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Zhirong Wan,1 Xiaolei Liu,2 Hui Yang,3 Fang Li,2 Lingling Yu,4 Lei Li,5 Yulin Wang,6 Hao Jiang,7 Junjie Zou,8 Jichen Du1 1Department of Neurology, Aerospace Central Hospital, Beijing, 100049, People’s Republic of China; 2Chinese Traditional Regimen Exercise Intervention Research Center, Beijing Sport University, Beijing, 100084, People’s Republic of China; 3China Wushu Academy, Beijing Sport University, Beijing, 100084, People’s Republic of China; 4Physical Education School of Inner Mongolia Normal University, Hohhot, Inner Mongolia, People’s Republic of China; 5School of Physical Education, Lu Dong University, Shandong, 264011, People’s Republic of China; 6Division of Sports Science and Physical Education, Tsinghua University, Beijing, 100084, People’s Republic of China; 7School of Humanities and Social Science, The Chinese University of Hong Kong, Shenzhen, 518172, People’s Republic of China; 8Neurology Department, Yantai Penglai People’s Hospital, Yantai, 265600, People’s Republic of ChinaCorrespondence: Jichen DuDepartment of Neurology, Aerospace Central Hospital, No.15, Yuquan Road, Haidian District, Beijing, 100049, People’s Republic of ChinaTel +86-13801015089Email djc721@163.comPurpose: To measure motor function improvements in patients with Parkinson’s disease (PD) using Health Qigong exercises.Patients and Methods: Fifty-two PD patients (Hoehn and Yahr stages I to IV) were randomly divided into experimental and control groups. Twenty-six PD patients in the experimental group were intervened with routine medicine and fitness Qigong exercise. The other 26 PD patients as the control group were treated only with regular medication. Twelve-week intervention had been conducted for the study, and participants completed the scheduled exercises 4 times per week for 60 minutes each time. Data which included the one-legged blind balance, physical coordination

Peifu Wang, Jilai Li, Shi Qiu, Honfeng Wen, Jichen DuDepartment of Neurology, Aerospace Center Hospital, Peking University Aerospace Clinical College, Beijing, People’s Republic of ChinaBackground and purpose: Published data on the relationship of hormone replacement therapy (HRT) with Parkinson’s disease (PD) were inconclusive. Thus, a systematic meta-analysis of observational studies was performed to clarify this topic.Methods: The databases of PubMed and EMBASE were searched for case–control or cohort studies published up till June 2, 2014. Meta-analysis of the relative risks (RRs) with 95% confidence intervals (CIs) was estimated using random-effects models.Results: A final total of ten case–control and four cohort studies were included in our meta-analysis. The overall combined RR of PD for ever users versus never users of HRT was 1.00 (95% CI: 0.84–1.20). Limited to those subjects who only use estrogen, a similar trend was detected (RR: 0.95, 95% CI: 0.69–1.30). In the subgroup analysis by study design, no significant association was observed in case–control studies (RR: 0.79, 95% CI: 0.62–1.02), whereas a positive association was found in cohort studies (RR: 1.24, 95% CI: 1.10–1.40). In further analysis according to study quality, an inverse association was found in the low-quality group (RR: 0.58, 95% CI: 0.40–0.82), whereas a positive association was found in the high-quality group (RR: 1.16, 95% CI: 1.02–1.31).Conclusion: In summary, our results of meta-analysis do not support a protective role of HRT in female PD development.Keywords: Parkinson’s disease, hormone replacement therapy, hormone meta-analysis