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This study introduces a hybrid control structure called Improved Interfered Fluid Dynamic System Nonlinear Model Predictive Control (IIFDS-NMPC) for the path planning and trajectory tracking of autonomous underwater vehicles (AUVs). The system consists of two layers; the upper layer utilizes the Improved Interfered Fluid Dynamic System (IIFDS) for path planning, while the lower layer employs Nonlinear Model Predictive Control (NMPC) for trajectory tracking. Extensive simulation experiments are conducted to determine optimal parameters for both static and dynamic obstacle scenarios. Additionally, real-world testing is performed using the BlueRov2 platform, incorporating multiple dynamic and static obstacles. The proposed approach achieves real-time control at a frequency of 100 Hz and exhibits impressive path tracking accuracy, with a root mean square (RMS) of 0.02 m. This research provides a valuable framework for navigation and control in practical applications. [ABSTRACT FROM AUTHOR]

Sirtuin 6 (SIRT6) is an NAD + -dependent deacetylase belonging to the sirtuin family. It has been shown to participate in wound healing and some inflammation-related disorders. However, the effect of MDL-800, a highly efficient and selective SIRT6 activator, on wound healing and inflammation has not been reported. Therefore, this study investigated whether MDL-800 confers anti-inflammatory effects and promotes wound healing and uncovered the molecular mechanisms involved. This was achieved using mouse models of full-thickness wounds. Results showed that MDL-800 significantly downregulated inflammation by attenuating the release of inflammatory mediators and improved collagen deposition and neovascularization of wounds, thereby accelerating cutaneous wound healing. Furthermore, MDL-800 significantly downregulated expression levels of TNF- α and IL-6 in the dorsal skin tissue of mice via the NF- κ B pathway. These results demonstrated that MDL-800 exerted anti-inflammatory and prohealing effects, indicating that the SIRT6/NF- κ B/I κ B signaling pathway may play an important role in wound healing., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Xiaoqi Jiang et al.)

Objective: To search for an excellent therapy for patients with large-angle exotropia., Methods: Strabotomy was performed on the master eyes in the 41 cases (master eye group) and slave eyes in the other 41 cases (slave eye group) with large-angle exotropia (>/= 60(Delta)). The post-operative visual acuity, ocular position, visual function and fixation, the average surgical amount and the frequency of strabotomy were statistically compared between the two groups., Results: Post-operatively, orthophoria occurred in 39 cases and mild exotropia remained in 2 cases in each group. The statistic analyses showed that the surgical results were better in the master eye group in the visual acuity (P < 0.05), visual function (P < 0.05), average surgical amount and frequency (P < 0.01)., Conclusions: The surgical results of strabotomy performed on the master eye in cases with large-angle exotropia are better than that on the slave eye, and the surgical damage in the master eye is less. Thus, the master eye strabotomy is especially suitable for children with large-angle exotropia under general anesthesia.