hydrophobic folded structure. © 2011 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2011 [ABSTRACT FROM AUTHOR]

In recent years, deep convolutional neural networks (DCNNs) have shown promising performance in medical image analysis, including breast lesion classification in 2D ultrasound (US) images. Despite the outstanding performance of DCNN solutions, explaining their decisions remains an open investigation. Yet, the explainability of DCNN models has become essential for healthcare systems to accept and trust the models. This paper presents a novel framework for explaining DCNN classification decisions of lesions in ultrasound images using the saliency maps linking the DCNN decisions to known cancer characteristics in the medical domain. The proposed framework consists of three main phases. First, DCNN models for classification in ultrasound images are built. Next, selected methods for visualization are applied to obtain saliency maps on the input images of the DCNN models. In the final phase, the visualization outputs and domain-known cancer characteristics are mapped. The paper then demonstrates the use of the framework for breast lesion classification from ultrasound images. We first follow the transfer learning approach and build two DCNN models. We then analyze the visualization outputs of the trained DCNN models using the EGrad-CAM and Ablation-CAM methods. We map the DCNN model decisions of benign and malignant lesions through the visualization outputs to the characteristics such as echogenicity, calcification, shape, and margin. A retrospective dataset of 1298 US images collected from different hospitals is used to evaluate the effectiveness of the framework. The test results show that these characteristics contribute differently to the benign and malignant lesions' decisions. Our study provides the foundation for other researchers to explain the DCNN classification decisions of other cancer types. [ABSTRACT FROM AUTHOR]

The Dallas-Fort Worth (DFW) area that experiences high temperature and intense solar radiation falls into the moderate nonattainment classification. The variation in meteorological parameters plays an important role in ambient ozone levels variation. Meteorological influences need to be decoupled from ozone data for long-term trend analysis. Temporal separation of maximum daily average 8-h ozone (MDA8 ozone), maximum daily temperature (TMAX), daily average solar radiation (DASR), and daily average wind speed (DAWS) were conducted using Kolmogorov-Zurbenko (KZ) filter for ozone records at Keller (C17), Arlington (C61), Red Bird (C402) monitoring stations in the DFW area from 2003 to 2017. Temporal separation, regression analysis, and meteorological detrending were performed. The long-term component had a clear and stable trend. The contribution of the long-term component to total variation was negligible, which is less than 2%. This is due to the removal of the data noise from the original time series data. The seasonal component had a major contribution (55% to 72%) in the total variation of the maximum temperature and solar radiation. However, the short-term component was dominant in the total variation of the MDA8 ozone (41–54%) and wind speed (68–79%). Regression analysis showed the baseline component bears the highest correlation than the short-term and raw. Solar radiation had the highest correlation to the MDA8 ozone, followed by temperature data in all three stations. Meteorological detrending showed the detrended long-term ozone had an increasing trend. The increasing trend was significant at C402 with a trend of 0.19 ± 0.006 ppb/y (0.398 R2), whereas slight increasing trends were found at C17 (0.072 ± 0.006 (0.107 R2)) and at C61 (0.019 ± 0.007 (0.005 R2)). The increasing trend of long-term components of MDA8 ozone was justified by the increasing level of NOx and VOCs from the mobile sources in the DFW area. [ABSTRACT FROM AUTHOR]

Chitosan has emerged as a biodegradable, nontoxic polymer with multiple beneficial applications in the agricultural and biomedical sectors. As nanotechnology has evolved as a promising field, researchers have incorporated chitosan-based nanomaterials in a variety of products to enhance their efficacy and biocompatibility. Moreover, due to its inherent antimicrobial and chelating properties, and the availability of modifiable functional groups, chitosan nanoparticles were also directly used in a variety of applications. In this review, the use of chitosan-based nanomaterials in agricultural and biomedical fields related to the management of abiotic stress in plants, water availability for crops, controlling foodborne pathogens, and cancer photothermal therapy is discussed, with some insights into the possible mechanisms of action. Additionally, the toxicity arising from the accumulation of these nanomaterials in biological systems and future research avenues that had gained limited attention from the scientific community are discussed here. Overall, chitosan-based nanomaterials show promising characteristics for sustainable agricultural practices and effective healthcare in an eco-friendly manner. [ABSTRACT FROM AUTHOR]

• The ratio law of structure evolution of Ti n O m is proposed. • Energy gap can be tuned by changing the size and configurations of Ti n O m clusters. • Provides insights into the evolution of cluster-to-bulk process in titanium oxide. Most theoretical investigations about titanium oxide clusters focus on (TiO 2) n. However, many Ti n O m clusters with m ≠ 2 n are produced experimentally. In this work, first-principles calculations are performed to probe the evolution of Ti n O m clusters. Our investigations show that for n = 3–11, there exist one relatively stable specie; while for n = 12–18, there are two relatively stable species: Ti-rich and O-rich species. HOMO-LOMO calculations show that the gap can be tuned by changing the size and configurations of Ti n O m clusters. Our investigation provides insights into the evolution of cluster-to-bulk process in titanium oxide. [ABSTRACT FROM AUTHOR]

Number connection test A (NCT-A) and digit symbol test (DST), the preferential neuropsychological tests to detect minimal hepatic encephalopathy (MHE) in China, haven't been standardized in Chinese population. We aimed to establish the norms based on a multi-center cross-sectional study and to detect MHE in cirrhotic patients. NCT-A and DST were administered to 648 healthy controls and 1665 cirrhotic patients. The regression-based procedure was applied to develop demographically adjusted norms for NCT-A and DST based on healthy controls. Age, gender, education, and age by education interaction were all predictors of DST, while age, gender, and education by gender interaction were predictors of log10 NCT-A. The predictive equations for expected scores of NCT-A and DST were established, and Z-scores were calculated. The norm for NCT-A was set as Z ≤ 1.64, while the norm for DST was set as Z ≥ − 1.64. Cirrhotic patients with concurrent abnormal NCT-A and DST results were diagnosed with MHE. The prevalence of MHE was 8.89% in cirrhotic patients, and only worse Child–Pugh classification (P = 0.002, OR = 2.389) was demonstrated to be the risk factor for MHE. The regression-based normative data of NCT-A and DST have been developed to detect MHE in China. A significant proportion of Chinese cirrhotic patients suffered from MHE, especially those with worse Child–Pugh classification. [ABSTRACT FROM AUTHOR]

• Monitoring during the rare exposure period of the dike due to climatic conditions. • Spur dike greater impact on plankton diversity and physicochemical factors. • Planktonic community similarity in upstream–downstream of dike greater than dike type. • Co-occurrence network complexity for eukaryote is in longitudinal dike, prokaryote is in spur dike. • Flow velocity effect on planktonic community in aquatic environment around dike. To investigate the effects of the waterway regulation structures on the hydraulic characteristics, water physicochemical factors, and the planktonic community in the upper Yangtze River, this study was conducted in August and September of 2022 on two ecological dikes in the Chongqing section of the upper Yangtze River: the longitudinal dike and the spur dike. High-throughput sequencing technology was used to explore the differences in planktonic community structures upstream and downstream of the waterway regulation structures during the dry season, as well as their main influencing factors. The results showed that the dissolved oxygen increased significantly, and the turbidity and flow rate decreased significantly in downstream of dikes. The spur dike exhibited more pronounced changes in water quality and hydrodynamic factors compared to the longitudinal dike. The diversity index of phytoplankton, zooplankton, and fungi in the downstream of dikes were higher than those in the upstream, and the bacterial diversity index was higher than those of eukaryotes at each sampling site. The impact of the spur dike on the planktonic biodiversity index was greater than that of the longitudinal dike, as it alters flow velocity, turbidity, and dissolved oxygen. The major phyla of phytoplankton, zooplankton, and bacteria, including Cryptophyta (70.37–80.57 %), Mollusca (7.56–37.50 %), and Proteobacteria (48.53–55.92 %), had a higher relative abundance in upstream of dike, and their relative abundance in spur dike was higher than that in longitudinal dike. In contrast, the relative abundance of the major phylum of fungi, Ascomycota (37.15–56.85 %), showed an opposite trend in both dike-to-dike comparison and dike upstream-to-downstream comparison to the above three plankton. The analysis of the neutral community model indicated that the predominance of stochastic assembly processes in the planktonic community was higher in the longitudinal dike compared to the spur dike, and longitudinal dike demonstrated higher rates of planktonic migration and speciation compared to the spur dike. Flow rate, dissolved oxygen, and turbidity were the significance influencing factors on the planktonic community structure in the aquatic environment around dike. Differences in dike-related environmental factors result in greater interactions among prokaryotes in the spur dike, while eukaryotes exhibited a more complex network of relationships in the longitudinal dike. These findings can provide a theoretical basis for the protection of biodiversity and the construction of ecological waterways in the waterway regulation engineering area. [ABSTRACT FROM AUTHOR]

Deep convolutional neural networks (DCNNs) have demonstrated promising performance in classifying breast lesions in 2D ultrasound (US) images. Exiting approaches typically use pre-trained models based on architectures designed for natural images with transfer learning. Fewer attempts have been made to design customized architectures specifically for this purpose. This paper presents a comprehensive evaluation on transfer learning based solutions and automatically designed networks, analyzing the accuracy and robustness of different recognition models in three folds. First, we develop six different DCNN models (BNet, GNet, SqNet, DsNet, RsNet, IncReNet) based on transfer learning. Second, we adapt the Bayesian optimization method to optimize a CNN network (BONet) for classifying breast lesions. A retrospective dataset of 3034 US images collected from various hospitals is then used for evaluation. Extensive tests show that the BONet outperforms other models, exhibiting higher accuracy (83.33%), lower generalization gap (1.85%), shorter training time (66 min), and less model complexity (approximately 0.5 million weight parameters). We also compare the diagnostic performance of all models against that by three experienced radiologists. Finally, we explore the use of saliency maps to explain the classification decisions made by different models. Our investigation shows that saliency maps can assist in comprehending the classification decisions. [ABSTRACT FROM AUTHOR]

In this paper, an effective numerical method is proposed for a linear complementarity problem (LCP) arising in the valuation of American bond options under the Cox–Ingersoll–Ross (CIR) model. Firstly, a variable substitution is used to simplify the linear complementary model. Secondly, the finite difference method is adopted to discretize the simplified model, and an equivalent variational form is obtained. Based on the positive definiteness of the discretized matrix, a projection and contraction method (PCM) is adopted for the resulting discretized variational problem. Finally, numerical experiments highlight the effectiveness and performance of the proposed algorithm. [ABSTRACT FROM AUTHOR]

In this study, a modified maximum tangential stress criterion by considering T-stress and uniaxial compression tests have been utilized to theoretically and experimentally reveal the fracture initiation mechanism of a center-symmetric closed crack in compacted clay. The results show that wing cracks occur in the linear elastic phase of the stress-strain curve. In the plastic phase of the stress-strain curve, the wing cracks extend gradually and the shear cracks occur. The crack initiation stress and peak stress of compacted clay first decrease with the rise in pre-crack inclination angle (β = 0°–40°), and then increase with the rise in pre-crack inclination angle (β = 50°–90°). When the pre-crack inclination angle is relatively small or large (β ≤ 10° or β ≥ 70°), the crack type is mainly tension cracks. Secondary shear cracks occur when the pre-crack inclination angle is 10°–80°. When the dimensionless crack length is larger than 0.35, the crack types include wing-type tension cracks and secondary shear cracks. The experimental results were compared with the theoretical values. It was found that the critical size rc of compacted clay under compression-shear loading was 0.75 mm, smaller than the value calculated by the empirical formula (12 mm). The MTS criterion considering T-stress can be used to predict the compression-shear fracture behavior of compacted clay. [ABSTRACT FROM AUTHOR]

• Estimated river bathymetry using the satellites data on river width and water level. • Derived nonlinear z-w relationship from generalized channel cross section. • Investigated the influences of channel exposure on river bathymetry estimation. • Studied the effects of reach-averaging length and remote sensing data on bathymetry. River bathymetry is a key variable in estimating river discharge by remote sensing. However, traditional methods of mapping river bathymetry are expensive and time-consuming, which hinders the estimation of river discharge. In this study, we propose and test a method for estimating river bathymetry by combining remotely sensed observations of water level (z) and river width (w) with a nonlinear z - w relationship derived from a generalized channel cross-sectional shape. The results from five reaches of the upper Yangtze River show that the absolute relative error for the estimate is between 1.25% and 6.18%, indicating the ability of this method to provide accurate estimates. The channel exposure (e) is the main limitation of the proposed method, and the river bathymetry estimates improve significantly with increasing e. For the upper Yangtze River, averaging reaches over an appropriate length can reduce variability in river bathymetry estimate, especially when data are reach-averaged over a length of 10 km. Considering that a priori bathymetric information is not required and its computational process is relatively simple, the proposed method could open up the possibility of bathymetry modeling of global rivers. [ABSTRACT FROM AUTHOR]

This paper investigates the effects of support friction on mixed-mode I/II fracture behavior of compacted clay using notched deep beam (NDB) specimens under symmetric fixed support. Numerical models of 330 NDB specimens were established considering the crack inclination angle, crack length, support span, and support friction coefficient, and the normalized fracture parameters (YI, YII, and T*) of NDB specimens were calibrated. The numerical results showed that the values of YI, YII, and T* decreased at different degrees after considering the support friction. Notably, the support friction coefficient could significantly change the loading pattern at the crack tip. To verify this phenomenon, 12 compacted clay NDB specimens were prepared, and a mixed-mode I/II fracture test was performed under fixed support conditions; the phenomenon of asymmetric crack propagation was studied. The test data were processed using the numerical calibration results of YI, YII, and T* with and without consideration of friction. Afterward, the test data were compared and analyzed by combining the generalized maximum tangential stress (GMTS) and the maximum tangential stress (MTS) criteria. The analysis indicated that the real fracture characteristics of compacted clay NDB specimens could not be reflected when conducting mixed-mode I/II fracture tests under symmetric fixed support conditions if the test results were analyzed by YI, YII, and T* without considering support friction, as in previous studies. [ABSTRACT FROM AUTHOR]

Objective. This aim is to evaluate the effect of Sijunzi decoction (SJZD) treating chronic atrophic gastritis (CAG). Methods. We performed searches in seven databases. The randomized controlled trials (RCTs) comparing SJZD with standard medical care or inactive intervention for CAG were enrolled. Combined therapy of SJZD plus conventional therapies compared with conventional therapies alone was also retrieved. The primary outcome included the incidence of gastric cancer and the improvement of atrophy, intestinal metaplasia, and dysplasia based on the gastroscopy and pathology. The secondary outcomes were Helicobacter pylori clearance rate, quality of life, and adverse event/adverse drug reaction. Results. Six RCTs met the inclusion criteria. The research quality was low in the trials. For the overall effect rate, pooled analysis from 4 trials showed that modified SJZD plus conventional medications exhibited a significant improvement (OR = 4.86; 95% CI: 2.80 to 8.44; P < 0.00001) and without significant heterogeneity compared with the conventional medications alone. None reported the adverse effect. Conclusions. Modified SJZD combined with conventional western medicines appears to have benefits for CAG. Due to the limited number and methodological flaw, the beneficial and harmful effects of SJZD for CAG could not be identified. More high-quality clinical trials are needed to confirm the results. [ABSTRACT FROM AUTHOR]

In this study, the inclined sandstone specimen is introduced into cyclic loading tests to fulfill the coupled compression-shear loading state. 21 cyclic coupled compression-shear loading tests are conducted on inclined specimens under different loading conditions, including maximum stress levels ranging in 0.80, 0.85, 0.90 and 0.95, and amplitude levels varying in 0.40, 0.50, 0.60 and 0.70. Our testing results systematically revealed the influence of cyclic loading parameters on fatigue mechanical response of rocks under coupled compression-shear loading, regarding the deformation characteristics, energy evolution, damage variable and failure mechanism. Under higher maximum stress or cyclic amplitude, inclined rocks are characterized by larger elastic modulus and higher dissipated energy, resulting in less irreversible strain, faster damage accumulation and shorter fatigue life. Furthermore, a fatigue life prediction method is proposed based on the energy dissipation, and its reliability is verified by comparing with experimental results. In addition, the progressive cracking behavior of rocks is analyzed during the fatigue tests by virtue of digital image correlation technique. Under cyclic coupled compression-shear loading, rock specimens are featured by a prominent shear-dominated failure along its short diagonal direction combined with local tensile damage along the loading orientation. [ABSTRACT FROM AUTHOR]

Achieving rapid response and recovery rates at low operating temperatures for NO 2 is desirable for the application of sensors in industrial safety. In this study, we integrate a thickness tunable 2D graphdiyne (GDY) film into ZnO nanowalls (GDY/ZnO) via thermal evaporation of GDY, where ZnO nanowalls are used as the template to confine the growth space of the GDY film. In situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) is used to reveal the transformation process of NO 2. Ultraviolet photoemission spectroscopy (UPS) is utilized to analyze changes about the energy band of the materials. Density functional theory (DFT) calculations explain the reason for the selectivity of the samples to NO 2. The scanning electron microscopy (SEM) results demonstrate that the thickness of the GDY film with a specific mesoporous structure (25‐53 nm) increases as the thermal evaporation temperature rises from 400 to 800°C.The representative ZG-600, synthesized with a thickness of 46 nm via thermal evaporation at 600°C, exhibits superior NO 2 sensing performance. This is evidenced by its ultrahigh response (13.86, at 100 ppm and 150°C) and rapid response/recovery speeds (150 s/198 s), outperforming the ZnO sensor (198 s and 326 s). Moreover, it offers remarkable stability. • GDY nanoparticles were decorated on the surface of ZnO nanowall. • GDY/ZnO heterojunction with adsorbed oxygen and oxygen vacancies has been synthesized. • GDY/ZnO composite nanowall exhibited highly better NO 2 sensing performance. • The electrons transfer and redox reaction between GDY and ZnO has been discussed. [ABSTRACT FROM AUTHOR]

The current two-dimensional (2D) material based NH 3 sensors generally suffer from low response values and sluggish recovery dynamics, which is resulted from their inferior conductivity. Herein, high conductivity (0.045 S/m) of 2D hydrogen substituted graphyne (HsGY) nanosheets are successfully synthesized employing aqueous/organic interface method and using them for the first time for the detection of NH 3 at room temperature. The resultant gas sensing performance shows that the 2D HsGY nanosheets exhibit a high gas response value (4.9) to 100 ppm NH 3 and fast recovery time (108 s) at the room temperature. The NH 3 gas sensing mechanism is discussed by utilizing density functional theory (DFT) calculations. The present study provides novel gas sensing material for the development of high-performance room temperature NH 3 sensors. This study successfully synthesized two-dimensional hydrogen substituted graphyne (HsGY) nanosheets using an aqueous/organic interface method and applied them for the detection of NH 3 at room temperature for the first time. HsGY nanosheets exhibit excellent sensing performance towards NH 3 , due to their high conductivity and continuous thin gauze like morphology, which facilitates gas transport. [Display omitted] [ABSTRACT FROM AUTHOR]

In recent years, the potential use and development of acetone gas sensors in health monitoring and self-diagnostic applications has attracted increasing attention. Thus, accurate sensing of acetone is of crucial importance in the non-invasive diagnosis of diabetes. However, challenges remain in the detection of acetone, such as high concentrations detection limit, high operating temperature and slow response dynamics. Herein, vertically aligned Ce-doped mesoporous NiO nanowalls are prepared on Ag-Pd interdigitated electrode substrate using an in-situ growth method. The gas sensing performances show that the as-made 4 mol% Ce-doped NiO nanowalls has excellent gas response value (3.2) to 10 ppm acetone at a lower operating temperature (175 ℃) with fast adsorption and desorption equilibrium (13 s/7 s). Vertically aligned mesoporous NiO nanowalls doped by Ce element could pave the way for ultra-sensitive and low power consumption acetone gas sensors for breath gas detection. • Simple method: in situ growth method. • Excellent detection conditions: Low lower detection limits at lower temperatures. • The fast equilibrium of adsorption and desorption. [ABSTRACT FROM AUTHOR]

The complex response of underground geomaterials subjected to dynamic disturbance arises from the microstructure redistribution under high in- situ stress and the resulting fracture behaviors at multiaxial stress states. Inclined specimens were employed in an axially constrained split Hopkinson pressure bar (SHPB) system to achieve a combination of compression-shear stress states and static-dynamic loads. The loading rate under investigation ranged from 500 to 4,000 GPa/s, along with the axial prestress of 7, 21, 35, 49, and 63 MPa on specimens with an inclination of 0°, 3°, 5°, and 7°. The modified SHPB experimentation and discrete-element method modeling were implemented to unravel the combined effects of the loading rate, preload, and stress path on the failure mechanism of sandstone specimens involving the failure strength and envelope, fracturing pattern, fragmentation, and microcracking process. The positive rate dependence of the failure strength and Drucker–Prager envelope was observed. The preload showed double effects on the failure strength, indicated by an upper bound of the failure envelope as it expanded with the increasing preload. The microdamage accumulated during preloading and the global stress field collectively influenced the failure pattern of the inclined specimen, altering from a shear fracturing mode under dynamic loading or high-preload static-dynamic loading to an axial splitting mode near the specimen surface under low-preload static-dynamic loading. [ABSTRACT FROM AUTHOR]

• The flower-like TiO 2 microspheres were synthesized by a tunable tetrabutyl titanate-assisted hydrothermal method. • The as-made gas sensors showed high sensitivity and selectivity to NH 3 at the room temperature. • The underlying mechanism for the high selectivity to NH 3 was discussed using DFT calculations. TiO 2 is proved to be a promising material in the detection of various hazardous gases at the high temperature. However, gas adsorption-diffusion capacity at the room temperature is limited by their insufficient specific surface area and surface active sites. Herein, we report a strategy to synthesis of flower-like TiO 2 microspheres assembled by nanosheets and characterize the selective adsorption of NH 3 by using density functional theory (DFT). The as fabricated flower-like TiO 2 microspheres show an outstanding gas sensitivities (∼122 to 50 ppm NH 3) and high selectivity for NH 3 detection at room temperature. The higher adsorption energy and smaller adsorption distance of NH 3 on TiO 2 (001) indicate the much stronger interaction NH 3 -TiO 2 system. The present studies provide useful gas sensing materials with fine morphologies for the development of high-performance room temperature NH 3 sensors. [ABSTRACT FROM AUTHOR]

Cracked rocks are quite susceptible to dynamic loading from drilling, blasting, and impacting events. Understanding the dynamic response of cracked rocks under dynamic loadings is crucial for the assessment of rock structure stability. In this study, dynamic compression tests were carried out on rock specimens with multiple parallel cracks using a split Hopkinson pressure bar apparatus. Effects of strain rate and crack intensity on dynamic responses, including strength and deformation properties, progressive failure behavior, rock fragmentation characteristics, and energy dissipation of cracked rock specimens, were systematically investigated. Stress–strain curves migrate from class I curves into class II with increasing strain rate. Dynamic strength shows clear rate dependence while dynamic elastic modulus is independent of strain rate. Progressive failure behavior of cracked rock specimens under high loading rates was analyzed using high-speed photography and digital image correlation technique. Results show that the X-shaped shear failure mode is the final failure modes of all specimens, regardless of crack intensity. Fragmentation analysis indicates that increasing strain rate intensifies fragmentation, decreases mean fragment size, and increases fractal dimension of rock fragments. At low strain rates, specimens remain unbroken or slightly spilt; at high strain rates, specimens are systematically pulverized. Energy utilization efficiency decreases while energy dissipation density increases with increasing strain rate. For a given strain rate, crack intensity has no significant influences on energy dissipation and fragmentation characteristics of cracked rock specimens under dynamic loading. [ABSTRACT FROM AUTHOR]

Background: Diarrhea is a ubiquitous digestive system disease, leading to loss of fluid and electrolytes, and may be life-threatening, especially in children and adults who are immunosuppressed or malnourished. Berberine has a broad-spectrum antibiotic activity and is very widely used to treat diarrhea in China. No systematic review has been carried out to evaluate the evidence presented in clinical trials. The aim of this study was to assess the effectiveness and safety of berberine in diarrhea treatment among children and adults. Methods: Seven databases and two clinical trial registries were searched on 1 September 2019. Randomized controlled trials were included, where participants were diagnosed (first diagnosed) as having diarrhea according to clear diagnostic criteria. Berberine alone or in combination with Western medication as intervention were included. Subgroup analyses were conducted based on children or adults, acute or persistent diarrhea, infectious or noninfectious and treatment courses. Primary outcomes were clinical cure rate and duration of diarrhea. The GRADE tool was used to assess the quality of evidence. Results: A total of 38 randomized controlled trials were included involving 3948 participants (including 27 trials on 2702 children) were included. Compared with antibiotics, berberine plus antibiotics showed better results in both adults and in children in general, especially when given for 7 days or 3 days in acute infectious diarrhea of children. Compared with the control groups, using berberine alone or in combination with montmorillonite, probiotics, and vitamin B increased the clinical cure rate of diarrhea. The use of berberine alone or berberine combined with montmorillonite reduced the duration of hospitalization. Using berberine had significantly better laboratory indicators (isoenzyme, inflammatory factors, myocardial enzyme, and fecal trait) and fewer systemic symptoms than the no berberine groups. Overall, 22 of 27 trials on children used berberine as an enema. No deaths and serious adverse events were reported. The quality of evidence of included trials was moderate to low or very low. The impact of different dosages, frequencies and treatment durations on the outcomes was not evaluated due to insufficient number of trials. Conclusion: This review demonstrated that berberine was generally effective in improving clinical cure rates and shortening the duration of diarrhea compared with control groups. No severe adverse event was reported. However, there is still a lack of high-quality evidence for evaluating the efficacy and safety of berberine. Trial registration: PROSPERO CRD42020151001 (available from http://www.crd.york.ac.uk/PROSPERO/). [ABSTRACT FROM AUTHOR]

• An oblique impact method using inclined cylinder specimens is employed in a split Hopkinson pressure bar (SHPB) apparatus modified with an axial pressure chamber to achieve the compression-shear loading in a combined static-dynamic mode. • Numerical simulations using both the finite element method and the discrete element method are conducted to assess the validity of this compression-shear specimen and to establish a new data processing method. • Experimental results highlight the combined effects of the loading rate and the axial confinement on the failure strength, fracturing mode and deformation characteristics of sandstone. The compression-shear behavior and failure mechanism of rocks under combined static-dynamic loading are of essential importance for mechanical characterization and construction safety in deep underground engineering applications. An inclined cylinder specimen is designed using a split Hopkinson pressure bar (SHPB) apparatus modified with an axial pressure chamber for laboratory studies. Specific issues on the validity of this compression-shear specimen that were not addressed previously have been numerically assessed involving the dynamic equilibrium of force and moment, stress uniformity, and interfacial friction effects. Experiments are conducted at different loading rates ranging from 500 to 4000 GPa/s and under axial pressures of 7, 21, 35, 49, and 63 MPa. Experimental results verify the dynamic equilibrium of inclined specimens in the axially constrained SHPB tests using pulse shaping techniques, which validates the data processing method newly proposed. Both the dynamic strength and total strength linearly increase with the loading rate. With the increasing pre-load ratio (ratio of the axial confining load to the unconfined compression strength of the tested material), the dynamic strength decreases, while the total strength increases and then keeps constant, where the turning point of the pre-load ratio approximates 0.7. High-speed photographs at a high loading rate illustrate that the increasing confinement can result in less shear but more tensile cracks. Particularly at a high confining condition, the inclined specimen fails by a feather-like shear fracture band where tensile secondary cracks extensively develop. The equivalent stress-strain relationships indicate the reinforcing effect of the confinement on the deformation and energy dissipation. Image, graphical abstract [ABSTRACT FROM AUTHOR]

Objective: Hepatocellular carcinoma (HCC) has become a pressing health problem facing the world today due to its high morbidity, high mortality, and late discovery. As a diagnostic criteria of HCC, the exact threshold of Alpha-fetoprotein (AFP) is controversial. Therefore, this study was aimed to systematically estimate the performance of AFP in diagnosing HCC and to clarify its optimal threshold. Methods: Medline and Embase databases were searched for articles indexed up to November 2019. English language studies were included if both the sensitivity and specificity of AFP in the diagnosis of HCC were provided. The basic information and accuracy data included in the studies were extracted. Combined estimates for sensitivity and specificity were statistically analyzed by random-effects model using MetaDisc 1.4 and Stata 15.0 software at the prespecified threshold of 400 ng/mL, 200 ng/mL, and the range of 20–100 ng/mL. The optimal threshold was evaluated by the area under curve (AUC) of the summary receiver operating characteristic (SROC). Results: We retrieved 29,828 articles and included 59 studies and 1 review with a total of 11,731 HCC cases confirmed by histomorphology and 21,972 control cases without HCC. The included studies showed an overall judgment of at risk of bias. Four studies with AFP threshold of 400 ng/mL showed the summary sensitivity and specificity of 0.32 (95%CI 0.31–0.34) and 0.99 (95%CI 0.98–0.99), respectively. Four studies with AFP threshold of 200 ng/mL showed the summary sensitivity and specificity of 0.49 (95%CI 0.47–0.50) and 0.98 (95%CI 0.97–0.99), respectively. Forty-six studies with AFP threshold of 20–100 ng/mL showed the summary sensitivity and specificity of 0.61 (95%CI 0.60–0.62) and 0.86 (95%CI 0.86–0.87), respectively. The AUC of SROC and Q index of 400 ng/mL threshold were 0.9368 and 0.8734, respectively, which were significantly higher than those in 200 ng/mL threshold (0.9311 and 0.8664, respectively) and higher than those in 20–100 ng/mL threshold (0.8330 and 0.7654, respectively). Furthermore, similar result that favored 400 ng/mL were shown in the threshold in terms of AFP combined with ultrasound. Conclusion: AFP levels in serum showed good accuracy in HCC diagnosis, and the threshold of AFP with 400 ng/mL was better than that of 200 ng/mL in terms of sensitivity and specificity no matter AFP is used alone or combined with ultrasound. [ABSTRACT FROM AUTHOR]

Background: Diarrhea is a ubiquitous digestive system disease, leading to loss of fluid and electrolytes, and may be life-threatening, especially in children and adults who are immunosuppressed or malnourished. Berberine has a broad-spectrum antibiotic activity and is very widely used to treat diarrhea in China. No systematic review has been carried out to evaluate the evidence presented in clinical trials. The aim of this study was to assess the effectiveness and safety of berberine in diarrhea treatment among children and adults. Methods: Seven databases and two clinical trial registries were searched on 1 September 2019. Randomized controlled trials were included, where participants were diagnosed (first diagnosed) as having diarrhea according to clear diagnostic criteria. Berberine alone or in combination with Western medication as intervention were included. Subgroup analyses were conducted based on children or adults, acute or persistent diarrhea, infectious or noninfectious and treatment courses. Primary outcomes were clinical cure rate and duration of diarrhea. The GRADE tool was used to assess the quality of evidence. Results: A total of 38 randomized controlled trials were included involving 3948 participants (including 27 trials on 2702 children) were included. Compared with antibiotics, berberine plus antibiotics showed better results in both adults and in children in general, especially when given for 7 days or 3 days in acute infectious diarrhea of children. Compared with the control groups, using berberine alone or in combination with montmorillonite, probiotics, and vitamin B increased the clinical cure rate of diarrhea. The use of berberine alone or berberine combined with montmorillonite reduced the duration of hospitalization. Using berberine had significantly better laboratory indicators (isoenzyme, inflammatory factors, myocardial enzyme, and fecal trait) and fewer systemic symptoms than the no berberine groups. Overall, 22 of 27 trials on children used berberine as an enema. No deaths and serious adverse events were reported. The quality of evidence of included trials was moderate to low or very low. The impact of different dosages, frequencies and treatment durations on the outcomes was not evaluated due to insufficient number of trials. Conclusion: This review demonstrated that berberine was generally effective in improving clinical cure rates and shortening the duration of diarrhea compared with control groups. No severe adverse event was reported. However, there is still a lack of high-quality evidence for evaluating the efficacy and safety of berberine. Trial registration: PROSPERO CRD42020151001 (available from http://www.crd.york.ac.uk/PROSPERO/). [ABSTRACT FROM AUTHOR]

Introduction: Ovarian tumors are the most common diagnostic challenge for gynecologists and ultrasound examination has become the main technique for assessment of ovarian pathology and for preoperative distinction between malignant and benign ovarian tumors. However, ultrasonography is highly examiner-dependent and there may be an important variability between two different specialists when examining the same case. The objective of this work is the evaluation of different well-known Machine Learning (ML) systems to perform the automatic categorization of ovarian tumors from ultrasound images. Methods: We have used a real patient database whose input features have been extracted from 348 images, from the IOTA tumor images database, holding together with the class labels of the images. For each patient case and ultrasound image, its input features have been previously extracted using Fourier descriptors computed on the Region Of Interest (ROI). Then, four ML techniques are considered for performing the classification stage: K-Nearest Neighbors (KNN), Linear Discriminant (LD), Support Vector Machine (SVM) and Extreme Learning Machine (ELM). Results: According to our obtained results, the KNN classifier provides inaccurate predictions (less than 60% of accuracy) independently of the size of the local approximation, whereas the classifiers based on LD, SVM and ELM are robust in this biomedical classification (more than 85% of accuracy). Conclusions: ML methods can be efficiently used for developing the classification stage in computer-aided diagnosis systems of ovarian tumor from ultrasound images. These approaches are able to provide automatic classification with a high rate of accuracy. Future work should aim at enhancing the classifier design using ensemble techniques. Another ongoing work is to exploit different kind of features extracted from ultrasound images. [ABSTRACT FROM AUTHOR]

• In the early stage of cirrhosis, there seems to be a possibility of cirrhosis reversal. • The development of cirrhosis is related to the intestinal microbiota and activation of toll-like receptors (TLRs) pathways, which could regulate cell proliferation, apoptosis, expression of the hepatomitogen epiregulin, and liver inflammation. • In this paper, we first reviewed the dynamic change of intestinal microbiota and TLRs during cirrhosis progression. And further discussed the interaction between them and potential therapeutic targets to reverse early staged cirrhosis. • The interference of toll-like receptors (TLRs) and its intracellular signaling pathway can regulate the liver inflammatory response and cirrhosis process. • Drug treatment of intestinal dysbiosis and TLRs activation may slow cirrhosis progression. • With the further study of intestinal microbiota and TLRs on the progression of cirrhosis, it offers a new way of preventing and treating inflammatory response and fibrosis diseases. Cirrhosis is a progressive chronic liver disease caused by one or more causes and characterized by diffuse fibrosis, pseudolobules, and regenerated nodules. Once progression to hepatic decompensation, the function of the liver and other organs is impaired and almost impossible to reverse and recover, which often results in hospitalization, impaired quality of life, and high mortality. However, in the early stage of cirrhosis, there seems to be a possibility of cirrhosis reversal. The development of cirrhosis is related to the intestinal microbiota and activation of toll-like receptors (TLRs) pathways, which could regulate cell proliferation, apoptosis, expression of the hepatomitogen epiregulin, and liver inflammation. Targeting regulation of intestinal microbiota and TLRs pathways could affect the occurrence and development of cirrhosis and its complications. In this paper, we first reviewed the dynamic change of intestinal microbiota and TLRs during cirrhosis progression. And further discussed the interaction between them and potential therapeutic targets to reverse early staged cirrhosis. [ABSTRACT FROM AUTHOR]

Fast detection of triethylamine, one of the effective indicators to assess the freshness of fish and seafood, becomes more and more important for the food safety. Yet, the gas transport and diffuse activity are limited by the solid internal structure or the unsuitable pores size of the gas sensing materials, which results in the sluggish surface reaction kinetics. Herein, a strategy was reported to synthesis of hollow Co 3 O 4 microtubes assembled by vertically aligned nanosheets via sacrificial template of MgO combined with the following thermal annealing. The gas sensing results reveal that the hollow Co 3 O 4 -200 microtubes exhibit fast response-recovery time (13 s and 81 s) and outstanding gas selectivity, stability towards 200 ppm TEA at 180 ℃, which is ascribed to the large specific surface area, rich oxygen vacancies, and suitable pore size. This unique approach sheds light on the designing potential gas sensing candidates for the fast detection of TEA gas used as safety food monitoring and healthcare. • The hollow nanosheet-assembled Co3O4microtubes were synthesized via a simple sacrificial template strategy. • The fabricated Co3O4-200sensor displayed excellent TEA-sensing performance with fast response and recovery properties. • The large specific surface area and suitable pore size are the main reasons for the improved sensing properties. [ABSTRACT FROM AUTHOR]

• Stability criterion for underground cavern sidewall subject to flexural toppling is deduced. • A dynamic approach for analyzing the flexural-toppling of cavern sidewall is proposed. • Secondary stress field and failure process are considered in the evaluation. • Stresses of bedding planes are obtained via a new comprehensive approach. Flexural toppling is a crucial engineering issue for high sidewalls of underground powerhouse caverns in low stress regions, when a small angle between cavern axis and bedding planes is formed. In this study, a novel dynamic method is proposed for stability evaluation of a high sidewall subjected to flexural-toppling, by integrating our derived criterion, continuum modelling and microseismic (MS) data. First, by virtue of cantilever slab theory, a geo-mechanical model is defined for analysing the toppling rock strata exposed on the high sidewalls of underground caverns. The Rayleigh-Ritz method is then adopted to deduce the equation for potential energies of toppling rock strata. A criterion for assessing the stability of high sidewalls considering a secondary stress field can thus be derived from catastrophe theory. Subsequently, stresses acting on the bedding planes are numerically obtained by continuum modelling coupled with MS data. Finally, a quantitative stability evaluation methodology is presented for flexural-toppling in view of progressive failure, considering the influence of fractures along bedding planes. A practical case of flexural toppling failure is analysed to verify our proposed approach. Good agreements indicate that our proposed approach is reliable for quantitatively evaluating the stability of larger underground powerhouse caverns against flexural toppling. [ABSTRACT FROM AUTHOR]

• Rate-dependent cracking behaviors of single-flawed rock specimen under dynamic loading are numerically observed via DEM simulation. • Tensile wing cracks dominate specimen failure under low strain rate, while anti-wing cracks and shear cracks are prevalent under high strain rate. • Different initiation locations of tensile wing cracks are explained by stress filed visualization and theoretical analysis. • The initiation angles of tensile wing cracks are predicted via GMTS criteria, and the length of FPZ increases with increasing strain rate. This paper numerically investigated the rate-dependent progressive cracking behaviours of single-flawed rock specimens in split Hopkinson pressure bar (SHPB) tests. First, a 3D numerical SHPB system is established based on the discrete element method (DEM). By comparing with our laboratory experiments, micro-parameters of the DEM model are calibrated, which guarantees the reliability of the numerical simulations results. Via slice-cutting view, the inner and surface progressive cracking processes are explicitly revealed and compared, which compensates some defects in laboratory tests. Our numerical simulation results show that the progressive cracking behaviours of the single-flawed rock specimens exhibit evident rate dependence. Under low strain rates, tensile wing cracks dominate the entire cracking process, and only a few shear cracks appear during the post-peak stage. In contrast, under high strain rates, tensile wing racks are significantly suppressed, while anti-wing cracks and shear cracks are fully developed, leading to the final X-shaped failure modes. In addition, progressive cracking behaviours of the single-flawed rock specimens with different flaw inclination angles are assessed. Via stress field visualization and theoretical analysis, the different initiation locations of tensile wing cracks are explained. Furthermore, based on the generalized maximal tangential stress (GMTS) criteria, the fracture initiation angles of tensile wing cracks are predicted. The results show that the fracture initiation angles and the fracture process zone (FPZ) are significantly affected by the strain rate. The length of FPZ under dynamic loads is evidently longer than that under static loads, and the length of FPZ generally increases with an increasing strain rate, exhibiting evident rate dependence. [ABSTRACT FROM AUTHOR]

• Breast and thyroid cancers are the two common cancers to affect women worldwide. • Both of them share common genetic features affected by similar hormone families. • A generic deep learning model to classify breast and thyroid cancers in US images. • Achieved 86.7% sensitivity and 87.7% specificity in classifying thyroid nodules. • Achieved 88.57% sensitivity and 84.6% specificity in classifying breast lesions. • Our model learns features commonly shared by breast lesions and thyroid nodules. • Our model achieved comparable or higher accuracy than that of radiologists. Breast and thyroid cancers are the two common cancers to affect women worldwide. Ultrasonography (US) is a commonly used non-invasive imaging modality to detect breast and thyroid cancers, but its clinical diagnostic accuracy for these cancers is controversial. Both thyroid and breast cancers share some similar high frequency ultrasound characteristics such as taller-than-wide shape ratio, hypo-echogenicity, and ill-defined margins. This study aims to develop an automatic scheme for classifying thyroid and breast lesions in ultrasound images using deep convolutional neural networks (DCNN). In particular, we propose a generic DCNN architecture with transfer learning and the same architectural parameter settings to train models for thyroid and breast cancers (TNet and BNet) respectively, and test the viability of such a generic approach with ultrasound images collected from clinical practices. In addition, the potentials of the thyroid model in learning the common features and its performance of classifying both breast and thyroid lesions are investigated. A retrospective dataset of 719 thyroid and 672 breast images captured from US machines of different makes between October 2016 and December 2018 is used in this study. Test results show that both TNet and BNet built on the same DCNN architecture have achieved good classification results (86.5% average accuracy for TNet and 89% for BNet). Furthermore, we used TNet to classify breast lesions and the model achieves sensitivity of 86.6% and specificity of 87.1%, indicating its capability in learning features commonly shared by thyroid and breast lesions. We further tested the diagnostic performance of the TNet model against that of three radiologists. The area under curve (AUC) for thyroid nodule classification is 0.861 (95% CI: 0.792–0.929) for the TNet model and 0.757–0.854 (95% CI: 0.658–0.934) for the three radiologists. The AUC for breast cancer classification is 0.875 (95% CI: 0.804–0.947) for the TNet model and 0.698–0.777 (95% CI: 0.593–0.872) for the radiologists, indicating the model's potential in classifying both breast and thyroid cancers with a higher level of accuracy than that of radiologists. [ABSTRACT FROM AUTHOR]

• Numerical modeling was performed to study dynamic mixed mode I/II fracture behavior of rocks. • Different mixed mode loading conditions and various loading rates were considered. • Dynamic mixed mode fracture of the specimens was mainly induced by tensile damages at the micro scale. • Mixed mode fracture resistance of rocks showed loading rate dependence. • A semi-analytical criterion could predict well the dynamic mixed mode fracture of rocks. Research on rock fracture behavior is usually limited to static mixed mode I/II fracture and static or dynamic mode I fracture. In this study, the notched semi-circular bend (NSCB) specimens with different notch inclination angles were introduced into the split Hopkinson pressure bar (SHPB) system to numerically investigate dynamic mixed mode I/II fracture behavior of cracked rocks. First, the feasibility and reliability of our discrete-element-method-based numerical system to model dynamic fracture behavior of rock were validated; then, the effects of different mixed mode loading conditions and various loading rates on the mixed mode fracture of NSCB specimens were studied. The dynamic mixed mode fracture of the specimens was found to be mainly induced by tensile damages at the micro scale. The results also showed the loading rate dependence of the mixed mode fracture resistance. Moreover, for the same increment of the loading rate, the dynamic mode I fracture toughness increases more than the dynamic mode II fracture toughness. Subsequently, the fracture resistance and fracture initiation angles observed in the modeling were compared with the theoretical predictions based on some brittle fracture criteria. It was demonstrated that a semi-analytical criterion could reproduce well the dynamic mixed mode fracture behavior of rocks. [ABSTRACT FROM AUTHOR]