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Objective To investigate the effects of citicoline sodium and Ureicrin on the expression of miR- 17-5p and miR-29b in patients with ischemic stroke. Methods A total of 100 patients with ischemic stroke treated in the hospital were divided into control group and combination group by random table method. From February 2023 to February 2024, they were respectively given Eurecrine monotherapy and citicoline sodium and eurecrine combination therapy. Cerebral blood perfusion indexes, inflammatory factors, oxidative stress, miR-17-5p, miR- 29b levels and clinical efficacy were detected in the two groups, and adverse reactions were statistically recorded. Results There was no significant difference in CBF, CBV, hs-CRP, miR-29b, IL-6, TNF-α and miR-17-5p between the two groups before treatment (P > 0.05). After treatment, the levels of CBF, CBV, miR-29b, SOD and GSH-Px increased, while the levels of hs-CRP, IL-6, TNF-α, miR-17-5p and MDA decreased, and the levels of CBF, CBV, miR-29b, SOD and GSH-Px in the combined group were higher than those in the control group. The levels of hs-CRP, TNF-α, IL-6, miR-17-5p and MDA were significantly different from those of the control group (P < 0.05). The incidence of adverse reactions and the total effective rate of treatment in combination group were higher than those in control group (P < 0.05), and the adverse reactions were mild and tolerable. Conclusion The combination of citicoline sodium and Ureicrin can improve the clinical efficacy and prognosis of patients. [ABSTRACT FROM AUTHOR]

An experiment relating chemical reactions involving halomethylenecyclobutanes was conducted to establish the effects the nature of the halogen exerts on the mechanistic course of the rearrangement of halomethyenecyclobutanes to 1-halocyclopentenes. The study also aimed to discover whether or not fluorines placed beta to the negative charge facilitate the rearrangement process in this particular reaction. Results of the experiment are discussed.

Background: Hainan Island, located in the South China Sea and separated from the Leizhou Peninsula by Qiongzhou Strait, is the second largest island after Taiwan in China. With the expansion of Han Chinese and the gradual formation of "South Hlai and North Han", nowadays, Hainan Hlai is the second largest population after Han Chinese in Hainan Island. Ha Hlai, distributed in southwest and southern Hainan Island, is the dominant branch of Hlai and speaks Ha localism. Methods: We utilized the Huaxia™ Platinum PCR Amplification System (including 23 autosomal STRs and 2 sex‐linked markers) to obtain the first STR profiling batch of 657 Ha Hlai individuals (497 males and 160 females). In order to explore the genetic relationships between the studied Ha Hlai and other reference populations with different language families, population genetic analyses, including PCA, MDS, STRUCTURE, and phylogenetic analysis, were conducted based upon the raw data and allelic frequencies of the polymorphic autosomal STR markers. Results: In total, 271 distinct alleles were observed at the 23 STR loci. The number of diverse alleles ranged from 7 at TPOX locus to 23 at FGA locus, and the allelic frequencies varied from 0.0008 to 0.5533. In addition, the CPE and CPD were 1‐7.39 × 10−10 and 1‐3.13 × 10−28, respectively. The phylogenetic analyses indicated that Ha Hlai is a Tai‐Kadai language‐speaking and relatively isolated population which has a close genetic and geographical relationship with Hainan Hlai, and M95 is the dominant haplogroup in Ha Hlai (56.18%). Conclusion: The 23 autosomal STR genetic markers were highly polymorphic as well as potentially useful for forensic applications in Hainan Ha Hlai population. The phylogenetic analyses demonstrated that small geographic scale gene flows could not be ignored and the shaping of the unique gene pool for each population was the combination effects of geographic, language, and cultural isolations. [ABSTRACT FROM AUTHOR]

Background: Hainan Island, located in the South China Sea and separated from the Leizhou Peninsula by Qiongzhou Strait, is the second largest island after Taiwan in China. With the expansion of Han Chinese and the gradual formation of "South Hlai and North Han", nowadays, Hainan Hlai is the second largest population after Han Chinese in Hainan Island. Ha Hlai, distributed in southwest and southern Hainan Island, is the dominant branch of Hlai and speaks Ha localism., Methods: We utilized the Huaxia ™ Platinum PCR Amplification System (including 23 autosomal STRs and 2 sex-linked markers) to obtain the first STR profiling batch of 657 Ha Hlai individuals (497 males and 160 females). In order to explore the genetic relationships between the studied Ha Hlai and other reference populations with different language families, population genetic analyses, including PCA, MDS, STRUCTURE, and phylogenetic analysis, were conducted based upon the raw data and allelic frequencies of the polymorphic autosomal STR markers., Results: In total, 271 distinct alleles were observed at the 23 STR loci. The number of diverse alleles ranged from 7 at TPOX locus to 23 at FGA locus, and the allelic frequencies varied from 0.0008 to 0.5533. In addition, the CPE and CPD were 1-7.39 × 10 -10 and 1-3.13 × 10 -28 , respectively. The phylogenetic analyses indicated that Ha Hlai is a Tai-Kadai language-speaking and relatively isolated population which has a close genetic and geographical relationship with Hainan Hlai, and M95 is the dominant haplogroup in Ha Hlai (56.18%)., Conclusion: The 23 autosomal STR genetic markers were highly polymorphic as well as potentially useful for forensic applications in Hainan Ha Hlai population. The phylogenetic analyses demonstrated that small geographic scale gene flows could not be ignored and the shaping of the unique gene pool for each population was the combination effects of geographic, language, and cultural isolations., (© 2020 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC.)